I had a wonderful time connecting with the research community at the Buck last week! Special thanks to Saam Doroodian, Malene Hansen, and Ashley Webb!

NIGMS is signed onto the F31 NOFO. grants.nih.gov/grants/guide...

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...

On my way to DC and looking forward to this exciting mini-symposium! #ASBMB26

Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/...

No Kings includes Draft Kings

We are organizing a mini-symposium on "Membrane and Organelle Dynamics" at ASBMB 2026! #ASBMB @asbmb.bsky.social @aydinlab.bsky.social and I have put together a fantastic lineup of speakers for Day 1 morning. Come learn about some cutting-edge research in the field.

Check out my first @prelights.bsky.social article, based on some great work done by Dr. Tejashree Waingankar & @samlewis.bsky.social at UC Berkeley 🔬🧬🧠 prelights.biologists.com/highlights/s...

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid

I found me!

I taught my grad-level cell bio seminar using the Socratic method in the fall, and shockingly (to me), students loved it. No slides, just yapping. I assigned two research articles per week as the starting point, but we were mostly led by their questions

I love this video of mitochondrial trafficking and POLG2-GFP in pLL neurons of live zebrafish larvae - from our awesome collaborator Katie Drerup @kdrerup.bsky.social at UW-Madison. She and her team are so talented!

The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from @seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online. 20 targets across an entire cell. Mr. Snouty also joined the fun. www.biorxiv.org/content/10.6...

The Raven Scholar, by Antonia Hodgson The Devils, by Joe Abercrombie The Angel of the Crows, by Katherine Addison

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Self-renewal of neuronal mitochondria through asymmetric division https://www.biorxiv.org/content/10.64898/2025.12.17.694973v1

How are people dealing with AI use in their grad programs, specifically for thesis proposal, qualifying exam, dissertation? Banned completely? Allowed, but have to recognize its use? No guardrails at all? We have to develop a policy and I’m totally at a loss.

I just submitted some work that we're really excited about - preprint loading! Here's a sneak peek 👀

why can’t replicators make pumpkin spice raktajino all year long

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

I wrote a bit for McSweeney's about Isaac Chotiner interviewing Santa Claus. Just a little something for the holiday season. Enjoy!

WE JUST KEEP WINNING. (UC President's Postdoctoral Fellowship Program RESTORED!!!!)

I learned how to read well because I was doing it all the time. A Goosebumps book and an encyclopedia volume hated to see me coming. I dont even know how you develop proper reading skills if you only read books at school.

Announcing such a major change to NSF GRFP this late in the cycle is incredibly cruel. 2nd yr students (mine included) have been working so hard on their proposals despite ongoing uncertainty. They are driven and passionate about being outstanding scientists and helping those coming up behind them.

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

mood today #blacksky:

I don't really care if the future is short videos. I like words. Words have gotten me this far and I'm gonna stick with 'em for the duration

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin. 👇 Reserve your spot using the link below. 📅 September 8 ⏰ 11:00 AM EST RSVP: bit.ly/4mUJeAc

I'm happy to share new work in collaboration with Elena Koslover's lab! First author Keaton developed a mathematical framework for diffusion of soluble material through mitochondrial networks. Then, Lewis lab PhD candidate Camryn used live cell imaging to parameterize... 1/3

Mitochondria finally made the headlines, yay! Oh wait, ... oh no ....

Happy to share the my lab's latest preprint, where we investigated sensorimotor circuit formation in the developing spinal cord. We show that proprioceptive axons target motor neurons in neighboring spinal segments to give rise to intersegmental reflex responses. www.biorxiv.org/content/10.1...

I have NIGMS R35, impact score 12 NIHGRI R21, 4th percentile NHGRI R01, 7th percentile (co-I) and it seems like none will be funded. 0/3. PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25." 😭

Just got an email that the NIH Early Independence award is "not going forward." This was an award that catapulted promising PhD students into faculty positions and is part of the High-Risk High-Reward grant program in the NIH Office of the Director. Deadline was 9.6.25!

One of the funnier things about the Yale prof who is advocating Niemollering the humanities is that his nirvana already exists. They are called Research Institutes. Why doesn’t he just change jobs to one of those and stop telling everyone else what to do?

Absolutely honoured to see our work featured on this month’s cover! 🎉🧬 Artwork by the incredibly talented @doroteaartscience.bsky.social 👇

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

Just look at those sweet, sweet phagophores Great job @kev-in-situ-et.bsky.social and team!

the 'defense' ants have abs...

Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉 🧫 New galactose #CRISPR screen 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂 Mito defects in #Menieres www.cell.com/cell-reports...

🚨 Out now! Autophagy keeps cells healthy - and when it goes wrong, diseases like Parkinson’s can emerge. @elias-adriaenssens.bsky.social (Martens lab) in @natureportfolio.nature.com Cell Biology challenge the conventional hierarchy of autophagy factors ➡️ tinyurl.com/y33nrtn2

i AM an artist and my studio is R STUDIO

ABSTRACTS CLOSE 18 July! The 11th International Symposium on Autophagy 2025 📅 16–20 November 2025 | Lorne, Victoria, Australia Registration: isa11.org We have a fantastic line-up of speakers and a wide range of topics focused on the fascinating world of autophagy.

Excited to share our latest work on how mitochondrial methylation shapes gene expression. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis. Thanks to everyone invovled. @ruthicglasgow.bsky.social @amunts.bsky.social 🔗 rdcu.be/etk12

Court invalidates NSF 15% indirect cost cap. Strong ruling. storage.courtlistener.com/recap/gov.us...