Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

Fabulous supervisors include @pdchristine.bsky.social @yiliangding.bsky.social @pierrebuscaill.bsky.social caill.bsky.social @morganlab.bsky.social and many more.... Webinar on Dec 10th - details in ads. Deadline Jan 19th. (UK students only unfortunately)

🌱🚨 Funded PhD for UK students 🇬🇧🌿 Take a look at this Plant BioDesign Doctoral Training Program. Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre. www.findaphd.com/phds/project...

Paper alert! We have created a bacterium that eats plastic! We named it PETBuster! Great work by PhD student Dekel Freund @dekel-freund.bsky.social. www.biorxiv.org/content/10.1...

The cold water tintinnid ciliate Parafavella elegans & some diatoms from the Chukchi Sea last summer- almost the end of the Arctic samples....

New carboxylases (and new pathway reactions) expand the possibilities for alternative carbon fixation cycles. Amazing work from the Claassens lab!! (Vittorio in particular, this is a huge body of work). This changes my assumptions around what can be expected from future new cycles. ♻️

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Rubisco is slow across the tree of life @omc111.bsky.social www.pnas.org/doi/10.1073/...

Our latest pre-print on TE-mediated tandem duplication of the ToxB effector is now online...still a puzzle for us but we think it is in a Helitron! Together with amazing collaborators, Reem Aboukhaddour and Ryan Gourlie #TE #fungi www.biorxiv.org/content/10.1...

Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/... Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social

We are delighted that our Alkis Seraphim Memorial Lecturer for 2025 is Prof Ben Lehner speaking on 'Mapping the energetic and allosteric structures of proteins at scale' on 4 December at 4.30pm in the Babbage Lecture Theatre. Further details and book here: www.eventbrite.com/e/alkis-sera...

excited to see this one with @leahtaylorkearney.bsky.social @prywes.bsky.social et al. out, bringing a truly interdisciplinary (comparative genomics/phylogeny + biochemistry) lens to our favorite enzyme rubisco

🔥🔥🔥 Friday Evening, Paper Out, Feierabend 🔥🔥🔥 When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy. doi.org/10.1016/j.ym...

Here are some “leaf” or phyllid cells from moss Physcomitrium patens gametophore. Cells are expressing a green fluorescence marker that labels the vacuolar membrane. Chloroplasts' autofluorescence is in magenta. Can you spot dividing chloroplasts? #microscopymonday #moss #plantcells

Applications are open for a fully funded PhD studentship: "Matchmaker: Prioritising the best cell line for expressing target proteins using CRISPR and machine learning" at @cambiochem.bsky.social and AZ. ⏳ Closing date: 31 October 2025 📆 Start date: 1 October 2026 🔗 www.cam.ac.uk/jobs/astraze...

Another #PhD project available for applications in #photosynthesis with @ecarmosilva.bsky.social @sci-tech-lancaster.bsky.social looking at ways to improve Rubisco. Details below including how the successful nominee will play a direct role in shaping the project proposal tinyurl.com/2a8szv3y

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here: www.nature.com/articles/s41...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

New Paper Alert! “The diversity of PET-degrading enzymes: A review”. We present a database of PET-plastic hydrolases, including sequence, structure, and function. From this, we discuss the distribution, efficiency, stability, and potential for biodegradation of PETases.

I am thrilled to announce that I just opened my lab at New York University in @nyucns.bsky.social and Biology! Our work will explore the richness of animal behavior, dissecting the genetic and circuit mechanisms that shape its evolution.

We are hiring! The #PlantBio department at UIUC is looking to recruit an Assistant Professor in Plant-Fungal interactions. Application deadline is October 31st @dallingjim.bsky.social see the link below for more details: illinois.csod.com/ux/ats/caree...

Applications are invited for our Independent Research Fellowship scheme to support early career scientists in establishing their own research groups. The deadline is 24 October 2025 and further details of how to apply are here: www.bioc.cam.ac.uk/research/ind...

Professor Susanne von Caemmerer FRS and Professor Graham Douglas Farquhar FRS are jointly awarded the Royal Medal (Biological) 2025 for refining the ways we monitor and model photosynthesis in leaves from molecular to global scales. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/

Excited to share our new preprint co-led by @jnoms.bsky.social! Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

!!! Yes!

I love this diagram

The first paper from my PhD is out now! doi.org/10.1111/jeu.... We describe a new photosynthetic #Paulinella species from a brackish beach in British Columbia 🇨🇦 Big thanks to the co-authors Maia Palka and @alive-in-the-ocean.bsky.social, and my supervisor @fburki.bsky.social #protistsonsky

You can't let those macroeconomic headwinds tell you how to live your life

🚨 We’re hiring! The Burlacot Lab @carnegiescience.bsky.social is recruiting a Postdoc to study how photosynthetic electron flows power CO₂ fixation in algae 🌱🧫 Cutting-edge microscopy + biophysics + sustainability 🚀 Apply: apply.interfolio.com/171656

Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...

Congrats to our savage lab undergrads on their research and presentations in our inaugural undergrad research symposium 🎉🥳

Honored to be among this amazing group and be recognized for the early career research award in memory of Günter Blobel

New from our lab in @narjournal.bsky.social: We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution. doi.org/10.1093/nar/... 1/5

Untangling phage immunity systems can be really challenging but @owentuck.bsky.social and team used phylogeny and biochemistry beautifully to show how a pair of genes got repurposed as a component in multiple defence systems.

Escherichia coli selection strains for growth-coupled metabolic engineering @cp-trendsbiotech.bsky.social Review by @helenasm.bsky.social, @beaubd.bsky.social, and Tobias Erb at @mpimicrobiomarburg.bsky.social www.cell.com/trends/biote...

Nice work showing it is possible to engineer increased oxygen tolerance of fast rubiscos using in vivo directed evolution via @pnas.org doi.org/10.1073/pnas...

SynBio: it’s what plants crave doi.org/10.1093/jxb/... J Exp Bot Insights article from *Dan Hong Loh* - she discusses the impacts of Rubisco SynBio tool expansions from Archer et al. 2025 (doi.org/10.1093/jxb/...).

Muqarnas are the "Oops, only spandrels" of cathedral ceilings. #gould #levontin #sanmarco #Pangloss #adaptationist #evolution #mosques #architecture #pendentive #squinch #persia #capncrunch #iwan #mihrab #corbel #stalactite #honeycomb en.wikipedia.org/wiki/Muqarna...

Exciting new work from Sattely lab with collaborator @pollyfordyce.bsky.social and coworkers @stanford-chemh.bsky.social, solving they biosynthesis of taxol! www.nature.com/articles/s41...

🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

This alphabet has 20 letters, and therefore integrates well with existing tree inference software (to which a 3di alignment looks like a regular old protein alignment). This means we can use this to infer trees.

6/10 dCas12f-Sigma factors are able to recruit their native RNA polymerase (RNAP) to drive RNA-guided transcription at programmable sites. Remarkably, we were able to generate RNA (see RNA-seq) without relying on promoters in intergenic sequences, even within genes, and on either DNA strand.

Check out our pre-print on ProteinGuide, a new method for conditioning protein generative models on experimental data! Thanks to the amazing team: @junhaobearxiong.bsky.social, @hnisonoff.bsky.social, Ishan, Luke, @jlistgarten.bsky.social and @davesavage.bsky.social! @savagecatsonly.bsky.social

Carbon-Efficient Conversion through Hydrogen and Formate-Driven Metabolism in Escherichia coli https://www.biorxiv.org/content/10.1101/2025.05.30.657096v1

A blast from the past! The Gonzalez Group, circa 2008, celebrating our first publication! Check out much, much younger versions of, from left to right, Pallav Kosuri, yours truly, Sam Sternberg, Mike Englander, @jingyifei.bsky.social, Daniel MacDougall, Margaret Elvekrog, and Subasree Das!

A novel CCM? Interesting! www.biorxiv.org/content/10.1...

The W-S lab is seeking to hire a research scientist! This person will lead wet-lab innovations in our team as we combine AI and experiments to understand and design dynamics! Thanks for sharing/RTs! jobs.wisc.edu/jobs/scienti...

Chemists Stuart Schreiber of Harvard University and Arena BioWorks and Peter Schultz of @scripps.edu will split the 2025 Welch Award in Chemistry for their work in the field of chemical biology. cen.acs.org/people/award... #chemsky🧪

Flowers unfold with surprising precision, despite unruly genes news.cornell.edu/stories/2025... Nice article in the Cornell Chronicle about our @natcomms.nature.com article rdcu.be/emNVQ @cornellcals.bsky.social