If you find a cracked 10x engineer, are you supposed to take them to a hospital, or reassemble them kintsugi-style?

Whatever Apple did with unread message necromancy in iOS 26.1, I want them to roll it back.

3/10 – On average across traits, we estimate that ~23% of our estimated WGS-based heritability is due to rare variants (0.01%<frequency<1%). We also show that coding and non-coding genetic variants account for 21% and 79% of rare-variant WGS-based heritability, respectively.

Achievement unlocked: so overwhelmed by emails that I missed a manuscript proofs email.

PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown

Act of Claude: something you attempt disclaim liability for because it was entirely vibe coded.

📊 Research Summary from @jama.com: Adults with #AFib who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine. #AHA25 @ahascience.bsky.social ja.ma/47Nwy8q

Soumith Chintala stepping away from PyTorch

I like how Voalte blocks the entire screen when you have weak internet. Innovative.

DataRater can continuously+adaptively learn which examples will improve an ML model the most during training. Delighted to have worked on this with @luisazintgraf.bsky.social, @dancalian.bsky.social, @gregfar.bsky.social, Iurii Kemaev, et al. (see full list at the of Luisa's thread).

Thank you to @pelosi.house.gov for your legendary service to our district and Godspeed to @scottwiener.bsky.social

This IS a place of honor

Regression to the kind

Oh

Yes, @microsoft.com Outlook, you’re absolutely right: I just typed in my username and password and then invoked my 2FA because I wanted to be logged out!

For those of you keeping score at home: we were talking about 67 at the American College of Cardiology today. 67 is officially over.

A view on Covid vaccines--its decision time. jamanetwork.com/journals/jam...

I was on a plane with no wifi for 5 hours and we’re doing nukes now???

Someone needs to invent a cologne/perfume-meter that we can place right after the metal detector at the airport.

Why is Grok fact-checking Bundt cake?

This is the most fundamental question that people often fail to ask in papers that I read that involve a cluster analysis.

this is specifically a problem with the memory feature, which everyone should have anticipated was dangerous.

Who called it “A House of Dynamite” when “Zeno Dark Thirty” was right there?

A House of Dynamite (2025)

Zero dark thirty-one was no good.

New event at #AHA2025! GPM Symposium Model Systems: Preclinical to Phase I Bridge Nov 7 12:30-5:15 Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!

I've never said yes to an interview so quickly as when @ashleybelanger.bsky.social reached out to discuss a topic that – it will surprise no one to learn – I feel pretty strongly about.

Sausalito and San Francisco

LIVE SOON: Governor Newsom makes major announcement on lowering drug costs. YouTube: www.youtube.com/live/cvuytKe... Facebook: facebook.com/events/s/gov... Instagram: @CAgovernor X: @CAgovernor

Mute-uals: you both follow each other and both have each other muted.

The street that tees into my apartment has a 5mph speed limit. I can easily tell when a Waymo is going down the street because it’s not going 5x the speed limit.

Oh no

APOLLO

Today is the day that @governor.ca.gov will sign @scottwiener.bsky.social ‘s SB79.

One detail that I appreciate from the 3 Body Problem (TV show) is that the North American military guy has, like, an Australian accent.

Pronouncing 'Toronto' like 'Totoro'

Get over here, folks. We're cubemaxxing in the Castro.

Good morning

Do these 120 million patients understand that they’ve opted into whatever this is?

It's anti-Italian discrimination!

The implication of this article is that 0.005% of the US's annual CO2 emissions are from inhalers (25 million metric tons cumulatively over 10 years, vs 50 billion/year overall). Conclusive demonstration that the CO2 release from inhalers is totally inconsequential. jamanetwork.com/journals/jam...

Physician certification should not be an ordeal; it is in vast need of improvement. My @jaccjournals.bsky.social Journals Editor’s Page explores how we can modernize physician certification to be relevant, humane, and effective. 🔗 www.jacc.org/doi/10.1016/...

All workslop and no playslop makes Jack a dull boy.

Perfect weather for Hardly Strictly. Way more packed than last year. Great vibes.

i declared email bankruptcy a week ago and i have to declare email bankruptcy again today

Apple Intelligence preferentially prioritizes spam texts.