It gives me no pleasure to report that I watched the first episode of Pluribus and hated it.

some thoughts on all of this madness from earlier in the morning youtu.be/-yUi-0vNlDA

We need to be a country where, actually, we would protect the Constitution even if it cost us. Neither party seems to be willing to say that anymore. We're in a death spiral of political cynicism.

Man, I just find it so incredibly morally corrosive that both parties are centering affordability above all else. It has often been the case that American values led to economic prosperity, but we're seeing the effects right now of a prioritization that permits abandoning those values.

Dems, it's OK to go off message when the President is committing war crimes. Maybe even more than OK. Maybe statements like this make you sound completely disconnected from reality!

You should be embarrassed to be a member of congress and issuing anything other than impeachment resolutions. You're in the model UN. They should give you legos and a propeller hat

I've been watching a split screen of network news and an empty lectern on dingy carpet in front of a shabby curtain at Mar-a-Lago for the past 20 minutes.

It was only a matter of time before the press found a new use case for the exonerative tense.

Manifesting

Fascinating

This was probably meant to be a late-night post: I spent eight months working on a stunt blog about a $200 sandwich. Or, no, I did an end-of-year post about my mental health and the federal funding crisis. I'm not sure which. Maybe you can figure it out. www.carlsonlab.bio/thoughts/epi...

Bruising on the back of the hand is so common in older adults that John Mulaney used to have a joke about it in his touring set in 2024. It is not a smoking gun for a peripheral IV no matter how badly journalists want it to be.

I have questions about the plan described in the article for a bilateral phrenic nerve block.

Administrators reading this study like, "I'd like to buy your model."

I held myself back from correcting someone who was being an asshole because I did not want to engage with them so I just have to say in public here that just because an article is on PubMed Central does not mean it is the position of the NIH. Do they need to change this to bright red or something?

They don't sell novelty socks at bodegas, come on

As a physician and ethicist (and person rewatching season 1) it still really pisses me off that the climax of TLOU Part 1 makes no sense.

I was in the mood to knit so I picked up a second sock I've had in progress for, apparently, almost ten years.

Oh, this aged well

Great video by @anamariecox.bsky.social: www.youtube.com/watch?si=gYx...

If you're not on ballet YouTube you're missing out on some of the most hilariously hypercritical observations on the planet

If you can avoid starting a new job on 1/1 I strongly advise against it

Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her “60 Minutes” colleagues in full:

It said sweet on the package... it was the only sweet thing in my life.

The best time to watch HBO's Watchmen was when it premiered in 2019, the second best time is now.

Man, I just find it so incredibly morally corrosive that both parties are centering affordability above all else. It has often been the case that American values led to economic prosperity, but we're seeing the effects right now of a prioritization that permits abandoning those values.

The least surprised I've ever been was finding out that Kwame Anthony Appiah rendered a verdict that no one should feel bad about concierge medicine www.nytimes.com/2025/12/20/m...

Commercial LLMs integrated into health care applications remain highly vulnerable to prompt injection attacks, with a 94% success rate for generating unsafe or contraindicated medical recommendations in simulated dialogues. ja.ma/4amWHhj

Achievement unlocked: invited to review a paper I already reviewed for a different journal ✅

A poorly designed analysis can travel halfway around the world while people who understand competing risks are still putting on their shoes, or however that saying goes

I don't want to put them on blast in an identifiable way but there is a lab that is trying to get physicians to do several HOURS of expert labeling in exchange for a *checks notes* $25 gift card?

Ever since reading that article that made the rounds a few weeks ago about bad reading pedagogy I can't help but view everything happening in consumer tech through the lens of "for most people, reading is very effortful now."

everyone who uses an llm to code more than me is voluntarily deskilling themselves, everyone who uses it less than me might as well be hand-wiring together vacuum tubes

Observational research, broadly speaking, seeks to expand our knowledge of the the data-generating processes underlying reality. Research using synthetic data expands our knowledge of the process that generated the synthetic dataset. They are explicitly, trivially, and facially not the same thing.

Was reminded again of how good Anora is so mentally I am here www.youtube.com/watch?v=AU9N...

Tread softly, if you say it you agree with it

There's a researcher I'm on the verge of naming and shaming who is scraping medRxiv to generate the mailing list for their unsolicited human subjects research and I feel pretty strongly that we need as a community to agree that this is Not OK

Yeah I have a question can I have 20% of my screen back so I can RTFA

I'm not the arbiter of how people should live their lives but I do think that more people should consider keeping performance metrics on the training set in their desk drawer and not, say, in a manuscript or podium talk.

I don't think about CYA in practice that much but I do think a helpful heuristic is to imagine how your actions would look in a ProPublica investigation.

I see that all the R girlies (laudatory) are excited about %notin% so I have to ask, is there already a better/more idiomatic way to say !is.na()? Because that is by far my most used awkward criterion...

Feels like a good day to shout into the ether that when a service is free, you are the product.

The woman who is smiling beatifically in the background while RFK Jr and Sean Duffy advance this extraordinarily anti-woman agenda is none other than Isabelle Brown, an influencer who can also be seen in this screen capture (from her own TikTok account) enjoying a, in her words, "hilarious meme."

I had a lot to choose from so I went with the GIF you can hear.

I was listening to NPR just now and they said "Elon Musk's X has garnered sanctions from the EU" and my first thought was "What happened to Grimes???"

Watching my favorite movie about rheumatic heart disease

I don't use Spotify so I don't have a wrapped to post but I do have this 🌟✨ This year ✨🌟 😄📬 I received 😄📬 🎈🎉🎈🎉 15 🎈🎉🎈🎉 🌟✨Desk Rejects🌟✨ 🔥🔥🔥 and 🔥🔥🔥 🥂 🥳 One 🥂 🥳 💫 Reject post Revision 💫

They should do MyChart Wrapped

I'd love to understand how special Fitbits for women came to be an NHLBI strategic priority