It's been an amazing year for the new PTM field of #MARUbylation - happy that I could get involved first-hand!

On the train to Montpellier for the #EMBOsumoylation conference - looking forward to the 2nd recurrence of this #EMBOevents workshop and to the latest research in the SUMO field! meetings.embo.org/event/25-sum...

I continue to be astounded by the recent resurgence of intriguing studies revolving around #PARPs and the interplay of ADP-ribosylation with other PTMs! Latest example that we published in @embojournal.org:

Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!

Our RNA & translation editor Cornelius Schneider is excited to be at #EMBLProtein starting tomorrow – make sure to say Hi to him and drag him to your posters 😀 @events.embl.org ‬

Fascinating new insights into evolutionary conservation/diversification/repurposing in the chromosome segregation machinery!

Another week, another great conference - happy to be at #EESAgeing on home turf

Senate Democrats warn Trump plan to wipe out public broadcasting funding will shut down stations, eliminate essential services. But House GOP scheduled to vote to clawback $1.1 billion next week.

This vital resource @flybase.bsky.social is in acute peril: its funding blocked by the vindictiveness of Trump. Emergency funds needed *now*, pending longer term solutions. Personal donations from Europe can be made here (UK taxpayers can gift-aid); other routes also possible. US appeal to follow.

A scary situation!

‘Anyone can do this’: Sleuths publish a toolkit for post-publication review @averyorrall.bsky.social reports on an initiative from @reeserichardson.bsky.social and colleagues

If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!

Today, these amazing NKI researchers are pushing their limits by climbing the Alpe d’Huez. Go for it lovely people! We are proud to see so many of you dedicate your time and effort to supporting cancer research. With @oncodeinstitute.bsky.social #AlpedHuZes #cancerresearch #ad6 #NKI

Grateful for the opportunity to meet with so many enthusiastic early-career scientists and sharing behind-the-scenes insights with them #wUeBI2025

Excited that the symposium #wUeBI2025 @grk2243.bsky.social is now about to start - looking forward to exciting news from the #ubiquitin field, and to meeting this great community again!

Ever wondered how it would be as an Editor? Here's your chance to try as an absence cover with our wonderful colleagues from @emboreports.org!

Tariffs xkcd.com/3073

Lungfish xkcd.com/3064

Great to get to publish another one on the emerging connections between ADP-ribosylation, immune signaling, ubiquitin and protein aggregation/degradation

💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) www.embopress.org/doi/full/10....

Highlighted in Issue 7: Lysosome-CDK4/6 co-targeting in cancer therapy Algal spliceosome structure Also: Opposite synaptic plasticity effects of Ras isoforms Novel biosensor for spatiotemporal dynamics of STING activation Cover: @plenart.bsky.social and coworkers www.embopress.org/toc/14602075...

From large language models (LLMs) to large reasoning models (LRMs) based on chain-of-thought. Are LRMs "“genuinely reasoning” or “merely mimicking” the kinds of human reasoning that is in the pretraining or post-training data"? Interesting read ➡️ www.science.org/doi/10.1126/...

Not to over-rate journal rankings - but this is nevertheless surely good news!

Lu Gan (甘露) and collaborators use cryo-electron tomography to reveal the nanoscale architecture of human #chromatin in situ: G1 and metaphase chromatin is devoid of mega-complexes beyond dinucleosome regularities www.embopress.org/doi/full/10....

In issue 6: Commentary: organoids for decoding host-microbe interactions Importance of mitochondrial DNA elimination during spermatogenesis How kinesin KIF12 promotes steatohepatitis Cancer cell adaptation strategies to aneuploidy Cover: Daniel Ott, Anne Spang et al www.embopress.org/toc/14602075...

Medicine & Society: The human condition A virtual seminar series coorganized by @embopress.org - feel free to subscribe & attend! cancerprev.com/medicine-soc...

In issue 5: Review: Arginine in the center of cellular nitrogen metabolism Elongator polymerizes polyglutamylated tubulin Shu complex HR factor to the replication fork! Ephrin as EGFR ligand promotes gastric cancer metastasis Cover by Ito, Hata, Kitagawa et al www.embopress.org/toc/14602075...

Register and submit your abstract now: The ageing genome: from mechanisms to disease www.embl.org/about/info/c...

don't tell our @embojournal.org RNA editor...

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

Happy that I got to handle and help publish this cool new work for @embojournal.org And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!

#Chlamydomonas on our latest @embojournal.org cover - nice flash-back to my Diploma work in this organism many many years ago 😯

Happy New Year with our first 2025 issue! With cover by Thomas Laux, Ning Zhang et al and: FNDC1 as myokine Tubulin glutamylation in axon guidance Chromatin remodelers aiding meiotic recombination Maintaining subunit essentiality during RUBISCO evolution www.embopress.org/toc/14602075...

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 20 – finishing with the most recent addition...

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 19

Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers. #Books #BookSky #BookChallenge Day 18

#Books #BookSky #BookChallenge Day 17

#Books #BookSky #BookChallenge Day 16

#Books #BookSky #BookChallenge Day 15: indeed "...deserves to sell more copies than the Bible" ☺️

Once more nice work coming to us through scientific conferences - with co-submission discussions easing pressure on both groups! Fascinating to see SMC protein binding/regulation via small linear motifs becoming a more general concept

Please take notice of this interesting symposium

#Books #BookSky #BookChallenge Day 14

#Books #BookSky #BookChallenge Day 13

Our new Executive Editor, Eric Sawey, is in San Diego attending #CellBio2024 If you’re in town, stop by @CSHLPress booth #514 to discuss your work! Or reach out at [email protected] to set up a good time to chat.

#Books #BookSky #BookChallenge Day 12

#Books #BookSky #BookChallenge Day 11

📣 SAVE THE DATE: EMBO workshop SUMOylation: from discovery to translation. 22-25 Sept 2025. La Grande Motte (France) Registrations will open soon: coming-soon.embo.org/w25-59

#Books #BookSky #BookChallenge Day 10

#Books #BookSky #BookChallenge Day 9

Was great to get to publish this new resource article, which had come to us c/o @reviewcommons.org - should become a very valuable tool for many types of studies!