Popgen folks, Jiseon, Nate, and Andy, along with Yuxin Ning and Franz Baumdicker, just released a really cool new method for simulation based inference (think ABC) using normalizing flows. It seems to work really well! full joint posteriors ftw! www.biorxiv.org/content/10.6...

This is concerning. NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES). 1/2

Good news. Faculty expressing their concerns seems to be having effects. If you are in academia, make sure your administration knows your views on the compact.

Wait till the Van Buren boys hear about this...

A summary of training, fellowship, and career development awards Fiscal year 2025 (compared to fiscal year 2024) 1/12

For more information about the Friday night massacre at CDC, I wrote up an analysis of who got terminated and what that means for public health. Grateful to @saveamericamvmt.bsky.social for supporting and amplifying. We are in really terrible trouble. rasmussenretorts.substack.com/p/the-death-...

When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety Who knows what will happen now Just in case, remember Euruope-PMC (europepmc.org )

ADD YOUR THOUGHTS ON LIMITING STUDENT VISA TO FOUR YEARS Comment period ends September 29th www.federalregister.gov/documents/20... 1/2

Interesting news about grants to prevent mass violence being canceled in MN and elsewhere. "Not all ...have been canceled. Asked about two grants awarded to the sheriff’s office in Palm Beach County, Florida – where Mar-a-Lago is located – a sheriff’s office spokesperson said the grants are active."

WARNING WARNING WARNING #ResearchAdmini I am hearing reports of NIH Awards being issued with ~15% indirect cost rate without comment. I believe the hope is that they will be accepted with noticing this.

I have a first serious attempt to estimate the consequences of multi-year funding for July. For new R01s, the amount of additional expenditure was $135 M The number of additional R01s that could have been funded is 182 1/9

This is an important point about the NIH's new multi-year funding model that many PIs (even some senior ones) aren't aware of:

Hello bluesky community! I'm hiring a postdoc to do machine learning in population genetics. Starting to build up a lab at Indiana University Bloomington where I just started a faculty position. Apply with the below link: indiana.peopleadmin.com/postings/30325

New, from an anonymous NIH insider: Trump is being pushed to spend more NIH money. The White House is ordering NIH to do multi-year budgets for awards. This budget trick means fewer awards, fewer labs funded, and lower paylines for researchers. 🧵 donmoynihan.substack.com/p/alert-the-...

Anyone know if NIH T funding mechanisms are still comatose?

Excellent work out from postdoc Remi Ketchum in @samurscicop.bsky.social's lab 👊🔥🦟

I heard it in the wind, and I saw it in the sky. I thought it was the end... www.youtube.com/watch?v=91rH...

Thank you to Natalie for being a voice for thousands of clinical trial patients who are not receiving the care they were promised. This is powerful. www.instagram.com/reel/DLflEqh...

I applied for this trial. This could EASILY have been me. Or someone else you know.

‘Dire implications’: Duke University president warns of ‘likely’ layoffs due to federal funding cuts www.wbtw.com/news/state-r...

Washington Post story about #BethesdaDeclaration www.washingtonpost.com/science/2025... 1/n

ATTENTION: I am working on a project and need some assistance. If anyone might have some time this weekend, particularly if you are in a red state, please DM me (and provide an email address and/or cell number) or reach me on Signal (jeremymberg.78). THANK YOU!

The preliminary program of ProbGen 2026, which will be held at UC Berkeley, is now up: probgen2026.github.io Sharing on behalf of Rasmus Nielsen who is not on this site. For more see his thread on that other site: x.com/ras_nielsen/...

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Every scientist should discuss the consequences of the NIH and NSF grant terminations and delays and failure to fund at their home institution at the end of a talk or seminar. Even if a scientist’s own funding is not threatened, I GUARANTEE there is someone at their institution affected.

New story up in Nature from @maxkozlov.bsky.social NIH killed grants on orders from Elon Musk’s DOGE Court documents and internal correspondence show the cost-cutting force has broad control over the world’s largest public biomedical funder. www.nature.com/articles/d41...

Who's calling the shots at NIH? Sworn testimonies and internal e-mails reveal for the first time the breadth of DOGE's control over the world's largest public biomedical funder. DOGE has provided lists of hundreds of grants to cut, and DOGE is now reviewing ALL NIH awards before they're released

Seeking an experienced tech or a postdoc stat!

The PopSim Consortium wants you! Please join us on zoom on May 27 at noon Eastern Time (1600 UTC) to tell us you would like to see in the next version of stdpopsim! DM me for meeting link, or just sign up for our email list: lists.uoregon.edu/mailman/list... (1/3)

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Bluetorial: Timing of getting grants out the door at NIH The pauses and low rate of releasing awards may be a problem in terms of getting the NIH appropriation spent by September 30, 2025

New research by @tylervkent.bsky.social @samurscicop.bsky.social & D. Matute analysed 131 genomes of the globally invasive Aedes aegypti, and found high genomic resilience despite historical eradication attempts for this globally invasive vector. 🔗 doi.org/10.1093/gbe/... #genome #mosquitoes

Crazy times, but I'll be advertising for a 2 year postdoc to work with me on new comp. methods to estimate evolutionary history soon - specifically to develop methods to handle missing data (e.g. ascertainment bias, allele dropout). Are you a comp. biologist graduating with a PhD soon? Reach out!

This looks like a very big deal. See thread below and consider commenting like your research program depends on it. (It just might.)

Per source, NIH has been instructed to hold off from issuing ALL awards to Harvard, Cornell, Columbia, Brown, and Northwestern (including med schools) Agency staff have also been instructed to not speak about this funding freeze to grantees and applicants

This is my Mom. The drug that saved her life was developed through NIH grants. That includes critical indirect costs for overhead and equipment. #HandsOffHigherEd #NIH #savescience

Check out @tylervkent.bsky.social's latest work, part of our ongoing collaboration with the Matute lab:

New article up in Barron's www.barrons.com/articles/nih... 1/3

Thousands of the best experts at FDA, NIH, and all across HHS are being terminated right now. These are the people who make sure the medications you and your children take are safe. These are the people who perform and oversee research on cancer, infant health, and so so so much more.

Does anyone have any inside info to suggest that this may change any time in the near future? Or is NIGMS effectively shut down? @jeremymberg.bsky.social, you happen to have any info on this?

New Guardian article about mRNA research www.theguardian.com/us-news/2025...

Excited to share my first PhD project with my mentor, @johriparul.bsky.social! We examine how Hill–Robertson interference (HRI) in highly selfing species biases estimates of the distribution of fitness effects of new mutations (DFE). doi.org/10.1093/evol... @journal-evo.bsky.social #popgen #evobio

Anyway, pseudo-overdominance is cool and we don't think about it a lot but maybe we should! Particularly if we also think about polyploids! Or perhaps even salmon or potatoes.

Every day I wake up to new horrors and my Id demands blood but I have written this paper on pseudo-overdominance in polyploids instead www.biorxiv.org/content/10.1...

The Schrider Lab has been trying to keep doing science amongst all of the nonsense, and we have put a couple of new preprints out over the last few weeks. Super-condensed thread (sharing these in order of appearance on biorxiv):

We are excited to share our new preprint describing the inclusion of selection models to stdpopsim, our community-maintained library with an extensive catalog of population genetic models. 1/n www.biorxiv.org/content/10.1...

stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...

The collaborative paper on adding selection to stdpopsim is out! Learn about how to easily simulate realistic population genomic data with background selection and sweeps, plus some benchmarking of methods for demographic history, DFE, and sweep inference. www.biorxiv.org/content/10.1...

Lungfish xkcd.com/3064