Curious to know how does auxiliary subunit Neto2 modulate kainate receptor (KAR) function? Read our latest study describing GluK2-Neto2 complex-captured in both its activated and true apo states. www.nature.com/articles/s41...

I'm excited to share that I've started my lab @stanford.edu in the Neurobiology Department! neurobiology.stanford.edu/who-we-are/f... #stanford #newPI #neuroscience

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Thrilled to be heading to Spain next week to speak at the EMBO Workshop on Peroxisomes! 🧫🔬👩‍🔬 Looking forward to sharing our latest research and learning from incredible scientists working on these fascinating organelles. #peroxisomes #EMBOmeeting #cellbiology meetings.embo.org/event/25-per...

First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...

Excited to announce the opening of the @fitzsimmonslab.bsky.social at @michiganstateu.bsky.social dept. of biochemistry & molecular biology! (1/3)

@ohsunews.bsky.social neuroscientist Dr. Eric Gouaux has earned a rare distinction as a two-time recipient of the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke! news.ohsu.edu/2025/06/23/o...

Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community. Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.

Take charge of your #brain health! Join us for a community conference on brain health, #aging and Alzheimer's science. Each event features Alzheimer's and dementia resources in Oregon and Southwest Washington. Learn more and find an event near you: bit.ly/brainhealth25

Registration for the 2025 Chemical Biology and Physiology meeting is open! This biennial symposium features the latest and most impactful work in chemical biology. Dec. 11-13 2025 in Portland, Oregon (USA). Register here: www.ohsu.edu/school-of-me... Pls share

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/ Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic ⚔️🦠❄️🔬

Congratulations to Dr. Shivaani Kummar on being honored with the prestigious 2024 National Cancer Institute Director’s Award! The award is one of the NCI’s highest accolades and is bestowed upon those who demonstrate excellence, innovation, and commitment throughout their organization.

DNA Methylation Ageing Atlas Across 17 Human Tissues https://www.biorxiv.org/content/10.1101/2025.07.21.665830v1

Thank you to the organizers for inviting me to speak at the 2025 FASEB: Optical Probes meeting. Stunning desert location. #OPTSRC

Check out our new study revealing how yeast cells regulate oxidative stress.

Bill Rutter passed away at age 97 yesterday. He chaired our Department through the 1970s and was instrumental in the development of UCSF basic science. He hired Christine Guthrie, Keith Yamamoto, Bruce Alberts, Marc Kirschner, Pat O’Farrell, Peter Walter, Ira Herskowitz among others.

Excited to contribute to the Mitoribosome collaborative study led by @wredenberglab.bsky.social in @natcomms.nature.com🎉 "The mitochondrial methylation potential gates mitoribosome assembly" The assembly starts before the completion of the rRNA gene cluster processing🧵 www.nature.com/articles/s41...

We have a preprint for you EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...

Excited to share our latest preprint! Using integrated global lipidomics and proteomics, we show that SARS-CoV-2 variants induce conserved changes in host lipid metabolism pathways. Congrats to Scotty for leading the work. @ohsummi.bsky.social @ohsunews.bsky.social www.biorxiv.org/content/10.1...

New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8 www.biorxiv.org/content/10.1...

Awesome review by Braden Lobingier and colleagues on ways to study compartmentalized GPCR signaling.

Excited to present our newest preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Please check it out! 🧪💊 www.biorxiv.org/content/bior...

The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments. www.biorxiv.org/content/10.1...

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines. Learn more about these exceptional scientists: www.leadingedgesymposium.org/fellows

Our latest preprint on peroxisomal fatty-acid transport is live!! @ohsunews.bsky.social #OHSU @uofcalifornia.bsky.social #UCSF

Molecular mechanism of substrate transport by human peroxisomal ABCD3 https://www.biorxiv.org/content/10.1101/2025.05.21.655323v1

Purkinje cells form inhibitory connections on cerebellar nuclei cells. So, when Purkinje cells fire abnormally, as in disease states, we should see the inverse in nuclei cells, right? Well - it may not be so straightforward: tinyurl.com/PCtoNC @fralinbiomed.bsky.social @vtneuroscience.bsky.social

Have you ever wondered how repeated vaccination shapes our immune responses, and whether timing between doses matters? Check out our latest work! @ohsunews.bsky.social @ohsummi.bsky.social www.nature.com/articles/s43...

Another awesome collaboration with @jnpruneda.bsky.social and team providing deeper insight into the writers of MARUbylation. Check out thread 👇!

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵 www.biorxiv.org/content/10.1...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY

Exciting news!! I’m joining the tenure-track faculty at University of Colorado Boulder this fall as an Assistant Professor of Psychology & Neuroscience! The Sosa Lab will study how memory is shaped by cognitive and physiological demands, including during pregnancy and the postpartum period. 🧵

Dear al, check out our latest paper with @uhammes.bsky.social . A great collaborative effort by Lukas and Lam!!

New paper from the Beatty Lab! 👇 Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation | mSystems journals.asm.org/doi/10.1128/...

A step forward towards understanding mechanism of action of potential therapeutics for tackling Mycobacterium tuberculosis. Happy to have co-led this work with @nkhandelwal.bsky.social 🎊🎉

Congratulations to all the co-authors- @meghnag27.bsky.social, Jim Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah Hung, Robert M Stroud Huge thanks to the funding agencies ! The National Institutes of Health

Our paper on " Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A" is published in Nature Communications 🥂 🎊 www.nature.com/articles/s41...

Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica #NMOSD www.science.org/doi/10.1126/...

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?

Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter pubmed.ncbi.nlm.nih.gov/39937868/ #cryoem

Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica pubmed.ncbi.nlm.nih.gov/39982991/ #cryoem

Join me in standing up for science on March 7. in Salem, Oregon! Tell your friends and bring them too!! This is a nation wide event, with every state having at least one gathering. We need to show up strong!!! standupforscience2025.org

#NIHFundedDiscovery How do cells avoid the "kiss of death"? Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage. #CryoEM reveals the molecular switches behind this process! www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

In this article, we established how fiducial marker can be used for small membrane protein structure determination and impact of their position on the protein. We established how urate interacts with SLC2A9 transporter, and we provide the mechanistic details of disease-causing mutations.

I am thankful to the wonderful team @meghnag27.bsky.social , Paras Kumar , Sree Ganesh Balasubramani, Ignacia Echeverria, and Robert M Stroud , whose contribution and help made it possible. Huge thanks to the funding agencies The National Institutes of Health.

I am happy to share my new publication in PNAS entitled “Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter” (www.pnas.org/doi/full/10....).

Our paper "Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica" is published in Science Advances today 🥂 🎊 tinyurl.com/MGuptaSA Huge congratulations to the team- @nkhandelwal.bsky.social, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey Bennett, ROBERT M STROUD!

Thanks to all who attended the #BPS2025 #cryoem symposium yesterday, and the happy hour last night! We heard some superb science at the symposium and had some great discussions which were continued in the evening. And congratulations to Dr. Elizabeth Wright, our inaugural Almeida Award winner!