Cricket and Willow hosted a W-S lab dinner!

The W-S lab is seeking to hire a research scientist! This person will lead wet-lab innovations in our team as we combine AI and experiments to understand and design dynamics! Thanks for sharing/RTs! jobs.wisc.edu/jobs/scienti...

We are looking to hire (yes, even in this economy!) a jr. specialist to train in protein prep/structural biology related to our AVOID-ome work as part of openadmet.org. A great position for someone who is looking to be a tech for a few years before grad or med school. aprecruit.ucsf.edu/JPF05424

Join us for the 2nd Macromolecular Conformational Ensembles Conference on June 9th/10th at UCSF. The most compelling questions in structural biology cannot be effectively addressed using only a single structure. conformationalensembles.github.io @fraserlab.bsky.social

someone said we need a meme

👏 models in nmr structure != thermodynamics 👏 Structures I’ve been part of include the top-X most probable structures. Same as how the top-X-scoring models from a Rosetta run wouldn’t be a thermodynamic ensemble.

Really nice resource from @delalamo.xyz !! Wanna mention the "AdK test" we're noticing newer DL methods fall short on: many proteins (like AdK) that have apo/holo conf change sample both the apo/holo state even without ligand bound. But w/o ligand bound, they *are mainly in the apo state*

Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

Unassigned nitrogens in nmr data often indicate biologically relevant motion in proteins, and this can be used train deep learning models of protein dynamics! Hannah Wayment-Steele @ginaelnesr.bsky.social @sokrypton.org www.biorxiv.org/content/10.1...

Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics? @hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1! 🧵

Protein dynamics was the first research to enchant me >10yrs ago, but I left in PhD bc I couldn't find big experimental data to evaluate models. Today w @ginaelnesr.bsky.social, I'm thrilled to share the big dynamics data I've been dreaming of, and the mdl we trained w them: Dyna-1. 📝: rb.gy/de5axp

Had a blast talking about topics ranging from the 1966 ALPAC report to pLM pitfalls on isoforms with @uwdsi.bsky.social! Thanks to COMBEE for hosting and recording! www.youtube.com/watch?v=Dxug...

Today @gogs-k.bsky.social, @tlhr.bsky.social, and I are launching @bindresearch.org, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠

Incredible moon over Lake Mendota waiting for the bus that iPhone can hardly do justice Unrelated: looking for recs for tech-sensitive gloves that can handle a “feels like” of -15F 😅

❄️🕸️!

Good roast near NeurIPS!

If you enjoy MLSB please consider filling out! Statistics may help us craft proposal for next year!

MLSB in its 5th year was fantastic! Here’s to passionate people from many backgrounds converging to one overcrowded room!

📣 Save the dates 📅 We are organizing a Benzon Symposium on "Protein structure prediction and design" with what I think is an amazing set of speakers Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and abstract submission will open in March (benzon-foundation.dk/benzon-sympo...)

First W-S lab dinner, selfie, and 0.5x selfie! Grateful so many awesome people around in what’s technically year -1 of the lab!

Naturally ornate RNA-only complexes revealed by cryo-EM https://www.biorxiv.org/content/10.1101/2024.12.08.627333v1

Re docking: @workshopmlsb.bsky.social has been piloting a leaderboard for the PLINDER benchmark. It would be awesome to get submissions using existing methods, then everyone can see comparisons better 😁 leaderboard & instructions are on mlsb.io

I think Bucky liked my nmr hoodie ☺️ @nmrfam.bsky.social @uwbiochem.bsky.social

This past year, the organizers at @workshopmlsb.bsky.social partnered with PRX Life to create a special collection focused on the topic of "machine learning in structural biology". Was a pleasure to work together trying to create a venue for workshop papers! journals.aps.org/prxlife/abst...

Hello again Bluesky! Excited to gain another platform that I do a bad job at checking

It took me this long to figure out that on a mac, option-m = µ. goodbye forever us, um, uM. Look at me, typing µ's this easy! Look there's another one. µ

A nice Sunday morning where one of us is working on job applications and one of us is destroying a cardboard box.

Hello world! (aka, Bluesky) Have you had a fun weekend? I sure did!