TIL: 10^60 is far greater than 10^67

TIL: 10^60 is far greater than 10^67

Math is hard

Look on the bright side. With AI's help, there's actually a chance you could run a 2:10:00 marathon, since you might actually be able to hold an 5:00/km (8:03/mile) pace. That's incredible news!

We're looking for a new lecturer, here at the Department of Biochemistry in Dunedin, New Zealand. "Applications are invited in all areas of biochemistry, molecular genetics, and bioinformatics." otago.taleo.net/careersectio...

I share this picture of a printed out genome every once in while. It just occurred to me: it's got to be cheaper to acquire a finished copy of your genome (high accuracy, phased, SV-resolved) than to print it as a collection of bound books. (back-of-envelope checks out - anyone done the math?)

I share this picture of a printed out genome every once in while. It just occurred to me: it's got to be cheaper to acquire a finished copy of your genome (high accuracy, phased, SV-resolved) than to print it as a collection of bound books. (back-of-envelope checks out - anyone done the math?)

It's strange to think how many times I've asked myself this very question

After some lengthy embargo period (like: 5 or 10 years). Cool. Next year. Abso-f-ing-lutely terrible. The scenario: I have an idea. Reviewer #3 torpedoes it. I need to wait months to submit again. Someone else scoops up the ideas and writes a similar proposal while I'm in the next cycle.

slightly diminishing a book: Kitty's Cradle

slightly diminishing a book: 1983

slightly diminishing a book: The Jogging Man

As well-stated as anything I've seen about the problem with "using AI to help me write"

Project in collaboration w/ @networksunknown.bsky.social. Goal: improve identity continuity in multi-animal tracking. Mix pose prediction from AI computer vision methods with classical Markov processes, add a dash of path pruning and a new UI for efficient error correction: diplomattrack.org

No more funny-looking than the top dog in my kitchen

NIH: After review, we note that you have a large unspent balance on your grant. Please explain immediately. me: well, uh, yeah, one reason we're not spending on that grant is because NIH terminated it in May along with all the rest of federal funding to Harvard, maybe you don't remember

A new maintenance release of RepeatMasker (4.2.1) is available. This version includes fixes for users having trouble importing Repbase into FamDB, and for several special-case issues reported by users. See the www.repeatmasker.org for more release details.

We're very happy to release our new database Metalog metalog.embl.de ! It offers manually curated and harmonised contextual data for 110k metagenomics samples across the globe, incl. precomputed taxonomic profiles, for interactive browsing and for download 🧵 1/7 #microsky

My company is hiring a computational biologist! This role is the same position as mine, and will involve building genomic prediction models, some bioinformatics, and a lot of independent research on developing new methods to improve our crop development initiatives. www.linkedin.com/jobs/view/42...

Deacon 0.9.0 can filter FASTA at well over 2Gbp/s on an AMD CPU from 2021. Compression is very limiting, but I suspect ~1Gbp/s is possible for fastq.gz with a modern CPU. Thanks @curiouscoding.nl for a monumental perf PR! Release 0.9.0 github.com/bede/deacon/... www.biorxiv.org/content/10.1...

EMBL is an amazing place to start a lab and bring new direction to your research program (ask me how I know) - come join us in Heidelberg !

Slightly diminish a band: ABAA

Slightly diminish a band: Thallium Zeppelin

precious little, I suspect.

Big update to Dfam viz. MAssive amount of work from Robert Hubley & team.

I'm co-running a conference session with a focus on predicting function for hard-to-label proteins. Anybody in my circle willing to volunteer to review one or two manuscripts? If yes, please DM me.

I'm co-running a conference session with a focus on predicting function for hard-to-label proteins. Anybody in my circle willing to volunteer to review one or two manuscripts? If yes, please DM me.

I talk a lot about Rust for building high-perf (& even non-perf critical) software, & scientific software in particular. I often discuss what's interesting to me, but wanted to offer the chance to those interested for me to answer their questions about Rust in science. Fire away with questions!🧬🖥️

Know an Evolutionary Genomicist looking for a faculty position? Join us in EEB @utknoxville.bsky.social Position is open for studying any organism, but personally I have some botany bias. 🌱 Apply before Sept 19 for full consideration. apply.interfolio.com/170735 Please share widely. Thanks!

My first first author manuscript has posted! I’m very excited to share SWIF-TE with yall. It is a fast, memory efficient tool to identify novel TE insertions from short-read data. 🧬 #TEworldwide #transposons

we asked a simple question: What does it take to learn the rules of RNA base pairing? using standard deep-learning technics, got a simple answer: don't need structures, nor alignments or many parameters only a few RNA sequences and 21 parameters; doi.org/10.1101/2025...

Watching @jonhoo.eu's vibe-coding stream exactly matches my personal experience using agentic AI for programming. That is, it's fine for things that are basiclly pattern matching, but fails quite badly (i.e. is slower than just doing it manually) for changes that require reasonable thought.

The new version is built on @wheelerlab.org's AvxWindowedFMindex and some other tricks we came up with, and is *so fast*.

We are creating new software to quantify genome mappability, a successor to Umap, our previous work described in the linked paper. What standard read lengths should we provide in BED/Wiggle format? Previous was 24/36/50/100 bp. academic.oup.com/nar/article/...

lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome github.com/lh3/longdust 🧬🖥️🧪

Interested in a tool that aligns millions of proteins in minutes with quality similar to or better than the state-of-the-art utilities? Please take a look at our FAMSA2 paper: www.biorxiv.org/content/10.1... and GH repo: github.com/refresh-bio/...

Really important points by @alexbateman1.bsky.social on the importance of curation, addressing some of the myths out there. Deeply resonates with the commentary Paul Thomas and I wrote last year www.nature.com/articles/s41...

it's longer than the drive from ANY house in Missoula to the Missoula airport.

A Representation Learning approach to virtual ligand-screening. Produces good enrichment for active ligands, and can scan billions of candidate small molecules in a few hours.. Simpatico: www.biorxiv.org/content/10.1...

Oh, I get it: their rides cost ... way mo ... than the other guys.

That is 54, 5-year NIH biomedical research grants. Or 270 years worth of biomedical research.

I am definitely NOT burning the candle at both ends

Hello bluesky world! Newbee here! I have a postdoc position immediately available in my lab. It will focus on identifying high-quality transposons in many genomes and finding their impacts in evolution and traits. Most works, including EDTA2 development and annotation of 400+ genomes, are done! 1/n

@googleworkspace.bsky.social : Is this ***yet another*** in an endless line of features that non-paying customers get to use, but I can't access because I have a paid workspace account? I'm running out of room to keep track of them all: blog.google/products/map...

👀 👀 👀

Very excited to share I’ll be starting my own group at University of Utah in the Department of Human Genetics in the new year! Reach out if you are interested! vollgerlab.com

🦠🧬Exciting news! BFVD predicted viral protein structures are now available in @InterProDB! For the first time, explore InterPro functional annotations directly on 3D structures of viral proteins not covered by AlphaFold DB. This bridges a critical gap in structural virology research.

Howard's: evolution of microbial genes, genomes and communities. Can be experimental or computational. If interested, contact Howard Ochman, [email protected] Homepage: web.biosci.utexas.edu/ochman/index...

An update on open postdoc positions, in my group and the adjacent group of Howard Ochman, here at UT-Austin. #SymbioSky Mine: insect-bacterial symbiosis with emphasis on intracellular endosymbionts and molecular mechanisms. web.biosci.utexas.edu/moran/contac...

mdrepo.org is still live and kicking, and still accepting new contributions.