Introducing nail - a Rust implementation of profile HMM sequence alignment for proteins. Near-HMMER sensitivity, but a lot faster: www.biorxiv.org/content/10.1... github.com/TravisWheele...

dream postdoc | | | V

hetro-di-mers are released now.

“Eddy received a letter from the [NIH], informing him that his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," he recalls. Eddy says he has given up on any dream that his funding would be restored”

This is freakishly reminiscent of an image I got when trying to get various image generators to create a picture of a man using a hammer to pound a nail into a string. Are we sure that's a real photo of the Prince?

Saw this chart and had a thought so I ran some numbers… r=0.85

Slightly increase a band Understated Mouse Bonus answers: - They Could Well Be Giants - Death Limo for Cutie - Bismuth Zeppelin - The The The - enoh (rap artist ... but still in the spirit)

I'm a bit hung up on how to define "hyper-prolific authors who span MANY fields". - What is "hyper-prolific"? 400 papers? 1000? - What is a "field"? (e.g. are genomics and drug discovery different fields?) - What is MANY? - Should I ignore work by George Church? Eugene Koonin? Richard Durbin?

Might not be true ? en.mediamass.net/people/craig...

Might not be true ? en.mediamass.net/people/craig...

Even if he has to throw all 10,000 of those pitches without taking a long break? (Funny thing: you probably want him throwing at 60 or 70, so you can get lucky contact; if he starts lobbing it at 20mph, I don't think I could get it to the warning track)

Not to be missed

The RasgonLab is anticipating several postdoc openings to work on development & application of CRISPR in arthropods, dependent on final approval of funds and HR approval of positions. Candidates must already be physically located in the USA. H1B visa sponsorship is not possible. Email me for info

No need for a study: From the chapter of Earthly Husbandry "Cut the Sign in fallowed earth. Pour soured milk of the black ewe. Bury the offering whole. Cry thrice: Iä! Shub-Niggurath! Gof'nn hupadgh! The Goat shall quicken the soil — yet mark ye the seventh harvest, for then doth She remember."

EXCITING NEWS 🚨 - Are you interested in microbial community analysis? Join us in Cambridge, MA (July 20–24) for a week-long, hands-on bioBakery course on multi-omics and statistics. Hosted by the Huttenhower Lab & HCMPH. No prior experience needed. Link - huttenhower.sph.harvard.edu/biobakerycou...

🖥️ 🧬 ⚛️ 🔬 Two slots at compbioasia.net have opened up for US residents. Apply quickly! No expenses. 2-week compbio workshop in Singapore, June 14-27. Protein annotation, function, structural modeling, simulation. ~32 attendees. Lectures and hands-on tutorials w/ intensive instructor interaction.

🖥️ 🧬 ⚛️ 🔬 Two slots at compbioasia.net have opened up for US residents. Apply quickly! No expenses. 2-week compbio workshop in Singapore, June 14-27. Protein annotation, function, structural modeling, simulation. ~32 attendees. Lectures and hands-on tutorials w/ intensive instructor interaction.

Same. (my ride home is probably a little bit rockier than yours)

This is exactly right. It's just flooding the zone with unserious shit (with name squatting as a consequence). I'm sure Henriksson is a serious scientist, but this shotgun effort (14 repos with large commits in 24 hours, w/o mention of LLM involvement) isn't doing the world (or his rep) any favors.

I disagree that the README helps. The port is clearly* implemented entirely by claude (or similar), with no real human input ... but: - no mention of claude in comments/docs - vacuous commit messages - no real details about validation *(this is one of >20 concurrent rewrites just this week)

Looking into spaced repetition for learning new things and revisiting old topics - languages, specific math/physics/CS, etc. Anyone have favorite Web sites, apps, approaches, blog posts, tips/tricks to share? Thank you!

Product of a terrific collaboration with @sdeorowicz.bsky.social, Marek Kokot, and Amit Roy: doi.org/10.1093/bioi... MDCompress produces compressed trajectory files that are up to 37% smaller than in the widely-used XTC format. Nice software library interfaces for fast (de-)compression.

A good day to remember not to judge all members of a religion by the actions of a political leader affiliated with that religion. Equally true of US, Afghanistan, Israel, or others. The corollary is that criticism of the politician or country is not criticism of an entire religion or ethnicity.

📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.

Have you considered using Gemini? I've been told repeatedly that this is the search engine I should be using.

🖥️ 🧬 ⚛️ 🔬 2-week computational biology workshop in Singapore. No registration fee or expenses for US citizens. Protein annotation, function, structural modeling, and simulation. compbioasia.net Due to an error on the website, application deadline is extended to March 30, so apply quickly.

Biotics Pro, LLC

𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗮𝗻𝗱 𝗣𝗵𝗗 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗚𝗲𝗻𝗼𝗺𝗶𝗰𝘀 / 𝗔𝗹𝗴𝗼𝗿𝗶𝘁𝗵𝗺𝗶𝗰 𝗕𝗶𝗼𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗰𝘀 I am currently recruiting for both: 🔹 Postdoc position su.varbi.com/what:job/job... 🔹 PhD position su.varbi.com/en/what:job/... Please share with anyone who might be interested!

We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru... #TEsky

🖥️ 🧬 ⚛️ 🔬 Plz spread the word. 2-week computational biology workshop in Singapore. No registration fee or expenses for US citizens. Protein annotation, function, structural modeling, and simulation. ~35 attendees. Lectures and hands-on tutorials with intensive instructor interaction. compbioasia.net

New neuroscience job at Wilfrid Laurier University. You may not know the name, but science has been growing fast. It is also down the street from Canada's top tech university (Waterloo) and a world class physics institute (Perimeter). I feel happy and lucky to be here careers.wlu.ca/job/Waterloo...

The FM-index LF mapping is just an LSB radix sort step!

🖥️ 🧬 ⚛️ 🔬 Plz spread the word. 2-week computational biology workshop in Singapore. No registration fee. No expenses for US citizens. Protein annotation, function, structural modeling, and simulation. ~35 attendees. Lectures and hands-on tutorials with intensive instructor interaction. compbioasia.net

Please spread the word: We invite applications to a two-week Computational Biology workshop in Singapore, June 14-27. This NSF-funded workshop brings together 16-20 US grad students with international peers. Apply by March 21: compbioasia.net 🧵 Details below:

22-year-old me would have been all-in on this advice. Pretty sure I did it once or twice. 53-year-old me is like: "Could I pull it off? I think I could do it ... honey, should I try it?!"

One might say that your social media influence is saaging

Xfinity for the win!

Anyone who has ever had the joy of using Google tech support will know that ... ugh. So it's completely on-brand that, when I tried to submit a bug report today, this happened: (1) Push buttons to raise "Bug Report" window (2) Click "Bug Report" button (3) nothing ... (Support couldn't help)

For I was hungry, and you gave me food… whatever you did for one of the least of these brothers and sisters of mine, you did for me. - Some woke schmuck

Exciting symposium on AI and Biology at EMBO | EMBL in Heidelberg on 10-13 March 2026! Excellent lineup of invited speakers across various scales of biology! Deadline for abstract submission is coming up — Dec 2. 🔗 www.embl.org/about/info/c... #EESAIBio @EMBLEvents

A new release of RepeatMasker is available. This version fixes a bug introduced in 4.2.1 that impacted the handling of poly-A tails and the naming of LINE annotations. See repeatmasker.org for more release details.

I'm recruiting PhD students for the Barker Lab @uofa-eeb.bsky.social We study plant evolutionary genomics - polyploidy, hybridization & machine learning for genome evolution. Work with Selaginella, Xanthisma, Brassica & more. Funding available via CAMBIUM Fellowships. Reach out if interested! 🧬🌵🤖

Please pass along - Our CAMBIUM NSF NRT provides fellowships to support new PhD students at @uarizona.bsky.social To train & prepare a new generation of scientists to harness the revolution in biodiversity big data to adapt to & mitigate the impacts of climate change. cambium.arizona.edu 🧪🌐🌾

Important open model for predicting structures for proteins (and friends)

Don't miss this opportunity to co-run a research group with @ewanbirney.bsky.social ! Ewan's science speaks for itself, and the EBI is an exceptional place to do cutting edge computational genomics.

Dream postdoc - Rob's science is excellent (and he's pretty great, too)

Important work being done here. vvvvvvvvv vvvvv vv

RNA Structure beyond Canonical Base Pairs Guided by Evolution 🧪🧬 #AcademicSky #higherEd www.mcb.harvard.edu/department/n... @rivaselenarivas.bsky.social @rachellegaudet.bsky.social @cryptogenomicon.bsky.social @dulaclab.bsky.social @neurovenki.bsky.social @naoshigeuchida.bsky.social

TIL: 10^60 is far greater than 10^67