Parul Johri
@johriparul.bsky.social
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Population geneticist Assistant Professor at UNC, Chapel Hill
reposted by
Parul Johri
Jeffrey Ross-Ibarra
20 days ago
PEQG! My favorite conference ever*. Single session, fantastic talks, great discussions. Only once every 2 years. And in the best conference location too! Abstract deadline coming up Feb 5! *Disclosure: I am required to say it's the best conference because it is and I told my mom I wouldn't lie.
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Homepage - 2026 Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
https://genetics-gsa.org/peqg-2026/
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Parul Johri
Yun Deng
3 months ago
The last work of my PhD is finally out:
www.pnas.org/doi/10.1073/...
! This work is about accurately estimating branch length in the Ancestral Recombination Graph (ARG), which is achieved by a really simple framework with minimal assumptions. (1/n)
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2504461122
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Parul Johri
Society for Molecular Biology and Evolution
about 1 month ago
The SMBE Graduate Student Excellence Award honors the best presentation at the Graduate Student Excellence symposium, which provides a forum for young investigators to showcase their exemplary research at the annual meeting. 📨 Award applications
smbe2026.org/abstracts
#SMBE2026
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We (with Fanny Pouyet and Brian Charlesworth) provide a theoretical perspective on rescaling forward simulations in population genetics, along with some guidelines:
arxiv.org/abs/2601.05367
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The rights and wrongs of rescaling in population genetics simulations
Computer simulations of complex population genetic models are an essential tool for making sense of the large-scale datasets of multiple genome sequences from a single species that are becoming increa...
https://arxiv.org/abs/2601.05367
about 1 month ago
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reposted by
Parul Johri
Dr. Arun Sethuraman
about 1 month ago
I wrote a short op-ed in
@genetics-gsa.bsky.social
G3 this month’s issue on missing data problems in population genomics that I’ve been thinking about for a couple of years. Lemme know your thoughts! Comments/suggestions/ideas welcome!
doi.org/10.1093/g3jo...
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The missing data problem in population genomics and statistical methods to address them
The “Missing Data” problem is prevalent across all statistical inference, owing to the “absence of some part of a familiar data structure” (Efron 1994). Po
https://doi.org/10.1093/g3journal/jkaf269
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We wrote a perspective piece about important considerations when building an evolutionary baseline model for population genomic inference in the deadliest malaria parasite- Plasmodium falciparum.
www.biorxiv.org/content/10.6...
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Towards an evolutionary baseline model of Plasmodium falciparum for population-genomic inference
Malaria has caused over 15.7 million deaths in the 21st century and was responsible for ∼600 thousand deaths globally in 2023 alone. Although many effective antimalarial drugs have been developed and ...
https://www.biorxiv.org/content/10.64898/2025.12.20.695730v1.abstract
about 1 month ago
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reposted by
Parul Johri
Gina Baucom
about 2 months ago
A final new paper out from the lab, work from Steve Johnson,
@joannarifkin.bsky.social
&
@stepheniwright.bsky.social
We asked what maintains the striking variation in floral color, size, and shape within and among populations of Dame's Rocket, Hesperis matronalis
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Color, size, shape: The drivers of floral variation in Hesperis matronalis (Dame’s Rocket)
Evolutionary biologists have long been intrigued by the factors that sustain genetic and phenotypic variation within and among natural populations. Polymorphisms underlying components of floral displa...
https://www.biorxiv.org/content/10.1101/2025.10.16.682931v2
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reposted by
Parul Johri
Mark Peifer (He, him)
about 2 months ago
I'm on the Board of
@biologists.bsky.social
. Many know them as publishers of
@dev-journal.bsky.social
,
@jcellsci.bsky.social
,
@jexpbiol.bsky.social
, DMM, and
@biologyopen.bsky.social
--but they also are a major funder of small grants that empower young biologists and enable scientific meetings 🧪
add a skeleton here at some point
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Parul Johri
Molly Przeworski
about 2 months ago
Happy to highlight an essay I wrote together with
@marcdemanuel.bsky.social
,
@natanaels.bsky.social
and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species:
www.biorxiv.org/content/10.6...
1/n
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What sets the mutation rate of a cell type in an animal species?
Germline mutation rates per generation are strikingly similar across animals, despite vast differences in life histories. Analogously, in at least one somatic cell type, mutation rates at the end of l...
https://www.biorxiv.org/content/10.64898/2025.12.19.695482v1
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Now accepted in Genetics!
academic.oup.com/genetics/adv...
We ask why and when rescaling of forward simulations in population genetics is not accurate. There are some interesting results for people performing simulations with selection.
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Effects of rescaling forward-in-time population genetic simulations
Abstract. Forward-in-time population genetic simulations enable modelling of a wide array of complex evolutionary scenarios. Simulating small genomic regio
https://academic.oup.com/genetics/advance-article/doi/10.1093/genetics/iyaf263/8381340
about 2 months ago
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reposted by
Parul Johri
Genetics Society of America
about 2 months ago
The December episode of Genetics in Your World is now live!🎙️ ECS Multimedia Subcommittee member Debraj Manna interviewed Dr. Matthew Rockman (
@wormsrock.bsky.social
) of New York University about inbreeding depression in C. elegans. Listen now:
buff.ly/7DVBt56
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Parul Johri
Molecular Biology and Evolution
4 months ago
@lntran.bsky.social
@castellanoed.bsky.social
@ryangutenkunst.bsky.social
introduce a systematic permutation approach for interpreting haplotype matrix-based methods in population genomics. 🔗
doi.org/10.1093/molbev/msaf250
#evobio
#molbio
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Interpreting Supervised Machine Learning Inferences in Population Genomics Using Haplotype Matrix Permutations
Abstract. Supervised machine learning methods, such as convolutional neural networks (CNNs), that use haplotype matrices as input data have become powerful
https://doi.org/10.1093/molbev/msaf250
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The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
4 months ago
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Our latest preprint about the effects of rescaling forward-in-time simulations in population genetics -
www.biorxiv.org/content/10.1...
9 months ago
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reposted by
Parul Johri
Austin Daigle
11 months ago
Excited to share my first PhD project with my mentor,
@johriparul.bsky.social
! We examine how Hill–Robertson interference (HRI) in highly selfing species biases estimates of the distribution of fitness effects of new mutations (DFE).
doi.org/10.1093/evol...
@journal-evo.bsky.social
#popgen
#evobio
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reposted by
Parul Johri
David Castellano
about 1 year ago
Short thread on my updated work with
@gutengroup.mcb.arizona.edu
"Detection of Domestication Signals through the Analysis of the Full Distribution of Fitness Effects", latest version at:
www.biorxiv.org/content/10.1...
Here we simulate a kind of canonical and idealised domestication process.
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Detection of Domestication Signals through the Analysis of the Full Distribution of Fitness Effects
Domestication is a process marked by complex interactions between demographic changes and selective pressures, which together shape genetic diversity. While the phenotypic outcomes of domestication ar...
https://www.biorxiv.org/content/10.1101/2022.08.24.505198v4
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reposted by
Parul Johri
Mike Barker
about 1 year ago
Come join us in Tucson!! I am excited to announce a tenure track faculty position on the genomics of resilience
@uofa-eeb.bsky.social
! Read more about the position in the updated link below! We will begin reviewing applications on December 9!
arizona.csod.com/ux/ats/caree...
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Parul Johri
Society for the Study of Evolution
about 1 year ago
Nominations due soon for the 2025 Dobzhansky Prize! This award recognizes the accomplishments and future promise of an outstanding early-career evolutionary biologist. Submit your nomination now!
https://buff.ly/4fNJk9k
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