Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.

@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses www.biorxiv.org/content/10.1...

Excited to share the most recent work from our lab! In which we seek out the cellular source of homeostatic IFNL in the gut and find that gut pDC are ‘rewired’ to produce IFNL over type I IFNs.

Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW! facultycareers-ohsu.icims.com/jobs/35624/c...

Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.

Excited to share with you my postdoctoral work published today in Nature Microbiology! www.nature.com/articles/s41... We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.

Cytokines 2025: Submit your abstract for an oral or poster presentation by June 30th! Student and post-doctoral travel grants are still available. Don’t miss out! seattle.cytokinesociety.org #Cytokines #Immunology #innate #adaptive #conferences #Seattle

Valerie Rodriguez Irizarry’s tour de force paper on murine norovirus adaptation/egress is now out in peer-reviewed form ‪@plosbiology.org‬. It highlights the power of forward genetics in virology research. 🧵 1/10 journals.plos.org/plosbiology/...

This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!

Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n

Norovirus tropism depends partly on entry receptors, but what is the role of cellular #lipids? @orchardlab.bsky.social &co show that TMEM30a-mediated lipid asymmetry is crucial for murine #norovirus infection, influencing membrane fluidity, viral binding & entry @plosbiology.org 🧪 plos.io/4409MtI

💐 To NIH and NSF program officers, and anyone else trying to keep those institutions alive: Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n

Co-Chairs, Michael Gale, Jr. and @ramlabuw.bsky.social invite abstract submissions for Cytokines2025. Topics include adaptive immunity, cytokine signaling, interferon stimulated genes, structure- function, and more. Submit: seattle.cytokinesociety.org/call-for-abs... Deadline is May 18, 2025.

Repost if you're planning to go.

Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/... Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n

Today, immunologists nationwide are making their voices heard! Our AAI Public Policy Fellows are on Capitol Hill, advocating for critical research funding and policies. Join them by participating in our letter-writing campaign: ow.ly/QLvQ50VaY23. #PPFPHillDay #SciPol #Advocacy

NEW: In every way, shape, form, actions being taken say ‘don’t go into science,’ Donna Ginther told me as NIH forced to cancel programs to train future researchers. More than 1,000 students, including one who emailed 60 PIs, now scrambling to find positions. www.statnews.com/2025/03/05/t...

@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new... It was signed by over 450 OHSU researchers! It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.

First post on Bluesky! Excited to share the first paper from our lab in 2025! cell.com/cell-host-mi.... Our study demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice, suggesting the host response also contributes to diarrhea to flush out the virus.

Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️ www.rarediseaseday.org

Mark your calendars Cytokines 2025 Westin Seattle! Abstract submission is opening soon. Make sure to note these important deadlines: -Abstract Submission deadline: Wednesday 18 June -Early-Bird Registration Deadline: Friday 25 July Group room rate $236 seattle.cytokinesociety.org for more details

The restriction on Federal Register posts appear to be still in effect. This is blocking the (legal) scheduling of study sections and, soon, advisory council meetings. I have heard that some study section meetings that had been scheduled have been cancelled. 4/n

Internal NIH guidance updated yesterday. Just canceling stuff each day from here on out I guess, pending new guidance. Killing science off both slowly and incredibly rapidly.

No new NIH study sections have been announced in the Federal Register since Jan 21. But I hear that colleagues have been asked to serve. Does your meeting appear in these announcements? If this applies to you, please check and reply here with info! www.federalregister.gov/documents/se...

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports... Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?

Norovirus is raging across the U.S. this winter. Moderna might soon have a vaccine for it.

Gentle reminder that if you truly value diversity in the workforce, top down executive orders may/will change implementation but it shouldn’t change your dedication to building the best possible team/group/cohort/generation of researchers

Want to see the numbers for how NIH funding impacts your state? Remind your Representatives, Senators, and fellow citizens how federally-funded biomedical research advances health, created jobs, and fosters innovation and economic growth. www.unitedformedicalresearch.org/nih-in-your-...

Some months ago, I received the great news that my #NIH RO1 grant received a likely fundable score. With the NIH not being able to hold meetings and take decision, I found out that the council meeting is canceled (it was planned next week). 🧵/1

Scientific advancements aside, this is economically irresponsible Every $1 spent by NIH generates $2.46 For example, in 2023, $47B in NIH spending generated ~$93B Halting NIH spending will LOSE the US a lot of money (and talent)

With recent 💰, we are recruiting a postdoctoral fellow & an #immunology PhD student to start this year! We have 1 summer undergrad position open too. Sadly, our university is not reviewing international student apps due to permit cuts. See here for the current team: sites.google.com/view/thesant...

So excited to share our recent work! We find that hyper-local 'hot pockets' of innate immune response within the intestine are correlated with local abundance of bacterial microbiota and their recognition by leukocytes. www.tandfonline.com/doi/full/10....