We just published a thing! www.frontiersin.org/journals/pha... Here we show that somatostatin interneurons display exaggerated LTP in a mouse model of Fragile X Syndrome, and which is sensitive to GABAB receptor activation; but which are not manifested at the circuit level - more work to do!

New @who.int Global Status Report on Neurology calls for urgent action to address the growing burden of neurological disorders & to promote brain health for ALL. @arinatam.bsky.social co-authored Ch4: Effective, timely & responsive diagnosis, treatment & care. Full report: edin.ac/43r3P7U

www.biorxiv.org/content/10.1... super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.

Hello world! We just released a thing! In this preprint we provide evidence questioning the ability of the axon initial segment to undergo rapid structural plasticity in intact neurons from mouse, rat, and human cortex.

Meet the Simons Initiative for the Developing Brain: a center devoted to deconstructing the secrets of neurodevelopmental disorders and the developing brain. Read more: annualreports.simonsfoundation.org/2024/scottis... #science #neuroscience

What, what! We just published our work studying GABAB receptors in human and rat brain. www.nature.com/articles/s41...

Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647

Friday saw two momentous occasions. The first major study accepted from our lab 🥳 and my 5 year old reciting to me the principles of synaptic strengthening in learning and memory. Immensely proud of both...

We just published a thing! In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function. www.nature.com/articles/s41...