Excited to get started!

Integration of biochemical and physical cues by patrolling CD8+ T cells www.sciencedirect.com/science/arti...

A team in #ScienceTranslationalMedicine untangles the immune mechanisms connecting Epstein-Barr virus to #MultipleSclerosis, showing that CD4+ T cells from patients respond to viral particle components and that this response can be calmed with B cell-depleting therapy. scim.ag/4wL5u4C

CD4+ T cells in MS preferentially recognize EBV viral particles rather than latent antigens, and responses are reduced by B cell–targeting therapies www.science.org/doi/10.1126/...

Cytomegalovirus-induced T cell responses accelerate Alzheimer’s disease progression in mice academic.oup.com/brain/advanc...

Promising news for the MOGAD community! A new international study found that IL-6 receptor blockers (primarily tocilizumab) were associated with lower relapse rates and a favorable safety profile in people living with MOGAD. https://jamanetwork.com/journals/jamaneurology/article-abstract/2851426

The challenge and promise of studying human antigen-specific T cells

Excited to be presenting our recent work. A big thank you to @hkoohy.bsky.social for the invitation!

The EBV Timing Hypothesis: How the Age of Primary Infection May Explain Global Variation in Multiple Sclerosis www.sciencedirect.com/science/arti...

Efficacy and safety of ofatumumab in participants with relapsing multiple sclerosis and breakthrough disease on oral fingolimod or fumarates: results from the ARTIOS study link.springer.com/article/10.1...

Rituximab vs. ocrevus for multiple sclerosis. This randomized trial (n=218, 30 month follow up) showed they are about equal in preventing relapses, disability, MRI outcomes, and side effects. www.nejm.org/doi/full/10....

@nejm.org Review Advances in Multiple Sclerosis www.nejm.org/doi/full/10....

Rituximab versus Ocrelizumab in Newly Diagnosed Relapsing Multiple Sclerosis www.nejm.org/doi/full/10....

Blood cytotoxic NK-like CD8 + CD94+ T cells migrate to the brain and predict multiple sclerosis severity academic.oup.com/brain/advanc...

Excited to share our new Nature paper published today: Vaccination elicits HIV broadly neutralizing antibodies in primates www.nature.com/articles/s41... A project 14 years in the making with an outstanding team at @lji.bsky.social, @scrippsresearch.bsky.social and many collaborating institutions

Review @natimmunol.nature.com @kleinlabuwo.bsky.social The neuroimmune system and cognition www.nature.com/articles/s41...

Review @natimmunol.nature.com @washumedicine.bsky.social Adaptive immunity in the pathogenesis of neurodegeneration www.nature.com/articles/s41...

What are our blind spots in human T cell immunology? In "Current Opinion in Immunology", M. Hiltensperger and I argue that we lack a coherent understanding of epitope-specific responses in secondary lymphoid organs. www.sciencedirect.com/science/arti... Grazie, Marco & Matteo, for the invite!

Great review - pretty much sums up the field!! link.springer.com/article/10.1...

Do give the full story a read: you'll find a play-by-play of all the steps NIH applications go through, with the new political reviews included. And a pdf of all 235 disfavored words. PS: If you hit a paywall trying to read the story, making a free account will open up the full story.

Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8⁺ T cells https://pubmed.ncbi.nlm.nih.gov/42244754/

Based on a new NOA recieved this month, we are looking for a postdoctoral fellow with solid foundation of molecular skills, creativity, and translational passion to help us develop innovative CARs for targeting discrete subsets of T cells. DM or email me if interested

WOW!! over 27k actions taken to fight against the OMB proposal through the #StandUpforScience action portal. Americans are taking action across the country, because scientific funding decisions should be guided by the expertise & the evidence, not political appointees & political ideology. 🧵:

DNA-barcode labelled MHCII multimers for detection of antigen-specific CD4 T cells across large libraries of epitopes https://www.biorxiv.org/content/10.64898/2026.06.23.733927v1

Epstein–Barr virus and multiple sclerosis: from associations to mechanisms to potential therapies www.sciencedirect.com/science/arti...

New research online! Can adding #rituximab and IV immunoglobulin therapy to plasma exchange lead to better long-term outcomes after severe inflammatory attacks of the brain and spinal cord? Find out more here: journals.sagepub.com/doi/full/10....

Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8+ T cells link.springer.com/article/10.1...

Computational prediction of TCR cross-reactivity: principles, challenges and translational opportunities https://pubmed.ncbi.nlm.nih.gov/42316179/

In contrast to strong evidence linking EBV to many autoimmune disease, EBV may actually protect against type 1 diabetes mellitus @natrevendo.nature.com www.nature.com/articles/s41...

Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis Congrats to Martineau Louine and Michael Wilson and colleagues! academic.oup.com/jid/advance-...

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1002/...

NKG2C+CD27- Defines Human CD8+ Regulatory T Cells https://www.biorxiv.org/content/10.64898/2026.06.15.732401v1

Deciphering small sequence differences in T cell receptor-antigen pairing www.nature.com/articles/s41...

Decoding autoimmune disease with single-cell immune repertoire and transcriptome sequencing: mechanisms and therapeutic opportunities www.frontiersin.org/journals/imm...

Thrilled that my friend and colleague Andy Josephson will be the next dean of the UCSF School of Medicine. Brilliant clinician, gifted teacher, and one of the warmest people I know – he's a perfect fit for the moment. Can't wait to work with him in this role. www.ucsf.edu/news/2026/06...

OBS Neuroimmunology Webinar — Monthly on the 3rd Thu at 12 PM ET PAPER HIGHLIGHT Aged circulating CD8+ T cells and their secreted factors drive cognitive decline *Zoom: us02web.zoom.us/meeting/regi...

Excited to be presenting our recent work. A big thank you to @hkoohy.bsky.social for the invitation!

Budgets and programs are being cut, decades of established science are being replaced with conspiracies, and every American's life is being put in danger. We are #StandingUpForScience and need you to help Fuel the Fight for Science at the link in our bio, or go here: zurl.co/sYzDZ#StandingUpForScience #Donate

BenchRep-T: A Systematic Evaluation of T-Cell Repertoire-Based Disease Diagnostics https://www.biorxiv.org/content/10.64898/2026.06.09.727013v1

@biorxivpreprint.bsky.social Spatial transcriptomics of compartmentalised inflammation in multiple sclerosis www.biorxiv.org/content/10.1... @qubelfastofficial.bsky.social

Potential multiple sclerosis treatments targeting Epstein-Barr virus. One of the authors is a colleague of mine, Dr. Hannah Zhao-Fleming www.frontiersin.org/journals/imm...

for those who #dont #believe in the #existence of #CD8 #Regulatory #cells -here is a #clear #evidence -they #DO exist and are #regulatory www.nature.com/articles/s41...

Cross-presentation of citrullinated antigens drives cytotoxic CD8+ T cell responses in rheumatoid arthritis https://www.biorxiv.org/content/10.64898/2026.06.03.729882v1

hello world. Excited to launch the Ingelfinger Lab account! We’re a young lab in Germany’s Black Forest tackling key questions in immunology with innovative single-cell technologies. Follow us for updates on systems immunology, machine learning & translational oncology. fi

Refined single-cell profiling captures a CCR5high CD4+ cytotoxic T-cell precursor in multiple sclerosis www.thelancet.com/journals/ebi...

Single-cell analysis of skin and blood reveals systemic immune responses to ultraviolet B and their impairment in MS link.springer.com/article/10.1...

Head's up to immune receptor researchers: our new bioRxiv preprint describes major improvements to epitope-specific TCR/BCR data in the IEDB! - Re-curation and standardization of receptor data - Improved receptor search interface - AIRR-compliant exports www.biorxiv.org/content/10.6...

Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis @cp-cellreports.bsky.social www.cell.com/cell-reports...

Really nice commentary on our recent manuscript: www.science.org/doi/10.1126/...