Ervin Fodor
@efodor.bsky.social
📤 1105
📥 300
📝 15
Molecular virologist and gardener.
Big welcome to
@corneliusleeyh.bsky.social
starting his DPhil with
@achilleskap.bsky.social
@kavlioxford.bsky.social
&
@efodor.bsky.social
@dunnschool.bsky.social
on influenza dynamics! Great to see this cross-disciplinary project getting underway.
add a skeleton here at some point
28 days ago
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reposted by
Ervin Fodor
Achilles Kapanidis
29 days ago
Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with
@efodor.bsky.social
,
@nicolerobb.bsky.social
academic.oup.com/nar/article/...
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High-throughput single-virion DNA-PAINT reveals structural diversity, cooperativity, and flexibility during selective packaging in influenza
Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in
https://academic.oup.com/nar/article/53/19/gkaf1020/8285782
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reposted by
Ervin Fodor
The Dunn School, Oxford
2 months ago
Our PhD studentship programme is officially open; pass it on If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details... Great science and a great environment!
www.path.ox.ac.uk/news-article...
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Applications now open for our PhD studentship programme - Dunn School
Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.
https://www.path.ox.ac.uk/news-article/applications-now-open-for-our-phd-programme-2/
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reposted by
Ervin Fodor
The Dunn School, Oxford
4 months ago
📣 Applications now open 📣 We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease! Please share!
www.path.ox.ac.uk/work-with-us...
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There is still time to apply; join our team to work on influenza virus replication mechanisms!
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6 months ago
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Exciting job opportunities! Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social
to study influenza virus transcription, genome replication, nuclear export and assembly. More info:
my.corehr.com/pls/uoxrecru...
6 months ago
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reposted by
Ervin Fodor
Nicole Robb
7 months ago
Thrilled to share that our latest manuscript using smFRET to study inhibition of SARS-CoV-2 is now out!
doi.org/10.1093/nar/...
Congrats and thanks to amazing co-authors and collaborators for all the hard work.
@efodor.bsky.social
@jeremykeown.bsky.social
@andrewmcmahon1345.bsky.social
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reposted by
Ervin Fodor
Nicole Robb
7 months ago
Massive congratulations to Dani from the lab who passed her PhD viva yesterday! Special thanks to her wonderful co-supervisor
@efodor.bsky.social
, to her examiners
@davidlvbauer.bsky.social
and
@jeremykeown.bsky.social
and to the Warwick MRC-DTP for funding her PhD! 🦠🎓🎂
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Many thanks to GfV for the invitation to present our collaborative work with Jonathan Grimes' group. It's a pleasure to attend
#GfV2025
!
add a skeleton here at some point
8 months ago
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reposted by
Ervin Fodor
GfV - Gesellschaft für Virologie
8 months ago
The last keynote speaker of day 2, Prof. Ervin Fordor from Oxford, presented interesting data on the multifunctionality of the RNA polymerase complex of the influenza virus.
#GfV2025
(HMB)
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reposted by
Ervin Fodor
The Lancet Infectious Diseases
9 months ago
New comment: Europe needs a sustainably funded influenza research and response network
www.thelancet.com/journals/lan...
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Europe needs a sustainably funded influenza research and response network
Influenza viruses have caused four pandemics during the last century.1 The 1918 H1N1 pandemic claimed 20–50 million lives, the 1957 H2N2 pandemic and the 1968 H3N2 pandemic claimed 1–4 million lives e...
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00068-4/fulltext
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reposted by
Ervin Fodor
Achilles Kapanidis
9 months ago
First BlueSky post + a breath of fresh air! Excited about our preprint on the packaging + structure of viral RNA segments in influenza virions:
doi.org/10.1101/2025...
. A saga from amazing Christof and Qing, and a great collaboration with
@nicolerobb.bsky.social
and
@efodor.bsky.social
.
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reposted by
Ervin Fodor
Nicole Robb
9 months ago
Happy to be part of this beautiful work using DNA-PAINT to study genome packaging in influenza 😊thanks to all co-authors
@efodor.bsky.social
& Christof, Achilles and Qing! Check it out here:
www.biorxiv.org/content/10.1...
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reposted by
Ervin Fodor
Ed Hutchinson
10 months ago
Our study on pasteurising influenza viruses in milk is now out! It's a nice simple story: influenza viruses (including H5N1) are killed really effectively by pasteurisation, but in raw milk they stay infectious - obvious public health implications of both points... (1/2)
rdcu.be/d73te
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reposted by
Ervin Fodor
Ed Hutchinson
10 months ago
What's going on with bird flu in the UK at the moment? I wrote a piece for
@uk.theconversation.com
explaining what we know at the moment, and why it's not yet time to worry
theconversation.com/bird-flu-cas...
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Bird flu cases surging in UK but risk to humans remains low
Restrictions have recently been put in place in England and Scotland to curb the spread of bird flu.
https://theconversation.com/bird-flu-cases-surging-in-uk-but-risk-to-humans-remains-low-248350
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reposted by
Ervin Fodor
The Dunn School, Oxford
10 months ago
We just can't stop recruiting! Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
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reposted by
Ervin Fodor
AJ te Velthuis
10 months ago
Excited to share this new preprint showing that non-canonical influenza virus transcripts are produced in a sequence/RNA structure-dependent manner on aberrant RNAs:
www.biorxiv.org/content/10.1...
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A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs
Influenza A virus (IAV) non-canonical replication products can be bound by various host pathogen sensors, including retinoic acid-inducible gene I (RIG-I). However, it is not clear why non-canonical I...
https://www.biorxiv.org/content/10.1101/2025.01.04.630666v1
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reposted by
Ervin Fodor
Tom Peacock
10 months ago
Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With
@influenzal.bsky.social
@vidhid.bsky.social
@drclairesmith.bsky.social
and many more!
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Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...
https://www.biorxiv.org/content/10.1101/2025.01.06.631435v1
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reposted by
Ervin Fodor
Franziska Günl
11 months ago
The last days of 2024 but hey: I am happy to share that our new paper is out!
www.embopress.org/doi/full/10....
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Structure of the Nipah virus polymerase complex | The EMBO Journal
imageimageThe RNA polymerase complex of the Nipah virus is responsible for both replication and transcription of the viral RNA genome. This study elucidates the structure of the RNA polymerase in comp...
https://www.embopress.org/doi/full/10.1038/s44318-024-00321-z?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20241230&utm_content=10.1038%2Fs44318-024-00321-z
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reposted by
Ervin Fodor
Ed Hutchinson
11 months ago
Delighted to hear that Andrew McMahon and Nicole Robb's study 'Engineering stress as a motivation for filamentous virus morphology,' which we and other
@cvrinfo.bsky.social
authors collaborated in, is now a beautiful cover image. You can read the paper here:
www.sciencedirect.com/science/arti...
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Just published - pandemic influenza PB1 genes of avian origin reduce polymerase activity and virulence in low-pathogenic avian influenza viruses. Insights into host adaptation and zoonotic risk.
www.science.org/doi/abs/10.1...
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Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and pathogenicity
Past influenza pandemics contained polymerase genes from avian influenza viruses, affecting viral replication and pathogenicity.
https://www.science.org/doi/abs/10.1126/sciadv.ads5735
11 months ago
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reposted by
Ervin Fodor
Jeremy Keown
11 months ago
Excited to share our work describing a series of structures that allow us to propose a new model for Hantavirus genome replication by the viral L-protein. Another great experience with
@loiccarrique.bsky.social
@ben-nilsson-payant.bsky.social
@efodor.bsky.social
Jon Grimes.
doi.org/10.1371/jour...
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Structural characterization of the full-length Hantaan virus polymerase
Author summary Hantaviruses are widely distributed viruses that can undergo zoonosis where they cause severe disease in humans. Old World hantaviruses, found predominantly in Asia and Europe, can caus...
https://doi.org/10.1371/journal.ppat.1012781
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reposted by
Ervin Fodor
AJ te Velthuis
about 1 year ago
We have found a capped flu RNA that was hiding in plain sight. In our preprint we show how this RNA activates RIG-I through a non-canonical mechanism. Fantastic work by Liza Elshina and many thanks to collaborators
@alistairrussell.bsky.social
and Joe Marcotrigiano!
biorxiv.org/content/10.1...
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reposted by
Ervin Fodor
Tom Peacock
about 1 year ago
Wendy Barclay and I will soon be recruiting a postdoc to work on a virology project investigating the evolution of swine influenza viruses and how this impacts future pandemic potential. Job will be based at Imperial's South Kensington campus. Drop me a DM/email for more details.
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reposted by
Ervin Fodor
The Dunn School, Oxford
about 1 year ago
There is still time to apply! Associate professor, immunity/inflammation/infection (defined broadly) especially welcome Come and join a great community of supportive colleagues! Deadline 25 October, please spread the word
www.path.ox.ac.uk/vacancy/asso...
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reposted by
Ervin Fodor
The Dunn School, Oxford
about 1 year ago
We are pleased to announce that eminent structural biologist Stephen Cusack, former head of EMBL Grenoble, has been appointed an Oxford University visiting professor
@dunnschool.bsky.social
www.path.ox.ac.uk/news-article...
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Stephen Cusack appointed new Visiting Professor of Structural Biology - Dunn School
The honour recognises our previous Head of Department’s pioneering work in fundamental and therapeutic immunology research, which spearheaded the development of engineered antibodies for treatment of ...
https://www.path.ox.ac.uk/news-article/stephen-cusack-appointed-new-visiting-professor-of-structural-biology/
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A great opportunity for a virologist/immunologist to join a fantastic community of supportive colleagues
@dunnschool.bsky.social
www.path.ox.ac.uk/vacancy/asso...
add a skeleton here at some point
about 1 year ago
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reposted by
Ervin Fodor
Daniel Goldhill
over 1 year ago
From
@efodor.bsky.social
www.nature.com/articles/s41...
Beautiful structures explaining the story behind some mutations which are relevant at the moment for cow flu. Also, nice to see that subtle differences between the FluC and FluA structures determine which mutations make a difference.
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Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation - Nature Communications
The authors demonstrate how avian H5N1 influenza A virus polymerase interacts with human ANP32B to facilitate the replication of the viral genetic information in mammalian hosts, revealing insights in...
https://www.nature.com/articles/s41467-024-48470-3
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RNA polymerase of the 1918 pandemic influenza A virus binds to the serine 5 phosphorylated C-terminal domain of host RNA polymerase II to promote viral mRNA synthesis.
www.biorxiv.org/content/10.1...
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Structural and functional characterisation of the interaction between the influenza A virus RNA poly...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
https://www.biorxiv.org/content/10.1101/2023.11.29.569222v1
almost 2 years ago
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Influenza virus RNA genome segments undergo a full cycle of replication in a test tube in the presence of viral RNA polymerase, viral nucleoprotein and human ANP32B, an essential host factor for influenza virus genome replication.
journals.plos.org/plosbiology/...
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Defining the minimal components of the influenza A virus replication machinery via an in vitro recon...
The influenza A virus genome is composed of eight single-stranded RNA segments. This study reconstitutes the replication of RNA genome segments in a test tube, using purified viral and host proteins, ...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002370
about 2 years ago
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reposted by
Ervin Fodor
Matthew Freeman
about 2 years ago
The Dunn School at University of Oxford just can't stop recruiting! This time an Associate Prof in cell/mol biology with focus on infection, immunology, inflammation Come and join us... Please spread the word
www.path.ox.ac.uk/vacancy/asso...
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A fantastic postdoc opportunity with Jon Grimes at Strubi, University of Oxford, to study the molecular mechanisms of viruses using the latest cryo-ET and cryo-SIM technologies.
my.corehr.com/pls/uoxrecru...
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Job Details
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10&p_internal_external=E&p_display_in_irish=N&p_process_type=&p_applicant_no=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y&p_recruitment_id=169248
about 2 years ago
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Very glad to have been able to contribute to this study of the interplay between the influenza A virus RNA polymerase and host ANP32 proteins.
add a skeleton here at some point
about 2 years ago
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