Siegenthaler Lab
@siegenthalerlab.bsky.social
📤 5127
📥 4335
📝 585
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
pinned post!
Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the
@siegenthalerlab.bsky.social
studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.
11 months ago
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Noelle Dwyer
about 8 hours ago
Our new preprint 😅 ! We show cytokinetic abscission completion is important to maintain polarized epithelial structure, and p53-mediated apoptosis guards the structure when there are failures of abscission. In vivo in brain.
#cellbio
#abscission
#devbio
#cilia
www.biorxiv.org/content/10.1...
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Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia
Cytokinetic abscission is the last step of cell division, during which the intercellular bridge between daughter cells is severed. While abscission genes are linked to cancers and developmental disord...
https://www.biorxiv.org/content/10.1101/2025.09.15.675942v1.full
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Siegenthaler Lab
Tiffany Ito
1 day ago
University of Colorado Boulder Psychology & Neuroscience is searching for TWO tenure track assistant professors!!
jobs.colorado.edu/jobs/JobDeta...
#socialpsychology
#cogpsyc
#PsychSciSky
#PsychJob
#psycjobs
#psychology
1/n
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Assistant Professor
https://jobs.colorado.edu/jobs/JobDetail/?jobId=67372
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Ele Willoughby
about 18 hours ago
Day 23
#SciArtSeptember
prompt scouting: Zofia Kielan-Jaworowska (1925-2015) a Polish
#paleobiologist
, famous for a series of Polish-Mongolian expeditions she lead from 1963-1971 to the Gobi desert! 🐡🧪👩🏼🔬⚒️
#histsci
There she discovered dinosaurs including the Deinocheirus, plus she & team found the 🧵
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BK. Titanji
about 18 hours ago
For the record Science is not done by feelings and emotions. There is a process, peer review and publication of data publicly for critique.
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Samarth Hegde
1 day ago
🔬Our paper from the
@miriammerad.bsky.social
lab is now online! This is a story shaped over years of cross-disciplinary endeavor at
@sinaiimmuno.bsky.social
and labs across the world. 🧵:
www.nature.com/articles/s41...
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Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
https://www.nature.com/articles/s41586-025-09493-y
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Siegenthaler Lab
Richard M. Carpiano, PhD, MPH
1 day ago
American Academy of Pediatrics statement on the 9/22 WH autism press conference: “Today’s White House event on autism was filled with dangerous claims and misleading information that sends a confusing message to parents and expecting parents and does a disservice to autistic individuals."
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AAP Statement on White House Autism Announcement
Today’s White House event on autism was filled with dangerous claims and misleading information that sends a confusing message to parents and expecting parents and does a disservice to autistic indivi...
https://www.aap.org/en/news-room/news-releases/aap/2025/aap-statement-on-white-house-autism-announcement/
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Trevon Logan
1 day ago
American Psychiatrist Association Statement on White House Announcement on Autism
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John Ngo
1 day ago
4️⃣ Plasmids are on
#AddGene
!
www.addgene.org/browse/artic...
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Addgene: RNA-Stabilized Coat Proteins for Sensitive and Simultaneous Imaging of Distinct Single mRNAs in Live Cells
https://www.addgene.org/browse/article/28252367/
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Siegenthaler Lab
John Ngo
1 day ago
🚀 Our new paper is out
@natmethods.nature.com
! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗
www.nature.com/articles/s41...
🧬
www.addgene.org/John_Ngo/
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Al Guiocoche
1 day ago
apnews.com/article/mack...
Scott gives $70 million to UNCF to financially strengthen HBCUs
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MacKenzie Scott gives $70 million to UNCF to financially strengthen HBCUs
Billionaire philanthropist MacKenzie Scott has donated $70 million to the UNCF, the largest private provider of scholarships to minority students.
https://apnews.com/article/mackenzie-scott-hbcu-donation-4db7e27b4b1180f2b7969f1a1910a350?utm_source=bluesky&utm_medium=share <br>MacKenzie
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Siegenthaler Lab
Sherry Pagoto, PhD
1 day ago
The Coalition of Autism Scientists have entered the chat: “The data cited do not support the claim that Tylenol causes autism and leucovorin is a cure, and only stoke fear and falsely suggest hope where there is no simple answer.”
www.thetransmitter.org/spectrum/aut...
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Autism experts question HHS statements on Tylenol, leucovorin
Concerns include the administration’s reliance on weak, correlational evidence rather than established research…
https://www.thetransmitter.org/spectrum/autism-experts-question-hhs-statements-on-tylenol-leucovorin/
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Siegenthaler Lab
Gitta Coaker
1 day ago
My department at UC Davis is hiring a mycologist, broadly interpreted. Please repost, share, and consider applying.
recruit.ucdavis.edu/JPF07339
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Assistant Professor of Plant Pathology
University of California, Davis is hiring. Apply now!
https://recruit.ucdavis.edu/JPF07339
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Siegenthaler Lab
Nature Portfolio
1 day ago
We are excited to present the shortlists for the 2025 Nature Awards for Inspiring Women in Science. Congratulations to the thirteen excellent candidates who made it to this year’s shortlist. Read more about the candidates and learn more about the award:
go.nature.com/46nlAWy
#WomeninStem
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Siegenthaler Lab
Mari Sosa
1 day ago
The Sosa Lab website is now live!
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
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Sosa Lab
https://www.sosaneurolab.com/
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Siegenthaler Lab
Jae Young Choi
1 day ago
Excited to share a new method developed from my group thats published at Genome Biology. This was an amazing effort by my grad student Linh
@linhngk.bsky.social
. We developed Topsicle, a method that analyzes long read data for telomere analysis and length measuring.
doi.org/10.1186/s130...
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Topsicle: a method for estimating telomere length from whole genome long-read sequencing data - Genome Biology
Telomeres protect chromosome ends and their length varies significantly between organisms. Because telomere length variation is associated with various biomedical and eco-evolutionary phenotypes, many...
https://doi.org/10.1186/s13059-025-03783-4
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Siegenthaler Lab
Sana Nasim
3 days ago
Thrilled to share our new publication in FASEB! We found that endothelial cells carrying the GNAQ p.R183Q mutation fail to align in response to blood flow. They show heightened activation of MAPK, inflammation, and adhesion pathways, pointing to a disrupted mechanosensory response.
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GNAQ p.R183Q Endothelial Cells Fail to Align in Response to Laminar Shear Stress and Exhibit Increased Expression of MAPK, Inflammation, and Cell Adhesion Genes
Endothelial cells with the GNAQ p.R183Q mutation do not align properly when exposed to laminar shear stress. Transcriptomic analysis of mutant versus wild type endothelial cells exposed to increasing...
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502180R
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Siegenthaler Lab
Vaughn Cooper
2 days ago
Lineage tracking using methylation states from longitudinal bulk sampling. Sounds 🆒 and given recent work by
@trevorgraham.bsky.social
and colleagues, looks real. Wondering about other applications like 🦠🧫 👉🏻News and views:
www.nature.com/articles/d41...
👉🏻Paper
www.nature.com/articles/s41...
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Epigenetic clues from cancer’s past foretell its future
An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.
https://www.nature.com/articles/d41586-025-02256-9
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Siegenthaler Lab
Franck Polleux
3 days ago
Excited to highlight a new paper from my graduate student Sergio Bernal Garcia who, together withLuke Hammond, developed RESPAN, a new deep-learning pipeline automating the segmentation of neuronal morphology and dendritic spines from fluorescent microscopy images:
www.cell.com/cell-reports...
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A deep learning pipeline for accurate and automated restoration, segmentation, and quantification of dendritic spines
Garcia et al. present RESPAN, a pipeline that enables automated dendritic spine analysis through seamless integration of deep learning image restoration and segmentation capabilities with comprehensiv...
https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(25)00215-2
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Siegenthaler Lab
Hao Yin
3 days ago
Fibroblast co-culture shapes Microvascular network on a chip HUVEC/human adult lung fibroblast (5/1) in fibrin hydrogel➡️a sustained, arborized & perfusable microvasculature Gravity-driven flow prunes the network 🤓 Void-based microvascular morphometry bioRxiv 2025
www.biorxiv.org/content/10.1...
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Anna Gifty
4 days ago
lol in case folks haven't noticed, every political and economic attack in this country is perfected on minorities FIRST and then scaled. 🤷🏿♀️
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Adrian Liston
5 days ago
For our
#flowcytometry
peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
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https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.70206
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We login with our university ID onto the imaging analysis computer & I always laugh being greeted by 'younger Julie' in my first faculty photo 😂 (**I am apparently am THAT kind of faculty that does not update their photo though I now understand why this happens...who has time for that?!?!)
4 days ago
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David Ho
5 days ago
The recommendation from the West Coast Health Alliance of Washington, Oregon, California, and Hawaiʻi is that all adults get the flu and COVID vaccines.
www.oregon.gov/oha/PH/PREVE...
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Robin Pranter
5 days ago
How does cell end developmental biology inform our understanding of evolution? Join us for an afternoon of discussion about
#cells
,
#development
,
#plasticity
and
#evolution
. Zoomlink Sep 25th:
lu-se.zoom.us/j/62473328732
Zoomlink Sep 26th:
lu-se.zoom.us/j/67411449026
#EvoDevo
@biologylu.bsky.social
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Siegenthaler Lab
The Atlantic
6 days ago
Nobel laureate Jennifer Doudna tells Jeffrey Goldberg that vaccinations have been so successful that "there's been a collective forgetting that measles, and mumps, and rubella—these used to be diseases that would kill people in fairly large numbers." #TAF25
bit.ly/46a5DUE
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bioRxiv Neuroscience
5 days ago
Morphological heterogeneity of human astrocytes in cerebral organoids
https://www.biorxiv.org/content/10.1101/2025.09.18.675430v1
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Siegenthaler Lab
Susie Dent
5 days ago
Today I offer a reminder of the word ‘forswunk’ (13th century): exhausted from too much work. To be ‘foreswunk’ (my own version) is to be exhausted before you even begin.
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Allan Carrillo-Baltodano
5 days ago
#FluorescenceFriday
Back at the confocal with lots of larvae to image from this spawning season. This a lateral view of the larva of Spirobranchus lamarcki from St Andrews, Scotland
#EvoDevo
#DevBio
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BK. Titanji
5 days ago
Here is a list of credible sources on vaccines in a thread I put together a while ago.
bsky.app/profile/bogh...
add a skeleton here at some point
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Siegenthaler Lab
Mathieu Preußner
7 days ago
1🧵 Excited to share my first PhD paper, published in
@dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function? We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...
#DevBio
#Zebrafish
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Kathleen Bachynski
5 days ago
“With an autocrat, you cannot give an inch,” Colbert said. “If ABC thinks that this is going to satisfy the regime, they are woefully naive. And clearly they’ve never read the children’s book If You Give a Mouse a Kimmel.”
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Late-Night Hosts Joke About Kimmel’s Suspension While Warning of Autocracy
https://www.nytimes.com/2025/09/18/arts/television/jimmy-kimmel-david-letterman-stephen-colbert.html?smid=nytcore-ios-share&referringSource=articleShare
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Siegenthaler Lab
Ardem Patapoutian
6 days ago
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by
@yunxiao-dr.bsky.social
, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
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PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
https://www.biorxiv.org/content/10.1101/2025.09.17.676899v1
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Needhi Bhalla 💅🏽
5 days ago
"STAT’s analysis of NIH Reporter data reveals that the agency will still fund far fewer new projects this year, due to a change in how it awards grants...the number of R grants issued has dropped much more precipitously — from 5,633 to 3,758 newly funded projects."
add a skeleton here at some point
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Siegenthaler Lab
Aurelie Hintermann
7 days ago
Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with
@chasebolt.bsky.social
,
@homeobox.bsky.social
and myself, coordinated by
@denisduboule.bsky.social
from
@college-de-france.fr
and published in
@nature.com
today!
#InHoxWeTrust
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Siegenthaler Lab
Dr. Lucky Tran
6 days ago
IT'S OFFICIAL: Connecticut, Maine, Massachusetts, New Jersey, New York State, Pennsylvania, Rhode Island and New York City have formed the Northeast Public Health Collaborative. The collaborative will issue their own vaccine recommendations and coordinate public health efforts.
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Alex Eve
6 days ago
I'm attending too! Please feel welcome to speak to me about your research and how the journal can better serve you. I'm taking part in the 'Ethics and Publishing' session on Thursday 25 September and I'm also bringing some
@dev-journal.bsky.social
goodies, including some of our popular posters.
add a skeleton here at some point
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Siegenthaler Lab
J. David Jentsch 🏳️🌈
6 days ago
New position: Research assistant in the Manzano Lab at Binghamton... early life development, reward seeking and inhibition and single neuron imaging in behaving mice... please repost!
binghamton.interviewexchange.com/jobofferdeta...
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https://binghamton.interviewexchange.com/jobofferdetails.jsp;jsessionid=785BBE16F0B1086B7D655F22599AD089?JOBID=192913
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Siegenthaler Lab
Ben Saunders
6 days ago
For those interested in a neuroscience PhD - the University of Minnesota Graduate Program in Neuroscience
www.neuroscience.umn.edu
is hosting virtual open house events coming up on Oct 6th and Oct 30th. Learn about the program and meet students and faculty! Register here:
forms.gle/kANEp4Fmd3ut...
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Siegenthaler Lab
6 days ago
George, our very first postdoc (super brave!), has been central to so many projects. Had a hugely risky project that paved the way for his regeneration work. Proud to share it here again
#PostdocAppreciationWeek
🐸 vs 🐭 👇 🔗
www.biorxiv.org/content/10.1...
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Children’s Hospital Colorado Research and Innovation
6 days ago
For
#ChildhoodCancerAwarenessMonth
, we're highlighting Dr. Adam Green's research on pediatric high-grade gliomas. Read how his research is bringing hope for new treatments.
#OncSky
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Grant for Pediatric Radiation-Induced Glioma Research
See how research could change the lives of kids with cancer.
https://www.childrenscolorado.org/advances-answers/recent-articles/glioma-research-grant/?slid=peds_ccbd_slr&utm_source=bluesky_hcp&utm_medium=social&utm_campaign=pediatriccancerawareness
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The Conversation U.S.
6 days ago
Kids who see themselves as “STEM people” are far more likely to pursue STEM careers, and new research shows caregivers play a key role in shaping that identity (or not).
buff.ly/TnWJFQP
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Identifying as a ‘STEM person’ makes you more likely to pursue a STEM job – and caregivers may unknowingly shape kids’ self-identity
STEM jobs – ranging from software engineer to physicist, to plumber – tend to be well paid. And women tend to be underrepresented in these fields. New research suggests one reason starts in kids’…
https://theconversation.com/identifying-as-a-stem-person-makes-you-more-likely-to-pursue-a-stem-job-and-caregivers-may-unknowingly-shape-kids-self-identity-254771
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Siegenthaler Lab
Guillermina Ramirez-SanJuan
6 days ago
Looks like I am late to this party but have exciting news. I’ve been awarded an ERC Starting Grant to study
#XtrmCells
! Thankful to @erc.europa.eus for this opportunity, and to my collaborators, mentors, and group for their support. Looking forward to exploring the mechanics of these cells!
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Siegenthaler Lab
Sarah Cohen
7 days ago
Wonderful to see our paper on the
#organelle
signatures of
#neurons
and
#astrocytes
out in final form - congratulations, Shannon Rhoads and team!🎉
t.co/BPxKlbU6Ou
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George Campbell
6 days ago
After seeing
@miguelcmestre.bsky.social
@lancasterlab.bsky.social
@jamesdmanton.bsky.social
's paper this week on deep and accessible ExM imaging with cerebral organoids, I think it's a good time to repost this Starter Pack of Expansion Microscopy people!
go.bsky.app/Qxks9WD
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UC Davis Center for Neuroscience
6 days ago
Celebrating
#PostdocAppreciationWeek2025
🎉Meet Amanda Iglesias, Ph.D., postdoc in the Fioravante Lab at CNS. She investigates the neural circuits underlying motivated behavior and reward-related psychopathologies. Learn more about research in the Fioravante Lab:
www.fioravantelab.ucdavis.edu
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Siegenthaler Lab
Zohran Kwame Mamdani
7 days ago
Before he was a Senator, a candidate for President, and our greatest champion in the fight against oligarchy, Bernie Sanders was the four-term Mayor of Burlington, VT. I sat down with Bernie in Astoria to talk about the lessons he learned—and the work ahead.
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Madhu Pai, MD, PhD
6 days ago
Peter Salama Refugee MPH Scholarship
@johnshopkinssph.bsky.social
hopkinshumanitarianhealth.org/sites/defaul...
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Siegenthaler Lab
Developmental Biology
6 days ago
CALL FOR PAPERS! 🧪 DB Special Issue highlights new insights into receptor tyrosine kinase signaling during development, with a focus on cell-cell interactions & signal transduction in the regulation of cell growth and division, differentiation & morphogenesis. Submit here:
tinyurl.com/RTKDevBio
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Kevin Reuning
6 days ago
The
@aaup.org
just shared guidance for academic workers on how to protect themselves online
www.aaup.org/news/advisor...
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Advisory to Academic Workers
In a moment when it is becoming increasingly difficult to predict the consequences of our online speech and choices, the AAUP and Faculty First Responders are issuing guidance to AAUP members and othe...
https://www.aaup.org/news/advisory-academic-workers?link_id=1&can_id=7004b559d3312e58df82fde0aa963b6f&source=email-advisory-to-academic-workers&email_referrer=email_2893062&email_subject=advisory-to-academic-workers&&
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Vinny Costa
6 days ago
A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (
www.science.org/doi/10.1126/...
). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions. Lots of updates from the preprint!
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Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.
https://www.science.org/doi/10.1126/sciadv.adw1029
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