Yongdeng Zhang
@yongdengzhang.bsky.social
π€ 64
π₯ 101
π 6
PI @ Westlake University working on super-resolution microscopy.
We are happy to share our latest work, 4Pi-SIMFLUX, which combines structured illumination with interferometric detection to achieve near-isotropic 3D localization precision of 2β3 nm and resolve sub-10 nm structural features across whole mammalian cells.
www.nature.com/articles/s41...
rdcu.be/eQVxt
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4Pi-SIMFLUX: 4Pi single-molecule localization microscopy with structured illumination - Nature Methods
4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves a near-isotropic resolution below 10βnm in whole mammalian cells.
https://www.nature.com/articles/s41592-025-02908-8
12 days ago
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Yongdeng Zhang
Reto Fiolka
about 2 months ago
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
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reposted by
Yongdeng Zhang
Christophe π¬ L
3 months ago
Our new preprint is up! This is the main postdoc work of
@wiesner-t.bsky.social
focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold:
www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings π§΅1/11
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reposted by
Yongdeng Zhang
Sauer Lab
3 months ago
π¨ New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. βΆοΈ
www.biorxiv.org/content/10.1...
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reposted by
Yongdeng Zhang
Florian Schueder
4 months ago
π¨ 2 Γ PhD positions @EPFL! π¨ Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne π¨π. Start Jan 2026. Send CV + motivation + 2 refs β
[email protected]
#PhD
#Hiring
#microscopy
#SuperResolution
#SpatialOmics
#DNAPAINT
#FLASHPAINT
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Yongdeng Zhang
Eli Slenders
5 months ago
Excited to share our paper on ISM-FLUX, our new
#MINFLUX-based
technology. Achieve sub-10 nm localization uncertainty on single molecules using a straightforward
#confocal-based
setup with an array detector. 1/6
www.nature.com/articles/s41...
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Array detection enables large localization range for simple and robust MINFLUX - Light: Science & Applications
Light: Science & Applications - Array detection enables large localization range for simple and robust MINFLUX
https://www.nature.com/articles/s41377-025-01883-1
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Yongdeng Zhang
James Manton
10 months ago
We present: Direct-view oblique plane microscopy
www.biorxiv.org/content/10.1...
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Direct-view oblique plane microscopy
The ability to rapidly image mesoscopic samples is critically important for many areas of biological research. Owing to its high throughput and gentle, volumetric imaging nature, light-sheet fluoresce...
https://www.biorxiv.org/content/10.1101/2025.02.11.635467v1
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This is fantasticοΌ
add a skeleton here at some point
10 months ago
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Yongdeng Zhang
Zach Marin
11 months ago
Incredible new work from Yongdeng Zhang demonstrating live 4Pi SIM--and in two colors!
www.nature.com/articles/s41...
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Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM - Nature Methods
The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic p...
https://www.nature.com/articles/s41592-024-02515-z
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