Now in Evolution: academic.oup.com/evolut/artic... This paper started when @3rdreviewer.bsky.social, Mike, and I had a lunch at which there was a lot of, "What do you mean when you say X?" Fun to spend time thinking about when terms get too muddy, and great work by Drew to pull it all together!

it's me, unnamed critter from bosch's triptych of the temptation of anthony!

I buy this argument and you all know I'm very critical about studies about the effect of using AI but this one makes a ton of sense. The design of total ease and agreeableness has always been bad for our rigorous thinking. It is bad when it comes from people too!

Why do complex traits differ in their genetic architecture? In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits. Thread: journals.plos.org/plosbiology/...

Arthropod Photo of the Week: October 22, 2025 Jagged ambush bug Phymata sp. Hemiptera: Reduviidae By Tom Astle (@tjalamont.bsky.social), Montana, USA #arthropodPOTW

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

very much enjoying this new greet death song about greeting death

Barren Planet (Part 1) - Sopranos: The Next Generation #startrek #sopranos #edit

I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA 10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)

"Common decency stigmatizes people that do not participate in it—removes them from voluntary association. We indeed have to live with one another, but terms and conditions apply." me on why Ezra Klein should be ashamed / why shame is Good Actually www.bostonreview.net/articles/how...

Friends: I'm recruiting at least one PhD student to join our lab in Atlanta in the Fall of 2026. Information about our research can be found at the link below. Please pass along to any students interested in the quantitative study of speciation, secondary contact, and the build-up of biodiversity!

This is truly an incredible breakthrough IMO. Really exemplifies what you get when deep domain expertise (popgen/evolution/disease genetics in this case) fuses with cleverly crafted ML. What u get r sleek, well thought out architectures that absolutely destroy the behemoths. Wow!! 1/

truly one of the most unintentionally funny things i've ever seen someone post online about themself

Oh goddamn hell yea they got the dome-a-dillo

Not technically what the post is discussing but using this opportunity to bring up the end credits song for Deep Blue Sea, a rap from the perspective of the mutant shark that goes incredibly hard youtu.be/6cYcdBVQ8NM?...

First pop gen paper from our lab! We find repeated evolutionary turn over of sex chromosomes in darters contributes to reproductive isolation. Turnover may be an escape hatch to resolve mitonuclear conflict & neo sex chromosomes evolved via a rare recessive mutation. www.biorxiv.org/content/10.1...

Just catching up – good grief. This man is unfit for office, as he has been since Cassidy voted to put him into it. Please call your congresspeople about this – this kind of nonsensical waffling on life and death matters, with no attention whatsoever to facts, will cause needless death & suffering.

New Preprint! This one led by Sam Gibbon, an outstanding undergrad I've worked with for the past year. We take a look at whether segregation patterns in tetraploids (disomic v polysomic) affects mut-sel dynamics. We found some surprising results, and some subtleties: www.biorxiv.org/content/10.1...

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

My very first post on here. I am stoked to share lab's latest paper led by @ethantolman.bsky.social. Ethan developed a highly scalable pipeline to differentiate between various gene flow models, including ghost introgression in phylogenomic datasets. Check it out! www.biorxiv.org/content/10.1...

Thank Zenithar it's Fredas

Excited to share our new preprint for the tskit_arg_visualizer Python package! ARGs can sometimes feel like a black box, so @yanwong.bsky.social and I have been developing a method to programmatically drawing these graphs. 🔗 arxiv.org/abs/2508.03958 1/6

My company is hiring a computational biologist! This role is the same position as mine, and will involve building genomic prediction models, some bioinformatics, and a lot of independent research on developing new methods to improve our crop development initiatives. www.linkedin.com/jobs/view/42...

NEW 🚨 The violence is the point. Elected Dems must call for widespread resignations (RFK, Bhattacharya, Prasad) in response to the CDC shooting. Public health must demand this of them, and the public must demand that of us. With @publichealthguy1.bsky.social in STAT: www.statnews.com/2025/08/15/c...

Application of a novel high-dimensional testing procedure under potentially strong correlation between genetic variants. academic.oup.com/genetics/adv...

Also if you're ever in the area, check out D's rod shop in Cliff, NM. The coolest fly shop I've been in, which was pretty much a tinkerer's basement where the owner is just thinking up unique rods/flys. Snagged this 11' 2-3 wt. that has a switch handle doubling it as a 5wt spey.

Also on the trip, managed to get the AZ rare and wild salmonid slam with Gila and Apache trout as well as arctic grayling. Very cool fish in some very unique places!

Banner morning before hitting the airport outta Tucson after a 10 day vacation in the deserts and sky islands of the southwest. A nice end that makes 8 species of Crotalus seen this trip.

when they close it all up, I do believe this will go down as the funniest video on the internet

this rules

this week's post is something I wrote in 2019 but has been offline for awhile, How To Live Like the World Is Ending. margaretkilljoy.substack.com/p/how-to-liv...

basking sharks Sarah-Kim Watchorn "Charle and I had the best day out there. just Ireland doing its thing. Finally showing you guys some footage that has been patiently waiting on my hard drive"

My talk from this year's probgen is finally out. Where do linear mixed models and random effects come from? They emerge from *mutations* on Ancestral Recombination Graphs.

i edited the Bill Gates scene in The Social Network so that it's the guy from Nathan For You

My first paper is finally out! 🥳 We explored how genes get lost in the process of rediploidization following polyploidization and found out that this loss primarly occurs through DNA deletion, rather than pseudogenization. #polyploidy @yvdp.bsky.social @zhen-li.bsky.social rdcu.be/evxBs

Just making this easier for everyone to find

Excellent work out from postdoc Remi Ketchum in @samurscicop.bsky.social's lab 👊🔥🦟

Tropical Storm Chantal Cleanup Hotline: (910) 218-1569 will connect you with volunteers from local relief organizations, community groups, and faith communities who may be able to assist with: muck out/trees/tarp/debris. All services are free, but service not guaranteed due to the overwhelming need.

An incredible film. It has so much going wrong in it, and it's beautiful.

Got lucky to sneak up on a couple of snapping turtles wrestling (mating?) while wading up the Eno last weekend. Hard to tell if it is mating, I would normally guess yes but seems a bit late for here. Either way the smaller one seems unconvinced.

not all heroes wear capes

Unfortunately timed Indycar promo reel to commercial:

Absolutely love this Behind the music clip

Super excited to release a huge evolution project on the works for many years: Evolution experiments synchronized across climates to understand rapid adaptation Preprint: doi.org/10.1101/2025... All data available: www.grene-net.org/data #MOILAB @ucberkeleyofficial.bsky.social @hhmi.org 🧵👇

Hwy 86 harvested gray and red fox gamechanger tied up to entice a smallie or two.

god bless the hardware store hotdog man