By the way, @dshb-antibodies.bsky.social is a non-profit that sells quality antibodies to many proteins at exceptionally reasonable prices, without AI generated faux-validation images. Check them out. dshb.biology.uiowa.edu

If you are looking for a cool PhD project on lysosome biogenesis under supervision of an excellent mentor in a thriving research community, this is your chance ungermannlab.bsky.social👇

Functional assignment of Golgi-associated vesicle tethers to specific membrane recycling pathways www.biorxiv.org/content/10.6...

@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...

🧪Are adolescents facing a crisis of connection? Healthy life years lost to mental-health disorders among 10-24y/os rose globally from ~27M to 47M between 1990 & 2023, Helen Pearson reports for Nature. In high-income countries, suicide rates among 15-19-y/os are 9/100K for boys & 3/100K for girls.

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.

Tracking primordial germ cell migration in mouse embryos helps LMB researchers answer fundamental questions about development & fertility. Only by using mouse models can this 3D, dynamic process be imaged in real time. 🔗 mrclmb.ac.uk/news-events/... #AnimalsInResearch @animalresearch.bsky.social

"My EMBO Membership, Young Investigator award and Fellowship have been a fantastic way to make connections with people all over Europe (...)," explains Madeline Lancaster (MRC Laboratory of Molecular Biology): https://www.embo.org/people/an-interview-with-professor-madeline-lancaster/ 🧪 #networking

This play about the discovery of the double helix is pretty interesting – far better than Photograph 51, including the gender-blind casting of Watson and the deconstruction of Watson's book at the end. www.youtube.com/watch?v=k17P...

Visualization of the interaction between sphingomyelin and cholesterol in lipid bilayer membranes | PNAS www.pnas.org/doi/10.1073/...

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

#membrane seminars are back this week with @javierespadas.bsky.social from the @rouxlab.bsky.social and Chris Burd from @yalecellbiology.bsky.social! Looking forward to seeing everyone online!

In 1986, John White published "The Mind of a Worm," the first complete wiring diagram of any animal's brain. 7,000+ synapses in C. elegans, mapped by hand. This year he won the Wiley Prize in Biomedical Sciences. And he's donating his share to OpenWorm.

Come and work with us on #cryoEM of alpha-synuclein amyloid filaments from #Parkinsons disease! 🥳 fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...

www.biorxiv.org/content/10.1... In situ cryo-ET defines the ultrastructure of ER exit sites in human cells

Intriguing report claiming N-glycosylation of nuclear proteins www.nature.com/articles/s41... I would personally be nervous doing follow-up experiments based on glycopeptide-spectral matches like this.

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

Nice preprint from Nicola Stevenson @bristoluni.bsky.social revealing domain-specific roles of TANGO1 in maintaining the architecture of the early secretory pathway. www.biorxiv.org/content/10.6...

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

Don’t miss the 20th Graduate Student Symposium at the LMB in July, organised by students from the LMB and École Polytechnique Fédérale de Lausanne (EPFL) School of Life Sciences. Registration is open now ➡️ www3.mrc-lmb.cam.ac.uk/sites/gsasym... Follow @lmbphdsymposium.bsky.social for updates!

The third round is now open! I will be hosting a webinar with my colleagues on Monday 27 April at 1pm. To sign up please go to: shorturl.at/Vuwib International applicants are eligible to apply!

Join speakers @felixmendu.bsky.social, @elisafadda.bsky.social, @cellbiol-mrclmb.bsky.social, @nlsamara.bsky.social and @nmriley.bsky.social at the 95th Harden Conference on Linking Golgi trafficking and glycan function in June. Submit an abstract or book by tomorrow for £50 off! 🧪 bit.ly/4cSnxzc

Congratulations to Manu Hegde, Group Leader & Joint Head of @cellbiol-mrclmb.bsky.social, who has been elected a member of the American Academy of Arts & Sciences. Congratulations also to the #LMBalumni joining him, Julie Ahringer & Edward Egelman. Read more: mrclmb.ac.uk/news-events/... #LMBNews

Oocytes store large amounts of proteins to support the earliest developmental stages. In @nature.com, the Leung group describes the structure of the cytoplasmic lattice in unprecedented detail. At least 13 different proteins assemble into a stable storage complex. hubrecht.eu/oocyte-storage-complex/

Design principles of human membrane protein topology https://www.biorxiv.org/content/10.64898/2026.04.18.719382v1

Happy Golgi Day

Krahn, Glick et al. use budding yeast to examine membrane recycling at the Golgi apparatus. They describe an in vivo vesicle capture assay that reveals which resident Golgi proteins recycle together in the same vesicles. rupress.org/jcb/article/... #Organelles #Trafficking

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year. Applications are open now! More details: mrclmb.ac.uk/careers-and-... Please share this post with anyone who may be interested!

This same claim was made 30 years ago pubmed.ncbi.nlm.nih.gov/8910609/ (not cited in the new version). It has not got more likely since.

The molecular basis of tricalbin-mediated membrane contact site organization in cells url: journals.biologists.com/jcs/article-...

Today is World Microscope Day! 🔬 Every year, we run our Microscopes4Schools competition for Year 5&6 students across Cambridgeshire, Peterborough & Bedfordshire to inspire the next generation of scientists 🧑‍🔬 Read more on our dedicated M4S website: microscopes4schools.co.uk#foogallery-6...

Looking to get back into research after a career break? Come and join us!

#BlackInNeuro, #BlackInSTEM? Heads up that this fantastic postdoc opportunity opens for applications this month (closing date 17th May). Come and join us at @mrclmb.ac.uk! mrclmb.ac.uk/careers-and-...

Been away from scientific research for over a year and want to get back to the bench? LMB's new Career Returner Fellowship bridges the gap for those who want to re-enter lab-based research. Applications open 13 April More info mrclmb.ac.uk/careers-and-... PLEASE SHARE THIS! @mrclmb.ac.uk

We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below: www.nature.com/naturecareer...

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...

A unique opportunity to lead the most wonderful company in scientific publishing (I might be slightly biased here). The Company of Biologists are searching for a CEO. www.inspiredselection.com/jobs/jo00000...

The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with ideas reshaped how we think about cellular organization. #InMemoriam from @adamgrieve.bsky.social and colleagues: rupress.org/jcb/article/...

This is a great list of techniques for getting real information out of a Google search and avoiding AI slop and paid results. (One thing not included is that if you add "-ai" to a search, you block the AI summary) cardcatalogforlife.substack.com/p/google-has...

Join speakers @felixmendu.bsky.social, @elisafadda.bsky.social, @cellbiol-mrclmb.bsky.social, @nlsamara.bsky.social and @nmriley.bsky.social at the 95th Harden Conference on Linking Golgi trafficking and glycan function in June. Book before Monday for £100 off the registration fees! 🧪 bit.ly/4cSnxzc

How do primordial germ cells (PGCs) migrate across a developing embryo? #LMBResearch from Katharine Goodwin and Kate McDole (@cellbiol-mrclmb.bsky.social) uncovers the mechanisms PGCs use in mouse embryos to navigate this long and surprisingly risky journey. Read more: mrclmb.ac.uk/news-events/...

Generate new ideas and collaborations regarding the relationships between #glycan biosynthesis and intracellular organisations, and glycan structures and cell biological functions, at our 95th Harden Conference: Linking #Golgi trafficking and glycan function bit.ly/4cSnxzc

A Rab1 interactome illuminates a dual role in #autophagy and membrane #trafficking, say Alexander R. van Vliet, Sean Munro and colleagues @mrclmb.bsky.social: rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #GRC

For our annual alumni newsletter, Sean Munro reflected on his time at the LMB, including how opportunity and curiosity have shaped his group’s research into the Golgi apparatus and his tenure as Head of Division for @cellbiol-mrclmb.bsky.social Watch the interview: youtu.be/xFGb7_RmO9c

FlyBase release FB2026_01 is live! There is news about FlyBase funding. Go to the FlyBase homepage flybase.org for details.