Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge #cryoem

#CryoEM how do we feel about this instrument? We may be in the market and I want to know what people are currently using.

Hummm

This is an auto include on my reading list because I know its going to be good. Congrats @vcushing.bsky.social @bjgreber.bsky.social and all!

When Macrophages Disappear, Skin Blood Vessels Age! Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology 👇👇 www.nature.com/articles/s41...

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

Congrats to #LMBAlumni Juan B. Rodriguez Molina, former Investigator Scientist in the LMB's Structural Studies Division, newly appointed Assistant Professor in the Dept of Molecular and Cellular Biosciences at the University of Cincinnati College of Medicine researchdirectory.uc.edu/p/1818215

Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.

Hey thats me.

Since when are vaults cool again? Loving it

My lab has developed mSHINE, allowing for both highly multiplexed and portable nucleic acid detection. Very exciting work led by the talented @sijbren-kramer.bsky.social, who is off to do a PhD at Stanford at the end of the month!

Now out in Science Advances: www.science.org/doi/10.1126/...

😍😍😍

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM. Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur... #LMBNews 🧪🔬

I somehow missed this piece about Jon in my lab: molbio.princeton.edu/news/2025/jo...

I just got it. This is great.

🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social Apply: euraxess.ec.europa.eu/jobs/359830 Please boost! #ArboRetro #Bioinformatics

Returned from a wonderful symposium in honour of the 50th anniversary of Richard Henderson's and Nigel Unwin's 1975 paper on the structure of bacteriorhodopsin - the paper that started the field of membrane protein structural biology. Also fulfilled my dream of ringing the LMB seminar bell.

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.

Hurray! 🥳🎉🥂

Goodbye Nucleic Acids GRC, goodbye Tuscany - this was great! Thanks to Jane Jackman and Brandt Eichman for organising this fantastic conference!

Calling all structural biologists in the NYC metro area! The nysbdg.bsky.social is back for in-person events! Register here 👉🏼 buff.ly/dGmJeau I look forward to seeing you there! 😎 #structuralbiology #cyrstallography #cryoEM #NMR #chromatography #proteinpurification #AKTAsystems

Congratulations to Dirk Hockemeyer on his promotion to MCB Professor of Cell Biology, Development and Physiology! 👏🎉 mcb.berkeley.edu/news-and-eve...

In Barbara we trust!

🧬Happy Transposon Day! 🎉Each year on the 16th of June we commemorate the birthdate of the founder of transposable element research, Barbara McClintock (1902-1992). #TransposonDay2025 #MobileDNAjournal

Keeping the dream alive.

Well deserved! 🥂🥂🥂 MolBio's newest tenured faculty: Adamson & Mallarino; and newest full professor: Petry. molbio.princeton.edu/news/2025/mo...

Devenport receives President’s Award for Distinguished Teaching. “She is inspiring, visionary, charismatic, relatable, empathetic, hardworking and organized. Having even a few of these traits is a hallmark of a good teacher, but she embodies all of them.” www.princeton.edu/news/2025/05...

The W-S lab is seeking to hire a research scientist! This person will lead wet-lab innovations in our team as we combine AI and experiments to understand and design dynamics! Thanks for sharing/RTs! jobs.wisc.edu/jobs/scienti...

1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/... @yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

My official stance this year is that no one should fool anyone on April Fools. The universe has already been messing with us all year.

I often heard murmurs of this ‘bubble’ technology at the LMB

From Princeton University President Christopher Eisgruber: www.theatlantic.com/ideas/archiv...

🚨 PostDoc opportunity at the MRC-LMB 🚨Join our team to explore transcription-coupled splicing using cryoEM and biochemistry! 🔬🧬 Please spread the news 🙏🏼 Apply here: mrc.tal.net/vx/mobile-0/... #Postdoc #CryoEM #MolecularBiology

This was really fun too because I get to make illustrations sometimes.

A blend of my two favorite systems... telomeres + transposons. Congratulations all! 🥳

International Women’s Day was yesterday, but I think we shouldn’t limit ourselves to one day per year to celebrate women. In these troubled times with fascism on the rise almost everywhere, I’d like to celebrate Danuta Danielsson, also known as “The Woman […] [Original post on fediscience.org]

Did you know that two jumping sequences (LINE-1 and Alu) make up nearly 30% of our genomes? Ever wonder how they jump into new genomic sites? We have some exciting discoveries to share new in @science.org on the structural mechanisms of LINE-1 retrotransposition (aka jumping 🧬➡️🧬) 🧪 #ScienceResearch

Jersey - who will I see in Trenton next Friday? Amazing speakers include @samwang.bsky.social @rburdine1.bsky.social. #standupforscience2025! #scienceforall. RT 🧪 @annikabarber.bsky.social @cate-cholamine.bsky.social @matiset.bsky.social @thejersygirl.bsky.social @standupforscience.bsky.social

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

I'm looking to buy vertical electrophoresis tanks. The ones that were used for old school sequencing gels. I really liked the ones made by Cambridge Electrophoresis, but they either don't make them anymore or don't ship to the USA. Any leads? www.electrophoresis.co.uk/EV400%20&%20... #biochemistry

Spotlight on the amazing microscopes at Princeton University, including those enabling state-of-the-art Cryo-EM/ET ❄️🔬 www.princeton.edu/news/2024/02/01/princetons-world-class-microscopes-are-making-giant-impact-realm-minuscule

This is wild.

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions pubmed.ncbi.nlm.nih.gov/39893634/ #cryoem

After many years at @mrclmb.bsky.social, I've moved back home to start my own lab at @princetonmolbio.bsky.social. I'm so thankful to my mentors, especially Kelly Nguyen and Don Rio! We have some exciting results on LINE-1 in the works and are recruiting. Find out more: ghanim.lab.princeton.edu

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

The microscope comparison datasets (Glacios vs. Krios, EF vs. no EF) from our high-resolution/high-throughput #cryoEM SBDD workflow project (the one with more than a dozen ligand-bound 2 Å structures of an 85 kDa complex) have been released on EMPIAR: www.ebi.ac.uk/empiar/EMPIA...