Congrats to the newest PhD from the @siegenthalerlab.bsky.social, Dr. Sophia Kim! Beautiful thesis document & presentation! 🧠🦠🔬🎉 Sophia's thesis work on arachnoid barrier breakdown in meningitis is on bioRxiv - check it out! www.biorxiv.org/content/10.6...

🚨 New preprint from our lab led by Sophia Kim w/ @kellydoran.bsky.social group @cuanschutz.bsky.social -- using neonatal 🐭 model of bacterial meningitis ➡️ arachnoid barrier is leaky, Cldn11 junctions are disrupted & cytokines are part of the problem. Lots of 🤩🧠🦠🔬 & compelling data, check it out! 1/5

Conserved cellular architecture and developmental mechanisms of the zebrafish https://www.biorxiv.org/content/10.64898/2026.02.14.703877v1

Excited to share my final postdoc project published. We looked into the striking amyloidosis of important brain waste clearance sites (bridging veins) in mouse and human. A great collaborative project with Rupal Mehta at Rush who did all the human studies. Thanks to everyone who contributed!

Postnatal Cerebral Perivascular Fibroblast #SciArt Fibroblast PDGFRα KO🐭(P0) 👉⏬Perivascular Fibroblast & Perivascular Mφ coverage of penetrating vessels (P10) 👉↔️SMC/Astrocyte coverage @hejcell.bsky.social @siegenthalerlab.bsky.social @devbiol.bsky.social 2025 www.sciencedirect.com/science/arti...

& a great time to share a life update! (better late than never) I’ve recently started as a Postdoc in the Wills lab at University of Washington where I’ll be studying the role of fibroblasts during regeneration in Xenopus 🐸🧠 On my way to becoming a frog wrangler @frogwranglers.bsky.social

Thrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!

Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!

SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT

"If we lose hope, we're doomed." We must continue Dr. Jane Goodall's mission and all fight for the future of the planet.

PhD Timeline xkcd.com/3081

@cshlmeetings.bsky.social Brain Barriers 2025 is a wrap! It was an honor to co-organize this meeting in 2023 & 2025, a highlight of my scientific career. I am amazed by all the great science presented by these awesome scientists over the last five days...the future of CNS barrier biology is 🤩 💫!

🚨 A new Daneman Lab preprint!! 🚨 Reid Larsen, one of the brightest scientists I know, studied the BBB glycocalyx, identified its structure, composition, and function and uncovered what makes the CNS glycocalyx unique. It was a true pleasure to be a part of this seminal study! shorturl.at/Wkhxr

I was imaging this weekend, took this image because it was beautiful to me, the blood vessels, fibroblasts, astrocytes, & macrophages as steadfast guardians at the brain's edges. Cheers to the 'guardians' of all that is important. ❤️

More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025

we’re standing up for science tomorrow! Made some signs tonight with Denver @standupforscience.bsky.social organizers ❤️🧬🔬🥼

"downsizes" is a weak way of saying "forced to cancel dozens of programs, which jeopardizes future STEM careers of talented undergrads" @science.org www.science.org/content/arti...

"Memoli had no choice, he insisted: He was following the direction of three HHS officials—Dorothy Fink, then the acting secretary; Heather Flick Melanson, chief of staff; and Hannah Anderson, deputy chief of staff of policy—who told him, in no uncertain terms, that the pause was to continue..." /1

A small museum says all but one sponsor of a Girls in STEM event backed out, fearing retaliation from the Trump administration over "DEI." Evan Kruegel reports for @nexton9news.bsky.social. www.youtube.com/watch?v=Zg1n...

Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠 sciencehomecoming.com

Maybe I wasn’t clear about this. I wanted more egg and no plane crash, not many plane crash and no egg.

“It’s really an elaborate infrastructure that’s required to do this research. One of the things that concerns me is the magnitude and rapidity of these changes.” VC for Research Tom Flaig, MD, recently spoke to @cbsnews.com about the potential impact the proposed NIH cuts could have on our campus.

On International Day of Women and Girls in Science, a reminder to not close your eyes and turn away from what is happening in the US right now. Fascism is an assault on scientific integrity, knowledge, and innovation. www.chron.com/news/space/a...

March for science? AAUP & other unions are working on action plans and messaging around NIH, DEI, and other slashes Feb 13: National call in 8PM (below) Feb 19: National day of action on campuses (details soon) Feb 25: National Action & Press Conference in DC (details soon) @aaup.bsky.social

I have not seen a crisis of this magnitude since yesterday

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

The number of people surprised by the long list of words NSF is targeting makes me think many of you all have not seen this: www.commerce.senate.gov/services/fil...

Are you interested in seahorses, sea dragons and pipefish? And single cell transcriptomics? And evolutionary genomics? Check out the version of record from our latest paper at eLife led by the awesome Dr. Hope Healey elifesciences.org/articles/97764

The Society for Developmental Biology has released a statement on the Unprecedented Disruptions to Biomedical Research in the United States.

The blood-brain barrier can prevent therapeutic drugs from reaching the brain. Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6

New podcast alert! Project Bridge at @cuanschutz.bsky.social - our trainee-led public outreach group - is launching 'The Science Bridge' tomorrow (1/15)! Current trainees host shows that demystify science, the research process, & research careers. #AcademicSky 🧪 open.spotify.com/show/0Q0bn3G...

This course WILL change your life in the best ways! 🐭🐟🐸🪱🐙🪰 apply apply apply

when cats curl up so much their faces go upside down rt if you agree

Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages www.science.org/doi/full/10....

A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates www.science.org/doi/full/10....

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Lots of interest in this course and many at the CSHL conference asking for an extension of the deadline. So we are adding one more week until December 17!!

Excited to announce that our 2025 Advanced Research Training Course schedule is up and applications are open! 🎉🎉🎉 See you in Woods Hole! mbl.edu/courses 🧪🐙🦑🧠🐟

@ondinecleaver.bsky.social gave the BEST talk yesterday @cuanschutz.bsky.social sharing this great work with the faculty & student in our CSD grad program - Ondine is an exceptional scientist & meeting with her was an 🤩 birthday gift! 🎁 Thanks to 🦋-less Dr. Hannah Jones for inviting & hosting!

I am 🦋-less no longer! Had an awesome time hosting & talkin' tubes with @ondinecleaver.bsky.social yesterday!