#AlphaFoldDB now has binary protein complexes! https://www.ebi.ac.uk/about/news/technology-and-innovation/first-complexes-alphafold-database/ #alphafold #AlphaFold2 #StructuralBiology

The Miners' Track at #GoldenHour on #MoelwynMawr. #MountainMonday Coming down the Miners' Track as the sun was setting is an experience I'll never forget... Mainly because it was the last leg of an arduous, stupid day which saw Aled and I get (somewhat) lost […] [Original post on pixelfed.social]

Hi I’m Ryan and I spent a month pooping in holes at -50c just to take a picture of a cat Here’s the cat: #mongolia #sonyalpha #wildlifephotography #conservation #pallascat #photography #travel

Go home #alphafold, you're drunk. 😆 https://alphafold.ebi.ac.uk/entry/Q8CDI7

I saw southern auroras last night!!!! Rakiura! Holy cow that was AMAZING (View from a bit south of Arthur's Pass, New Zealand)

Go home #alphafold, you're drunk. 😆 https://alphafold.ebi.ac.uk/entry/Q8CDI7

An old one, but appropriate for the day. #piday

Happy pi-day!

I put together a #chimerax plugin to display circos-like contact maps between proteins/DNA. I'm using it all the time now (after doing this manually for years) so I hope someone else may find it useful! https://cxtoolshed.rbvi.ucsf.edu/apps/chimeraxcircoscontacts […]

I am offered a talk at the #ccpem Spring Symposium and this is making me excited and scared at the same time. Strange mix of feelings. 🙃 This is the coolest #CryoEM conference I have been to. Very happy to have an opportunity to attend again!

I talked about David W. Hogg's "Why do we do astrophysics?" in our seminar today. Thank to @aleks who posted about it here first! I can only encourage everyone working in or interested in science and/or fundamental research to read it, it has broad relevance and the crucial parts, to me, are […]

Good news everyone, my solar powered website has survived through the last two nights, winter is over :ggsun: https://solar.stfn.pl/

You don’t hate peer-review, you hate the deadline attached to it. #academicchatter

My experience with generative-AI has been that, at its very best, it is subtly wrong in ways that only an expert in the relevant subject would recognise. So I don't worry about us creating super-intelligent AI, I worry about us allowing that expertise to atrophy through laziness and greed. I […]

On the topic of bug-fixing: "It took 15 years for anyone to notice errors in the ubiquitous BLOSUM62 amino acid substitution matrix used for protein sequence alignment". Even weirder, this bug makes the results better. https://www.nature.com/articles/nbt0308-274 #softwarecarpentry #bugs […]

PSA: If you block the `claude` user on GitHub, you'll get a warning every time you view a repo with that user in its commit history. This allows you to, the moment you look at a repo, immediately adjust your expectations. You may do so here: https://github.com/settings/blocked_users

I am looking for papers that report on quantum chemistry computations performed on quantum computers. NOT theory NOT running on simulators NOT benchmarks (all those are easy find) but computations of real chemical interest on real quantum devices.

#silentsunday ice skating on lake Ekoln. ☀️ 🧊 🤩 #icetodon #frostodon

Reflect Orbital wants to destroy the night sky to deliver "sunlight as a service". SpaceX wants to destroy Low Earth Orbit to launch one million "AI datacentres" The only way to formally protest these two ideas is to file a comment with the US FCC, which is horribly complicated, but the […]

"AI is built on the collective knowledge of humankind." No. Nononononono. It is not built on _knowledge_, it it built on _data_. And not everyone's experiences are available as data, many communities are included. Also: "Collective" implies some sort of collaboration and shared activity. But […]

RE: https://mastodon.world/@AaronDavid/116031139149726891 This cartoon had been attached to my glove box for 30 years…. A classic!

On @CoMaps, I see buoys marked on a lake. They are categorized as "lateral buoy" when I edit them. Today I went skating on said lake (it's all frozen, wonderful!) and went by a lateral buoy that's not on #openstreetmap yet. Trying to add it from CoMaps, I couldn't find the "lateral buoy" […]

Love Data Week is coming! https://www.nordiclovedataweek.org #lovedataweek #researchdata

I recently returned from an incredible trip to Antarctica and I need everyone to look at my penguin photos.

“pandoc for the people”, the pandoc wasm web-app, is now available at https://pandoc.org/app/ It allows to run any kind of document conversion that pandoc supports in the browser. The documents never leave the computer, thus ensuring *full privacy*. Conversions to pdf are done via Typst […]

If I want to do calculations reasonably fast I use 20th century computing... If i want to do calculations very fast I use 17th century mathematics... Then again if I want to do calculations wrong I use 21st century computing.

Just received an unsolicited email with subject line "Your research is invisible to AI". Great, best news I got today. Then AI won't make up nonsense about my work. Didn't read past the subject line before hitting the spam button. 😀

If you write about the messy reality behind "free" internet services: we're seeing #OpenStreetMap hammered by scrapers hiding behind residential proxy/embedded-SDK networks. We're a volunteer-run service and the costs are real. We'd love to talk to a journalist about what we're seeing + how […]

OK, I am probably going to miss out on some content about the solid state of water, but it is high time to set up a filter for this three-letter word... the timeline is becoming too depressing.

Finally tried #ghostty and wow, it's going to win me over and make me abandon kitty! 🤩 Just as fast, better integrated with the OS. It apparently supports the kitty image protocol, but I haven't yet found an equivalent to kitty's 'kitten icat' command.

They say AI isn’t profitable. That’s not true. Twice just this past week, I’ve been contacted and paid to fix problems caused by developers who relied on AI to configure servers. #ai

J'aurais jamais dû fermer ce compte #framadrive... 🤦

RE: https://sunny.garden/@firda/115934067060821051 There are often amazing pictures on #seawednesday, and it is great when the location is indicated, like in the post below! It is uncommon, and I always find it frustrating to see a beautiful seascape without being told where it is.

root@kaka:~ sudo apt-get install inetutils-telnetd telnet root@kaka:~ sudo sed -i 's/#<off># telnet/telnet/' /etc/inetd.conf root@kaka:~ sudo /etc/init.d/inetutils-inetd start root@kaka:~ USER='-f root' telnet -a localhost ... root@kaka:~# https://seclists.org/oss-sec/2026/q1/89

I'm sorry to see obituaries for Dr. Gladys West this morning: https://thezebra.org/2026/01/18/dr-gladys-west-mathematician-whose-work-made-gps-possible-dies-at-95/ She was brilliant and did a lot of incredibly important scientific work, a lot of which was hidden/uncredited early on, because she […]

Datacenters/compute should be a thing that states provide to their citizens kind of as public utility that is run only on renewables in regions where the negative externalities would not affect people (requiring a public vote with a high threshold for acceptance). with everyone getting a fair […]

As promised, here is a summary of this new preprint on the ALC1-nucleosome complex. 🧵 https://doi.org/10.1101/2025.11.10.687450 First, a reminder of some structural features of the #nucleosome. Histones H2A and H2B form a negatively charged cleft exposed […] [Original post on fediscience.org]

RE: https://fediscience.org/@Guillawme/111534984107819771 Something really cool happened to me this year! @HRBridges re-processed a #CryoEM dataset from some previous work of mine and colleagues (publicly available as EMPIAR-10739; see quoted post below for a summary of this work). She […]

Remember, when something in the news upsets you, you are *not obligated* to spend the next hour hunched over your phone reading live updates and social media hot takes. You *can* stay informed without succumbing to this urge -- an urge deliberately conditioned into us for decades by the 24-hour […]

An interesting account of how the gunpowder plot ended. The Gunpowder Plot’s Forgotten Ending in Staffordshire https://www.theredhairedstokie.co.uk/the-gunpowder-plots-forgotten-ending-in-staffordshire/ There's a call for help, which I'll repeat here: > Ideally, I would like to identify who […]

Help me fediverse: I vaguely remember a website offering various simple services, with the defining feature that everything it provides is accessed exclusively over ssh (except the website itself documenting how to access the services). I think it was made by some small entity that, on the […]

You are not a "human resource", you are a human being. For people new to the workforce, Human Resources Departments might be staffed by nice people, but they work for the interests of management. If you want an entity that looks out your interests as a worker, that's what labor unions are for.

RE: https://fediscience.org/@Guillawme/111534984107819771 Something really cool happened to me this year! @HRBridges re-processed a #CryoEM dataset from some previous work of mine and colleagues (publicly available as EMPIAR-10739; see quoted post below for a summary of this work). She […]

JOB: Research Scientist at Wikimedia "We’re hiring a Research Scientist strongly committed to the principles of free knowledge, open source, privacy, and collaboration to join the Research team. As a Research Scientist, you will conduct applied research on the integrity of Wikipedia knowledge […]

Instead of a Mozilla fuck-up drinking game: Donate to @servo every time Mozilla gives its community another middle finger. 😁

If your #fediverse instance is run by an entity accepting donations (typically, an individual or an association), and you can afford to make a donation, do it! Even small donations are better than nothing and will help keep the lights on!

Books are art, and art is labor. Welcome to the rereading Project! We're working to build and maintain tools that respect and support the relationship between readers, authors, editors, and independent publishers by making it easier to read and archive books. Check us out at […]

«Kovid betrayed us with Calibre 8.16.2, and we as a community never should have let that happen, never have placed such a burden on individual generosity. The synthesis of these two truths, then, is nearly self-evident. There must be a new effort, free from AI encumbrances, that is built from […]