The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...

That’s a wrap on our @embo.org #cryoFIB & #cryoET course! It was an incredible week of hands-on learning, collaboration, and shared expertise, made possible by dedicated organizers, incredible trainers, and an engaged group of participants.

An exciting PhD opportunity investigating ribosome hibernation in cancer is available in my lab, in collaboration with Steffen Scholpp and Ke Li! The interdisciplinary project will span cell biology, structural biology, and AI-guided modelling. Please get in touch if you are interested!

We’ve kicked off our @embo.org Practical Course on #cryoFIB & #cryoET! Participants from around the world are joining us this week for hands-on training, from lamella milling to tomogram reconstruction 🔬

napari needs your help! Has napari helped you make cool and groundbreaking discoveries? We'd love to highlight that in our docs. Please tell us about it! You can fill in this survey: napari.typeform.com/to/vTCKeTKv and/or, as ever, drop by our chat room or meetings: napari.org/dev/community/ 🙏

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...

Come visit our @mpibp.bsky.social booth at the @biophysicalsoc.bsky.social #bps2026 meeting in San Francisco! We’re looking forward to chat about our research, PhD opportunities, and international career paths! 🥳 We’d love to connect and take your #cellfie! 🦠 Find us in booth 630! #imprs #imprs_cbp

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes pubmed.ncbi.nlm.nih.gov/41712727/ #cryoem

Out now in @science.org Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Ribosomes in pairs: A survival strategy inside stressed cells. When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...

What a great example of collaborative science enabled by people sharing things early on. Well done @lifeonthewedge.bsky.social and others!

Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET! 🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...

I’m excited to share my PhD work on localized mRNAs and protein synthesis in cortical layer 1 on bioRxiv! www.biorxiv.org/content/10.1...

Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....

#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids. Link: www.biorxiv.org/content/10.1...

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social

Excited to share our latest collaborative work from Erin Schuman's lab @mpibrain.bsky.social : An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution, now published in @natcomms.nature.com. Here’s a thread summary 🧵 doi.org/10.1038/s414...

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...

Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...

Beautiful. I loved every moment of this project ❤️

Very proud of Lea and well deserved! Watch out for more to come..

New Preprint out ! The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator www.biorxiv.org/content/10.1... Lead by: @sgiando.bsky.social with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more Short thread below 🧵1/4

🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

Please enjoy our (@pamornelas.bsky.social and I) work on the cryoEM structures of TOM from Chaetomium thermophilum, revealing insights into the early stages of preprotein translocation. The paper is still under review, so fingers crossed 🤞. www.biorxiv.org/content/10.1... @mpibp.bsky.social

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

Excited to share our latest work on nuclear pore complex scaffold integrity and its perturbation. Now out in Nature Cell Biology: rdcu.be/eg4i9 Great work by Reiya Taniguchi who just opened his own research group back in Japan! 🥳

I remember Sven showing me these images almost three years ago, late at night, after many beers. We brainstormed what these things might be.. Turns out I was really far off and it's so much cooler! Congrats Sven, beautiful as always.

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?

Congratulations to @mpibrain.bsky.social director Gilles Laurent for being awarded the 2025 Louis-Jeantet prize for Medicine! The @louisjeantetfdn.bsky.social recognizes Laurent's pioneering work on the operations of #neurons and dynamics of neuronal networks. More infos 👉 bit.ly/4hqk6ie

I'm thrilled to be opening my own lab this Fall at the @maxplanck.de MPI for Brain Research in Frankfurt. The lab is going to investigate the neuronal and genetic underpinnings of behavioral evolution. We are hiring on all levels. Don't hesitate to share widely and reach out if interested.

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO

At the intersection of art and science 🎨🧪 some masterpieces reveal fascinating lessons in #biophysics! Join Prof. Werner Kühlbrandt on a unique tour of the Städel Museum, where he explores mirror symmetry, cellular energy, and more. Read more: www.biophys.mpg.de/2840124/art-... 🔗 #ArtMeetsScience

Happy and super excited to share that I started my new position in the lab of Erin Schuman at the MPI for Brain Research!! #cryoET #teamtomo 🎉❄️🔬

Did you know that nuclear pore complexes can show up outside the ☢️ ✉️? This study by Jenny Sachweh and her colleagues uncovers that the surrounding cellular milieu determines NPC composition via the nuclear transport system. #teamtomo #NPC #cryoET ❄️🔬

Amazing #cryoET study of mitochondrial ATP synthase under native working conditions in whole cells, by Lea Dietrich and colleagues, out now 👇🏻