New from Mishima & Balasubramanian (@sporemohan.bsky.social) labs in @warwickmed.bsky.social: “Actin arginylation alters myosin engagement & F-actin patterning despite structural conservation.” Explore the physiology of #arginylated #actin 👉 rupress.org/jcb/article/...

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Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡

mStayRose is published in JBC 🥳🎉 Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable: www.jbc.org/article/S002...

⚗️ Take a read of our new preprint presenting a one-step method for conjugating strained alkyne groups onto fluorescent groups 🧪 Drop me a message if you're interested in trying it out! doi.org/10.26434/che...

I was privileged to be interviewed by Biology Open last week about our new paper, what inspired me to become a scientist, and how research is as creative as any artform 🔬 Take a read here: doi.org/10.1242/bio....

🔬 Take a read of our paper out today, presenting improved tools for comparing human tropomyosin isoforms in live cells 🧬 My first publication as lead author 🥳 Please reach out if you'd like to give any of these tools a try 🔬 doi.org/10.1242/bio....

Fluorescent protein tags for human tropomyosin isoform comparison https://www.biorxiv.org/content/10.1101/2025.02.25.640032v1

Fluorescent protein tags for human tropomyosin isoform comparison https://www.biorxiv.org/content/10.1101/2025.02.25.640032v1

Take a read of our brand new preprint 🥼 We built a toolbox of new live cell imaging probes for comparing human isoforms of the surprisingly mysterious cytoskeletal protein tropomyosin 🔬 This started as a side project during my PhD and grew into something quite huge! 🧫

StayRose: a photostable StayGold derivative red-shifted by genetic code expansion https://www.biorxiv.org/content/10.1101/2024.12.13.628370v1

Our new preprint on StayRose is out now - we used an unnatural amino acid to produce the first red version of the super photostable fluorescent protein StayGold 🥰 My first as lead author! 🥳

StayGold red-shifted by non-natural aminoacid mutagenesis. see our reprint, another fruitful collaboration with @midbody @Allister_Crow. Well done Esther & Will Scott first authors. This tool is being developed further for imaging. Watch this space. www.biorxiv.org/content/10.1...

StayRose: a photostable StayGold derivative red-shifted by genetic code expansion https://www.biorxiv.org/content/10.1101/2024.12.13.628370v1

Glad to connect with everyone! I'm a synthetic biologist and chemist imaging the actin cytoskeleton in Mohan Balasubramanian's group (University of Warwick) on an end-of-PhD transition fellowship. Here are my yeast from throughout my PhD (can you see which weeks I was particularly stressed 😂)