Preview @cp-immunity.bsky.social Cutting the Gordian knot: Untangling gasdermin C from pyroptosis www.cell.com/immunity/ful... on www.cell.com/immunity/ful...

Thanks for highlighting our work!

Congrats, @catmphelps.bsky.social !

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

🔬 OBS Seminar Shaping CD8+ T Cell Response Through Microbiota Metabolites 🗣️ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social 🗣️@catmphelps.bsky.social @meisellab.bsky.social 🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET 👇 us02web.zoom.us/meeting/regi...

#ResearchHighlight In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality. 👇

Congratulations to the team! Excited to see the study in print!!

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

AAI Members in the News! For her grad thesis with Dr. Marlies Meisel at ‪@pittdeptofmed.bsky.social‬, ‪@catmphelps.bsky.social‬ showed how #exercise improves #cancer outcomes and enhances the response to #immunotherapy in mice by reshaping the gut #microbiome 🔗 www.medschool.pitt.edu/news/gut-mic...

Thanks @nature.com for highlighting our recent study #exercise #microbiota #cancer

Exercise seems to help prevent cancer and reduce the growth of tumours, but until now, we didn’t know why. The key seems to lie in the gut’s microbiome.

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social www.cell.com/cell/fulltex...

📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P

Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today. Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃‍♀️🦠 authors.elsevier.com/c/1lPCrL7PXu...

How exercise works through the gut microbiome to enhance response to cancer immunotherapy www.cell.com/cell/fulltex... @cellpress.bsky.social

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy. www.cell.com/cell/fulltex...

A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial @nejm.org nejm.org/doi/full/10....

not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM

also a new N&V www.nature.com/articles/d41...

Having a great time at #AACR25 in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new @meisellab.bsky.social research on #exercise, #microbiome, and cancer immunity🏃 #WICR #WomenInSTEM

Excellent excellent excellent from Princeton president and constitutional/ political theorist Chris Eisgruber. There's been far too little of this kind of thing; here's hoping others follow his good example. www.theatlantic.com/ideas/archiv...

Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration Are you thinking about leaving? https://go.nature.com/424ejK8

🚨🧪 We’ve been talking to scientists at rallies today across the country in DC, Boston, Seattle, and NJ. Here’s why scientists are “Dismayed, depressed, disgusted” and what they’re doing about it 🧵 ⤵️ for more #StandUpforScience #StandUpforScience2025 @nature.com

LIVE STREAM UP! m.twitch.tv/standupforsc...

Stand Up for Science Rally in Pittsburgh

Six award-winning female scientists highlight women who have inspired them by pushing innovative research and creating opportunities for others https://go.nature.com/43n0J5R

@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new... It was signed by over 450 OHSU researchers! It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.

Pittsburgh universities receive $840M from the NIH annually, making us one of the nation’s leading biomedical research centers. It’s part of our bedrock and it’s being undermined. www.wtae.com/article/pitt...

New post with the WTAE Pittsburgh news story www.wtae.com/article/pitt...

Tom Maniatis coming in hot in @CellCellPress to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science. And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯 www.cell.com/cell/fulltex...

As of today, at least 73 study sections have not met. If they review 50 applications, plus 30 triaged, 10% funding rate = 8 grants per SS. That's 584 fundable grants on hold. Probably 5000 researchers affected in those teams composed of our best and brightest. SABOTAGE.

I was scheduled for study section starting tomorrow. Everything's all done and ready to go. Just heard it's being "rescheduled." No reason given.

We are excited to have @immunologypodcast.com as a partner for #IUIS2025! Listen to their latest podcast to hear Drs. Wilfried Ellmeier, Laurence Zitvogel, and Dan Littman discuss what to expect at the upcoming #IUIS2025 congress taking place in Vienna! Listen now: bit.ly/4jUqeB4

Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives. An assault on science anywhere is an assault on science everywhere; the global community must unite 🧪 www.nature.com/articles/d41...

Excellent JAMA article describing that > 99% of new drug approvals (2010-2019) were backed by NIH funding. Why dismantle the very engine that made the U.S. a global leader in drug development ? "#DoNotDefundScience jamanetwork.com/journals/jam...

Yinz ready to stand up for science?

Thanks #UCLA Graduate class for having me present some of the background, rationale and future outlook of our previous study @CellPress where we showed how #probiotic bacterium enhances antitumor immunity within #melanoma

"Those in the scientific community who enjoy the protections of academic and other freedoms afforded by the US Constitution’s First Amendment should do and say more...It is a strength of the scientific enterprise that we have diverse ideas, identities, and approaches to communication." 🧪

Excellent Info Graphic. Share everywhere!

#KSHostMicrobe25 in beautiful Banff-such an awesome meeting. Was great to talk at the @keystonesymposia.bsky.social about exciting work from the lab about how we can take advantage of the microbiota metabolites to improve cancer immunotherapy efficacy #microbiota #immunometabolism #cancer

We’re more than just science enthusiasts! Join us in Banff for 2 exciting upcoming events: Human Microbiome / Host-Microbe Co-Evolution in Human Health from February 18-21 and Obesity & Adipose Tissue / MASH from February 23-26. Discover more at keysym.us/KS25 #keystonesymposia #keystoneconferences

Excited to speak today at the @keystonesymposia.bsky.social about new and exciting work from the lab about how we can harness microbiota metabolites to improve cancer immunotherapy efficacy #microbiota #immunometabolism #cancer

Also a summary of the work here #neuroimmunology

Amazing study! So glad my lab could be helpful.

🧪 The Human Microbiome Compendium processed 168k gut microbiome samples, revealing geographic and technical influences on variation. Findings highlight regional differences, such as between Asia and Europe/North America, and the impact of methods like primers and DNA extraction. 🧬💻

Don't miss your chance to showcase your research with a poster presentation! Submit by Jan. 28, 11:59pm MST. Be part of an exciting gathering with experts like @institutimagine.bsky.social, @reisesousalab.bsky.social and many others this February in Banff, Canada. hubs.la/Q032JT3R0 #KSHostMicrobe25

was a joy to write review about the systemic immunoregulatory functions of L. reuteri with @pitt-pmi.bsky.social student Amanda and postdoc Daphne. check it out. www.tandfonline.com/doi/full/10....