There is someone out there who has listened to one song more times than anyone else has ever listened to any other song.

Is that lightning?! 😭

I can't wait to ask the radiologists about this

United Airlines has sent exactly 10 messages about my flight, many with mutually-conflicting information, and I would just like them to settle down and communicate with me once they have a plan.

We’re passing it on the right and we’re doing it more and more, folks.

Curling is too high stress for me.

Interesting paper using genomic language models to assist with discovery. But not immediately obvious from a statistical standpoint that this should do much beyond a standard GWAS (barring close-proximity epistasis)—or that the gene-level analysis (stage 3) would beat MAGMA (not compared).

RIP to MGH’s John D Goodson. He was the platonic ideal of a PCP and a shining example to those of us who trained there.

All of my banger Olympic tweets are currently in limbo while I seek out the express written consent of the International Olympic Committee.

Bad Bunny got a bunch of post-graduate educated people talking about the legal status of Puerto Rico and I think that is magnificent.

Is the NFL blaring fog horns or are those real fog horns because of all the fog that I see rolling in all around me?

Malinin!

About to turn on the air conditioning in San Francisco.

Cooking up one spaghetto

For both #RareDisease month and #MarfanSyndrome awareness month, I thought I'd share this article I wrote for the @ahajournals.bsky.social about being a patient-scientist working on developing genetic therapies for my condition and related conditions.

My ride to work this morning

Can we discuss how the "opera" in Tenet was very clearly an orchestral concert, not an opera?

Inside of you there are two wolves:

Publication in Circulation. #UCSFCardiology Drs. Javid Moslehi and Amir Munir generated a new preclinical model of Immune Checkpoint Inhibitor myocarditis and identified cardiac CXCR6+ T-cells as a key pathogenic mediator of the disease. www.ahajournals.org/doi/10.1161/...

Constitutional amendment to ban political fundraising text messages. Who is working on this?

Sunset from Twin Peaks today. Nice Super Bowl weather.

OK the nuclear helicopter thing flies incredibly low above the rooftops, TIL.

What just blew up

Earthquake?

Congrats to a great Californian.

Market Street. San Francisco, CA. January 30, 2026.

Some guy on Market Street just shouted "I'm walkin' here" and I had to check my GPS to make sure I was still in SF.

Say what you will about the 'no free lunch' theorem, but at least it implies lunch.

You may have abandoned the gold standard, but the gold standard hasn't abandoned you.

I actually don't need a text message every time there is a car accident in San Francisco.

AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

Will no one rid me of these turbulent political fundraising text messages?

Thee Empire Strikes Back

The Presumption of Irregularity

I'm sorry, "malding" is internet slang invented in the past decade???

Physical VIX delivery: who is making this?

As an Originalist, I'm reading up on what the Founders thought about Customs Enforcement.

San Francisco, CA

Opening up a polymarket for whether the 14th Amendment becomes a Bluesky trending topic before 2028.

polymarket shutdown probability now ~70%

He has kept among us, in times of peace, Standing Armies without the Consent of our legislatures.

The federal government extrajudicially executed a VA nurse.

FYI “Wilhoit’s Law” comes from comment #26 on this article if you want to see the original — March 22, 2018. crookedtimber.org/2018/03/21/l...

Is this Davos Device a teensy on a breadboard?

ethically sourced microplastics

What did they know? (Hackers, 1995)

Neither a wordcel nor a rotator be.

Artificial Intelligence Gore's Internet