Ruth Franklin
@ruthfranklinlab.bsky.social
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Assistant Professor @Harvard Immunologist and Tissue biologist Proud mama www.ruthfranklinlab.com
pinned post!
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n
www.science.org/doi/10.1126/...
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Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
https://www.science.org/doi/10.1126/science.adi8828
9 months ago
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New preprint to share! Incredible collab w/ Fei Chen’s lab: developed in vivo CRISPR screening platform for 🫁 epithelium, allowing single cell perturbation in post-flu repair. Take a peek to see what we found! Huge congrats to the leaders of this work
@daisyah.bsky.social
&
@sundakao.bsky.social
🎉
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https://www.biorxiv.org/content/10.64898/2026.03.13.711474v1.article-metrics
21 days ago
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Another fabulous pre-print from the McKinley lab!
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about 1 month ago
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🎉🎉🎉 Can’t wait to see the amazing science that is sure to come from the Sullivan lab!!!
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3 months ago
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So exciting to see this out!! More cool biology sure to come!! 🤩👀
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6 months ago
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Had a fantastic visit
@roswellpark.bsky.social
for the Post-Doctoral Symposium!! So many inspiring scientists doing cool work! Grateful for the invitation!
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7 months ago
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Can’t wait to read this!! Sure to be a fantastic resource!
#InterferonPower
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8 months ago
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Exciting week! Congrats to
@xuzhoulab.bsky.social
, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉
www.sciencedirect.com/science/arti...
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Regulation of inflammatory responses by pH-dependent transcriptional condensates
Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…
https://www.sciencedirect.com/science/article/pii/S0092867425007354
9 months ago
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reposted by
Ruth Franklin
Ivan Zanoni
9 months ago
#WeekendRead
!
#InterferonsFriendsOrFoes
?!
@ruthfranklinlab.bsky.social
, Medzhitov, Hoagland, Rodriguez-Morales &co show
@science.org
that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
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Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
https://www.science.org/doi/10.1126/science.adi8828
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Ruth Franklin
Alan Y. Baez Vazquez
9 months ago
I’m so proud to have been able to contribute to this story! Check it out for a cool tale about tissue repair under inflammatory conditions! Congrats
@daisyah.bsky.social
and
@ruthfranklinlab.bsky.social
on putting out the lab’s first paper 🫁🐁🦠
www.science.org/doi/10.1126/...
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Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
https://www.science.org/doi/10.1126/science.adi8828
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🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n
www.science.org/doi/10.1126/...
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Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
https://www.science.org/doi/10.1126/science.adi8828
9 months ago
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Was so much fun to catch up with some of my IMP family!!
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10 months ago
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Jennifer Waters
10 months ago
"The money the government sends to Harvard is, in effect, not a subsidy to advance the university’s mission. It’s a payment for the role Harvard plays in advancing the research mission of the United States."
www.nytimes.com/interactive/...
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Here Is All the Science at Risk in Trump’s Clash With Harvard (Gift Article)
More than 900 research grants worth $2.6 billion are in jeopardy. So is the 80-year-old model of American science.
https://www.nytimes.com/interactive/2025/06/22/upshot/harvard-funding-cuts.html?unlocked_article_code=1.RE8.2JTb.hojwJZ17AI6u&smid=url-share
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Today was a happy day!! Very proud of Dr. Rodríguez-Morales and very proud to be a professor at Harvard!!
11 months ago
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Ruth Franklin
Dr. David Miller 🏳️🌈
11 months ago
🚨 Action alert: Two days left!! Help protect NSF/NIH from political interference. 👎 A new rule (Sched. F) would allow for replacing career program officers with political appointees. ➡️ Action: Object here by THIS FRIDAY. Comments can be brief and/or anonymous. Helps future litigation.
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Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
https://www.federalregister.gov/documents/2025/04/23/2025-06904/improving-performance-accountability-and-responsiveness-in-the-civil-service
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Jon Levy
11 months ago
On a day when all research grants at Harvard were terminated, and in a context where Congress seems to broadly accept the notion that destroying science and health research in the US is fine, it’s worth noting that this is not what the public wants.
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Just said goodbye to my NIH MIRA award. Really hurts to see the word “terminated” in writing. Even worse to see it next to the F31 awarded to a fantastic PhD student in my lab
@aybv.bsky.social
. I REFUSE to let this stop us!!!
11 months ago
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Our paper was accepted!!!!!! 🎉🥳 I can’t wait to share it with you all soon!!!
11 months ago
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Ruth Franklin
Shruti Naik
11 months ago
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere. It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇 📖
www.nature.com/articles/s41...
#SciComm
@sinaiimmuno.bsky.social
@aspeninstitute.bsky.social
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Beyond the lab: trust, storytelling and the fight for America’s attention - Nature Reviews Immunology
Shruti Naik, an immunologist and a strong advocate for diversity in science, has joined forces with Aaron Mertz, who leads programmes that help to explain, connect and maximize the benefits of science...
https://www.nature.com/articles/s41577-025-01184-z
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The first student from my lab defended her thesis today!!! Huge congratulations to Patricia Rodríguez-Morales, PhD!!!!! 🎉
12 months ago
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Emily Goldberg
12 months ago
Hey
#immunosky
Looking at the AAI website for advocacy website I found this very easy letter you can send to your congressional reps by filling in your information. It's easily modifiable for non-immunologists 🧪 every small action matters
www.aai.org/Public-Affai...
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The American Association of Immunologists - Take Action
https://www.aai.org/Public-Affairs/Take-Action
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Ryan Flynn
about 1 year ago
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with
#glycoRNA
. Critically support by
#NIH
@cp-cell.bsky.social
www.cell.com/cell/abstrac...
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RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.
https://www.cell.com/cell/abstract/S0092-8674(25)00109-6
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What a fantastic idea!!
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about 1 year ago
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Today I did the same! First post on Facebook in years to share what we will lose and why everyone should care!
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about 1 year ago
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reposted by
Ruth Franklin
Jeremy Berg
about 1 year ago
From Harold Varmus (Former NIH and NCI Director and Nobel laureate) Why Would We Undermine the Marvel of American Science?
www.nytimes.com/2025/02/14/o...
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Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
https://www.nytimes.com/2025/02/14/opinion/trump-public-health-funding-nih.html?unlocked_article_code=1.w04.07FX.2ZaMg60SKXay&smid=url-share
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In honor of International Day of Women & Girls in Science, call your reps & remind them the importance of scientific research, innovation, and education (cuts & freezes affect everyone, not just scientists and universities!) Research=lifesaving treatments, medical care, clinical trials, jobs & more!
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FASEB Home
https://www.votervoice.net/mobile/FASEB/Home
about 1 year ago
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