New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors! www.science.org/doi/10.1126/...

Happy Halloween! 🎃 Continuing my tradition of Nobel-prize-winning discoveries, this year's costume is Ubx!!! It honors Edward B. Lewis, Christiane Nüsslein-Volhard, & Eric Wieschaus's work on the genetics of development 🧬🪰 (Please clap for the accuracy of those wing veins on *both* pairs of wings.)

Minimal CDK continues delivering 💥 www.biorxiv.org/content/10.1...

📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for PhD students www.crg.eu/en/content/t... Postdocs gimm.pt/jobs/postdoc... Other calls to open, also for an experienced lab manager. Get in touch!

PREACH! www.nature.com/articles/s41...

Great Job - Great Colleagues - Great Science👍 Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows Relocation to DC is required, perfect for academic PIs looking for their next chapter hhmi.wd1.myworkdayjobs.com/External/job...

I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!

Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

What if the legendary psychologist and grandfather of behavioral economics, Daniel Kahneman took a sabbitical in a fly lab? How would the lab culture change? Explored this imaginary scenario in a blog post @the-node.bsky.social thenode.biologists.com/the-kahneman...

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome. www.nature.com/articles/s41...

We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...

New Online! Towards a unified framework for the function of endoplasmic reticulum exit sites

📣🧪 Read our latest #research on joint regeneration in #zebrafish, published today in @natcomms.nature.com www.nature.com/articles/s41... @columbiauniversity.bsky.social

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Are you excited?? Because I am! 25 years ago I was 10 and had just started secondary school yet our journal was already covering groundbreaking science, long before I'd even heard of molecular cell biology 🧐 Safe to say I'm fairly familiar with it now 🤭 Enjoy our issue!!!!!!!!!!!

This is absolutely a must read. We are in deep trouble and I am even less optimistic than the authors.

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

New cell cycle meeting starts next summer! events.faseb.org/event/c40174...

I’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵 doi.org/10.1101/2025... A thread 👇

David Baltimore, giant of molecular biology, has died.

🧵Does the nucleus set the cell cycle clock? 🕒 In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked. 👉 doi.org/10.1016/j.cu...

Exciting preprint on organelle mechanoadaptation from Stephanie Miserey and Felix Campelo @felixmendu.bsky.social! Extracellular forces modulate Golgi secretory output by tuning carrier biogenesis via microtubule acetylation, DAG, and PKD. Golgi is a mechanoregulator! www.biorxiv.org/content/10.1...

“‘She uncovered the social experience of women in science’ — the lab assistants who never became managers, the geologists poring over data in government offices while their male peers were doing fieldwork, those who despite their advanced degrees didn’t get hired or promoted, or who were sidelined…”

This is so thought-provoking… ourworldindata.org/data-insight...

If you're finishing PhD soon and thinking of postdocs, see below! Especially if you're keen on combining biochemistry, imaging and cell biology, we are onto some exciting findings on molecules and mechanisms underlying a cytoplasmic division cycle autonomously of CDKs!!

#Postdoc-opportunity at Columbia U. in New York!! Looking for a postdoc position? We are interested in candidates from biochemistry background & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. with @aydinlab.bsky.social at NYU!

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

Excited to share that I will be a co-director for the upcoming Workshop on Phylogenomics @evomics.bsky.social, alongside the amazing main team lead @rosafernandez.bsky.social and Erin K. Molloy We are putting together an amazing workshop with details to come - can't wait to share it with everyone!🥳

Funny that the virtual cell virtually encapsulate everything except....cell biology...(yes, there is a full world of complex behaviour outside the realm of gene expression) 🤷‍♂️

FINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy

Interesting hypothesis piece by @bungoakiyoshi.bsky.social. Printed now, and will read. Will send you comments!

Despite all what's going on, let's remember that part of being academics is to have the privilege of knowing thoughtful people we can rely on and do science with. Here is one of those fine people (@dudinlab.bsky.social‬) we have the pleasure of collaborating: www.cell.com/current-biol...

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

Another question for the #genetics hive-mind: Any recent comprehensive reviews on genomic imprinting? Leads would be highly appreciated!!

Thanks to editors Amelia Glazier and Heidi McBride for the opportunity to share a little about me in this special Mitochondria issue of J Cell Science - includes how I became a scientist, some thoughts on current attacks on science/funding in the US, parenting as a PI, & more doi.org/10.1242/jcs....

One of the most original reviews I've come across lately - such a refreshing piece! Thanks @ibudin.bsky.social and team!

Hey @flybase.bsky.social! Is the "Interactions" tab down for genetic and physical interactions? Seem to get the following error.. Tried in different browsers too.

Have you ever seen the black box that is the inside of a microscope objective? Today Dr. Stephen Ross of Nikon gave a fascinating lecture on what goes into the design and manufacturing of an objective.

Please RT!! Bumping this up for the geneticists out there!

A growing list of genetically encoded biosensors helps to shine light on plant metabolism. We reviewed - also for the non-expert - available probes and recent advances in the field: www.sciencedirect.com/science/arti...

🧪Q for the genetics hive-mind: Is there a way to calculate the odds of synthetic lethality from double heterozygosity b/w any two random genes? Say I have a gene list and want to see whether they are functionally related, could I define a "randomness" score to screen against to see if it beats odds?

This is a remarkable study by the Lewis Lab! A must read that I had the privilege of listening to it in person 🌟

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n) 📖 www.biorxiv.org/content/10.1...

Important to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out! We use TurboID sub-organelle proteomics to map the ER network. We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. www.sciencedirect.com/science/arti...

Ever stuck choosing the right plot or trying to figure out how to make it look just right? My go-to resource is the R Graph Gallery (r-graph-gallery.com), which is full of examples and clear code for everything from scatterplots to Sankey diagrams! #dataviz #rstats #rladies

Fly researchers - mark your calendars and register for the 2025 Boston Area Drosophila meeting! It will be held at @umassboston.bsky.social on June 6. Registration deadline is April 25! #Drosophila 🪰 Registration link and more info here: bostonflymeeting.mgb.org/2025-bad-mee...