E. Rosalie (@erosalie.infoepi.com)

Quantifying the Cost of Measles Outbreak in the U.S. and How Costs Scale with Outbreak Size Importance In 2025, the United States experienced the largest number of measles cases since its elimination in 2000. These outbreaks require extensive public health responses to mitigate, consume substantial hospital resources, and impose an economic and financial burden on state and federal budgets. Objective To review evidence on the costs of measles outbreaks in the United States between 2000 and 2025, as well as to examine how costs scale with outbreak size to better model the costs associated with measles outbreaks. Evidence Review We conducted a literature review using PubMed to identify studies published between January 1, 2000, and October 7, 2025, using terms related to measles cases, costs, and outbreak response, across all 50 states in the United States of America. Additional publicly available reports beyond the PubMed published literature were identified through a review of official CDC and state health department reports. Findings A total of 120 articles were screened, https://www.medrxiv.org/content/10.1101/2025.10.24.25338724v2