Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage onlinelibrary.wiley.com/doi/full/10....

A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams. www.biorxiv.org/content/10.1...

The study shows how intestinal macrophages can modulate synucleinopathy along the gut-brain axis, strengthening the growing view that the gut plays an important role in the earliest stages of Parkinson’s disease. www.nature.com/articles/s41...

Where does Aβ come from in Alzheimer’s disease? 🔍 In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting. link.springer.com/article/10.1...

Mammals regrowing their brain? 🧠🤯 Shrews can shrink their brains by ~20% in winter and grow them back later. No brain cells die, they just lose water and keep working. A wild reminder of how flexible brains can be, and why nature still has a lot to teach us. #Neuroscience #AnimalResearch

The Microbiota Shapes Central Nervous System Myelination in Early Life advanced.onlinelibrary.wiley.com/doi/10.1002/...

Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APPNL-F neurons #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.64898/2026.01.10.697647v1

Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy! link.springer.com/article/10.1...

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy @nature.com www.nature.com/articles/s41...

Spatial transcriptomics reveals effects of maternal immune activation and microbiome depletion www.nature.com/articles/s41...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...

Menopause hormone therapy does not appear to impact dementia risk ucl.ac.uk/news/2025/de... by @ucl.ac.uk #Alzheimers #dementia #WomensHealth #menopause

Gonadal hormones contribute to sex differences in behavior, pathology and epigenetic modifications in the 3×Tg-AD mouse model of Alzheimer’s disease link.springer.com/article/10.1...

Aducanumab reduces plaques and other pathologies but significantly increases vascular Aβ deposits. Seems that whether you clear plaques or limit plaque deposition (via microglial depletion in vivo pre-plaque deposition), the consequence is vascular Aβ deposits 🤨 www.alzforum.org/news/confere...

I really liked this paper - data supporting super interesting idea that Alzheimer's disease pathology may have evolved as part of an innate immune defense response to microbial infection. www.nature.com/articles/s41...

Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model link.springer.com/article/10.1...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons www.nature.com/articles/s41... @natneuro.nature.com

Lesion-remote astrocytes govern microglia-mediated white matter repair www.nature.com/articles/s41...

The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages www.biorxiv.org/content/10.6...

Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease @jem.org @jonykipnis.bsky.social @leonsmyth.bsky.social @washumedicine.bsky.social rupress.org/jem/article-...

Microglial phagocytosis in Alzheimer disease www.nature.com/articles/s41...

Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease Fascinating study from the lab of @lukensjohnr.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease www.nature.com/articles/s41...

The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia www.nature.com/articles/s41...

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy www.sciencedirect.com/science/arti...

Circadian rhythms and the light‐dark cycle interact to regulate amyloid‐beta plaque accumulation and tau phosphorylation in 5xFAD mice alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Our new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...

Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease www.nature.com/articles/s41...

Worth a read 'Comparative study of pre- and post-mortem perfusion of fixative for the quality of neuronal tissue preparation' www.nature.com/articles/s41...

and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz

Stoked to see this essay on the involvement of the white matter in Alzheimer’s disease published and Constanze Depp being one of the finalists for the Eppendorf & Science Prize for Neurobiology this year! 🎉 www.science.org/doi/10.1126/...

Online now: Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions

In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me! Hope this tool helps more people see it too.

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis www.nature.com/articles/s41...

Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation www.nature.com/articles/s42...

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes alz-journals.onlinelibrary.wiley.com/doi/full/10....

Happy #FluorescenceFriday! This is a maximum intensity projection of depth shaded actin (🌈) in a section from an E9.5 🐭 neural tube (NT). 🔬 by postdoc @christinaadaly.bsky.social 👩‍🔬 🧪 Image shows the floor plate and lumen of the developing NT. #SciArt #DevBio #DevNeuro

Dendritic nanotubes! What’s next? www.science.org/doi/10.1126/...

Presented our work at the Glia Congress 2025 a few months ago on the topic of oligodendrocytes in Alzheimer’s disease and was awarded the stipend! Many thanks to the organizers and grateful for the wonderful discussions with old and new connections.

New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com #Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1... Read the thread below for a summary of our findings 🧵1/11

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes link.springer.com/article/10.1...

Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota gut.bmj.com/content/earl...

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

Important validation of our reported transgenic inheritance effect in a distinct 5xFAD line from the lab of David Holtzman! www.cell.com/neuron/abstr...

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl... #tao @nfranzme.bsky.social

Mitochondria delay action potential propagation. www.nature.com/articles/s42...

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies www.science.org/doi/10.1126/...