A microbial growth-coupled platform for in vivo interrogation of Rubisco oxygenase activity www.biorxiv.org/content/10.6...

Join our HFSP team on this amazing project! This will be an experimental postdoc position based in Amsterdam. There will be a more bioinformatic/evolutionary postdoc position based in Cambridge coming up soon. #socialfluids

There are three different size systems (mini, midi, super) to cope with different scales, up to about a kilogram of fresh weight of liverwort per tray for the super size. Can take plants through the entire life cycle - great for plant spore production.

Form I and II Rubiscos Exhibit Temperature Dependent Carbon Kinetic Isotope Effects https://www.biorxiv.org/content/10.64898/2026.06.29.735352v1

Congratulations to Iva Tchasovnikarova who has been awarded the Lister Prize from @thelisterinstitute.bsky.social to expand her work on fundamental epigenetic pathways. Read more about Iva's research group and the Lister Prize: www.bioc.cam.ac.uk/news/iva-tch... #ListerPrize2026 #GurdonInstitute

Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth @utokyo-yamori.bsky.social ! www.nature.com/articles/s41...

Wow! Incredible work especially working in nitrogen fixing bacteria!

Congratulations to @claudiabonfio.bsky.social on her Harrison-Meldola Early Career Prize from @rsc.org for developing biophysical and supramolecular approaches to understand the origins and evolution of primitive cells. Read more about the prize and her lab: www.bioc.cam.ac.uk/news/claudia...

A bifunctional coiled-coil protein generates the membrane-within-condensate architecture of the CO2-fixing pyrenoid @mjonikas.bsky.social lab www.biorxiv.org/content/10.6...

Excited to release #OpenSplice - the impact of >500,000 mutations on the alternative splicing of 600 human exons www.biorxiv.org/content/10.6... Led by @gioia-quarantani.bsky.social + funded by @opentargets.org ‬ @sangerinstitute.bsky.social @crg.eu #cshlsymp26 #RNA2026 @rnasociety.bsky.social

Partitioning of Rubisco activase into the pyrenoidal Rubisco condensate is mediated by a functional protein-protein interaction "https://doi.org/10.1038/s41467-026-70724-5" www.nature.com/articles/s41...

7/8 The full mechanistic model 🏛️: every step gated, every checkpoint structural. A complete blueprint for engineering better gene insertion tools. 🛠️

1/23 New preprint! Been thinking about the origin of cellular life. Specifically, how protocells (or *any* compartments) just aren't enough to support the evolution of increasingly complex cells. You gotta de-Darwinize the parts! The ribosome/genome do this. www.biorxiv.org/content/10.6...

🥳 @savagecatsonly.bsky.social

With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...

A de novo CO2 Reductase Featuring a Cysteine-Ligated Cobalt Porphyrin Cofactor https://www.biorxiv.org/content/10.64898/2026.05.07.723500v1

in vivo mutagenesis technique development continues to heat up, congrats to Max, @erika-alden.bsky.social and the whole team!

Structural Insights into the Coupling Mechanism of Vectorial CO2 Uptake by DAB1 https://www.biorxiv.org/content/10.64898/2026.05.01.722082v1

Hornwort pyrenoids: a terrestrial exception with engineering lessons. @tarobison.bsky.social @fernway.bsky.social @laura-gunn.bsky.social @jcarlosvillarreal.bsky.social academic.oup.com/plphys/advan...

This #EarthDay we're featuring Rockefeller's @flamholz.bsky.social#EarthDay who studies how microbes contribute to #climatechange and how they could offer solutions to this problem via their metabolisms.

We are recruiting a postdoc interested in using machine learning and AI to understand and control post-transcriptional gene regulation. Please apply and join us at @cambiochem.bsky.social ⏳ Closing date: 16 May 2026 🔗 www.jobs.cam.ac.uk/job/55254 Learn more about us: www.sblab.uk

bbc.com/audio/brand/... Now free for all archaea lovers to hear!

New paper where we report that Npc2 - a shuttle-like lipid transfer protein - in yeast directly transports sphingolipids to the = vacuole membrane during formation of microautophagy-linked ordered domains #lipidtime www.sciencedirect.com/science/arti...

Out recently in @natbiotech.nature.com — first authors @ddingding.bsky.social and @evangroover.bsky.social premier a cell-based method for understanding how #photosynthesis genes can be turned "up" or "down". Read here: ow.ly/KHWg50YyWbR

📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.

Excited to see the major chapter of my PhD in print! We present a massively-parallel approach for screening CRISPR edits in plants to speed up agricultural test cycles + benchmark genomic LMs. Thanks to my fantastic co-authors and advisors. Link below!

Can CRISPR edits enable precise tuning of plant gene expression? We think: yes. In our newest manuscript, we measured the effects of >30,000 CRISPR-like promoter mutations in sorghum protoplasts.

We have been cooking up this story for a while and we are excited to finally be able to share! Read on if you're interested in whole plant regeneration WITHOUT the application of hormones!

Out today in Nature Biotechnology — a team of IGI scientists including Brian Staskwicz, Kris Nyogi, Dave Savage (Savage Lab), Peggy Lemaux, & first author Evan Groover premier a cell-based method for understanding how #photosynthesis genes can be turned "up" or "down" https://ow.ly/KHWg50YyWbR

Expansion microscopy of a loricate choanoflagellate, generated by Mylan Ansel in our lab 🤩 (yes, the lorica expands. No, we don't understand how either)

Archaea hit prime time: www.bbc.co.uk/programmes/m...

"My motto is: just do it!" We love this interview w/ Maren Nattermann, Research Group Leader @ Max Planck Institute for Terrestrial Microbiology, on Marjory Stephenson (1885–1948), pioneer of chemical microbiology as well as her own path into science www.mpg.de/26210626/mar... #IWD2026

Do you like it when weird organisms do silly things?? Then you're going to love this!

Our work on #hornwort #pyrenoids is finally out in @science.org! 🎉 We uncovered how hornworts pack their Rubisco into pyrenoids and successfully recreated them in Arabidopsis. A key step toward engineering more efficient photosynthesis in crops @btiscience.bsky.social www.science.org/doi/10.1126/...

Job opportunity! Research Assistant / Research Associate An opportunity to join our team working on the generation of a completely engineered chloroplast genome (= synplastome). Apply by Thursday 02 April 2026: www.jobs.cam.ac.uk/job/54695/

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

Iron-only Fe-nitrogenase underscores common catalytic principles in biological nitrogen fixation www.nature.com/articles/s41...

We are recruiting for a postdoc with a background in cell biology and an interest in infection research to join the @camillagodlee.bsky.social Lab to study how Salmonella remodels host membrane dynamics. Apply here by 24 Feb: www.cam.ac.uk/jobs/researc...

Working on an “origin of animals” review paper with @thibautbrunet.bsky.social and Nicole King in Paris. Andy Knoll is joining us on Zoom from chilly Boston!

Nature research paper: Construction of complex and diverse DNA sequences using DNA three-way junctions go.nature.com/4qu2ExZ

Read more in the new article by @hannahritchie.bsky.social and @pablorosado.com: ourworldindata.org/biofuel-land...

New paper from the Hanson lab - KO of all 11 rbcS genes (!!) in tobacco to create a null line for rubisco engineering, plus resurrection of ancestral forms www.pnas.org/doi/10.1073/...

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

Fabulous supervisors include @pdchristine.bsky.social @yiliangding.bsky.social @pierrebuscaill.bsky.social caill.bsky.social @morganlab.bsky.social and many more.... Webinar on Dec 10th - details in ads. Deadline Jan 19th. (UK students only unfortunately)

🌱🚨 Funded PhD for UK students 🇬🇧🌿 Take a look at this Plant BioDesign Doctoral Training Program. Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre. www.findaphd.com/phds/project...

Paper alert! We have created a bacterium that eats plastic! We named it PETBuster! Great work by PhD student Dekel Freund @dekel-freund.bsky.social. www.biorxiv.org/content/10.1...

The cold water tintinnid ciliate Parafavella elegans & some diatoms from the Chukchi Sea last summer- almost the end of the Arctic samples....

New carboxylases (and new pathway reactions) expand the possibilities for alternative carbon fixation cycles. Amazing work from the Claassens lab!! (Vittorio in particular, this is a huge body of work). This changes my assumptions around what can be expected from future new cycles. ♻️

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Rubisco is slow across the tree of life @omc111.bsky.social www.pnas.org/doi/10.1073/...