Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice www.nature.com/articles/s41...

Early Myelination Supports the Establishment of Consistent Handedness onlinelibrary.wiley.com/doi/10.1002/...

Dysregulated oligodendrocyte and myelin dynamics as an early pathological feature of neuropil degeneration in Alzheimer’s disease: an ultrastructural study link.springer.com/article/10.1...

Like macrophages in general, Lipid-associated “foamy” 🚿macrophages come in different flavors. Here a new story on these big beauties in #multipleSclerosis Foamy microglia link oxylipins to disease progression in multiple sclerosis | @natneuro.nature.com www.nature.com/articles/s41...

Astrocytes reduce microglial activation and enhance adult hippocampal neurogenesis in acute inflammation www.sciencedirect.com/science/arti...

Actin disassembly triggers CNS myelin compaction and wrapping https://www.biorxiv.org/content/10.64898/2026.05.14.722739v1

Hot off the press new insights on #microglia states in #alzheimers #disease by the Ajami lab: Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states | @natneuro.nature.com www.nature.com/articles/s41...

Our review published earlier this year made the cover of the May 2026 issue of Neuroscience Bulletin! ✌️

😍😍😍😍

Submicrometre sampling of living cells by macrophages www.nature.com/articles/s41...

PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential https://www.biorxiv.org/content/10.64898/2026.04.23.720488v1

Nature research paper: Focal white matter lesions drive grey matter inflammation and synapse loss go.nature.com/3Qgd47r

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Gut microbial metabolite indole-3-acetic acid inhibits microglia-mediated synaptic loss in Alzheimer’s disease by targeting CCR4 www.sciencedirect.com/science/arti...

Now online! Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression

Our paper is now online at @nataging.nature.com! Alzheimer’s disease begins decades before symptoms—but what drives those earliest changes is still not well understood. We set out to understand how APOE4 disrupts neuronal and network function across aging. 🧵: 1/15 www.nature.com/articles/s43...

Flexible ensheathment of axons enables myelination of complex CNS networks What a tour de force in the field of myelin biology 😍 www.nature.com/articles/s41...

Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice www.nature.com/articles/s41...

Reactive microglia (🟠) and astrocytes (⚪️) as well as Aβ plaques (🔵) in the hippocampal dentate gyrus of a 5xFAD mouse model of Alzheimer's disease. #FluorescenceFriday

Oligodendrocyte precursor cells–microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer’s disease www.nature.com/articles/s41...

Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum www.pnas.org/doi/full/10....

Gut #dysbiosis has been linked to #NeurologicalDisease, but what's the mechanism? @grakoui.bsky.social @dweisslab.bsky.social &co show that a high-fat diet increases gut permeability, enabling bacterial translocation from gut to brain via the vagus nerve in mice @plosbiology.org 🧪 plos.io/4ruE6EP

Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosis www.pnas.org/doi/full/10....

The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model www.nature.com/articles/s41...

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity www.pnas.org/doi/10.1073/...

New @nature.com The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills nature.com/articles/s41...

Selective Cortical Myelination Reflects Axon-Driven Progression of the BCAS1-positive Oligodendrocyte Lineage https://www.biorxiv.org/content/10.64898/2026.02.15.705957v1

Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage onlinelibrary.wiley.com/doi/full/10....

A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams. www.biorxiv.org/content/10.1...

The study shows how intestinal macrophages can modulate synucleinopathy along the gut-brain axis, strengthening the growing view that the gut plays an important role in the earliest stages of Parkinson’s disease. www.nature.com/articles/s41...

Where does Aβ come from in Alzheimer’s disease? 🔍 In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting. link.springer.com/article/10.1...

Mammals regrowing their brain? 🧠🤯 Shrews can shrink their brains by ~20% in winter and grow them back later. No brain cells die, they just lose water and keep working. A wild reminder of how flexible brains can be, and why nature still has a lot to teach us. #Neuroscience #AnimalResearch

The Microbiota Shapes Central Nervous System Myelination in Early Life advanced.onlinelibrary.wiley.com/doi/10.1002/...

Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APPNL-F neurons #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.64898/2026.01.10.697647v1

Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy! link.springer.com/article/10.1...

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy @nature.com www.nature.com/articles/s41...

Spatial transcriptomics reveals effects of maternal immune activation and microbiome depletion www.nature.com/articles/s41...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...

Menopause hormone therapy does not appear to impact dementia risk ucl.ac.uk/news/2025/de... by @ucl.ac.uk #Alzheimers #dementia #WomensHealth #menopause

Gonadal hormones contribute to sex differences in behavior, pathology and epigenetic modifications in the 3×Tg-AD mouse model of Alzheimer’s disease link.springer.com/article/10.1...

Aducanumab reduces plaques and other pathologies but significantly increases vascular Aβ deposits. Seems that whether you clear plaques or limit plaque deposition (via microglial depletion in vivo pre-plaque deposition), the consequence is vascular Aβ deposits 🤨 www.alzforum.org/news/confere...

I really liked this paper - data supporting super interesting idea that Alzheimer's disease pathology may have evolved as part of an innate immune defense response to microbial infection. www.nature.com/articles/s41...

Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model link.springer.com/article/10.1...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons www.nature.com/articles/s41... @natneuro.nature.com

Lesion-remote astrocytes govern microglia-mediated white matter repair www.nature.com/articles/s41...

The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages www.biorxiv.org/content/10.6...

Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease @jem.org @jonykipnis.bsky.social @leonsmyth.bsky.social @washumedicine.bsky.social rupress.org/jem/article-...

Microglial phagocytosis in Alzheimer disease www.nature.com/articles/s41...

Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease Fascinating study from the lab of @lukensjohnr.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...