This is absolutely a must read. We are in deep trouble and I am even less optimistic than the authors.

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

New cell cycle meeting starts next summer! events.faseb.org/event/c40174...

I’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵 doi.org/10.1101/2025... A thread 👇

David Baltimore, giant of molecular biology, has died.

🧵Does the nucleus set the cell cycle clock? 🕒 In frog egg extract “mini-cells” we see that as nuclei grow, cycles slow down. The period scales with the nuclear-to-cytoplasmic ratio, across Xenopus species, and even when DNA replication or transcription are blocked. 👉 doi.org/10.1016/j.cu...

Exciting preprint on organelle mechanoadaptation from Stephanie Miserey and Felix Campelo @felixmendu.bsky.social! Extracellular forces modulate Golgi secretory output by tuning carrier biogenesis via microtubule acetylation, DAG, and PKD. Golgi is a mechanoregulator! www.biorxiv.org/content/10.1...

“‘She uncovered the social experience of women in science’ — the lab assistants who never became managers, the geologists poring over data in government offices while their male peers were doing fieldwork, those who despite their advanced degrees didn’t get hired or promoted, or who were sidelined…”

This is so thought-provoking… ourworldindata.org/data-insight...

If you're finishing PhD soon and thinking of postdocs, see below! Especially if you're keen on combining biochemistry, imaging and cell biology, we are onto some exciting findings on molecules and mechanisms underlying a cytoplasmic division cycle autonomously of CDKs!!

#Postdoc-opportunity at Columbia U. in New York!! Looking for a postdoc position? We are interested in candidates from biochemistry background & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. with @aydinlab.bsky.social at NYU!

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

Excited to share that I will be a co-director for the upcoming Workshop on Phylogenomics @evomics.bsky.social, alongside the amazing main team lead @rosafernandez.bsky.social and Erin K. Molloy We are putting together an amazing workshop with details to come - can't wait to share it with everyone!🥳

Funny that the virtual cell virtually encapsulate everything except....cell biology...(yes, there is a full world of complex behaviour outside the realm of gene expression) 🤷‍♂️

FINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy

Interesting hypothesis piece by @bungoakiyoshi.bsky.social. Printed now, and will read. Will send you comments!

Despite all what's going on, let's remember that part of being academics is to have the privilege of knowing thoughtful people we can rely on and do science with. Here is one of those fine people (@dudinlab.bsky.social‬) we have the pleasure of collaborating: www.cell.com/current-biol...

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

Another question for the #genetics hive-mind: Any recent comprehensive reviews on genomic imprinting? Leads would be highly appreciated!!

Thanks to editors Amelia Glazier and Heidi McBride for the opportunity to share a little about me in this special Mitochondria issue of J Cell Science - includes how I became a scientist, some thoughts on current attacks on science/funding in the US, parenting as a PI, & more doi.org/10.1242/jcs....

One of the most original reviews I've come across lately - such a refreshing piece! Thanks @ibudin.bsky.social and team!

Hey @flybase.bsky.social! Is the "Interactions" tab down for genetic and physical interactions? Seem to get the following error.. Tried in different browsers too.

Have you ever seen the black box that is the inside of a microscope objective? Today Dr. Stephen Ross of Nikon gave a fascinating lecture on what goes into the design and manufacturing of an objective.

Please RT!! Bumping this up for the geneticists out there!

A growing list of genetically encoded biosensors helps to shine light on plant metabolism. We reviewed - also for the non-expert - available probes and recent advances in the field: www.sciencedirect.com/science/arti...

🧪Q for the genetics hive-mind: Is there a way to calculate the odds of synthetic lethality from double heterozygosity b/w any two random genes? Say I have a gene list and want to see whether they are functionally related, could I define a "randomness" score to screen against to see if it beats odds?

This is a remarkable study by the Lewis Lab! A must read that I had the privilege of listening to it in person 🌟

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n) 📖 www.biorxiv.org/content/10.1...

Important to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out! We use TurboID sub-organelle proteomics to map the ER network. We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. www.sciencedirect.com/science/arti...

Ever stuck choosing the right plot or trying to figure out how to make it look just right? My go-to resource is the R Graph Gallery (r-graph-gallery.com), which is full of examples and clear code for everything from scatterplots to Sankey diagrams! #dataviz #rstats #rladies

Fly researchers - mark your calendars and register for the 2025 Boston Area Drosophila meeting! It will be held at @umassboston.bsky.social on June 6. Registration deadline is April 25! #Drosophila 🪰 Registration link and more info here: bostonflymeeting.mgb.org/2025-bad-mee...

EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...

I'm thrilled to share that CTB faculty Fred Chang has been elected as a AAAS fellow! Congratulations to Fred on this well-deserved honor. @fredchanglab.bsky.social @ctbatucsf.bsky.social www.ucsf.edu/news/2025/03/429681/ucsfs-fred-chang-honored-election-aaas

Hi Fly, Mouse, Rat, Zebrafish, Worm, and Yeast communities- Looking for the latest numbers on gene conservation between your favorite species and humans (like I was!)? Please see this excellent review (Table 2) by S Yamamoto, @okanca.bsky.social, M Wrangler, and H Bellen rdcu.be/efiXa

🚨New paper!🚨 A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬 Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏 Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

🚨New preprint!🚨 How do bacteria sense stress and activate survival pathways? We solved multiple cryo-EM structures of Listeria stressosomes in different phosphorylation states, revealing how phosphorylation fine-tunes stress responses and virulence. 🦠🔬 📄 Read more: www.biorxiv.org/content/10.1...

The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...

Fascinating paper! No G2/M checkpoint for under-replicated cells! academic.oup.com/nar/article/...

Self-generated gradients guide collective cell movement -but often different cell types must move together, e.g. in immune response. We develop a theory of self-generated chemotaxis in mixed populations -are there optimal principles for this cooperation?🤔 www.biorxiv.org/content/10.1...

Have you ever wanted to *see* receptor activity in embryos? If so, our new preprint is for you! In it, we showcase a new live-cell biosensor for visualizing receptor tyrosine kinase activity in living embryos – pYtags! www.biorxiv.org/content/10.1...

How hard do bacteria-eating nematodes bite in order to break the bacterial cell wall? Check out our new paper, led by Jason Casar & collab with Jen Dionne, using pressure sensing beads that change color upon compression (bluetorial coming soon) rdcu.be/d5n7v

Thrilled to announce that the Jao Lab is relocating to Syracuse University in Jan 2025 🐮➡️🍊. We continue to study macromolecular assembly and more. We are hiring at all levels! The first postdoc position: www.sujobopps.com/postings/107.... Come join us! #CellBiology #DevelopmentalBiology #zebrafish

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

Striking biology! Makes one wonder whether this Stentor species at some point gulped its endosymbiont as a whole and somehow retained their nuclei as is? Could that possibly explain the crazy strings of semi-separate nuclei that Stentor has? Might be totally dreaming here..

Very glad to see our story on the choreography of #ESCRT proteins in #archaeal cell division finally published in mBio - Junfeng Liu et al "A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon" journals.asm.org/doi/10.1128/...

Excited to share the major work of my dissertation, out now in @currentbiology.bsky.social! We use Drosophila genetics to dissect the evolution of phage-derived toxins that were horizontally transferred to insects and now function as potent anti-parasitoid defenses (1/n): tinyurl.com/2k9ypyxr