Al Gore is a name with a really disturbing amount of foreshadowing if you believe he really invented the internet

In summary, we find that the user's ID is the strongest predictor of the outcome in the training set.

No ❤️

Ahh yes, 11:30pm, the classic time for people to be hammering the Anthropic servers

Some slides from a recent talk on missing heritability. www.dropbox.com/scl/fi/kvogj...

Huh!

Yeah I mean, you’ve gotta impeach for that.

Amazing fake Google scam call just now. "If you are not deceased, please press 1."

Kathy Hochul gave up on trying to convince NYS lawmakers to allow autonomous vehicles upstate, and now Waymo’s testing permit in NYC has expired. Mamdani says AV regulation must “center workers.” New York is where innovation goes to die. www.thecity.nyc/2026/04/06/w...

New ACC/ESC guidelines are out today for Masters Athletes, including helpful expert guidance about exercise for those with aortic dilation: www.jacc.org/doi/10.1016/...

Large facsimile

The thing I see most often immediately after signing into Microsoft Outlook: "You've been signed out"

About once a month I remember how Hue launched a v1 of their multicolored bulbs that couldn't properly display shades of green.

"𝘛𝘩𝘦𝘴𝘦 𝘢𝘤𝘤𝘶𝘴𝘢𝘵𝘪𝘰𝘯𝘴 𝘢𝘳𝘦 𝘯𝘰𝘵 𝘯𝘦𝘤𝘦𝘴𝘴𝘢𝘳𝘪𝘭𝘺 𝘯𝘦𝘸. 𝘉𝘶𝘵 𝘵𝘩𝘦 𝘢𝘴𝘴𝘰𝘤𝘪𝘢𝘵𝘪𝘰𝘯’𝘴 𝘱𝘳𝘰𝘱𝘰𝘴𝘦𝘥 𝘳𝘦𝘮𝘦𝘥𝘺 𝘪𝘴. 𝘐𝘵 𝘸𝘢𝘯𝘵𝘴 𝘵𝘩𝘦 𝘴𝘵𝘢𝘵𝘦 𝘋𝘦𝘱𝘢𝘳𝘵𝘮𝘦𝘯𝘵 𝘰𝘧 𝘏𝘰𝘶𝘴𝘪𝘯𝘨 𝘢𝘯𝘥 𝘊𝘰𝘮𝘮𝘶𝘯𝘪𝘵𝘺 𝘋𝘦𝘷𝘦𝘭𝘰𝘱𝘮𝘦𝘯𝘵 𝘵𝘰 𝘥𝘦𝘤𝘦𝘳𝘵𝘪𝘧𝘺 𝘵𝘩𝘦 𝘤𝘪𝘵𝘺’𝘴 “𝘩𝘰𝘶𝘴𝘪𝘯𝘨 𝘦𝘭𝘦𝘮𝘦𝘯𝘵”"

For decades, molecular biology and human genetics have been built around measurements of average gene expression. That was partly conceptual, but also technological: for a long time, the mean was the quantity we could measure most reliably. Our new preprint argues that this framework is incomplete.

Corporations misinterpreting the 2026 ACC/AHA dyslipidemia guidelines to directionally favor their own products in *my* inbox!? 🥴

Didn't have time to comment during the conference, but these are really interesting null results for a triglyceride-lowering therapy. www.ahajournals.org/doi/10.1161/...

Ask not for whom the April Fools; it Fools for thee.

Waymo, I’ve seen what you’ve done for others and I want [curbside access] for SFO.

We are destroying species' habitats, leading to a mass extinction event. This habitat destruction also reduces the genetic diversity _within_ species. Our latest work develops quantitative models to predict how much genetic diversity has been and _will be_ lost. 🧬🧪🧵 www.pnas.org/doi/10.1073/...

More acrocentric investigations, this one led by @arhie.bsky.social 🕵🏻‍♀️ “Biobank-scale genotyping of Robertsonian translocations reveals hidden structural variation on the human acrocentric chromosomes” 🧵[1/8] 📄 www.biorxiv.org/content/10.6...

I asked my AI (Claude Haiku) to provide the solution to the Riemann hypothesis (no errors) and its answer was bad. Why did it lie to me?

Dario Amodei implies the existence of Wario Odiodei

Learn Cursive.

Excited to share our new preprint on gnomAD v4! We present the full analysis of 730,947 exomes — new constraint metrics, improved LoF annotation (LOFTEE-2), LLM-based literature curation, and a unified framework for gene discovery and rare disease diagnosis. www.medrxiv.org/content/10.6...

New innovation: running validation after every minibatch.

Saw the BTS Waymo on Hayes Street this evening

SF military flyby suggests that baseball season is starting

Ed Milliband implies the existence of Ed Microband.

Asked the AI to make a fun slide about potential de-skilling from AI use. Need to specify more clearly what I mean by "fun".

Look up on MS Word, ye mighty, and despair

Waymo is a friend to cyclists.

Drivers love honking at Waymos at red lights with “no right on red” signals and pedestrians that are crossing right in front of them.

We shouldn’t be bombing schools or power plants.

Why discourse about it? Just code.

Book of “Why not”

Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...

Lee Pace is definitely in Invincible Season 4?

Want to lead next-wave breakthrough of cardiovascular genetics & epidemiology?🤠 Want to use computer vision to explore the population biobanks?👹 Do Not miss this fantastic Postdoc opportunity at Dr. Pirruccello's lab, UCSF🔥 (I want to be 10 or 20 years younger......🥺)

Physically delivered VIX, who is making this?

Hamoet

👇👇👇

Just created a new postdoctoral position at UCSF doing cardiovascular deep learning and common-variant genetics in my lab. Please take a look at the posting and send me an email if interested! postdocs.ucsf.edu/postdoctoral...

CAS9 from CRISPR Labs

>meeting to explain how to use a new tool for clinic >Ask if meeting is going to be helpful or browbeating for using it wrong. > they don’t understand > pull out diagram explaining what is helpful and what is browbeating > they laugh “it’s a good meeting sir” > go to meeting > it’s browbeating

Kinda bold to be tilting at windmills while oil goes parabolic.