James Pirruccello ๐
@jamespirruccello.com
๐ค 2552
๐ฅ 2389
๐ 2218
AI slop (except one) enjoyer
Who will be the first to start reporting LDL in micrograms per deciliter?
1 day ago
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Sigh
1 day ago
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New Aella write-up just dropped and I trust bluesky to be normal about this
www.sfgate.com/sf-culture/a...
1 day ago
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Hypothesis: It's not great that TC MITS can buy "peptides" but not rosuvastatin 5mg OTC.
1 day ago
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reposted by
James Pirruccello ๐
Kate Klonick
2 days ago
Al Gore is a name with a really disturbing amount of foreshadowing if you believe he really invented the internet
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In summary, we find that the user's ID is the strongest predictor of the outcome in the training set.
2 days ago
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No โค๏ธ
2 days ago
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Ahh yes, 11:30pm, the classic time for people to be hammering the Anthropic servers
3 days ago
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reposted by
James Pirruccello ๐
Sasha Gusev
4 days ago
Some slides from a recent talk on missing heritability.
www.dropbox.com/scl/fi/kvogj...
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Huh!
3 days ago
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3 days ago
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Yeah I mean, youโve gotta impeach for that.
3 days ago
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Amazing fake Google scam call just now. "If you are not deceased, please press 1."
4 days ago
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reposted by
James Pirruccello ๐
Stephen Jacob Smith
4 days ago
Kathy Hochul gave up on trying to convince NYS lawmakers to allow autonomous vehicles upstate, and now Waymoโs testing permit in NYC has expired. Mamdani says AV regulation must โcenter workers.โ New York is where innovation goes to die.
www.thecity.nyc/2026/04/06/w...
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Waymoโs Robot Car Testing Ends in NYC After Permits Expire
The companyโs eight autonomous vehicles had been driving in the city since last summer.
https://www.thecity.nyc/2026/04/06/waymo-driverless-cars-testing-roads-autonomous-vehicle/
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New ACC/ESC guidelines are out today for Masters Athletes, including helpful expert guidance about exercise for those with aortic dilation:
www.jacc.org/doi/10.1016/...
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Masters Athletes With Abnormal Cardiovascular Findings: A Clinical Consensus Statement of the European Association of Preventive Cardiology of the ESC and the American College of Cardiology
Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.
https://www.jacc.org/doi/10.1016/j.jacc.2026.03.025
4 days ago
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Large facsimile
5 days ago
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The thing I see most often immediately after signing into Microsoft Outlook: "You've been signed out"
5 days ago
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About once a month I remember how Hue launched a v1 of their multicolored bulbs that couldn't properly display shades of green.
6 days ago
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"๐๐ฉ๐ฆ๐ด๐ฆ ๐ข๐ค๐ค๐ถ๐ด๐ข๐ต๐ช๐ฐ๐ฏ๐ด ๐ข๐ณ๐ฆ ๐ฏ๐ฐ๐ต ๐ฏ๐ฆ๐ค๐ฆ๐ด๐ด๐ข๐ณ๐ช๐ญ๐บ ๐ฏ๐ฆ๐ธ. ๐๐ถ๐ต ๐ต๐ฉ๐ฆ ๐ข๐ด๐ด๐ฐ๐ค๐ช๐ข๐ต๐ช๐ฐ๐ฏโ๐ด ๐ฑ๐ณ๐ฐ๐ฑ๐ฐ๐ด๐ฆ๐ฅ ๐ณ๐ฆ๐ฎ๐ฆ๐ฅ๐บ ๐ช๐ด. ๐๐ต ๐ธ๐ข๐ฏ๐ต๐ด ๐ต๐ฉ๐ฆ ๐ด๐ต๐ข๐ต๐ฆ ๐๐ฆ๐ฑ๐ข๐ณ๐ต๐ฎ๐ฆ๐ฏ๐ต ๐ฐ๐ง ๐๐ฐ๐ถ๐ด๐ช๐ฏ๐จ ๐ข๐ฏ๐ฅ ๐๐ฐ๐ฎ๐ฎ๐ถ๐ฏ๐ช๐ต๐บ ๐๐ฆ๐ท๐ฆ๐ญ๐ฐ๐ฑ๐ฎ๐ฆ๐ฏ๐ต ๐ต๐ฐ ๐ฅ๐ฆ๐ค๐ฆ๐ณ๐ต๐ช๐ง๐บ ๐ต๐ฉ๐ฆ ๐ค๐ช๐ต๐บโ๐ด โ๐ฉ๐ฐ๐ถ๐ด๐ช๐ฏ๐จ ๐ฆ๐ญ๐ฆ๐ฎ๐ฆ๐ฏ๐ตโ"
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This S.F. neighborhood wants more market-rate housing amid homelessness
OPINION: SoMa and the Tenderloin have long served as de facto corridors for San Franciscoโs most pervasive social woes. Residents want economic development, columnist Emilyย Hoeven writes.
https://www.sfchronicle.com/opinion/article/tenderloin-soma-san-francisco-homeless-22160262.php
6 days ago
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reposted by
James Pirruccello ๐
Yoav Gilad
6 days ago
For decades, molecular biology and human genetics have been built around measurements of average gene expression. That was partly conceptual, but also technological: for a long time, the mean was the quantity we could measure most reliably. Our new preprint argues that this framework is incomplete.
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Corporations misinterpreting the 2026 ACC/AHA dyslipidemia guidelines to directionally favor their own products in *my* inbox!? ๐ฅด
7 days ago
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www.reddit.com/r/sanfrancis...
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Iamnotanorange's comment on "Car driving the wrong way in the Broadway Tunnel"
Explore this conversation and more from the sanfrancisco community
https://www.reddit.com/r/sanfrancisco/comments/1sao4am/comment/odx9w7q/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button
8 days ago
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Didn't have time to comment during the conference, but these are really interesting null results for a triglyceride-lowering therapy.
www.ahajournals.org/doi/10.1161/...
add a skeleton here at some point
9 days ago
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Ask not for whom the April Fools; it Fools for thee.
9 days ago
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Waymo, Iโve seen what youโve done for others and I want [curbside access] for SFO.
10 days ago
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reposted by
James Pirruccello ๐
Jeff Spence
11 days ago
We are destroying species' habitats, leading to a mass extinction event. This habitat destruction also reduces the genetic diversity _within_ species. Our latest work develops quantitative models to predict how much genetic diversity has been and _will be_ lost. ๐งฌ๐งช๐งต
www.pnas.org/doi/10.1073/...
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Large future genetic diversity losses are predicted from conservation indicators even with habitat protection | PNAS
Genetic diversity within species underpins evolutionary adaptation and has recently been included as a target for protection in the United Nations’...
https://www.pnas.org/doi/10.1073/pnas.2514371123
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reposted by
James Pirruccello ๐
Adam Phillippy
11 days ago
More acrocentric investigations, this one led by
@arhie.bsky.social
๐ต๐ปโโ๏ธ โBiobank-scale genotyping of Robertsonian translocations reveals hidden structural variation on the human acrocentric chromosomesโ ๐งต[1/8] ๐
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.03.08.710242
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www.acc.org/latest-in-ca...
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Essence-CTA: Does Olezarsen Reduce Noncalcified Coronary Plaque Volume? - American College of Cardiology
https://www.acc.org/latest-in-cardiology/articles/2026/03/25/21/27/mon-830am-essence-acc-2026
11 days ago
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I asked my AI (Claude Haiku) to provide the solution to the Riemann hypothesis (no errors) and its answer was bad. Why did it lie to me?
13 days ago
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Dario Amodei implies the existence of Wario Odiodei
15 days ago
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Learn Cursive.
add a skeleton here at some point
15 days ago
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reposted by
James Pirruccello ๐
Konrad
15 days ago
Excited to share our new preprint on gnomAD v4! We present the full analysis of 730,947 exomes โ new constraint metrics, improved LoF annotation (LOFTEE-2), LLM-based literature curation, and a unified framework for gene discovery and rare disease diagnosis.
www.medrxiv.org/content/10.6...
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Integrating 730,947 exome sequences with clinical literature improves gene discovery
Accurate estimates of allele frequencies aid in genetic discovery, including rare disease diagnosis, common disease investigations, and population genetics. Here, we present the Genome Aggregation Dat...
https://www.medrxiv.org/content/10.64898/2026.03.23.26349081v1
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New innovation: running validation after every minibatch.
15 days ago
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Saw the BTS Waymo on Hayes Street this evening
16 days ago
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SF military flyby suggests that baseball season is starting
16 days ago
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Ed Milliband implies the existence of Ed Microband.
16 days ago
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reposted by
James Pirruccello ๐
Sasha Gusev
18 days ago
Asked the AI to make a fun slide about potential de-skilling from AI use. Need to specify more clearly what I mean by "fun".
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Look up on MS Word, ye mighty, and despair
18 days ago
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Waymo is a friend to cyclists.
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19 days ago
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Drivers love honking at Waymos at red lights with โno right on redโ signals and pedestrians that are crossing right in front of them.
19 days ago
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We shouldnโt be bombing schools or power plants.
20 days ago
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reposted by
James Pirruccello ๐
Doll
20 days ago
Why discourse about it? Just code.
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20 days ago
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reposted by
James Pirruccello ๐
Julia M. Rohrer
20 days ago
Book of โWhy notโ
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reposted by
James Pirruccello ๐
Hiten Madhani
21 days ago
Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture.
youtube.com/watch?v=CDv7...
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Michael Bishop, Nobel Prize in Physiology or Medicine 1989: Official Lecture
YouTube video by Nobel Prize
https://youtube.com/watch?v=CDv77rmzKR4
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Lee Pace is definitely in Invincible Season 4?
21 days ago
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reposted by
James Pirruccello ๐
Hao Yin
21 days ago
Want to lead next-wave breakthrough of cardiovascular genetics & epidemiology?๐ค Want to use computer vision to explore the population biobanks?๐น Do Not miss this fantastic Postdoc opportunity at Dr. Pirruccello's lab, UCSF๐ฅ (I want to be 10 or 20 years younger......๐ฅบ)
add a skeleton here at some point
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Physically delivered VIX, who is making this?
21 days ago
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Hamoet
21 days ago
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reposted by
James Pirruccello ๐
Haobo Li, PhD
21 days ago
๐๐๐
add a skeleton here at some point
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