Stephen McLaughlin
@lmbbiophysics.bsky.social
š¤ 423
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Biophysics@MRC Laboratory Molecular Biology, Cambridge All opinions are my own
pinned post!
Excited for our program of speakers at Next Generation Biophysics 2025. Come join us as registration is now open either in person or online:
www3.mrc-lmb.cam.ac.uk/sites/nextge...
5 months ago
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
7 days ago
Excellent
#postdoc
opportunity available in
@sjorsscheres.bsky.social
ā group, working on new image processing algorithms for
#cryoEM
structure determination in their
#RELION
open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs
#ScienceJobs
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reposted by
Stephen McLaughlin
Suyang Zhang
22 days ago
Our lab
@mrclmb.bsky.social
in Cambridge is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 𧬠Feel free to get in touch directly
#PhD
#cryoEM
#biochemistry
www2.mrc-lmb.cam.ac.uk/students/int...
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reposted by
Stephen McLaughlin
Sjors Scheres
29 days ago
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. š¤
beta.ideas.lego.com/product-idea...
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Biological Laboratory | LEGOĀ® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publā¦
https://beta.ideas.lego.com/product-ideas/ab52d2c2-0688-48e7-a7d1-77ae54a6aa4b
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
about 1 month ago
Considering a PhD in molecular biology? Make sure to check out the projects on offer at the LMB!
www2.mrc-lmb.cam.ac.uk/students/int...
General applications by 2nd DEC. US Gates Scholarship applications by 15th OCT.
#PhD
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Excited that we are only two weeks away for our Next Generation Biophysics Symposium 2025. We have a fantastic line-up of speakers. Registration is closing soon. Come in person or view on-line
#Biophysics
#SingleMolecule
#CryoEM
#nmr
#proteindynamics
3 months ago
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reposted by
Stephen McLaughlin
Syma Khalid
3 months ago
Carol Robinson on Desert Island Discs - have a listen friends:
www.bbc.co.uk/sounds/play/...
An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes Iām biased, but itās true nevertheless)
@kavlioxford.bsky.social
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Desert Island Discs - Professor Dame Carol Robinson, scientist - BBC Sounds
Dame Carol Robinson, scientist, shares the soundtrack of her life with Lauren Laverne.
https://www.bbc.co.uk/sounds/play/m002gzqj
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reposted by
Stephen McLaughlin
Sjors Scheres
3 months ago
Sofia Lƶvestam's vault structure is now online in Structure
@cellpress.bsky.social
. š„³ How beautifully explorative is
#cryoEM
! We never planned to do this. The vaults just came down with
#amyloids
from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
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Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
Lƶvestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...
https://www.cell.com/structure/fulltext/S0969-2126(25)00262-X
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reposted by
Stephen McLaughlin
Phil Holliger
4 months ago
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry (
www.jobs.ac.uk/job/DNW809/r...
) at the MRC Laboratory of Molecular Biology (LMB).
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Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
https://www.jobs.ac.uk/job/DNW809/research-group-leader-in-chemical-synthetic-biology
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reposted by
Stephen McLaughlin
Alessandro Costa
4 months ago
Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
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Postdoctoral Fellow - Costa Lab
Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Costa Lab Reports to: Alessandro Costa Closing Date: 03/Aug/2025 23.59 GMT Job Desc...
https://crick.wd3.myworkdayjobs.com/External/job/London/Postdoctoral-Fellow---Costa-Lab_R2283-2
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
4 months ago
Want to hear from experts about how new and emerging technologies can be harnessed to answer complex biological questions? Donāt mis the 2025 Next Generation Biophysics Symposium on Wednesday 3rd September! Find out more details and register here:
www3.mrc-lmb.cam.ac.uk/sites/nextgen/
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reposted by
Stephen McLaughlin
Kelly Nguyen
4 months ago
Highly collaborative efforts that involved 6 lab members and the labs of
@yiliangding.bsky.social
and
@rdaslab.bsky.social
. We uncovered a telomerase dimer and its potential role in telomere maintenance.
add a skeleton here at some point
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
5 months ago
Great opportunity for a Research Support Officer to join
@cellbiol-mrclmb.bsky.social
, supporting
@deriverylab.bsky.social
in their studies of the molecular mechanisms behind receptor sorting in endosomes. More info:
www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
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reposted by
Stephen McLaughlin
Derivery Lab - MRC LMB
5 months ago
šØ JOB ALERT šØ We're hiring a Research Assistant ā no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired š§«š¬ Apply now š
www.nature.com/naturecareer...
#STEMCareers
#ResearchJobs
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Excited for our program of speakers at Next Generation Biophysics 2025. Come join us as registration is now open either in person or online:
www3.mrc-lmb.cam.ac.uk/sites/nextge...
5 months ago
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reposted by
Stephen McLaughlin
Ewerslab
6 months ago
Madhavi Krishnans lab with an absolutely amazing new measurement technique: Measurements of molecular size and shape on a chip | Science
www.science.org/doi/10.1126/...
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Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
https://www.science.org/doi/10.1126/science.adt5827
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
8 months ago
How do SMC complexes capture DNA? š§Ŗ Led by Frank Bürmann, Jan Lƶweās & Mark Dillinghamās groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway. Read more:
tinyurl.com/4s8nrrkk
#LMBResearch
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Great opportunity in a fantastic lab
add a skeleton here at some point
8 months ago
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reposted by
Stephen McLaughlin
Kelly Nguyen
8 months ago
Excited to share our latest work, led by the incredible
@automnenine.bsky.social
(now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome.
www.science.org/doi/10.1126/...
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Structural mechanism of LINE-1 target-primed reverse transcription
Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...
https://www.science.org/doi/10.1126/science.ads8412
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reposted by
Stephen McLaughlin
Journal of Cell Science
9 months ago
Our latest āCell Scientist to Watchā interview is with Kelly Nguyen
@kellythd-nguyen.bsky.social
@mrclmb.bsky.social
. We learn about Kellyās career, her advice on collaborative research and her passion for martial arts.
journals.biologists.com/jcs/article/...
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
9 months ago
Great position for a postdoc to join
@igreger.bsky.social
ās group in the LMBās Neurobiology Division, using diverse methods to study synaptic AMPA glutamate receptors. Read more about the job here:
www.nature.com/naturecareer...
Apply by 20 FEB
#PostdocJobs
#ScienceJobs
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reposted by
Stephen McLaughlin
Sjors Scheres
10 months ago
The
@mrclmb.bsky.social
believes in the benefits of a diverse workforce, and is proud of its history in training next-gen scientists. Three-year postdoc fellowships are now available for those who self-identify as being from a (mixed) Black heritage background.
www2.mrc-lmb.cam.ac.uk/recruitment/...
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Rising Talent Fellowship - MRC Laboratory of Molecular Biology
RISING TALENT FELLOWSHIP The MRC Laboratory of Molecular Biology (LMB) is proud to launch the next application round of its three-year fully funded
https://www2.mrc-lmb.cam.ac.uk/recruitment/rising-talent-fellowship/
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reposted by
Stephen McLaughlin
Science of the Times Podcast
10 months ago
We (Tim Coulson & Syma Khalid) are launching a new science podcast. We will discuss recently published work of world leading scientists in an accessible and non-technical style. Topics will include, AI, search for alien life, latest treatments for diseases, quantum computers, science of football.
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
10 months ago
The LMB Rising Talent Fellowship for Black heritage scientists is open for applicants! With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience. To apply and for full details check here:
www2.mrc-lmb.cam.ac.uk/recruitment/...
⯠Please share!
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
10 months ago
Congratulations to John Sutherland, Group Leader in the LMBās PNAC Division, who has received the Award in Early Earth and Life Sciences ā Stanley Miller Medal from
@nasonline.org
for his work investigating the chemical origins of life on Earth.
www2.mrc-lmb.cam.ac.uk/john-sutherl...
#LMBNews
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reposted by
Stephen McLaughlin
Vicente Planelles Herrero
10 months ago
Check it out, is finally out!!
add a skeleton here at some point
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reposted by
Stephen McLaughlin
Janet Kumita
10 months ago
ā¼ļøDeadline 16th January 2025ā¼ļøApplications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!!
@cambridgebiosci.bsky.social
@corpuscambridge.bsky.social
www.exppg.lifesci.cam.ac.uk
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Experience Postgrad Life Sciences | Enhancing diversity among life scientists of the future
https://www.exppg.lifesci.cam.ac.uk
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reposted by
Stephen McLaughlin
Alessandro Costa
11 months ago
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.
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If you missed this year's Next Generation Biophysics Symposium 2024 follow the link below to catch up on the talks.
add a skeleton here at some point
12 months ago
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reposted by
Stephen McLaughlin
Alessandro Costa
12 months ago
Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! āļøš¬š§¬šš„³ Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors!
rdcu.be/d1F7m
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reposted by
Stephen McLaughlin
MRC Laboratory of Molecular Biology
12 months ago
Benjamin Ryskeldi-Falconās
@brfalcon.bsky.social
group in the LMBās Neurobiology Division, with Karen Duff's group at the UK DRI, have discovered that tau filaments are tethered to the membranes of extracellular vesicles in
#Alzheimers
Read more:
www2.mrc-lmb.cam.ac.uk/cryo-et-reve...
#LMBResearch
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reposted by
Stephen McLaughlin
Matthew Clark
12 months ago
I am excited to share this animation of the budding yeast inner kinetochore. Created for David Barford's lab
@mrclmb.bsky.social
This DNA-binding protein complex acts as an anchor for the spindles that pull chromosomes apart during mitosis.
www.science.org/doi/10.1126/...
#blender
#animation
#b3d
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reposted by
Stephen McLaughlin
Katja Rƶper
12 months ago
Lots of exciting PhD projects, including from my lab on how to make tubular organs, either in Drosophila or human renal organoids in culture! Apply!
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reposted by
Stephen McLaughlin
Sjors Scheres
12 months ago
Yay, our institute is here now too!
add a skeleton here at some point
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reposted by
Stephen McLaughlin
Matthew Freeman
12 months ago
Hereās my spreadsheet of starter packs (>80!) related to broadly āmechanistic biologyā plus some intriguing extras Complete with collective nouns Iāve been tracking these but now canāt keep up Hope itās helpful 2/2
docs.google.com/spreadsheets...
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@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists
https://docs.google.com/spreadsheets/d/1r74eYlX9CxrauOjPWUwYrzVfQGkeKs5HsxxQCqlaceY/edit?gid=0#gid=0
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Stephen McLaughlin
Tom McLaughlin
12 months ago
A cartoon for you
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Stephen McLaughlin
Carter Lab
12 months ago
As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December Lots of talk slots to be selected from abstracts. Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ
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reposted by
Stephen McLaughlin
Matthew Freeman
about 1 year ago
Two quanta of biophysicists and allies - (looks quite cell biological to me!) By
@ijayas.bsky.social
bsky.app/starter-pack...
bsky.app/starter-pack...
add a skeleton here at some point
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reposted by
Stephen McLaughlin
Lori Passmore
about 1 year ago
New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression.
biorxiv.org/cgi/content/...
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Phosphorylation-dependent tuning of mRNA deadenylation rates
mRNA decay is a major determinant of gene regulation that is controlled through shortening of mRNA poly(A) tails by the Ccr4-Not complex. The specificity of deadenylation can be mediated through RNA a...
https://biorxiv.org/cgi/content/short/2024.10.18.618793v1
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Registration is now open for
#NGBS2024
#Biophysics
@MRC_LMB, for more info visit
www3.mrc-lmb.cam.ac.uk/sites/nextge...
and register here:
www3.mrc-lmb.cam.ac.uk/sites/nextgen/
over 1 year ago
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Excited to announce.....
over 1 year ago
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The Introduction to Biophysical Techniques Lecture Series is back for 2024! Weāve heard 6 great talks already and there are lots more to come. Catch up on the LMB YouTube channel here:
youtube.com/playlist?lis...
#biophysics
over 1 year ago
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reposted by
Stephen McLaughlin
Sjors Scheres
almost 2 years ago
New at @MRC_LMB: the Rising Star Fellowship, which funds 3yr-postdoc for scientists who self-identify as from a (mixed) Black heritage background and who are UK domiciled or have studied in the UK.
#BlackInSTEM
www2.mrc-lmb.cam.ac.uk/recruitment/...
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Fantastic new work from the Barford Lab and Chris Batters @lmbbiophysics .bsky.social Facility. Using optical tweezers, he measured the force required to break the interaction between the kinetochore and the microtubules. Read more below..
www2.mrc-lmb.cam.ac.uk/molecular-me...
almost 2 years ago
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reposted by
Stephen McLaughlin
Athene Donald
almost 2 years ago
If you missed hearing
@dianecoyle1859.bsky.social
Tabitha goldstaub and me talking about Why we need more
#womeninSTEM
and beyond, you can catch up with the recording here
www.bennettinstitute.cam.ac.uk/events/why-w...
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Why we need more women in science and beyondĀ - Bennett Institute for Public Policy
What progress has been made, and what more is needed to bring more women into science and other professions where they are underrepresented? Explore the impacts of societal expectations and...
https://www.bennettinstitute.cam.ac.uk/events/why-we-need-more-women-in-science-and-beyond/
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If you missed our 2023 Next Generation Biophysics Symposium at the MRC LMB, some of the talks are now online:
#Biophysics
#2023NGBS
www.youtube.com/playlist?lis...
about 2 years ago
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