@meisellab.bsky.social
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📥 69
📝 19
Assistant Professor, Dept. Immunology, University of Pittsburgh; scientist, athlete, mom 👦🐈
pinned post!
Our lab just completed a +6 year
#marathon
, describing for the first time that the
#microbiome
is critical for
#exercise
- induced increases in antitumor CD8 T cell immunity and improved of
#cancer
#immunotherapy
.
www.cell.com/cell/fulltex...
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900684-1
4 months ago
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reposted by
Waggoner Lab
about 1 month ago
Preview
@cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
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Thanks for highlighting our work!
add a skeleton here at some point
about 2 months ago
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reposted by
Pitt Department of Immunology
about 2 months ago
Congrats,
@catmphelps.bsky.social
!
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reposted by
Pitt Program in Microbiology & Immunology
about 2 months ago
Congratulations to PMI student
@catmphelps.bsky.social
who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!
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reposted by
Open Box Science
3 months ago
🔬 OBS Seminar Shaping CD8+ T Cell Response Through Microbiota Metabolites 🗣️ Joseph Stevens
@cincyresearch.bsky.social
@cincykidsallergyim.bsky.social
🗣️@catmphelps.bsky.social
@meisellab.bsky.social
🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET 👇
us02web.zoom.us/meeting/regi...
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reposted by
Nature Reviews Cancer
3 months ago
#ResearchHighlight
In a study published in
#Cell
, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality. 👇
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No strain, no formate gains - Nature Reviews Cancer
In a study published in Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota and anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.
https://www.nature.com/articles/s41568-025-00860-5?utm_source=dlvr.it&utm_medium=bluesky
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Congratulations to the team! Excited to see the study in print!!
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4 months ago
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reposted by
Reinhard Hinterleitner
4 months ago
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity
www.cell.com/immunity/ful...
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Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...
https://www.cell.com/immunity/fulltext/S1074-7613%2825%2900287-0
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reposted by
The American Association of Immunologists
4 months ago
AAI Members in the News! For her grad thesis with Dr. Marlies Meisel at @pittdeptofmed.bsky.social, @catmphelps.bsky.social showed how
#exercise
improves
#cancer
outcomes and enhances the response to
#immunotherapy
in mice by reshaping the gut
#microbiome
🔗
www.medschool.pitt.edu/news/gut-mic...
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Thanks
@nature.com
for highlighting our recent study
#exercise
#microbiota
#cancer
add a skeleton here at some point
4 months ago
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reposted by
New Scientist
4 months ago
Exercise seems to help prevent cancer and reduce the growth of tumours, but until now, we didn’t know why. The key seems to lie in the gut’s microbiome.
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Exercise helps fight cancer – and we may finally know why
Exercise seems to help prevent cancer and reduce the growth of tumours, and that protective effect may be due to the way working out changes the gut microbiome
https://www.newscientist.com/article/2487669-exercise-helps-fight-cancer-and-we-may-finally-know-why/?utm_medium=SOC&utm_source=Bluesky#Echobox=1752073496-3
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reposted by
Waggoner Lab
4 months ago
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression
@cellcellpress.bsky.social
@catmphelps.bsky.social
@meisellab.bsky.social
www.cell.com/cell/fulltex...
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reposted by
Adriana Forero
4 months ago
📄🧫🔬🐭What are you reading this weekend? Check out
@catmphelps.bsky.social
,
@meisellab.bsky.social
, et al’s brand new work!
#H2P
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www.upmc.com/media/news/0...
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Gut Microbes Key to Understanding How Exercise Boosts Cancer Immunity
Gut Microbes Key to Understanding How Exercise Boosts Cancer Immunity
https://www.upmc.com/media/news/070925-gut-microbes
4 months ago
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reposted by
Cell - a Cell Press journal
4 months ago
Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
http://dlvr.it/TLqLW7
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reposted by
Catherine Phelps
4 months ago
I am BEYOND excited to share that my PhD thesis research is officially published in
@cellpress.bsky.social
today. Read on for an exciting story about how
#exercise
promotes antitumor
#immunity
by modulating behavior of the
#microbiome
🏃♀️🦠
authors.elsevier.com/c/1lPCrL7PXu...
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https://authors.elsevier.com/c/1lPCrL7PXuFJv
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reposted by
Eric Topol
4 months ago
How exercise works through the gut microbiome to enhance response to cancer immunotherapy
www.cell.com/cell/fulltex...
@cellpress.bsky.social
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Our lab just completed a +6 year
#marathon
, describing for the first time that the
#microbiome
is critical for
#exercise
- induced increases in antitumor CD8 T cell immunity and improved of
#cancer
#immunotherapy
.
www.cell.com/cell/fulltex...
loading . . .
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900684-1
4 months ago
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25
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reposted by
The New York Times
6 months ago
A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.
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Exercise Extends Life for People With Cancer, Study Shows
The trial, in people treated for colon cancer, showed clear evidence that an exercise program lowered the risk of disease recurrence and death.
https://trib.al/LsHYgI3
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reposted by
Eric Topol
6 months ago
The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....
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not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (
@Catmphelps.bsky.social
) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM
7 months ago
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reposted by
Barbara Marte
7 months ago
also a new N&V
www.nature.com/articles/d41...
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Microbial molecule of ageing gut nudges blood stem cells towards cancer
The risk of developing blood cancer increases with age. The finding that a molecule from gut bacteria plays a part points to new ways to intervene.
https://www.nature.com/articles/d41586-025-01137-5
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reposted by
Catherine Phelps
7 months ago
Having a great time at
#AACR25
in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new
@meisellab.bsky.social
research on
#exercise
,
#microbiome
, and cancer immunity🏃
#WICR
#WomenInSTEM
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reposted by
Jacob T. Levy
8 months ago
Excellent excellent excellent from Princeton president and constitutional/ political theorist Chris Eisgruber. There's been far too little of this kind of thing; here's hoping others follow his good example.
www.theatlantic.com/ideas/archiv...
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The Cost of the Government’s Attack on Columbia
American universities have given the country prosperity and security. The Trump administration’s attack on academic freedom endangers all of that.
https://www.theatlantic.com/ideas/archive/2025/03/columbia-academic-freedom/682088/?gift=U6ENXdMSx-3rXawTZ5-kgEAupFFXjAZTYpHwZULdBj4&utm_source=copy-link&utm_medium=social&utm_campaign=share
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reposted by
Nature
8 months ago
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration Are you thinking about leaving?
https://go.nature.com/424ejK8
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These frustrated scientists want to leave the United States – do you? Take Nature’s poll
In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.
https://go.nature.com/424ejK8
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reposted by
Julian A Nowogrodzki
8 months ago
🚨🧪 We’ve been talking to scientists at rallies today across the country in DC, Boston, Seattle, and NJ. Here’s why scientists are “Dismayed, depressed, disgusted” and what they’re doing about it 🧵 ⤵️ for more
#StandUpforScience
#StandUpforScience2025
@nature.com
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‘Scientists will not be silenced’: thousands protest Trump research cuts
Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration.
https://www.nature.com/articles/d41586-025-00704-0
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reposted by
Stand Up for Science!
8 months ago
LIVE STREAM UP!
m.twitch.tv/standupforsc...
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reposted by
Kevin Keegan
8 months ago
Stand Up for Science Rally in Pittsburgh
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reposted by
Nature
9 months ago
Six award-winning female scientists highlight women who have inspired them by pushing innovative research and creating opportunities for others
https://go.nature.com/43n0J5R
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Behind every great woman in science, there’s another great woman in science
To mark International Women’s Day on 8 March, six award-winning female scientists highlight women who have inspired them by pushing innovative research and creating opportunities for others.
https://go.nature.com/43n0J5R
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reposted by
Bella Rauch
9 months ago
@laurenrodda.bsky.social
,
@nicelab.bsky.social
,
@jnpruneda.bsky.social
and I wrote an OpEd on the impacts of NIH cuts on Oregon:
www.bizjournals.com/portland/new...
It was signed by over 450 OHSU researchers! It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
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Opinion: Scientists on how NIH cuts will hurt all Oregonians. - Portland Business Journal
"These cuts will cripple biomedical research and drug development in the U.S. We should be investing more in science, not less."
https://www.bizjournals.com/portland/news/2025/03/04/ohsu-researchers-nih-warnings.html
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reposted by
Vaughn Cooper
9 months ago
Pittsburgh universities receive $840M from the NIH annually, making us one of the nation’s leading biomedical research centers. It’s part of our bedrock and it’s being undermined.
www.wtae.com/article/pitt...
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reposted by
Jeremy Berg
9 months ago
New post with the WTAE Pittsburgh news story
www.wtae.com/article/pitt...
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Pittsburgh biomedical research funding hit hard by Trump policies, warns former NIH director
Berg explained that President Donald Trump's first tactic to halt biomedical research came with a general federal funding freeze, which a judge later reversed. His second tactic: Not updating the Fede...
https://www.wtae.com/article/pittsburgh-trump-biomedical-research-funding/63976097
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reposted by
Angie Rasmussen
9 months ago
Tom Maniatis coming in hot in @CellCellPress to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science. And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯
www.cell.com/cell/fulltex...
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Safeguarding the future of biomedical science in the United States
NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...
https://www.cell.com/cell/fulltext/S0092-8674(25)00212-0
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reposted by
Vaughn Cooper
9 months ago
As of today, at least 73 study sections have not met. If they review 50 applications, plus 30 triaged, 10% funding rate = 8 grants per SS. That's 584 fundable grants on hold. Probably 5000 researchers affected in those teams composed of our best and brightest. SABOTAGE.
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reposted by
Dan Kaplan
9 months ago
I was scheduled for study section starting tomorrow. Everything's all done and ready to go. Just heard it's being "rescheduled." No reason given.
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reposted by
International Union of Immunological Societies
9 months ago
We are excited to have
@immunologypodcast.com
as a partner for
#IUIS2025
! Listen to their latest podcast to hear Drs. Wilfried Ellmeier, Laurence Zitvogel, and Dan Littman discuss what to expect at the upcoming
#IUIS2025
congress taking place in Vienna! Listen now:
bit.ly/4jUqeB4
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Ep. 98: "IUIS 2025: Waltzing into the Future of Immunology" Featuring Drs. Wilfried Ellmeier, Laurence Zitvogel, and Dan Littman - The Immunology Podcast
Dr. Wilfried Ellmeier is a Co-Chair of the Scientific Planning Committee at the International Union of Immunological Societies (IUIS) and Professor of Immunobiology and Head of the Institute of Immuno...
https://bit.ly/4jUqeB4
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reposted by
Magdalena Skipper
9 months ago
Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives. An assault on science anywhere is an assault on science everywhere; the global community must unite 🧪
www.nature.com/articles/d41...
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Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://www.nature.com/articles/d41586-025-00562-w
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reposted by
Miriam Merad
9 months ago
Excellent JAMA article describing that > 99% of new drug approvals (2010-2019) were backed by NIH funding. Why dismantle the very engine that made the U.S. a global leader in drug development ? "#DoNotDefundScience
jamanetwork.com/journals/jam...
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Comparison of Research Spending on New Drug Approvals by the NIH vs the Pharmaceutical Industry
This cross-sectional study examines National Institutes of Health and pharmaceutical industry investments in recent drug approvals.
https://jamanetwork.com/journals/jama-health-forum/fullarticle/2804378
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reposted by
Vaughn Cooper
9 months ago
Yinz ready to stand up for science?
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Thanks
#UCLA
Graduate class for having me present some of the background, rationale and future outlook of our previous study @CellPress where we showed how
#probiotic
bacterium enhances antitumor immunity within
#melanoma
9 months ago
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reposted by
Needhi Bhalla 💅🏽
9 months ago
"Those in the scientific community who enjoy the protections of academic and other freedoms afforded by the US Constitution’s First Amendment should do and say more...It is a strength of the scientific enterprise that we have diverse ideas, identities, and approaches to communication." 🧪
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reposted by
E John Wherry
9 months ago
Excellent Info Graphic. Share everywhere!
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#KSHostMicrobe25
in beautiful Banff-such an awesome meeting. Was great to talk at the
@keystonesymposia.bsky.social
about exciting work from the lab about how we can take advantage of the microbiota metabolites to improve cancer immunotherapy efficacy
#microbiota
#immunometabolism
#cancer
9 months ago
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reposted by
Keystone Symposia
9 months ago
We’re more than just science enthusiasts! Join us in Banff for 2 exciting upcoming events: Human Microbiome / Host-Microbe Co-Evolution in Human Health from February 18-21 and Obesity & Adipose Tissue / MASH from February 23-26. Discover more at
keysym.us/KS25
#keystonesymposia
#keystoneconferences
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Excited to speak today at the @keystonesymposia.bsky.social about new and exciting work from the lab about how we can harness microbiota metabolites to improve cancer immunotherapy efficacy
#microbiota
#immunometabolism
#cancer
9 months ago
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reposted by
Dan Kaplan
11 months ago
Also a summary of the work here
#neuroimmunology
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Feeling Itchy? Study Suggests Novel Way to Treat Inflammatory Skin Conditions - UPMC & Pitt Health Sciences News Blog
A new approach to treat rosacea and other inflammatory skin… Read more
https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Finside.upmc.com%2Ffeeling-itchy-study-suggests-novel-way-to-treat-inflammatory-skin-conditions%2F&data=05%7C02%7Cdankaplan%40pitt.edu%7C417638e8da6947e97edd08dd1a195fd1%7C9ef9f489e0a04eeb87cc3a526112fd0d%7C1%7C0%7C638695418534268531%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=1w6CrFjYfnUg56TCjtc5IQXo%2FFUBG6Vab9gW4yC75xo%3D&reserved=0
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Amazing study! So glad my lab could be helpful.
add a skeleton here at some point
10 months ago
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reposted by
Scott McGrath
10 months ago
🧪 The Human Microbiome Compendium processed 168k gut microbiome samples, revealing geographic and technical influences on variation. Findings highlight regional differences, such as between Asia and Europe/North America, and the impact of methods like primers and DNA extraction. 🧬💻
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reposted by
Keystone Symposia
10 months ago
Don't miss your chance to showcase your research with a poster presentation! Submit by Jan. 28, 11:59pm MST. Be part of an exciting gathering with experts like
@institutimagine.bsky.social
,
@reisesousalab.bsky.social
and many others this February in Banff, Canada.
hubs.la/Q032JT3R0
#KSHostMicrobe25
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was a joy to write review about the systemic immunoregulatory functions of L. reuteri with
@pitt-pmi.bsky.social
student Amanda and postdoc Daphne. check it out.
www.tandfonline.com/doi/full/10....
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Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity
The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. The historical roots of probiotics are traced back to Nobel Laureate Élie Metchni...
https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2451088
10 months ago
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