An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Lots of exciting PhD projects on offer at the LMB, including in our group 😊

We are delighted to announce the Strathclyde Optical Microscopy Course 2026 (SOMC26), taking place in Glasgow from 21st July – 30th July 2026! Please find more details at shorturl.at/xmUiZ and apply at shorturl.at/MxTlI. Deadline 16 January 2026.

We've now discovered some neat cell culture dishes that feature a 50 micron thick film of a proprietary polymer with refractive index even closer to water than FEP. They work just as well as our homemade FEP assembly and are available in multiwell plate format too! www.sarstedt.com/en/products/...

A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch

Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)

📣 Two week left to apply! 👇 Apply in the link below or, if you have specific questions, reach out!

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues. www.biorxiv.org/content/10.1...

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Excellent opportunity for an enthusiastic #postdoc to join Kate McDole in @cellbiol-mrclmb.bsky.social, using interdisciplinary approaches to investigate tissue formation during early organogenesis in mouse embryos. More info: www.nature.com/naturecareer... Closes 20 OCT #ScienceJobs #PostdocJobs

LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…

📣📣We're seeking a postdoc to join us at the @mrclmb.bsky.social to investigate neuroimmune interactomes in tumour & viral immunity. If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply! 🧠🫁👀🩸🔬 mrc.tal.net/vx/mobile-0/...

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

Latest imaging data from our completely re-designed ExA-SPIM system. Expansion-assisted imaging (3X expansion, 0.3 NA) enables brain-wide imaging with high-contrast and <400 nm effective resolution.

Live stream of the talks at #GEF25! Experience the best of ExM first hand! Tomorrow 9 am it is me btw. Monday 9 am Ed Boyden himself!

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠 I'm looking for people who are excited about revealing the many molecular layers of the "hidden connectome" with expansion microscopy, in a highly intersectional environment exploring ideas in meta-science. mrc.tal.net/vx/mobile-0/...

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠 I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science. mrc.tal.net/vx/mobile-0/...

Calling all prospective PhD students! Why not consider the LMB for your PhD? Applications are now open! www2.mrc-lmb.cam.ac.uk/students/int... General deadline: 2nd DEC US Gates Scholarship deadline: 15th OCT

@science.org🧬🔬Functional maps of a #genomic locus reveal confinement of an enhancer by its target #gene | Science www.science.org/doi/10.1126/...

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

After seeing @miguelcmestre.bsky.social @lancasterlab.bsky.social @jamesdmanton.bsky.social 's paper this week on deep and accessible ExM imaging with cerebral organoids, I think it's a good time to repost this Starter Pack of Expansion Microscopy people! go.bsky.app/Qxks9WD

🚨Publication alert🚨 My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41... The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

The cat is officially out of the bag! The LMB is home to a unique community of outstanding connectomics scientists — I'm so excited about adding my own molecular and expansion microscopy expertise to the mix! This is going to be the most exciting journey of my scientific career — more soon! 🌈🧠

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

I'll soon be recruiting a postdoc fellow to join us @mrclmb.bsky.social to continue developing our programme to understand neuroimmune modulation🧠🔬🧬🩸🫁 If you're interested in joining us check also @erc.europa.eu MSCA actions, @wellcometrust.bsky.social & www2.mrc-lmb.cam.ac.uk/recruitment/... DM'me

The only good use I've managed to find for generative AI is rewriting my paper abstracts in quatrain. The Mind's Decay, A Fading Light

Massive congratulations to Niamh Burke @niamh-deburca.bsky.social on winning the 2025 @rmsearlycareer.bsky.social Early Career Award, with her talk on the enderscope community project, co-developing accessible imaging tools with the public. 😀🙌🔬👍 @bioimaginguk.bsky.social

Nuts and bolts! A good stock and organizational system pays dividends over the years... -> Here's a good @thorlabs.bsky.social system with 19" racks (RK3884), shelves (RK4101), boxes (S19228) and trays (www.schallercorporation.com). If you can bare the initial setup effort it's well worth it! ;)

#PhysicsTrivia what is the link between these two pictures?

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.

Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social @jamesdmanton.bsky.social @jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social

Spending some time at #lsfm25 cleaning up code. It now has distributed GPU gradient-consensus RL decon (@jamesdmanton.bsky.social @andrewgyork.bsky.social) our fast orthogonal deskew, and stitching/fusion to ome-ngff v0.5. Example AO-OPM data on uncleared mouse brain slice github.com/QI2lab/opm-p...

Hour-long voltage imaging in behaving mice! Capitalizing on the high photostability and brightness of mBaoJin, we developed eFRET GEVIs, named ElectraOFF, which extends reliable single spike detection at cellular resolution beyond one hour biorxiv.org/content/10.1...

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

I am desirous of this rather impressive objective lens.

Now out in JACS. pubs.acs.org/doi/full/10.... Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...

In a deviation from our previous updates, our automatic parameter-free deconvolution code is now slightly _slower_ than before (~4.5 %), but more robust for low SNR data. Standard: beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/ Biggs-Andrews accelerated: beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/

Need to play more with it but so far works great on this OPM data.

Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...

Thanks to a dose of activation energy from @dpshepherd.bsky.social, I've finally cleaned up my Biggs–Andrews accelerated version of our automatic parameter-free deconvolution code and made it available at beryl.mrc-lmb.cam.ac.uk/rlgcba_noteb.... This is ~2.75× faster than the previous version. 1/4

Thanks to some CUDA trickery*, our automatic parameter-free deconvolution code is now ~3× faster than the previous version (~9× faster than the original) while still producing exactly the same results as before. Try it out for free using Google Colab at beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/ 1 / 2