Congratulations to @karishmabisht.bsky.social with her paper on the effect of fever on influenza replication and innate immune activation! www.science.org/doi/10.1126/...

RNA structure modulates Cas13 activity and enables mismatch detection - @cambearon.bsky.social @princetonmolbio.bsky.social go.nature.com/4oglebG

There is still time to apply; join our team to work on influenza virus replication mechanisms!

Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠

Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...

3-year-old girl dies from H5N1 bird flu in Mexico’s first human case bnonews.com/index.php/20...

Yep, Pubmed here down as well

It is worth paying close attention to the new bill "Dangerous Viral Gain of Function Research Moratorium Act" introduced by Senator Roger Marshall. If enacted, it will effectively stop all of virological research, including for vaccines. www.marshall.senate.gov/wp-content/u... 🧵👇

We are at risk of abandoning “a deal where the government provides funding, and in exchange it gets products, research, national security, prestige, and the next generation of qualified scientists.” #academicsky www.princeton.edu/news/2025/02...

FWIW, it's perhaps worth noting that when Benjamin Franklin visited France between 1776 and 1778 to ask for military support for the then-new-formed United States of America, he wore a coonskin cap. "Proper" French court attire at this time was a powdered wig.

My new piece in @theguardian.com Techno-optimism is human pessimism. www.theguardian.com/commentisfre...

Despite everything, I still really want to celebrate the wonderful folks in my group, so I hope it is ok if i write about our latest work. I am very proud of all the authors, and our collaborators, on our work just published in Nature communications. www.nature.com/articles/s41...

Negative-Strand RNA Virus meeting #NSV2025 registration is now open! Visit www.negativestrandvirus.org/home

Excited to share this new preprint showing that non-canonical influenza virus transcripts are produced in a sequence/RNA structure-dependent manner on aberrant RNAs: www.biorxiv.org/content/10.1...

A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs https://www.biorxiv.org/content/10.1101/2025.01.04.630666v1

They can all be downloaded from here: cvr-engagement.co.uk/virus-snowfl..., except for...

What we are waiting for to wake up? "The patient had been in contact with sick and dead birds in backyard flocks, the Centers for Disease Control and Prevention said" @adamjkucharski.bsky.social discusses effective outbreak response @plosbiology.org plos.io/3ZnpcnE apnews.com/article/bird... 🧪

We have another new preprint up! www.biorxiv.org/content/10.1...

(this is very consistent with another work from @ajtevelthuis.bsky.social which we were happy to contribute to, found at www.biorxiv.org/content/10.1...)

We have found a capped flu RNA that was hiding in plain sight. In our preprint we show how this RNA activates RIG-I through a non-canonical mechanism. Fantastic work by Liza Elshina and many thanks to collaborators @alistairrussell.bsky.social and Joe Marcotrigiano! biorxiv.org/content/10.1...

We have a new preprint up! www.biorxiv.org/content/10.1...

Transient RNA structures contribute to highly pathogenic flu emergence! Fantastic work by Mathis Funk and Mathilde Richard now on BioRxiv: biorxiv.org/content/10.1... For supporting data see: science.org/doi/10.1126/...

Excited to share a preprint on quantifying aberrant viral RNAs using Cas13. We reveal surprisingly reproducible kinetics of individual influenza virus mvRNAs in infection and detect mvRNAs even in clinical samples! www.biorxiv.org/content/10.1...

The Scientific American mask article with @sameo416.bsky.social and @jvipondmd.bsky.social www.scientificamerican.com/article/mask...