I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia! pubs.rsc.org/en/content/a...

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09... #KeioMedicalSciencePrize

Frog drank the tea, and then he said, “Tell me a story while I am resting.”

September 21 is #WorldAlzheimersDay Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.

Kinetic organization of the genome revealed by ultraresolution multiscale live imaging www.science.org/doi/10.1126/...

Chuffed to be recognized with an Early Career Award for work on the chromatin-nucleated phase separation of BRD4. ✨ Give it a read! www.molbiolcell.org/doi/full/10.... Shout-out @drjorine.bsky.social @brangwynnelab.bsky.social And huge thank you @ascbiology.bsky.social

Congratulations to the Fritz Lipmann Lecturer Michael Rosen (Dallas) by the GBM president Harald Kolmar.

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

In another exciting development our new preprint is online: www.biorxiv.org/cgi/content/... This is the work of my brilliant graduate student Katerina Kourkoulou in collaboration with Maggie Liu and Arnold Mathijssen. Here is a video of the subject of our study:

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

Paper alert!🧪 We derive a theory that underpins interface resistance with a physical foundation and look at how it changes droplet growth and recovery kinetics! Awesome collab with @bosste.bsky.social Tyler Harmon @hymanlab.bsky.social @m-pol.bsky.social and Frank Jülicher @mpipks.bsky.social 1/4

Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

What a pleasure to collaborate with Laura #Schaedel and her team at @uni-saarland.de to study #microtubule damage and repair under mechanical load.

Thanks a lot to @elisecutts.bsky.social for nicely highlighting and putting in context our article! It was very interesting to discuss together, notably about the analogies between the emergence of order in Hydra and other physical phenomena.

Our Autumn PhD call is OPEN! 20+ fully funded positions across diverse life science disciplines. Explore projects in Cell & Chromosome biology + more 👉 www.vbcphd.at Apply by 10 Oct 2025

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Damn, if only someone had predicted this. www.ft.com/content/9a8a...

Excited to share that my paper on Tau–Microtubule interactions is now published in Nature Physics!🎉 Our work shows that tau goes beyond stabilizing microtubules—it also promotes the removal of defects in the microtubule lattice. www.nature.com/articles/s41...

Please re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September

For a lay summary in English or German: www.mpi-cbg.de/news-outreac...

Congratulations to Patrick and his team! Tremendous work carried out over the last years @mpi-cbg.de and @poldresden.bsky.social as collaboration between Hyman lab, Brugues lab and Andrei Shevchenko

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA. www.cell.com/cell/fulltex...

The papers have been improved by reviewers @amartinezarias.bsky.social, @thibautbrunet.bsky.social & Cassandra Extavour. Thibaut synthesized the work beautifully in the #News_and_Views. None of that can happen without The Editor: @endofthepier.bsky.social (11/12) www.nature.com/articles/d41...

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

Happy to see this wonderful story out in @prxlife.bsky.social !!! 🧼🧬⚡ Thanks @vsorichetti.bsky.social , Paul Robin, @ivnpla.bsky.social , Šaric & Cuylen Labs for this wonderful collaboration!!! journals.aps.org/prxlife/abst...

Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!

1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...

Liquid-liquid phase separation of HP1? Not in our mouse fibroblasts… This paper by the Fabian Erdel group offers a fresh perspective on how this can be reconciled with seemingly conflicting reports: The phase separation propensity of HP1 decreases from yeast → fly → mouse. doi.org/10.1038/s414...

RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1

Excited to share our new @pubs.acs.org paper! We engineered cells with ~10% photolipids in the ER membrane. This enabled optical control of membrane viscosity to study its impact on ER→Golgi protein transport. @dirktrauner.bsky.social @noemijimenezrojo.bsky.social pubs.acs.org/doi/10.1021/...

New paper from the Trcek lab, with Siran Tian as the lead author - congratulations Siran!: www.nature.com/articles/s41...

Dear MBL alumni (that's you!), What do you wish everyone knew about the MBL? Share with #MyMBLMoment to enter our giveaway. A winner will be randomly chosen at the end of the month! #MyMBLMoment

One more movie! Using the RL algorithm (from pnas.org/doi/10.1073/...), @masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility. Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)

Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity www.biorxiv.org/content/10.1...

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

New research offers a glimpse of how RNA might have helped form the first simple proteins—an event that could have set the stage for evolution. https://scim.ag/4mVxEok

YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...

The latest issue of Scientific American is the 180th anniversary, and they have a series of articles about "180 degree turnarounds" in science. Here's mine on RNA.

Birds can see in four colors - red, green, blue, and ultraviolet - which suggests that they exist in a sensory world far richer than our own. Tune in to "The Joy of Why" with co-host @jannalevinastro.bsky.social: www.quantamagazine.org/do-beautiful...

Aggresomes protect mRNA under stress in Escherichia coli www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky

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🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab Deadline 31 August www.nature.com/naturecareer...

Belated post, but I really enjoyed working as a theory buddy with the Gladfelter lab at MBL physiology. Was refreshing to work on an array of beautiful problems in fungi and slime molds. These big, syncytial cells challenge preconceptions about cell cycles, distribution of resources, and more.

The first paper of our lab is finally out, and I feel very proud and grateful to our wonderful team! @Jannik Rothkegel, @Sylvia Kaufmann, @Michaela Wilsch-Braueninger, @Catarina Lopes <3 onlinelibrary.wiley.com/doi/10.1002/...

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins www.biorxiv.org/content/10.1...