ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline

Spatial mapping of microbial communities by an integrated automation platform of sequential FISH

R-PLA enables enhanced detection of R-loops in mammalian cells using proximity ligation

Cellular-state control using ribozyme-scaffolded miRNA-sensing and CRISPR-mediated actuation

A lightweight TcrLM model predicts T cell receptor and epitope binding specificity

A high-speed attention network for MHC-bound peptide identification and 3D modeling

Microfluidics-enabled proteomic profiling reveal iron-driven immune evasion by an antimicrobial-resistant pathogen

Multiscale domain identification for spatial transcriptomics via persistent homology

3D imaging with enhanced transparency, signal-to-background ratios, and antigen detection using HyPer-3D

A homecage operant paradigm reveals behavioral dynamics of social motivation in mice

Topography-aware optimal transport for alignment of spatial omics data

Wnt activation and dual SMAD inhibition for induction and maintenance of hindbrain-like neural stem cell from hiPSCs

Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss

Assessing leaky expression of Cre-dependent DNA constructs in the mouse genome using sensitive bioluminescent reporters

Projection-specific intersectional optogenetics for precise excitation and inhibition in the marmoset brain

Benchmarking RNA velocity methods across 17 independent studies

Electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines

Development of motif-specific monoclonal antibodies for global protein citrullination detection with minimal cross-reactivity to homocitrullination

Persistent homology-based segmentation tool for membrane images

Intensity modulation of trichromatic split fluorescent proteins for live cell mapping

Immune response to adeno-associated viral vectors in a human iPSC-derived microglia chimeric mouse model

Integrating single-cell and single-nucleus datasets improves bulk RNA-seq deconvolution

Single-cell assessment of iron content in primary human T cells using laser ablation inductively coupled plasma mass spectrometry

MASTR-seq enables multiplexed analysis of short tandem repeats with sequencing

Metapipeline-DNA: A comprehensive germline and somatic genomics Nextflow pipeline

Convpaint—Interactive pixel classification using pretrained neural networks

Comprehensive cellular analysis with single-nucleus RNA-seq of archived PAXgene whole blood samples

Application of spectral flow cytometry for comprehensive detection of immune metabolism in patient-derived microsamples

Tissue morphology predicts telomere shortening in human tissues

MitoTracker transfers from astrocytes to neurons independently of mitochondria

Practical AI-based cell extraction and spatial statistics for large 3D bone marrow tissue images

A genetic strategy for targeting local astrocytes in adult Drosophila

Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data

Ontology-aware DNA methylation classification with a curated atlas of human tissues and cell types

A streamlined, nanopore-compatible 5PSeq protocol for rapid phenotypic antimicrobial sensitivity testing

A robust method for on-chip production and manipulation of lipid vesicles by inverted emulsion

Rapid expansion of primary human vocal fold epithelial cells via targeted pathway inhibition and anchorage-independent sphere culture

CBLN2 promoter enables genetic access to wide-field neurons of the tree shrew superior colliculus

Projection targeting with phototagging to study the structure and function of retinal ganglion cells

Human neuromuscular organoids mimic cancer-induced muscle cachexia

Non-invasive ovulation tracking enables genetic engineering in wild rodents

Efficient global accuracy estimation for protein complex structural models using multi-view representation learning

A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity

2P-FENDO-II: A fiber bundle microscope for all-optical, large field-of-view brain studies in freely moving mice

HazardPyMatch: A tool for identifying reproductive and other hazards in scientific laboratories

An integrative spatial multi-omic workflow for unified analysis of tumor tissue

A unified framework combining linear and 3D molecular features for robust drug-protein interaction prediction

Dynamic estimation of metabolic state during CAR T cell production

An orthogonal CRISPR/Cpf1 platform for precise spatiotemporal gene regulation and osteoporotic fracture repair

Predictive modeling of molecular activity underlying physical cell-cell interactions