Manideep Chavali
@manideep.bsky.social
📤 192
📥 313
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Assistant Professor @ OHSU 🧠 | Neuroscientist: OPCs, vessels & brain mysteries.
#newPI
Delighted to see our paper featured on the cover of JNeurosci. this week. While this study focused on the role of SCD1 in developmental myelination, the data also pointed us toward potentially broader functions for SCD2 that we are now actively pursuing
#sfnjournals
www.jneurosci.org/content/46/1...
18 days ago
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Manideep Chavali
gregduncan.bsky.social
29 days ago
The Duncan lab is hiring a postdoctoral fellow! We study how neurons respond to and are injured by demyelination. We use snRNAseq, microscopy, electrophysiology and molecular biology approaches. If interested, please send a statement of interest and CV.
www.neuroscience.umn.edu/faculty/curr...
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Manideep Chavali
about 2 months ago
Latest offering. How myelin ensheathes axons! Born from chat with Dwight Bergles on "weird things" we saw oligodendrocytes do, like making "bridges" between sheaths. Driven forward by Cody Call, Kelly Monk, and myelin folks
@edinburgh-uni.bsky.social
Enjoy!
www.nature.com/articles/s41...
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Flexible ensheathment of axons enables myelination of complex CNS networks - Nature
The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide ...
https://www.nature.com/articles/s41586-026-10312-1
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Manideep Chavali
Robert Hill
3 months ago
Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin.
www.science.org/doi/10.1126/...
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Manideep Chavali
Sachin Gadani
3 months ago
How does inflammation kill neurons, and what can we do about it? Check out our latest paper where we consider this question:
rdcu.be/e4nfP
.
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Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos
Nature Neuroscience - Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective...
https://rdcu.be/e4nfP
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Manideep Chavali
Priya Prakash
4 months ago
Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors
www.science.org/doi/10.1126/...
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Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors
Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...
https://www.science.org/doi/10.1126/science.adu2896
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Manideep Chavali
Amit Agarwal
5 months ago
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron
www.cell.com/neuron/fullt...
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Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...
https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900856-6
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Manideep Chavali
Journal of Cell Biology
6 months ago
Rodriguez Salazar,
@caglaeroglu.bsky.social
et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral
#astrocyte
process formation.
rupress.org/jcb/article/...
📕 Part of The Year In Cell Biology:
rupress.org/jcb/collecti...
#CellBio2025
#Mitochondria
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Manideep Chavali
Yamuna Krishnan
5 months ago
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
add a skeleton here at some point
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Manideep Chavali
bioRxivpreprint
5 months ago
Organelles harbour pH gradients
https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1
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Manideep Chavali
Siegenthaler Lab
6 months ago
Our work out in
@devbiol.bsky.social
, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones
@hejcell.bsky.social
w/ Kelsey Abrams, Sophia Kim, excited for more projects w/
@fantauzzolab.bsky.social
!
add a skeleton here at some point
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Manideep Chavali
6 months ago
Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish."
lnkd.in/gN7z6th4
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Manideep Chavali
Pedro Pimentel-Coelho
6 months ago
Obituary: Jose Manuel García-Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers Arantxa Cebrian-Silla, Mercedes Paredes, Arturo Alvarez-Buylla
onlinelibrary.wiley.com/doi/10.1002/...
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Obituary: Jose Manuel García‐Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers
Click on the article title to read more.
https://onlinelibrary.wiley.com/doi/10.1002/cne.70108
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Manideep Chavali
Bret Pearson
9 months ago
Our postdoc ad is up on the SDB website! Come to Portland and study regenerative neurogenesis in planarians and zebrafish:
www.sdbonline.org/resource?Res...
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Society for Developmental Biology | Resource
https://www.sdbonline.org/resource?ResourceID=4496
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Manideep Chavali
Nature
9 months ago
Nature research paper: Axonal injury is a targetable driver of glioblastoma progression
go.nature.com/4lFmpiN
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Axonal injury is a targetable driver of glioblastoma progression - Nature
Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.
https://go.nature.com/4lFmpiN
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Manideep Chavali
Baptiste Lacoste
10 months ago
Another beautiful study by the lab of
@andyshihlab.bsky.social
published today in
@natureportfolio.nature.com
👏🏻👏🏻👏🏻
#cerebrovascular
#aging
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Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience
How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...
https://doi.org/10.1038/s41593-025-02023-z
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Manideep Chavali
Ardem Patapoutian
10 months ago
Fantastic new study on the role of TMEM63a in oligodendrocyte-dependent myelination in the CNS from the Swetha Murthy lab:
pubmed.ncbi.nlm.nih.gov/40694323/
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TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination - PubMed
Infantile hypomyelinating leukodystrophy 19 (HLD19) is a rare genetic disorder where patients exhibit reduced myelin in central nervous system (CNS) white matter tracts and present with varied neurolo...
https://pubmed.ncbi.nlm.nih.gov/40694323/
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Manideep Chavali
Baptiste Lacoste
11 months ago
#Cerebrovascular
#Neurovascular
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Reduction of neuronal activity mediated by blood-vessel regression in the adult brain - Nature Communications
The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regre...
https://www.nature.com/articles/s41467-025-60308-0
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Manideep Chavali
bioRxiv Neuroscience
11 months ago
Directional growth of developing myelin mediated by Wnt gradient and required for proper axon functions
https://www.biorxiv.org/content/10.1101/2025.06.13.659097v1
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Manideep Chavali
about 1 year ago
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
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Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
https://www.nature.com/articles/s41593-025-01956-9
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Manideep Chavali
Ethan Hughes
over 1 year ago
New paper out from the lab! Led by
@gdfnunes.bsky.social
and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠
www.nature.com/articles/s41...
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Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications
Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...
https://www.nature.com/articles/s41467-025-56092-6
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Manideep Chavali
bioRxiv Neuroscience
over 1 year ago
Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity
https://www.biorxiv.org/content/10.1101/2024.12.27.630559v1
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