Oliver Mueller-Cajar
@omc111.bsky.social
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Cellular biochemistry of CO2 assimilation, NTU Singapore
reposted by
Oliver Mueller-Cajar
Martin Jonikas
14 days ago
We genetically disconnected starch from the matrix in the algal pyrenoid! A saga1;saga2 double mutant lacks a starch sheath! Our model: SAGA1 & SAGA2 locally initiate starch on the pyrenoid surface by enriching starch precursors. 🌞🦠🔬🔌👀
www.biorxiv.org/content/10.6..
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Oliver Mueller-Cajar
James Barrett
16 days ago
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com
@phaips.vd.st
@biologyatyork.bsky.social
#Rubisco
#PhaseSeparation
#Condensates
#Pyrenoid
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Sign up for the inaugural Singapore Biosciences Symposium at SBS, NTU. We have an outstanding lineup of speakers at the intersection of plant biology and biomolecular condensates!
www.ntu.edu.sg/sbs/symposiu...
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SBS 2025
https://www.ntu.edu.sg/sbs/symposium/sbs-2025
5 months ago
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reposted by
Oliver Mueller-Cajar
Savage Lab
about 1 year ago
What limits rubisco function? Is it the chemical mechanism? Evolution? In this paper,
@prywes.bsky.social
et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7)
doi.org/10.1038/s415...
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Noam presents the most state of the art Rubisco search engine.. great to see this out!
add a skeleton here at some point
about 1 year ago
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Wow, chloroplast base editing leads to faster Rubisco and more biomass in Arabidopsis!
www.biorxiv.org/content/10.1...
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Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth
Photosynthetic inefficiencies limit the productivity and sustainability of crop production and the resilience of agriculture to future societal and environmental challenges. Ribulose-1,5-bisphosphate ...
https://www.biorxiv.org/content/10.1101/2025.01.02.631008v1
about 1 year ago
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Oliver Mueller-Cajar
Owen Atkin
about 1 year ago
A great way to end the week - catching up with
@omc111.bsky.social
and Shawn Lum to discuss links between ANU and NTU, and ideas for how to extend thermal tolerance of photosynthesis. @ouranu.bsky.social
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Oliver Mueller-Cajar
Ben Engel
about 1 year ago
Beautiful study by Martin, Alistair, and crew on the membrane tubules that traverse the Chlamydomonas pyrenoid and help deliver a high concentration of
#CO2
to Rubisco 🧪🌾
add a skeleton here at some point
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reposted by
Oliver Mueller-Cajar
Nature Plants
over 1 year ago
New Letter: "Rubisco supplies pyruvate for the 2-C-methyl-d-erythritol-4-phosphate pathway"
rdcu.be/dVZMj
Rubisco fixes CO2. Its lesser-known side job is supplying pyruvate in the chloroplast, an observation that solves a long-standing paradox of central metabolism.
#PlantScience
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Oliver Mueller-Cajar
Gustaf Degen
about 1 year ago
go.bsky.app/ErhhGGU
add a skeleton here at some point
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Oliver Mueller-Cajar
Itai Yanai
over 1 year ago
Doing good science is 90% finding a science buddy to constantly talk to about the project.
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Oliver Mueller-Cajar
Alex Holehouse
over 1 year ago
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
add a skeleton here at some point
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reposted by
Oliver Mueller-Cajar
David Kuster
about 1 year ago
Biomolecular condensate starter pack! Trying to compile & to bring together biomolecular condensate enthusiasts & critics! Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates
,
#phaseseparation
,
#granules
,
#IDPs
go.bsky.app/NFqmffa
add a skeleton here at some point
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Oliver Mueller-Cajar
Chenxin Li, PhD
about 1 year ago
I have a YouTube playlist (10 videos) for
#MolecularBiology
for my undergrad interns in the lab.
www.youtube.com/playlist?lis...
I usually have my interns watch these videos to get introduced to the basic concepts before I go show them how to in the lab.
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Nice, would be interesting to see whether RbcL is identical between clones or has diffused in sequence space given massive changes in CO2 concentration since the seed germinated..
add a skeleton here at some point
about 1 year ago
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Oliver Mueller-Cajar
Seth Abramson
about 1 year ago
I learned some stuff about Bluesky I did not know by reading this. Maybe worth passing it on to others so we can all start getting the full benefit of the 🦋.
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Here’s some cool stuff you can do with Bluesky
It’s not just an Alf pics repository.
https://www.theverge.com/24295933/bluesky-social-network-custom-how-to
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reposted by
Oliver Mueller-Cajar
Marc Somssich
over 1 year ago
Yup, the Plant Science Starter Pack has been doing an amazing job. 👌
go.bsky.app/8Zfmwf7
add a skeleton here at some point
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Oliver Mueller-Cajar
Mike Haydon 🌱 🌾 🧬 ⏰
about 1 year ago
Here is a starter to a starter pack for the Aus plant science community. Let’s rebuild.
#plantscience
Let me know if you want to be added. Help me find more.
go.bsky.app/AiLTKHH
add a skeleton here at some point
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reposted by
Oliver Mueller-Cajar
Razvan Borza
about 1 year ago
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1:
bsky.app/starter-pack...
Structural Biology 2:
bsky.app/starter-pack...
Crystallography:
bsky.app/starter-pack...
Synchrotron&CryoEM:
bsky.app/starter-pack...
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I have a PhD scholarship available for a student to join my group at NTU Singapore in the January 2025 intake. The student will work on a project related to the cellular biochemistry of the diatom pyrenoid. Here is our first paper on the topic:
www.pnas.org/doi/abs/10.1...
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A linker protein from a red-type pyrenoid phase separates with Rubisco via oligomerizing sticker motifs | PNAS
The slow kinetics and poor substrate specificity of the key photosynthetic CO2-fixing enzyme Rubisco have prompted the repeated evolution of Rubisc...
https://www.pnas.org/doi/abs/10.1073/pnas.2304833120
over 1 year ago
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I love the periodic articles about chilly weather in Singapore. Some days we will have to deal with 23 degrees Celsius..
about 2 years ago
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you reached the end!!
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