I love artificial intelligence.

Everybody (Backstreet's Back) is a Halloween song, right?

Haven't read in depth yet, searched for doubly-ranked method, found it: strong starting point. Fits with the previous genetic literature on the topic. Looking forward to reading in depth.

low-background internet

Microsoft's AI knows that I really wanted to write "salaried position with with"

Aftershock?

Fyi the data is clear there is no link. jamanetwork.com/journals/jam...

Earthquake

With a large enough 'N', you don't need randomization. - Keith Rabois

So is @governor.ca.gov gonna sign SB79?

AirPods 3 noise cancelling is noticeably better than AirPods 2.

Deep learning

👀👀👀

If it weren't for the tweet, I would believe that the filing was fake.

Although this article is focused on linking heritability to AUROC, you can replace heritability with R² from a linear model and it still works: if certain assumptions are met, you can infer the AUROC based on model R² and the prevalence of the positive class. journals.plos.org/plosgenetics...

it’s cool that they invented gambling for writing code

Some people say that the real Torment Nexus has never been tried.

Purely a technical comment: the iPhone is the best product that money can buy, no matter how much money you have. But I would think that for background blur, you could actually spend money to build a better, personalized model that would have less clipping around the edges.

Recombination is so fast that selection can't act based on specific combinations of genotypes that may exhibit non-linear effects lol

Get me to God’s country.

Are the Apple Watch hypertension test characteristics peer reviewed and published? Or is the FDA gonna answer our patients’ questions directly when this gets suddenly turned on for tens of millions of people?

🚨🚨🚨 Finally out!!, Our study describing the development and deployment of a bespoke CRISPR–Cas9 base editor for palliation of a severe monogenic vasculopathy by genome editing is published today in Nature Biomedical Engineering 🧵 to follow Here is a free link: rdcu.be/eFAEz

Better than Ezra

Police drones over SoMa

Settings -> Content and media -> uncheck 'autoplay videos and GIFs'

This looks neat:

But how does this relate to human disease?? Through an awesome collaboration with the @anshulkundaje.bsky.social lab, we trained ChromBPNet models with scATACseq datasets for each cell type and vascular site, and predict human variant effect on a cell type/site basis @soumyakundu.bsky.social

The Holey Bible

M4 at max screen brightness is just enough brighter vs prior macbook generations that it's usable outdoors in sunlight.

Classic Sunset moment: dude in a jacked up truck brushed by my Waymo at high speed, prompting the Waymo to honk.

Microsoft 365 products "let the user log in no more than once every hour" challenge level: impossible

Just getting up to speed on the news of the day.

Get me to God’s country.

There’s a lot to recommend Madrid; however:

Yes!! JAMA Cardiology joins JAMA & other JAMA Network journals on Bluesky! Just in time for #ESCCongress @jamacardiology.com @jama.com @jamanetworkopen.com #MedSky

Life update: got to meet Rory Collins.

🎉 The wait is almost over! #ESCCongress kicks off tomorrow! Meet our amazing Social Media Ambassadors 🙌 Follow their journey, join the conversation, and catch the hottest updates & highlights straight from Madrid!💙

Hey I’m your friendly local critical care physician. I am a person who wants a COVID vaccine and can no longer access it. Please advise.

In my view, common state-of-the-art methods for protein structure representation cannot reasonably capture pockets, cavities, and surfaces—the very features that drive binding and function.

Me: Please, Microsoft, may I find a work email that I sent ~2 months ago? It's for an important administrative task that I have finally blocked off time to complete. Outlook [indignantly, and materialized somehow as Clippy]: We absolutely do not support that!

Imagine, if you will, a place in the dessert latent space that sits in between fudge, brownies, and oatmeal cookies.

It was the best of vibes. It was the worst of vibes.

Demerzel is now available to give medical lectures.

We already did this (Budapest Memorandum), and then we didn't follow through.

A real Bay Area crime: the Cinnabon in Daly City isn’t near the Daly City BART stop.

No taxation without representation.

Neat: unless I manually delete my Outlook cookies after login, I never progress past the @microsoft.com loading page.