‼️For our final invited speaker interview, we talked with the amazing Titia Sixma about her work on the role of ubiquitin in DNA regulation, and some #AusUb2025 highlights. Thank you to everyone who came, it was an amazing conference and a great chance to see the breadth of global ubiquitin research!

‼️It was wonderful to have Professor Kay Hoffmann at the #AusUb25 - and even better to get the chance to interview him! Hear about his experiences in industry and academia as well as his love for proteins😁

Today we have Brenda Schulman, Director of the Department of Molecular Machines and Signalling at Max Planck Institute of Biochemistry, as our interviewee at #AusUb2025. Jump in to find out her research focus and conference tips!

It’s hard to believe that #AusUb2025 has already come to an end 😢. Don’t worry though - we’ll still be posting our speaker interviews in the next couple of days. Here’s what Sonja Lorenz thought of the Australian Ubiquitin Summit. 👇

‼️Have a listen to a little about Kylie Walter’s exciting new research, conference talk, and her experience at #AusUb2025. What did she enjoy most about the conference? More interviews to come in the next week so stay tuned 😁

‼️ Following on from our “M1 chains everywhere!” session at #AusUb25 we took the chance to interview one of the pioneering researchers in this field, Kazuhiro Iwai. Have a look below! ✨✨✨

‼️Towards the end of #AusUb25, we caught up with Jonathan Pruneda to discuss ubiquitin signalling and its relationship with host-pathogen interactions. It was an amazing conference and such a great chance to meet people from across the ubiquitin field 🤩

While everyone is hustling for the holidays, hopefully folks will have time to submit abstracts or register for #ASMMicrobe2026 in DC! Please repost!

Identification of novel ubiquitin receptors on the 26S proteasome by photo-crosslinking mass spectrometry https://www.biorxiv.org/content/10.64898/2025.12.19.695558v1

Very important 🧵 🧪 Amplifying for greater reach

New work from my team, identifying drug targets in M. abscessus. Pre-print posted here: www.biorxiv.org/content/10.6...

NIGMS R35 Maximizing Investigator's Research Award (MIRA) for Outstanding Investigators new NOFO is available!! Submission dates starting in January 2026 through May 2028. See link below: simpler.grants.gov/opportunity/...

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

🚨New faculty job opportunity 🚨 Please share this ad for a faculty position in our department at UC Irvine, in the fields of microbiology and infectious disease. MD/PhDs and PhDs are desired and should apply! recruit.ap.uci.edu/JPF09954

As 2026 chair of the Biophysical Society Cryo-EM subgroup, I am thrilled to announce that Dr. Melanie Ohi has been selected as the recipient of the June Almeida Award: an honor recognizing women scientists whose leadership, scholarship, and mentorship have profoundly shaped the field of cryo-EM.

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

SAVE THE DATE! The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026. Exciting line up of talks and an amazing location! Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro. Registration open soon.

For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...

ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

A key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...

Differential targeting of human pyroptotic Caspase-5 and Caspase-4 by Shigella OspC2 and OspC3 https://www.biorxiv.org/content/10.64898/2025.12.04.692159v1

In our latest study we show that ligand-activated transcription factor AHR (environmental sensor) is ADP-ribosylated by PARP7. This ADP-ribose mark is recognised by the E3 ubiquitin ligase DTX2 targeting AHR for proteasomal degradation, enabling cells to rapidly shut down AHR-mediated transcription.

Mono-ADP-ribosylation as a degradation mark? @andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch www.embopress.org/doi/full/10....

Pleased to share our latest work by Annesha Ghosh. Using genetic screens, we identify that the deubiquitinase USP-14 regulates innate immunity in C. elegans. www.biorxiv.org/content/10.1...

We’ve made some new tools to manipulate N-recognins. Check them out in our preprint. www.biorxiv.org/content/10.1...

Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8

The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.

So proud of the lab for its achievements - Thank you to the Pettenkofer foundation for recognising our contributions - here’s to some more bacterial effector related fun in the future! @dunnschool.bsky.social

🚨 Postdoc position in my lab! A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available. 📍 DTU, Copenhagen, Denmark ⏰ Deadline: 18 December 2025 Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.

⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?). More interviews to come in the next few days so watch this space 😉

The Rowley/Ytreberg/Patel labs at UI have led a multidisciplinary study to characterize a new yeast toxin! Published in the ASM's flagship Journal - mBio. Eight undergraduate authors contributed to the study, a great team effort! journals.asm.org/doi/10.1128/... @uidaho.bsky.social

ASM NW was wonderful this year! In addition to the great science, this trainee-focused meeting plays such an important role in providing the next generation of scientists, microbiologists, and clinicians an opportunity to learn, network, and share their own research. 🧪🦠

Our latest preprint is out! We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4. @livuni-ismib.bsky.social www.biorxiv.org/content/10.1...

Excited to share our latest work, where we create Salmonella mutants deficient for cohorts of SPI-2 T3SS effectors. These strains can be used to efficiently identify particular effectors that contribute to SPI-2 phenotypes doi.org/10.1038/s414...

Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better. And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings: solvingfor.org/news-posts-d...

SUMO interactions: the 1st of two reviews which Aanchal (@origichals.bsky.social), El Hadji, and I have recently written on non-covalent interactions of SUMO is now out. The 1st covers interactions with E1, E2, and deSUMOylating enzymes; the 2nd - on interactions with SIMs etc. - will appear soon.

Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD! Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!

🚨Thrilled to share our latest work, published online today @nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/ www.nature.com/articles/s41...

It's been an amazing year for the new PTM field of #MARUbylation - happy that I could get involved first-hand!

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social Day 20/31 Prompt RIVALS Pdb: 8V27 & 8G6S Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them. Next: BLAST Suggestions?

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

Our latest review is now online! 👇 @martenslab.bsky.social Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social! www.embopress.org/doi/full/10....

Exciting! Yet another Spotlight article has come out today in @cp-trendsparasitol.bsky.social, featuring our work on kinase-ligase crosstalk in a Leishmania virulence factor. Thanks so much, @jnpruneda.bsky.social and Shun-Je Bhark! www.sciencedirect.com/science/arti...

Job alert! We are recruiting a postdoc to study a novel RNA modification: ADP-ribose. 🔬Do you have experience working with RNA? Are you eager to explore new frontiers in RNA biology? Join our team and help uncover the secrets of RNA ADP-ribosylation: adpribosylationlab.wordpress.com/2025/10/28/p...

The unique lipopolysaccharide composition of Salmonella Typhimurium ST313 dampens pyroptosis and inflammasome activation and suppresses host cell death https://www.biorxiv.org/content/10.1101/2025.09.29.679141v1

Come join us in Knoxville! The Dept. of Microbiology 🧫🦠 at the University of Tennessee is hiring 2 Assistant Professors (tenure track, 9-month appt.). Microbial Drivers of Chronic Disease: apply.interfolio.com/173153Quantitative Microbe-Plant-Environment Interactions: apply.interfolio.com/173345

UMN's Department of Microbiology and Immunology is hiring! Come be our colleague in the Twin Cities! Searches are open for Virology and Fungal Biology (links below). Virology: hr.myu.umn.edu/jobs/ext/365... Fungal Biology/Medical Mycology: hr.myu.umn.edu/jobs/ext/365...