4/ We propose that this conserved architecture reveals a strategy for metabolic compartmentalization that couples efficient catalysis with increased molecular robustness.

3/ Structure-guided perturbation abolishes the assembly in vivo without measurably altering intrinsic catalytic activity, suggesting that the main role of the assembly is spatial organization rather than allosteric regulation.

2/ Urate oxidase homotetramers assemble into helical fibers that laterally tile into a stable, porous lamellar scaffold. This organization preserves accessible surface area while allowing substrate and product exchange.

Preprint with new server~ Using in situ cryo-ET, we identify a previously uncharacterized higher-order architecture of urate oxidase in mouse liver. langtaosha.org.cn/lts/en/prepr...

It is exciting to see closely related biology highlighted in a recent Science paper as well, underscoring the importance of this field. science.org/doi/10.1126/...

The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...

Excited to share what we uncovered using in-tissue cryo-ET in mouse liver: a structural snapshot of lipid droplet biogenesis in situ. Timely reading—particularly after a lipid-rich Chinese New Year😂 The lipid homeostasis story governed by CLCC1 with more details here: www.nature.com/articles/s41...

Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...

How do cells trigger an antiviral response so quickly? 🤔 Our new paper proposes an "Intermitochondrial Activation" model. By visualizing MAVS with Cryo-ET, we saw that activated mitochondria use MAVS fibrils to "fish" for dormant mitochondria, spreading the alarm signal fast. doi.org/10.1038/s414...

Really excellent work by the bluesky-less Marie and Sara +coauthors in our lab @embl.org! Check it out for cool combinations of light microscopy and #cryoET, and if you're interested in how yeasts reorganize structurally in response to stressors. #teamtomo

We usually learn that centrioles/basal bodies are made of microtubule triplets. But our work on Plasmodium shows its basal body is built from singlets, which then mature into the doublets of a functional cilium. #TEAMTOMO www.nature.com/articles/s41...

What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...

Wow, nice story~ This interaction is suprising for me~ Back 2018, after the HTT-HAP40 story, we screened a lot of interactiors of HTT, and none of them really stable enough for structural study. We should try these filamental structuctures as well😀