Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons. Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)

EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...

In case you missed it, check out our recent preprint on developmental timing and how slower means bigger, axons that is! Led by the extraordinary @felinewlindhout.bsky.social www.biorxiv.org/content/10.1...

A superb review with the latest insights on the Axon Initial Segment from @ameliefreal.bsky.social & Casper Hoogenraad, was a joy reading this 😀

A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience Thanks @frantecol.bsky.social for putting this together. Especially relevant for these dark days for USA science🧪

New preprint 📣! Excited to share the result of several years of work, led by @ellylewerissa.bsky.social & @olivieroleonardi.bsky.social, in collaboration with friends @naelnadifkasri-lab.bsky.social & Giuseppe Testa. On CHD2, a chromatin remodeller, its role in evolution & development [🧵] 🧪🧠🧫🧬

Okenve-Ramos, P., Gosling, R., Chojnowska-Monga, M., Gupta, K., Shields, S., Alhadyian, H., Collie, C., Gregory, E., Sanchez-Soriano, N. (2024). Neuronal ageing is promoted by the decay of the microtubule cytoskeleton. PLoS Biol, 22(3):e3002504 journals.plos.org/plosbiology/...

We just published a thing! In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function. www.nature.com/articles/s41...

Why is human brain development, and particularly neuron morphogenesis, so slow and how is this linked to evolution? doi.org/10.1101/2024.12.28.630576 We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881 🧵 (1/n)

Excited to reconnect with old science friends and meet new ones here on Bluesky! I study human neuron development using brain organoids, other in vitro models, and lots of microscopy 🧠🔬