And here we are. Another damn’d thick, square book. A real wrist-sprainer. UK edition (pictured) has endpapers showing Crick and Brenner’s blackboard and colour plates. Both U.K. and US editions have sections heralded by a double page photo as here. Loads of illustrations. Out in November!

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

US folk! If you a Barnes & Noble Rewards Member you can get 25% off your pre-order of my forthcoming biography CRICK (an extra 10 if you are a Premium member!). Offer applies to hardback, ebook and audio, and ends 5 September. Use code PREORDER25.

LMB PhD students in @cellbiol-mrclmb.bsky.social Razina Kazi @dr-anna-edmondson.bsky.social and Katherine Brown share their experiences completing policy internships at @acmedsci.bsky.social‬ and ‪@senseaboutsci.bsky.social‬ ‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬ www2.mrc-lmb.cam.ac.uk/exploring-sc... #LMBNews

Supracellular actomyosin assemblies: master coordinators of development In this Review, Katja Röper @katjaroeper.bsky.social discusses supracellular actomyosin structures, tissues where they function, their known roles as well as potential properties journals.biologists.com/dev/article/...

Supracellular control and coordination of tissue morphogenesis, through supracellular actomyosin assemblies, that is what my lab @cellbiol-mrclmb.bsky.social @pdncambridge.bsky.social and I like to dig into at the moment! Fascinating and beautiful! journals.biologists.com/dev/article/...

Yes. In fact, quality of reviews goes up when you pay reviewers.

Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8

The staff at the Written Archives Centre were incredibly helpful in squirrelling out material relating to Crick's early broadcasts on the BBC. That would now be impossible, and those letters would remain unstudied. These abrupt changes will hamper our understanding of the BBC and its role.

Sad news - Catherine was an exceptional cell biologist with a force-of-nature personality that brought passion and integrity to everything that she did. She will be greatly missed.

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments go.nature.com/45GeSM0

In the fullest description of the double helix, incl a clear account of their debts to Wilkins and Franklin - the Crick and Watson paper no one ever reads - they describe their approach, which Watson liked to call “model building”. In this edit, Crick gave an earthier and more accurate description:

Dung beetles can navigate at night using the milky way as a guide, and yet it has taken 12 years and 170 citations for humans to notice that 3.8 metres per second might be a bit fast for them to do it! www.cell.com/current-biol...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work. www.biorxiv.org/content/10.1...

I spent months on this investigation and gathered docs from the UK courts, Land Registry and a French local authority, to show that Raynor and Moth Winn's story is not as they claim. @tortoisemedia.bsky.social @observeruk.bsky.social observer.co.uk/news/nationa...

A reminder for those headed to UK this summer

We , @lbm-epfl.bsky.social and @gisouvggoot.bsky.social #EPFL together with and tf Sean Munro and John Briggs have today released two complementary preprints on GOLPH3 mediated intra-Golgi recycling #CellBiology #MembraneTrafficking www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

See also this related work on the role of GOLPH3 in retention at the Golgi: www.biorxiv.org/content/10.1...

Wow! GOLPH3 binding to COPI is competitive with binding of canonical -KKXX cargos, providing an elegant mechanism for differential sorting of COPI cargos during Golgi maturation. Congratulations to all the authors on an impressive and important study: www.biorxiv.org/content/10.1...

The Maria Leptin | EMBO Science Journalism Fellowships support life scientists pursuing a career in #ScienceJournalism and science journalists who wish to further their scientific education. Apply now: www.embo.org/funding/fell... #LifeSciences #funding 🧪

This is tomorrow (Thursday), looking forward to it! #MembraneTrafficking

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩 www.nature.com/naturecareer...

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

Great nod to the photography work of Bernd and Hilla Becher

In fact, it’s already up there!

Excited for our program of speakers at Next Generation Biophysics 2025. Come join us as registration is now open either in person or online: www3.mrc-lmb.cam.ac.uk/sites/nextge...

Interested in a postdoc position combining computational protein design and molecular simulation? There is an open position in my group at the MRC-LMB in Cambridge, UK. www.nature.com/naturecareer... Feel free to message me with any questions.

Are you wondering what the next step in your career is? Join us on Wednesday 16th July to hear from three inspirational #LMBAlumni who have gone on to pursue diverse career paths: Claudia Ferreria, Jillian Barlow & Sarah Burge. See our website for more info: www2.mrc-lmb.cam.ac.uk/news-and-eve...

🗓️#CambridgeFlyClub 2nd meeting this year on July 16th (Weds) 4pm at @gurdoninstitute.bsky.social. Our speakers are Carmina Santa-Cruz Mateos from Sarah Bray's lab @pdncambridge.bsky.social and Jimena Berni from University of Sussex. It's not the Dmel on our poster, guess what species is it?

If you are in London a week today and are free early evening, please come along to my talk at @royalsociety.org (free!). If you can’t make it, it will be live-streamed and subsequently available online…

European Fly PIs: please respond to the email we sent out yesterday and help save FlyBase!

#drosophila @flybase.bsky.social request emergency funding: "As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate! www.philanthropy.cam.ac.uk/give-to-camb...

Join Kate McDole’s group at the LMB as a #postdoc in @cellbiol-mrclmb.bsky.social! Be part of cutting-edge research using advanced imaging and developmental biology to explore early organogenesis in mice. Apply by 24 June www.nature.com/naturecareer... #ScienceJobs #Postdocjobs

Over 140 people attended the recent Hidden Cell, Dark Genome meeting organised by @hannahlong.bsky.social, Shipra Bhatia and @drphcb-uoe.bsky.social, and a lot of interest in a follow-up meeting to hear the next updates and discoveries. You can catch up on what was discussed here: edin.ac/3HtXpwA

Following the annual tradition, the student symposium of MRC LMB is happening on July 10th and 11th this year. This year we are collaborating with Institut Pasteur! Details 👇

Next time, consider submitting to Biology Open. Decision with reviews within 7 working days of submission journals.biologists.com/bio/pages/fa...

Whew! We’ve just recovered from that #UniversityChallenge final! Congratulations to Christ’s College for their first victory, captained by Oscar Despard, PhD student in @cellbiol-mrclmb.bsky.social. Read about the incredibly close match here: www2.mrc-lmb.cam.ac.uk/oscar-despar... #LMBNews

This article is available under our Read & Publish Open Access initiative. Researchers can find out about the wide range of benefits, read what researchers are saying and view a list of participating institutions at www.biologists.com/library-hub/... #OpenAccess #ReadandPublish

Its #UniversityChallenge Final Day! We’ll be cheering on LMB PhD student Oscar Despard as he captains Christ’s College, Cambridge against Warwick University tonight. Learn about how he prepped for the show here: www2.mrc-lmb.cam.ac.uk/starter-for-...

We are delighted to welcome Dr Caren Norden to PDN as the new Charles Darwin Professor of Animal Embryology. This position plays a vital role in sustaining our thriving community of developmental and reproductive biologists. Read the story in full at www.pdn.cam.ac.uk/news/dr-care... #WomenInSTEM 🧪

Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by @ycharos.bsky.social : zenodo.org/records/1162...

At membrane contact sites, bridge-like transport proteins, e.g. LPD-3, mediate bulk lipid transfer between cellular organelles. @nature see cryo-EM structure of native LDP-3, and gain insights into its functioning and interaction with other proteins and lipids. shorturl.at/lycuz & shorturl.at/ARpUK

How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827

Latest paper from the lab @cellbiol-mrclmb.bsky.social, Anna's PhD work hot off the press @plosbiology.org ! Using single cell genomics to understand tube morphogenesis, and why it's as important to switch things off as it is to switch them on!

Excited to announce the Molecular Biology of Archaea (MBoA) 2026! Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.

Check out new work @plosbiology.org from Daniel St Johnston´s lab visualizing how secretory cargo is targeted to apical vs. basolateral domains in #epithelial cells in real time. Nice collaboration highlighting the power of #RUSH in #Drosophila!

Dear proteomics aficionados, The famous MaxQuant Summer School is organized again July 21–25, 2025, but spots are filling up! Join the team of Jurgen Cox for hands-on training in MaxQuant, register here: www.eventbrite.de/e/maxquant-s... Best regards, Jürgen Cox, Albert Heck & Pavel Sinitcyn