Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️

We just preprinted one of my favorite studies @FlatironInst . I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...

Excited to announce this postdoc position at the intersection of experiment and computation for time-resolved cryo-EM! It's a collaboration between the Enchev group at the Crick and myself and @pilarcossio.bsky.social at the Flatiron Institute! Plz share. crick.wd3.myworkdayjobs.com/External/job...

This was fun to pull together! Such a fast moving field!

Congrats!! 👏🥳🎉

ROCKET came out on Nature Methods today. It takes a tremendous amount of effort to translate a research concept into a practical tool—one that researchers can seamlessly drop into their existing pipelines. We learned a lot along the path and will carry that spirit forward.

After three inspiring days filled with excellent science our @cecamevents.bsky.social meeting has come to an end!

What a treat! What do you think is the future of Biophysics?

This was so fun!

So excited for this!

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

A great start to the Biophysical Society Annual Meeting in San Francisco! Check out the various projects being presented on work from Flatiron Institute people! #bps2026

Thanks @fraserlab.com ! It was great to have your feedback during the journey that was this paper!

Super excited to be at my first ASCB in Philly! Here's a photo dump, including @mahsamofidi.bsky.social presenting her poster! #cellbio2025

Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/challenge #cryoem

From a Twitter research project to an independent rival — Bluesky’s journey under CEO Jay Graber shows how a decentralized, user-first platform gained millions users by prioritizing control & openness in social media. A true alternative in a billionaire-dominated space. www.cnbc.com/2025/08/29/b...

Super excited our preprint on the Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge is up! 🎉 🥳 Check out Miro's thread below for more details!

New preprint 🚨--protein language models + MD training ➡️ allosteric networks! @sonyahanson.bsky.social and I are developing RocketSHP 🚀 for rapid genome-scale inference of local+correlated fluctuations + structure token distributions! 📄: www.biorxiv.org/content/10.1... 💻: github.com/flatironinst...

You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!

The EMBL #ARISE2 Fellowship Programme, funded by MSCA, will open for applications on 30 June. This unique opportunity trains researchers to lead #ResearchInfrastructures & innovate in the #LifeSciences. 🧪 🗓️ Join our webinar on 17 June at 15:00 CET: embl-org.zoom.us/meeting/regi... #careers

This is so cool!

I was asked an interesting question at a (worky/networky) dinner this week. "What percentage of the human proteome has experimentally determined structures?" - Do you know the answer off the top of your head?

Science is an economic driver in Hamilton, Mont., thanks to Rocky Mountain Laboratories, a federal research lab. Now, layoffs and funding cuts are having an impact in this town far from Washington.

👏👏👏 @miroastore.bsky.social

#FlatironCCB scientist @sonyahanson.bsky.social was a guest editor for the Journal of Physical Chemistry B's new Membrane Protein Simulations Special Issue. Read here: pubs.acs.org/toc/jpcbfk/1... #science #biology

Happening today with @sonyahanson.bsky.social!

A French University is funding a Safe Place For Science program meant to recruit scientists who cannot continue their work in the US. www.univ-amu.fr/fr/public/a...

It's been a great #bps2025 ! 🎉 Some snapshots of the week for us. So proud of everyone's hard work! @miroastore.bsky.social @samsl.io

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227

Nice time catching up with folks from @foldingathome.org at #bps2025

Checkout the Flatiron Institute Structural and Molecular Biophysics at #BPS2025 @sonyahanson.bsky.social @miroastore.bsky.social @samsl.io

I'm at @biophysicalsoc.bsky.social #BPS2025 with a bunch of folks from the Structural and Molecular Biophysics @flatironinstitute.org group-- come say hi and check out our posters/talks! @sonyahanson.bsky.social @pilarcossio.bsky.social @miroastore.bsky.social

Excited for the @biophysicalsoc.bsky.social annual meeting! Checkout what SMBp is up to at these posters and talks:

Our co-founder Jim Simons led an extraordinary life, championing new ideas and ways of thinking as a mathematician, an investor and a philanthropist. Learn more about his incredible legacy in a new short film: simonsfoundation.org/2025/01/09/w... #science #math #finance

Excited to be at the Ringberg workshop on Structural Biology! Has been a thought-provoking conference with lots of great discussions!