Andrew Octavian Sasmita (@aosasmita.bsky.social)

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an Alzheimer’s risk gene hijack triglyceride biosynthesis to acquire a basal immune activated state. Targeting triglyceride metabolism can modulate immune reactivity and disease phenotypes. http://dlvr.it/TM0N9Z