Multi-omics analysis reveals important role for microbial-derived metabolites from B schlosseri in metal interactions journals.asm.org/doi/10.1128/... @balunaslab.bsky.social Insights into B. schlosseri’s biological and chemical interactions with microorganisms and their environment.

Multiplexed PCR to measure in situ growth rates of uropathogenic E. coli during experimental UTI journals.asm.org/doi/10.1128/... @proteusqueen.bsky.social This study provides a cost-effective/efficient alternative to WGS for studying bacterial replication dynamics during infection.

Multiplexed PCR to measure in situ growth rates of uropathogenic E. coli during exp. UTI journals.asm.org/doi/10.1128/... @proteusqueen.bsky.social Cost-effective/efficient alt. for studying bacterial replication during infection, offering new info re pathogen behavior/host-microbe interactions.

pmc.ncbi.nlm.nih.gov/articles/PMC... @teresaomeara.bsky.social Study highlights the critical role of Als4112 in C. auris colonization and virulence, and explores potential strategies to reduce the pathogen’s adherence to abiotic surfaces and thus its spread in healthcare settings.

@bmoore-beth.bsky.social We are delighted to announce that Dr. Teresa O'Meara ‪was awarded the Henry Russel award at U-M. Our highest honor for an early-mid career faculty member for her outstanding research and teaching! @teresaomeara.bsky.social ‬ @umichmicroimmuno.bsky.social

Checkout this article I found at PLOS: dx.plos.org/10.1371/jour... @drsprggs.bsky.social Highlights a key difference btw MCPyV & other polyomaviruses that will improve our understanding of its pathogenesis & aid in the development of targeted therapeutic strategies vs MCPyV-associated malignancies.

journals.lww.com/pidj/fulltex... @jason-weinberg.bsky.social Ganciclovir should be used with caution and close monitoring. Approaches to mitigate the risks of nephrotoxicity should be investigated.

www.sciencedirect.com/science/arti... @teresaomeara.bsky.social @drbadbug.bsky.social Overall, our findings illustrate non-canonical IRE1α activation during infection and a function for IRE1α in supporting organelle contact sites to safeguard against rapidly growing microbes.

pmc.ncbi.nlm.nih.gov/articles/PMC... @teresaomeara.bsky.social Study prospectively designed de novo chaperones and demonstrate that artificial proteins can rescue complex biological processes in the context of the whole cell.

Macropinosomes are a site of HIV-1 entry into primary CD4+ T cells | PNAS www.pnas.org/doi/10.1073/... @kingrasa1.bsky.social Altogether, this study identifies macropinocytosis as one pathway for HIV-1 entry into primary CD4+ T cells.

www.sciencedirect.com/science/arti... @drbadbug.bsky.social @teresaomeara.bsky.social Findings illustrate non-canonical IRE1α activation during infection and a function for IRE1α in supporting organelle contact sites to safeguard against rapidly growing microbes.

www.ahajournals.org/doi/10.1161/... @drbadbug.bsky.social A role for FXII in responding to bac. infection & suggests that by inhibiting the contact & KKSs & impairing neutrophil activation, CpaA may blunt the innate immune response/help prevent the elimination of A baumannii from the human host.

www.sciencedirect.com/science/arti... @drbadbug.bsky.social @teresaomeara.bsky.social Overall, our findings illustrate non-canonical IRE1α activation during infection and a function for IRE1α in supporting organelle contact sites to safeguard against rapidly growing microbes.

Metabolic adaptability and nutrient scavenging in Toxoplasma gondii: insights from ingestion pathway-deficient mutants MSphere journals.asm.org/doi/10.1128/... @verncarruthers.bsky.social This work advances our understanding of the metabolic adaptability of Toxoplasma.

HIV-1 single-transcription start-site mutants display complementary replication functions restored by reversion journals.asm.org/doi/full/10.... @telesnitsky.bsky.social When mutants that expressed only one RNA were forced to revert, they regained functions associated with the second RNA.

Metabolic adaptability/nutrient scavenging in T gondii: insights from ingestion pathway-deficient mutants Msphere journals.asm.org/doi/10.1128/... @verncarruthers.bsky.social This work advances our understanding of the metabolic adaptability of Toxoplasma.

www.sciencedirect.com/science/arti... @anukulshenoy.bsky.social Using our model of neutrophilic asthma, we identify lung epithelial-CD4+ TRM cell crosstalk as a key rheostat of allergic airway neutrophilia.

JCI Insight - CD103+ dendritic cell–fibroblast crosstalk via TLR9, TDO2, and AHR signaling drives lung fibrogenesis insight.jci.org/articles/vie... @bmoore-beth.bsky.social For the first time to our knowledge, evidence that AHR exon 2 floxed mice retain the capacity for ncAHR signaling.

Toxoplasma gondii PROP1 is critical for autophagy and parasite viability during chronic infection MSphere journals.asm.org/doi/full/10.... @verncarruthers.bsky.social Results reveal a critical role for TgPROP1 in autophagy and underscore the importance of this pathway in parasite persistence.

www.sciencedirect.com/science/arti... @verncarruthers.bsky.social The detection of AsGM1 prior to Eomes expression, and its persistence in known transitional states, positions AsGM1 as a pivotal marker for tracing NK-to-ILC1 transitions, transcending ambiguity inherent to the NK-to-ILC1 continuum.

onlinelibrary.wiley.com/doi/10.1002/... @jason-weinberg.bsky.social Mutagenicity is not considered a plausible initial key event in the mode of action for styrene-induced mouse lung tumors as these data support that styrene is not an in vivo mutagen.

pubmed.ncbi.nlm.nih.gov/40035516/ @telesnitsky.bsky.social Despite this very minor difference, the RNAs perform different and complementary replication functions. When mutants that expressed only one RNA were forced to revert, they regained functions associated with the second RNA.

pubmed.ncbi.nlm.nih.gov/40053607/ @drbadbug.bsky.social Results highlight Z-DNA and ZBP1 as critical mediators for UVB-induced inflammation and uncover how type I IFNs prime for cutaneous inflammation in photosensitivity.

A call for the United States to continue investing in science | mSphere journals.asm.org/doi/full/10.... @patschloss.bsky.social

journals.asm.org/doi/10.1128/... @patschloss.bsky.social

The pneumococcal bacteriocin streptococcin B is produced as part of the early . . . | mBio journals.asm.org/doi/10.1128/... @suzydawid.bsky.social Observations contribute to our understanding of the competitive interactions that precede the development of S. pneumoniae disease.

CD103+ dendritic cell — fibroblast crosstalk via TLR9, TDO2, and AHR signaling drives lung fibrogenesis insight.jci.org/articles/vie... @bmoore-beth.bsky.social For the first time, we identify that AHR exon-2 floxed mice retain capacity for ncAHR signaling.

www.sciencedirect.com/science/arti... @anukulshenoy.bsky.social Using our model of neutrophilic asthma, we identify lung epithelial-CD4+ TRM cell crosstalk as a key rheostat of allergic airway neutrophilia.

Toxoplasma gondii PROP1 is critical for autophagy and parasite viability during chronic infection journals.asm.org/doi/10.1128/... @verncarruthers.bsky.social Results reveal a critical role for TgPROP1 in autophagy and underscore the importance of this pathway in parasite persistence.

Lung CD4+ resident memory T cells use airway secretory cells to stimulate/regulate onset of allergic airway neutrophilic disease Cell Reports www.cell.com/cell-reports... @anukulshenoy.bsky.social We identify lung epithelial-CD4+ TRM cell crosstalk as a key rheostat of allergic airway neutrophilia.

Lung CD4+ resident memory T cells use airway secretory cells to stimulate/regulate onset of allergic airway neutrophilic disease Cell Reports www.cell.com/cell-reports... @anukulshenoy.bsky.social We identify lung epithelial-CD4+ TRM cell crosstalk as a key rheostat of allergic airway neutrophilia.

Huge congrats to Ande Garretto who did a wonderful job successfully defending her thesis today!! And congrats to co-PIs Bob Woods and Suzy Dawid!! @suzydawid.bsky.social

journals.asm.org/doi/10.1128/... @suzydawid.bsky.social Demonstrates that isolates that produce the bacteriocin streptococcin B have an advantage over non-producers. Observations contribute to our understanding of the competitive interactions that precede the development of S. pneumoniae disease.

journals.asm.org/doi/10.1128/... @patschloss.bsky.social Making these algorithms accessible through the R ecosystem will foster their further development, broader application, and integration within other R packages.

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Hello Bluesky! The University of Michigan Department of Microbiology and Immunology has opened up a new account here to share news about our science and our people. Follow us here at @umichmicroimmuno.bsky.social