Super cool talk today by @jrossibarra.bsky.social! #PEQG26 Learning a lot about ARGs 😬

Re-upping this! Come find me at #PEQG26 to learn more about this postdoc/sci-programmer opportunity in my lab.

I know Calvin’s dad is already having a moment, but every terrible “outsource precious and fleeting moments with your children to tech so that you can spend more time on your work” pitch makes me think of that one strip I never really cared about as a kid, but care a lot about as an adult.

An inevitable development for for-profit Open Access publishers is Fordism: automation & massification. If you earn money piece-rate for each paper you want to increase the flow of papers while minimizing cost. e.g. very low and *uniform* turnaround times at Frontiers and MDPI

1/ New paper with Elizabeth Borden, Karen Hastings, and Ryan Gutenkunst on immunoediting in human tumors. Ryan and I built the modeling side, so that's what I'll focus on here.

This year’s Genomic History Inference Strategies Tournament includes challenges in inferring relatedness. ghist.bio. If you haven’t worked in this problem before, here’s a great resource to help you get started.

Genetic Estimates of Relatedness: Established Practices and New Opportunities Through Low Coverage Whole-Genome Sequencing onlinelibrary.wiley.com/doi/10.1111/...

Enjoyed leading a workshop on the Genomic History Inference Strategies Tournament at #PEQG26. The 2026 competition is live at ghist.bio. Start your inferences!

So good to be at #PEQG26 ! * Congrats to PhD student @siyuan-feng.bsky.social on giving 2 talks (DNA->music and evol. multi-omics) within ~16 hours! * Look for posters by Jamie Freeman and Myron Child. * Searching for a postdoc! Glad to talk here at PEQG, online, or later this month at #SMBE2026

#PEQG26 such a wonderful meeting at Asilomar. Fantastic science, beautiful views, adorable wildlife, great friends! 🫶

Just saw David Tian give a great talk about this work at #PEQG26!

Long-term small effective population size, inbreeding, and a recessive lethal haplotype drive premature death in the endangered Devils Hole pupfish (Cyprinodon diabolis) https://www.biorxiv.org/content/10.64898/2026.06.06.730634v1

Mentioning Teller-Ulam nuclear weapons design parenthetically in all future grant proposals and manuscripts to ensure that I get a human review.

Wooo-hooo!!! Stoked to be at #PEQG26

#PEQG26 is ready for you! We can't wait to get started creating connections, building networks, and of course, sharing research. 🧬 📲 Download the Conference App to navigate the conference, plan your schedule, and chat with fellow attendees! Let us know, are you already at Asilomar?⬇️

Some heroes don't wear capes

obsessed with thomas. happy pride 🪿🌈✨

#PEQG26 folks! I will be presenting my postdoc project with @jkpritch.bsky.social and @jeffspence.github.io about inferring population structure dynamics over time with tensor decomposition on ARG. The talk will be at the James Crow Talk session on Wednesday. Look forward to seeing everyone there!

Now published: journals.plos.org/plosbiology/...

NIH T32 proposal with @joannamasel.bsky.social and @wheelerlab.org to renew the Computational and Mathematical Modeling in Biological Systems program for PhD students is funded, starting July 1! I look forward to supporting the next generation of quantitative biology researchers! cmmbs.arizona.edu

We are actively searching for a postdoc to join the lab! Details provided here - johrilab.org/join Please share. I will be at PEQG and will be happy to chat if you're interested!

The actual challenge in slide preparation is how to structure the story and what evidence to use to support it. AI cannot help with either. We're failing students by not teaching what matters in slide preparation.

Circling back around to this post in light of what happened at the ADA Annual Meeting yesterday. The actions of Kahn, et al., had all the elements of Good Trouble. - The action, itself, was harmless but agitating - They used their position to legitimize the action - They recorded everything

Our new paper doi.org/10.1098/rspb... on long-term genetic threats to small populations finds that "mutational meltdown" (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass.bsky.social @uliseshmc.bsky.social @jeremyjberg.bsky.social 1/5

If the goal was to not let them share reprints of an editorial, maybe having the police escort them out was not the best choice 😭😭 @altmetric.com www.altmetric.com/details/1954...

Happy Tuesday! Who's ready to hear about 1. Flesh-eating maggots (mostly go after cattle) 2. They're native to the US 3. The USDA has kept them out of the US since the 1960s 4. But the flesh-eating maggots are making a 21st century comeback. And believe it or not it may be thanks to MAGA.

Headed to #PEQG26 next week? The Sethuraman Lab will be presenting a buncha recent work! Come find us at both poster sessions, and DM/message me if you'd like to chat about the open postdoc position in my lab.

There are few researchers for whom an entire field is so clearly distinct before and after their work. The gap between evolutionary biology "before Joe" and "after Joe" is just awesome. It is a measurably different enterprise, and the reach of his influence doesn't end at the phylogeny. Hats off!

Karolinska Institutet KI is inviting applications for 21 Assistant Professor positions in medicine and health @ki.se ki.se/en/about-ki/...

1. How common is LLM use in scientific publishing, and how does it vary across field, publisher, journal prestige, author demographics etc.? @kylesiler.bsky.social has new paper in PNAS that addresses this question on a massive scale: 7.3 million papers from Elsevier, PLOS, MDPI, and Frontiers.

New from @gvbarroso.bsky.social in our lab: quantifying the relative importance of mutation rate variation and background selection to levels of diversity along the human genome.

Eep. It's official. I'll be stepping into a new role as Chair of the Department of Biology @sandiegostate.bsky.social this Fall. Exciting times for our Department and SDSU - as a newly minted R1, a swanky new life sciences building, enrollment growing ~25% at SDSU, several new hires in our Dept!

Sweeping draft regulations released by OMB pose one of the most significant threats to federally funded research in decades. The proposal would affect nearly every aspect of the scientific process. Read more: https://www.ascb.org/science-policy/federal-research-regulations-threat-american-science/

Ancestral Genomes xkcd.com/3252/

Check out our new paper presenting pg-gpu, a GPU-accelerated population genetics python package: www.biorxiv.org/content/10.6... 1/3

The 2026 Genomic History Inference Strategies Tournament is live! ghist.bio Today was the kickoff tutorial at the Modeling and Theory in Population Biology workshop at @icerm.bsky.social . Looking forward to summer workshops at PEQG @genetics-gsa.bsky.social and at SMBE @official-smbe.bsky.social .

Andy Kern, who doesn't (really) have an account here, would like to share his group's new tool for speeding up pop gen summary stat calculations using GPUs. Check it out here: www.biorxiv.org/content/10.6... And see his thread over at the other place: x.com/pastramimach...

Accounting for recurrent mutation in the frequency spectrum of rare alleles https://www.biorxiv.org/content/10.64898/2026.05.29.728884v1

GPU accelerated population genetics statistics using pg_gpu https://www.biorxiv.org/content/10.64898/2026.05.29.728868v1

postdoc alert 🚨! NIH-funded postdoc in my lab to work on Ancestral Recombination Graphs in space. Please spread the word widely in your networks, and please reach out if you're interested! (2-3yr position, start date flexible, pay/benefits good!). details here: careers.umich.edu/job_detail/2...

I’m looking to hire one or two postdocs - possible projects include pop gen theory, methods development, and human evolutionary inference. Please share, and email if you are interested. More info: evoldir.net/brian/evoldi...

This is what Trump's done to the people's house: A third of it is rubble. Another third is a cage match. What a metaphor.

Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule. Russell Vought is going destroy American Science. elizabethginexi.substack.com/p/summary-of...

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

✨ 𝗠𝗲𝗲𝘁 𝘁𝗵𝗲 𝗦𝗠𝗕𝗘 𝗜𝗗𝗘𝗔 𝗧𝗮𝘀𝗸 𝗙𝗼𝗿𝗰𝗲! ✨ 👤 Name: Wei-Chin Ho, he/him 🌎 From: Taiwan 🇹🇼 📋 Role: Co-chair of the IDEA task force 👔 Occupation: Assistant Professor 🏛️ Institution: University of Texas at Tyler 🇺🇸 🔬 Research: Microbial Evolution @official-smbe.bsky.social

NIH Definition of Foreign components. grants.nih.gov/grants/guide...

Postdoctoral job announcement: come to Cambridge and work on population genetic modelling with environmental and ancient DNA, jointly with @gamzeandgursoy.bsky.social and me. Details at www.jobs.cam.ac.uk/job/55580/ - applications by June 16th.

The National Science Foundation is terminating and suspending grants again, and at Grant Witness we need you to help to track them! 🧪 We can only identify research being suppressed by under-the-radar suspensions directly from researchers. Please report! grant-witness.us/posts/2026-0... #NSF

Just when you thought you'd seen it all

Proteins are the machinery of life. Billions of their sequences have been cataloged—but the biology behind most is still unknown. Today we're releasing ESMFold2, ESMC and ESM Atlas to help change that. Open source, open to every scientist. biohub.ai/esm/protein