Siegenthaler Lab
@siegenthalerlab.bsky.social
📤 5327
📥 4804
📝 619
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
pinned post!
Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the
@siegenthalerlab.bsky.social
studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.
about 1 year ago
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Zoe McElligott
7 days ago
Missing local man call 843-833-1890 or 704-724-2105 if you see him
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UK Glia Network
7 days ago
🎉 Join us at the UK Glia 2026 meeting, 8–9 June. Registration open now, abstracts due 16 Jan. 🔗
www.physoc.org/events/uk-gl...
.In this post, meet Blanca Díaz Castro
@bdiazcastro.bsky.social
from UK DRI
@ukdri.ac.uk
and the University of Edinburgh
@edinburgh-uni.bsky.social
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Katharine Hayhoe
7 days ago
You probably heard the US admin is threatening to break up the National Center for Atmospheric Research: but did you know they already froze funding for the 9 regional Climate Science Adaptation Centers? From tracking invasives to helping tribes with drought, here's why the CASCs matter ⬇️
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From invasive species tracking to water security – what’s lost with federal funding cuts at US Climate Adaptation Science Centers
The people who manage America’s aquifers, wetlands, shorelines and recreation areas rely on federal science as they face new and rising risks in a changing climate.
https://theconversation.com/from-invasive-species-tracking-to-water-security-whats-lost-with-federal-funding-cuts-at-us-climate-adaptation-science-centers-269908
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FocalPlane
7 days ago
Last couple of days to vote for your favourite 'Featured image' from 2025 ❤️🔬!
focalplane.biologists.com/2025/12/19/v...
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Paul Haine
8 days ago
With Bardot's passing, the only named individuals in Billy Joel's We Didn't Start The Fire that are still alive are Bob Dylan, Chubby Checker, and Bernie Goetz. The last one standing will claim The Prize.
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Nature Portfolio
7 days ago
A paper published in Nature in September suggests a quarter of heatwave events from 2000-23 would have been near impossible without anthropogenic climate change. The paper also indicates that major carbon emitters are responsible for around 50% of the increase in intensity of these events. ⚒️ 🧪
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Systematic attribution of heatwaves to the emissions of carbon majors - Nature
Climate change made 213 historical heatwaves reported over 2000–2023 more likely and more intense, to which each of the 180 carbon majors (fossil fuel and cement producers) substantially contributed.
https://go.nature.com/46e7vdF
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BK. Titanji
7 days ago
It's always a different type of excitement when you get an advanced book copy in the mail and it's a project you contributed to. Very excited that this gets released in early 2026. It was a joy and privilege to author a chapter in this text alongside a stellar cadre of co-authors and amazing editors
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Kathleen Bachynski
8 days ago
Statement from the American Academy of Neurology: “This decision was made without consulting key neurology stakeholders, and there was no formal announcement nor a clear succession plan for NINDS leadership. NINDS plays a vital role in funding and directing research into the brain”
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Statement on Sudden Departure of NINDS Director
https://www.aan.com/policy-and-guidelines/policy/position-statements/statement-on-sudden-departure-of-ninds-director/
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Florian Jug
8 days ago
🚨 Alarm!!! 🚨 AI/ML course for microscopy image analysis!!! 🧐 In 2026 at Janelia (
@hhmijanelia.bsky.social
), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!? 20 students, ~14 TAs and lecturers 🗓️ June 4-18 2026 ✍️ Jan 15 2026 ✍️ 🔁 pls!!
www.janelia.org/you-janelia/...
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Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
https://www.janelia.org/you-janelia/conferences/bootcamp-course-on-deep-learning-for-microscopy-image-analysis
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Zohran Kwame Mamdani
8 days ago
Two weeks ago I spent the whole day at the Museum of the Moving Image to listen to New Yorkers. This is what Liam shared with me.
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Gregg Gonsalves
9 days ago
More on the continuing purges at
#NIH
. Now 13 out of 27 institute directors have been gotten rid of. This is not normal.
@jonathanwosen.bsky.social
www.statnews.com/2025/12/27/n...
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Director of NIH neurological disorders institute is ousted, adding to leadership churn
Walter Koroshetz, director of the National Institute of Neurological Disorders and Stroke, will soon be leaving his role, STAT has learned. His departure
https://www.statnews.com/2025/12/27/nih-neurological-disorders-stroke-institute-director-koroshetz-ousted/
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Needhi Bhalla 💅🏽
8 days ago
“Recovering her story is important because it allows her scientific contributions to be appropriately recognised. Perhaps more importantly, her story reminds us that women have belonged in quantum physics from the beginning.” 🧪
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Jonathan Edward Durham
8 days ago
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Sam J Wilson
about 1 month ago
How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
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Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
https://www.science.org/doi/10.1126/science.adq4691
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Molecular Biology and Evolution
10 days ago
Lee et al. used B-lymphoblastoid cells from three great ape species and humans to show that human ZEB2 is distinct in regulating a larger repertoire of genes implicated in neuronal development. 🔗
doi.org/10.1093/molbev/msaf318
#evobio
#molbio
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Comparing great apes reveals human-specific ZEB2 roles in neural development
Abstract. Humans differ from other primates in various traits, despite nearly identical protein-coding sequences. Understanding the evolution of these diff
https://doi.org/10.1093/molbev/msaf318
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Guillaume Jacquemet
15 days ago
I will be recruiting two postdocs early next year. - One image analyst - one biologist interested in working on lymphatics! Reach out if you are interested 👍
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Hao Yin
8 days ago
#Atherosclerosis
Smooth Muscle Cell PCSK9 transgenic🐭 👉Ferroptosis (⏫Iron deposit ⏫4HNE ⏫PTGS2 ⏬GPX4) 👉Plaque instability PCSK9 binds to YAP1 for lysosomal degradation▶️ ⏬NUPR1 (ferroptosis suppressor) Cadd4 - a PCSK9 PROTAC ⏫Lesion stability Research 2025
spj.science.org/doi/full/10....
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Jeremy Berg
8 days ago
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective). Read!
elizabethginexi.substack.com/p/the-quiet-...
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The Quiet Power of Program Officers
How invisible decisions shape what science gets done—and whether it matters
https://elizabethginexi.substack.com/p/the-quiet-power-of-program-officers
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Josie Glausiusz
9 days ago
In 1977, American physicist John H. Van Vleck won the Nobel prize for his work on magnetism. In his Nobel lecture, amid a discussion of rare earth elements, one sentence leaps out: "Miss Frank and I made the relevant calculations." Who was Amelia Frank?
theconversation.com/who-was-amel...
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Who was Amelia Frank? The life of a forgotten physicist
In the 1930s, this quantum mechanical pioneer faced obstacles that still confront women in physics today.
https://theconversation.com/who-was-amelia-frank-the-life-of-a-forgotten-physicist-270953
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Allen Institute
9 days ago
Applications are open for the 2026 Computational Cell Types Workshop! 🧠📈 🗓️ May 11-14 in Seattle 💻 Python experience required 💰 Support for travel 🔗
https://alleninstitute.org/events/2026-computational-cell-types-workshop/
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2026 Computational Cell Types Workshop
Workshop in Seattle, WA to gain in-depth exposure to how Allen Institute defines "cell types" and walk away with direct applicable examples on using our free, open tools for their research
https://alleninstitute.org/events/2026-computational-cell-types-workshop/
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Ted Price
9 days ago
I had the opportunity to do the most enjoyable and, hopefully, meaningful work of my scientific career thanks to the leadership of former NINDS Director Walter Koroshetz. He and his team at NINDS created visionary scientific programs for the pain field. He will be missed...
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Jonathan Wosen
9 days ago
Thanks for mentioning, Jeremy. We had a story about this go up a little while ago. 👇
www.statnews.com/2025/12/27/n...
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Director of NIH neurological disorders institute is ousted, adding to leadership churn
Walter Koroshetz, director of the National Institute of Neurological Disorders and Stroke, will soon be leaving his role, STAT has learned. His departure
https://www.statnews.com/2025/12/27/nih-neurological-disorders-stroke-institute-director-koroshetz-ousted/
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Jeremy Berg
9 days ago
More news (not good) from NIH The renewal request from National Institute of Neurological Diseases and Stroke Director Walter Koroshetz has been denied. I guess the NIH_leadership™ needed another position to fill with their time-tested recruitment process.
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Andrew D Thaler
9 days ago
Kristina Gjerde was a mentor to me in high seas policy. I, and many others, owe our careers to her. May her memory be a blessing.
news.mongabay.com/2025/12/kris...
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Kristina Gjerde, defender of the deep ocean, has died
Half the planet lies outside any country’s border. In those waters, rules have long been thinner than the myths: freedom to fish meant freedom to take; “out of sight” became “out of mind.” The deep oc...
https://news.mongabay.com/2025/12/kristina-maria-gjerde/
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Thiago Carvalho
9 days ago
'Mechanistically, the distribution of GLP- 1R expression differs in the mouse versus the human heart, challenging the utility of preclinical studies for inferring underlying mechanisms in humans.'
www.science.org/doi/10.1126/...
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The benefits of GLP-1 drugs beyond obesity
Glucagon-like peptide–1–based medicines have weight loss–independent actions
https://www.science.org/doi/10.1126/science.adn4128
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Carole V. Bell
9 days ago
Monumental work. Artifacts from the São José have become a centerpiece of the Smithsonian’s National Museum of African American History and Culture (N.M.A.A.H.C.). The Clotilda inspired a Netflix documentary and a new museum in Africatown, Alabama, and similar hopes are riding on the Camargo…
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Maximilian Ganser
9 days ago
Finally, we’ve solved a long-standing mystery: what tintinnid shells are actually made of: A new class of biomaterial formed by remarkable structural proteins unique to tintinnids. A major milestone after 3 years of work! Read about it in our preprint:
doi.org/10.64898/202...
#ProtistsOnSky
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Immunity
10 days ago
Online now: Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
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Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
How distinct hematopoietic waves generate specialized macrophage lineages remains unclear. Chen et al. identify separate transcriptional pathways controlling macrophage development during primitive versus definitive hematopoiesis and identify Maf and Jun as key regulators of Zeb2 expression that drive microglia formation during primitive hematopoiesis, revealing a unique regulatory program for microglia development.
http://dlvr.it/TQ1Y4g
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Ben Sivyer
2 months ago
We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.
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Jeremy Berg
9 days ago
My kids and grandkids have returned to their homes. Back to the real world. I just emailed NIH Director Bhattacharya. My last email of the year (I hope). 1/13
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The Onion
10 days ago
Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken
https://theonion.com/heroic-dog-saves-family-of-5-from-herb-roasted-chicken/
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Jess Calarco
10 days ago
Make a Bond movie academic: For Your Eyes Only: Two-Factor Authentication in Higher Ed
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ACCORDS
10 days ago
Inspired by her family, Channing Tate, PhD, has dedicated her career to serving the most vulnerable people in our 4th most read blog of 2025: https://bit.ly/4iZyGiD
@cumedicalschool.bsky.social
#ACCORDSInnovation
#ACCORDSCommunity
#HealthCareServicesResearch
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CU Researcher Works to Improve Dementia and Hospice Care in Underserved Communities
Inspired by her family, Channing Tate, PhD, has dedicated her career to serving the most vulnerable people in our health care system.
https://news.cuanschutz.edu/accords/cu-researcher-works-to-improve-dementia-and-hospice-care-in-underserved-communities
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CU Anschutz School of Medicine
10 days ago
GLP-1s were a hot topic this year. Joseph Schacht, PhD, co-director of the Division of Addiction Science, Prevention, and Treatment, is investigating whether the pill form of Ozempic could help people with alcohol use disorder reduce their cravings to drink.
https://bit.ly/44wI2w9
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CU Researcher Studying Effects of GLP-1 Drugs on Alcohol Addiction
Joseph Schacht, PhD, of the CU School of Medicine, is investigating whether the pill form of Ozempic can curb alcohol cravings.
https://news.cuanschutz.edu/medicine/cu-researcher-studying-effects-of-glp-1-drugs-on-alcohol-addiction
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John Holbein
11 days ago
Experimental evidence that students are more likely to contest grades when they are delivered by an evaluator with a female-sounding name. "These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
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erin pineda
10 days ago
the last time a student pursued a grade grievance for one of my classes my dept chair was astounded at the meticulousness of the records I keep. This is why
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The Onion
10 days ago
Cat Clinging To Side Of Christmas Tree Admits That Was Extent Of Plan
https://theonion.com/cat-clinging-to-side-of-christmas-tree-admits-that-was-1849899567/
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Tim
10 days ago
And I must give credit to people smarter than me i.e.
@dacrotty.bsky.social
who notes that any journal will very gladly publish a negative result as long as it is exciting enough. The bias against null results is really just another form of same old bias *for* perceived significance/impact.
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Trevon Logan
10 days ago
From threats of violence to racially segregated restaurants to sundown towns, holiday travel required careful, deliberate planning from Black people. The Green Book project documents this history, and you can add your story as well:
greenbookproject.osu.edu
#GreenBookProject
#CommunityMap
#EconSky
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Alex Stark
12 days ago
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv:
www.biorxiv.org/content/10.6...
. Amazing collaboration by
@shenzhichen1999.bsky.social
, Vincent Loubiere (
@impvienna.bsky.social
,@viennabiocenter.bsky.social),... (1/2)
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Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
https://www.biorxiv.org/content/10.64898/2025.12.22.695948v1
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My doggo Clark 'asked' for a hike for his Christmas 🎁...who am I to refuse? I hope everyone is having a relaxing, joy-filled day! ❤️
11 days ago
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BWJones
11 days ago
Christmas Eve, 2025 Sitting in front of the fireplace with Alice the cat, reflecting upon a very bad, no good year. So many people have suffered and are suffering this year. Let’s work to use whatever privilege and advantages we have to better life for everyone who has it harder than we do.
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Marine Neuroscience Laboratory
11 days ago
A Christmas present from us and the rest of the
#OCTRON
team to you:
www.biorxiv.org/content/10.6...
🎁
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Katie O'Reilly
11 days ago
Atlantic sturgeon is one of ~27 species in the sturgeon family Acipenseridae, a group whose looks haven’t changed much since the Cretaceous. They have bony plates (scutes) instead of scales, barbels by their mouths + heterocercal tails (one side larger than the other - like sharks)
#25DaysofFishmas
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Katie O'Reilly
11 days ago
The big day is finally here - and with it, a very big fish! Our
#25DaysofFishmas
road trip ends on the East Coast with the ancient-looking Atlantic Sturgeon (Acipenser oxyrinchus). Once close to becoming a Ghost of Fishmas Past, their ongoing recovery represents a possible brighter Fishmas Future
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United Farm Workers
11 days ago
Wishing all of our friends a very happy holiday season full of peace, love & happiness! Gracias Ignacio Gomez for this wonderful piece of art.
#WeFeedYou
Deseándole a todos nuestros amigos unas felices fiestas llenas de amor, paz y felicidad! Gracias Ignacio Gómez por está increíble pieza de arte.
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Benjamin Kay
12 days ago
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in
@cellpress.bsky.social
.
doi.org/10.1016/j.ce...
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Benjamin Kay
12 days ago
I’ve been teaching medical students stimulants treat hyperactivity by “stimulating” the brain’s attention systems, but it turns out I was wrong. Stimulants mimicked the effects of getting more sleep and anticipated reward, not attention.
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Horst Obenhaus
13 days ago
Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting
#OCTRON
- a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!
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Nadia Maria van Eekelen
11 days ago
My first ever paper as a xmas present! 🎄 Check out this amazing pipeline created by
@octoscience.bsky.social
to track squishy animals 🐙 Very happy I could contribute to this,
#OCTRON
works great on my gossamer worms! 👇
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