Mary O'Riordan
@drbadbug.bsky.social
📤 519
📥 1676
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Professor of Microbiology & Immunology at the University of Michigan | views my own
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Mary O'Riordan
jamelle
15 days ago
the democratic party’s basic problem is it has almost no control over how its message reaches the ears of voters, especially outside of presidential election years. but rather than devote serious time, attention and cash to that problem its consultants and pundits want to fight factional battles
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Jeremy Berg
about 2 months ago
This paper does a great job with a "It's a Wonderful Life" scenario about NIH, supposing the consequences of the bottom 40% of the funding NIH grants never existed.
www.science.org/doi/10.1126/...
tl:dr The world would lose a lot, but directly and indirectly
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What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
https://www.science.org/doi/10.1126/science.aeb1564
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Sarah McAnulty, Ph.D.
about 2 months ago
I wanted to get a video of this ghost crab but every time I got close to their hole they scuttled back in, so I tried getting clever with it. I made a little sandcastle and shoved my phone into it, hit record, and walked away. Crab was VERY suspicious of this addition to their environment.
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Brent Toderian
about 2 months ago
So Flint, Michigan gave $1,500 to all pregnant people, plus $500 each month for the first year of the child’s young life. It saved Flint $6.2 million dollars a year, due to lower rates of rates of prematurity and low birth weight, with fewer corresponding admissions. The right thing, AND cheaper.
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The US town that pays every pregnant woman $1,500: ‘We’re not OK with our babies being born into poverty’
Infants in Rx Kids in Flint, Michigan, saw lower rates of prematurity and other issues, saving millions in NICU visits
https://www.theguardian.com/us-news/2025/sep/15/rx-kids-flint-michigan-pregnancy
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Christian Frezza
about 2 months ago
Peroxisomal metabolism of branched fatty acids regulates energy homeostasis
www.nature.com/articles/s41...
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Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature
A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...
https://www.nature.com/articles/s41586-025-09517-7
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Mary O'Riordan
Infectious Diseases
2 months ago
There have been 22 cases of Vibrio vulnificus reported across the U.S. South, including 2 recent deaths in Louisiana. That brings the state’s 2025 toll to 6 fatalities. It’s a bit of a “perfect storm,” as shifting ocean conditions and loss of CDC capacity collide.
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Flesh-eating bacteria cases climb to 22 in Louisiana; 2 deaths tied to Louisiana oysters
Louisiana has reported 22 cases of flesh-eating Vibrio vulnificus this year, with four deaths. Health officials warn of risks from warm Gulf waters.
https://www.nola.com/news/gulf_coast/louisiana-flesh-eating-bacteria-cases-2025/article_6ebe8f79-024c-42ca-8f79-393ad68c387b.html
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Mary O'Riordan
Dr. Rabbithole
3 months ago
Welcome FEMA to the letter resistance!! The Katrina Declaration was released today out of concern that we are going back to a time when our response was its own man-made disaster. Say Never Again and sign in support!!!
@rebelfema.altgov.info
act.standupforscience.net/forms/sign-o...
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Nature Portfolio
3 months ago
A study published in Scientific Reports reveals that an online game can enhance individuals' ability to identify vaccine misinformation. The game uses inoculation theory to expose players to manipulation techniques that are commonly used by anti-vaccine groups.
go.nature.com/3JiHq5L
🧪
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Mary O'Riordan
Jeremy Berg
3 months ago
New report from AAMC about clinical trials, other grants, and training
www.aamc.org/about-us/mis...
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Clinical trials and research training stalled as billions in NIH funds sit idle
Billions in NIH research funds remain unspent, stalling clinical trials, halting grants, and disrupting training for future scientists.
https://www.aamc.org/about-us/mission-areas/medical-research/publication/clinical-trials-and-research-training-stalled-billions-nih-funds-sit-idle
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Mary O'Riordan
Nick Sousanis
3 months ago
my statement on Ai from the mini-comic I'm making as syllabus for a new class I'm teaching this fall. It's simple, but I pretty much said all I have to say on it - it robs you of decisions and struggle - and the joy of being surprised. It robs you of learning...
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Leslie Rissler
3 months ago
“This Executive Order is nothing short of obscene," said Ranking Member Zoe Lofgren (D-CA). "In what world does Donald Trump think that Americans want political appointees – who, need I remind the President, are unelected bureaucrats – making decisions on what science gets funded?”
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Ranking Member Lofgren Calls Trump Out for Corrupt Executive Order Requiring Political Appointees to Approve Federal Grants | House Committee on Science, Space and Technology
The House Committee on Science, Space and Technology
https://democrats-science.house.gov/news/press-releases/ranking-member-lofgren-calls-trump-out-for-corrupt-executive-order-requiring-political-appointees-to-approve-federal-grants
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Mary O'Riordan
Mallory McMorrow
3 months ago
We outraised every single candidate in this race without a DIME from corporate PACs. How? YOU. Every dot on this map is someone who believes in what we’re building — and the latest polling shows I’m the *strongest* Democrat to beat Rogers. Let’s do this, Michigan 💪
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Mary O'Riordan
Alex Merz 🇺🇸🇨🇦🇺🇦
3 months ago
A remarkable paper. Davisson and colleagues describe an in vitro reaction running under plausible prebiotic conditions that efficiently and stereoselectively aminoacylates a model tRNA. This suggests a path through which nature may have chosen L vs. D amino acids!
www.biorxiv.org/content/10.1...
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Mary O'Riordan
Ferric Fang, MD
3 months ago
Public health officials have linked 21 Campylobacter and Shiga toxin-producing E. coli infections to raw milk from a Florida farm. Six of the infections were in children younger than 10. In Florida, sale of raw milk is permitted for animal consumption only.
www.tampabay.com/news/health/...
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State health officials warn about infected raw milk
More than 20 cases of infections linked to consumption of raw milk from single farm.
https://www.tampabay.com/news/health/2025/08/04/state-health-officials-warn-about-infected-raw-milk/
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Mary O'Riordan
Garrett M. Graff
3 months ago
We are losing the last of the generation who understand just how evil actual fascism is, how hard it is to rid the world of authoritarian governments once they’re established, and how hard it is to build a successful alternative.
www.doomsdayscenario.co/p/what-we-lo...
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What We Lost When We Lost the Greatest Generation
It's no coincidence that democracy is backsliding in the US exactly eighty years after the end of World War II.
https://www.doomsdayscenario.co/p/what-we-lost-when-we-lost-the-greatest-generation-ef639d4f8848ed02
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Mary O'Riordan
Max Kozlov
3 months ago
BREAKING: Watchdog government agency finds the NIH and the Trump administration have illegally withheld funds in violation of the Impoundment Control Act, and rips into HHS for failing to justify its slow-walking of funds.
www.gao.gov/products/b-3...
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Department of Health and Human Services—National Institutes of Health—Application of Impoundment Control Act to Availability of Funds for Grants
Congress appropriated amounts to the National Institutes of Health (NIH) to carry out various research objectives for fiscal year 2025. In accordance...
https://www.gao.gov/products/b-337203
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Mary O'Riordan
Rick Hasen
3 months ago
My New One at
@slate.com
on the Supreme Court Potentially Killing the Remaining Pillar of the Voting Rights Act: “The Supreme Court Just Signaled Something Deeply Disturbing About the Next Term”
slate.com/news-and-pol...
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The Supreme Court Just Signaled Something Deeply Disturbing About the Next Term
A court fundamentally hostile to the rights of voters places the court increasingly at odds with democracy itself.
https://slate.com/news-and-politics/2025/08/supreme-court-voting-rights-act-clarence-thomas-message.html
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Josh Mattila
4 months ago
"While members of Congress asked the CBO to model cuts on the scale of Trump’s fiscal year 2026 budget proposal, the reductions are so large that they broke the models."
www.statnews.com/2025/07/28/n...
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New analysis predicts sprawling effects of proposed NIH budget cuts
Initial analyses of the Trump administration’s proposed NIH cuts neglect key aspects of their long-term economic and health impact, study says.
https://www.statnews.com/2025/07/28/nih-cuts-new-study-says-long-term-they-will-cost-more-than-saved/
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Mary O'Riordan
Xu Zhou lab @ BCH & HMS
4 months ago
Beyond excited to share our
#NewPaper
in
@cellcellpress.bsky.social
! Inflamed environments acidify intracellular
#pH
. BRD4 senses this via transcriptional condensates, tuning
#macrophage
responses to match demand and consequences of
#inflammation
authors.elsevier.com/sd/article/S...
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Mary O'Riordan
Ailani 🌺 Brown Eye Girl
4 months ago
I'm done adulting! Let's just be mermaids. 🧜♀️ 🧜♂️ 🧜♀️ 🧜♂️ How about you?
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Mary O'Riordan
Jeremy Berg
4 months ago
My quote of the day A Video Quote Medical miracles don't happen overnight. You have to invest in them. Our investments are in trouble. (From Francis Collins on The Late Show with Stephen Colbert, July 16, 2025)
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Schooley
4 months ago
Colbert should just run for President. I mean, it worked for Trump when his show was cancelled.
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Great time to support your NPR and your local PBS stations
add a skeleton here at some point
4 months ago
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Mary O'Riordan
Brian Stelter
4 months ago
The rescission bill has passed the Senate. Once it passes the House, as expected, the Corporation for Public Broadcasting's budget will be zeroed out for the first time since 1967, back when TV stations still broadcast in black and white.
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John Tuthill
4 months ago
i wrote an essay for
@thetransmitter.bsky.social
about what it feels like to serve on an NIH grant review panel (study section) right now
www.thetransmitter.org/craft-and-ca...
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Fear and loathing on study section: Reviewing grant proposals while the system is burning
As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But it’s more important than ever.
https://www.thetransmitter.org/craft-and-careers/fear-and-loathing-on-study-section-reviewing-grant-proposals-while-the-system-is-burning/
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Mary O'Riordan
Brent Toderian
4 months ago
The “E-Bike Effect:” Those who bought e-bikes increased their average daily bicycle use from 2.1km (1.3 miles) to 9.2km (5.7 miles), a 340% increase. The e-bike share of all their transportation increased dramatically too; from 17% to 49%. E-bikes support fewer car trips. V
@lloydalter.bsky.social
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E-Bikers Ride Much Farther and More Frequently Than Regular Bikers
They are not 'cheating,' but are serious transportation.
https://www.treehugger.com/e-bikers-ride-much-farther-and-more-frequently-than-regula-bikers-5076231
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Mary O'Riordan
KatajistoLab
4 months ago
Proudly presenting Simon’s
@simonsterson.bsky.social
paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social
www.nature.com/articles/s42...
@helsinki.fi
@metastem.bsky.social
🧵1/8
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Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
https://www.nature.com/articles/s42255-025-01325-7
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Mary O'Riordan
Alex Merz 🇺🇸🇨🇦🇺🇦
4 months ago
Maybe not the most beautiful experiment in biology but certainly top ten. What are your nominees? 1/
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Mary O'Riordan
STCmicrobeblog
4 months ago
RIP Franklin W. Stahl (1929–2025) here is Frank explaining semiconservative replication of DNA in the marvelous interview from 2020 together with Matt Meselson (
youtu.be/7-tnuAqEp9g
)
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Mary O'Riordan
Ryan Cordell
4 months ago
The academic’s mid-summer crisis is a mid-life crisis in miniature: You realize summer is half gone, & not only that: you see that the longest & least burdened days came early, & they are well past. You compare all you thought you’d do against the days remaining & grieve for what never will be
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Christopher Webb
4 months ago
Wow! France gifted her to us, and now they’ve captured what so many Americans are feeling on Independence Day. The values the Statue of Liberty stood for are no more. 📌 A stunning mural of the Statue of Liberty covering her face was unveiled in Roubaix, France, on July 3, 2025.
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Sandieglo
4 months ago
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Kevin M. Kruse
4 months ago
“Congress” didn’t pass this murder budget. Republicans did it. Republicans did it without a single Democratic vote in the House, without a single Democratic vote in the Senate. Be precise and give, uh, credit where credit is due
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Clare Fieseler, PhD
4 months ago
The retaliatory firing today of over 100 EPA employees who stood up for scientific integrity — it’s shocking. But it’s also July 3. So this won’t even get on people’s radar.
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Mary O'Riordan
Atul Gawande
4 months ago
STAGGERING: This new study of 133 countries is the first to estimate the impact of all USAID’s work. In 2 decades, it has saved *92M* lives. Current cuts, if not reversed, are forecast to cost up to *14M* lives thru 2030.
www.thelancet.com/journals/lan...
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Adam Bonin
5 months ago
Justice Ketanji Brown Jackson, in dissent, on the Court's ruling on universal injunctions and birthright citizenship: "The Court’s decision to permit the Executive to violate the Constitution with respect to anyone who has not yet sued is an existential threat to the rule of law."
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Nature Portfolio
5 months ago
A paper in Nature describes the enzymes that regulate the production of a pheromone responsible for locust swarms. The paper also identifies several candidates capable of inhibiting the production of this pheromone. 🧪
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Decoding 4-vinylanisole biosynthesis and pivotal enzymes in locusts - Nature
In locusts, the aggregation pheromone 4-vinylanisole is derived from dietary phenylalanine, and its production is dependent on two 4-vinylphenol methyltransferases that are potential targets for locust pest control.
https://go.nature.com/4eifQRg
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Mary O'Riordan
Jeremy Berg
5 months ago
NIH BREAKING NEWS NIH BREAKING NEWS Hearing from multiple sources that an email went out late yesterday afternoon Effective immediately: Please do not terminate any additional grant projects. Please pull back all grant projects that are in the cue to be terminated.
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Matt Wilkins
5 months ago
These figures are from a perspective I wrote with a veteran science teacher, an education researcher, a biologist, and a leader in science outreach. "Scaling the wall: overcoming barriers to STEM knowledge mobilization"
www.frontiersin.org/journals/com...
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Frontiers | Scaling the wall: overcoming barriers to STEM knowledge mobilization
Improving science literacy is crucial amidst global challenges like climate change, emerging diseases, AI, and rampant disinformation. This is vital not only...
https://www.frontiersin.org/journals/communication/articles/10.3389/fcomm.2024.1366207/full
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Mary O'Riordan
Dan Garisto
5 months ago
NEW: NSF will be kicked out of their building. Announcement will be made tomorrow by HUD Sec. and Governor of VA. HUD will take over the NSF building over the next two years. NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
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Mary O'Riordan
Andrew Freedman
5 months ago
I was surprised when working on this story about global warming's role in this heat wave to find scientists concerned that our models are underestimating future extreme heat severity, frequency and duration. (1/2)
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Gal Haimovich ☣ 🧪🔬🎗
5 months ago
An inspiring talk by
@leeat-keren.bsky.social
from Weizmann:
www.facebook.com/leeat.keren/...
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Leeat Keren
On Thursday, we had a lab BBQ. On Saturday, my life’s work has been destroyed by an Iranian missile. Today, I received the Heidenthal award in Systems Biology. Here is what I said in my lecture: I...
https://www.facebook.com/leeat.keren/posts/pfbid02SCbPsBUUoYQe7UJhj9wXnEuyU6GeRHy6CXP7QLTkNkUyBt1gC8p86phqFdpjcRRJl?rdid=7MOQVoW4KdynDTK4#
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Mary O'Riordan
The Times of Israel
5 months ago
From heart tissue to DNA samples, Weizmann scientists mourn work vaporized in Iran attack
https://www.timesofisrael.com/from-heart-tissue-to-dna-samples-weizmann-scientists-mourn-work-vaporized-in-iran-attack/
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From heart tissue to DNA samples, Weizmann scientists mourn work vaporized in Iran attack
Some 45 labs in the prestigious sciences center were damaged and might take years -- and tens of millions -- to rebuild. Multiple researchers lost their life's work
https://www.timesofisrael.com/from-heart-tissue-to-dna-samples-weizmann-scientists-mourn-work-vaporized-in-iran-attack/
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Mary O'Riordan
Gbenga Ajilore
5 months ago
I know my colleagues already dropped this line (h/t:
@brendanvduke.bsky.social
), but it bears repeating - there already exists a rural hospital fund and it is called: 🚨🚨MEDICAID🚨🚨
www.politico.com/live-updates...
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Senate leadership ponders rural hospital fund to sway megabill holdouts
The fund would help rural hospitals that could be hurt by the Senate's cut to provider taxes.
https://www.politico.com/live-updates/2025/06/18/congress/senate-leadership-rural-hospital-fund-00413628
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Mary O'Riordan
Jeremy Berg
5 months ago
Here is a link you can blast out to all of your networks to ask them to consider signing on in support of our NIH heroes.
actionnetwork.org/forms/add-na...
We are at 5000 folks who have signed on. But we can do better Only for people who have ever been sick or knows someone who has been.
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ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
https://actionnetwork.org/forms/add-name-bethesda-declaration/?source=nihBluesky&utm_source=nihBluesky&utm_campaign=bethesdadec
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Mary O'Riordan
Abby Schindler
6 months ago
Girl, SAME. “I can’t tell you how heartbreaking and frustrating and exhausting it is to be a federal scientist,” one federal worker told Mother Jones recently. “I still love my job and the mission of my agency, and I truly and fervently hope I don’t lose it.”
www.motherjones.com/politics/202...
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When it comes to Trump's brain drain, “the damage is already done”
How the DOGE-triggered attack on government research left America in the dark.
https://www.motherjones.com/politics/2025/05/trump-administration-knowledge-loss-research-cuts/
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Peter Gleick
5 months ago
There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.
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Matt Shipman (he/him)
6 months ago
I think most people don't understand exactly what universities do or how they are funded. It's worth reading this and then talking with folks you know about it.🧪
www.npr.org/2025/04/25/n...
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What losing billions in federal grants means for universities, and the nation
The Trump administration has so far frozen about $11 billion in research funding. University leaders say no other source can fill the void.
https://www.npr.org/2025/04/25/nx-s1-5375033/trump-federal-grants-cuts-universities-could-mean
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Mary O'Riordan
Josh Marshall
6 months ago
A Path Forward to Save American Bio-Medical Research
talkingpointsmemo.com/edblog/a-pat...
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A Path Forward to Save American Bio-Medical Research
Over the past four months I’ve spoken to dozens of biomedical researchers...
https://talkingpointsmemo.com/edblog/a-path-forward-to-save-american-bio-medical-research/sharetoken/4fe3b515-63d4-40ad-92f8-5946d867ff9d
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Ciara Torres-Spelliscy
6 months ago
Translation I’m very busy cutting Medicaid over here. 👈 I cannot be bothered with Congressional oversight of an unconstitutional emolument over there👉🏾 .⚖️
add a skeleton here at some point
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