Unbiased identification of responding T cell clones from longitudinal repertoire sequencing with CloneSearch https://www.biorxiv.org/content/10.64898/2026.05.29.728700v1

Children who underwent tonsillectomy "had a 63% increased odds of MS (adjusted odds ratio (OR) = 1.63, 95% confidence interval (CI) = 1.01-2.64, p = 0.046)." Case control study; senior author Dr. Emmanuelle Waubant (UCSF) pubmed.ncbi.nlm.nih.gov/42212792/

Vought is trying to destroy American science as we know it. Here's what you can do to stop him: 👉 Visit our action center: zurl.co/Hsflw 👉 Donate to Fuel the Fight for Science: zurl.co/mQlwe LINK IN BIO

Human neurons stimulated with IFNγ present HLA class I-restricted autoantigens to cytotoxic CD8+ T cells https://www.biorxiv.org/content/10.64898/2026.05.22.727243v1

Do you like beach, summer, Greek food AND T cells??? Then please join us for the 1st Aegean conference on T cells in health and disease aegeanconferences.org/conferences/... Registration closes soon (June 15th)!!!

Myelin antigen–specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell–dependent manner academic.oup.com/jimmunol/art...

Genetic-Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis onlinelibrary.wiley.com/doi/full/10....

The Effect of Ocrelizumab on Anti-JC Virus Antibody Index onlinelibrary.wiley.com/doi/10.1002/...

Characterization of HLA-restricted GAD65-specific CD8+ T cell responses in patients with GAD65 antibody-associated neurological disorders https://www.biorxiv.org/content/10.64898/2026.05.20.726502v1

Asking for #help -has anyone tried or #recommend #commercial #crystallography company for #TCR-#peptide #MHC, specifically mouse class II (I-Ab) with self peptide and #CD4 #TCR.

#immunosky I'm skeptical that nonspecific effects of vaccines can be explained by trained immunity. If you'd humor me (longish 🧵): Trained immunity refers to sustained changes in how cells of the immune system function (more or less responsive) because of epigenetic imprinting.

Identification of an immunogenic epitope from RASGRP2 with specificity for HLA-DR15 in multiple sclerosis www.sciencedirect.com/science/arti...

Aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal of aged T cells, or their secreted factor granzyme K, rescues cognition in mice @cp-immunity.bsky.social @ucsfhealth.bsky.social www.cell.com/immunity/ful...

Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery - @stanfordmedicine.bsky.social go.nature.com/3QWMRet

On July 1st, I'll be joining the faculty at UC Berkeley, with a joint appointment in the Division of Molecular Therapeutics within MCB and the Helen Wills Neuroscience Institute.

HLA-B7 (MS Risk allele)-restricted EBV-specific CD8+ T cells mainly recognize EBNA3A, display an exhausted phenotype, expressed CNS residency markers, and were most abundant in postmortem CNS compartments www.sciencedirect.com/science/arti... @cp-iscience.bsky.social

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD https://www.biorxiv.org/content/10.64898/2026.05.06.722823v1

Exciting new work from Aaron Bodanksy and Joe DeRisi and colleagues on finding antigen-specific B cells and T cells in ROHHAD, a rare pediatric neuroendocrine disorder www.biorxiv.org/content/10.6...

GET IN, DORKS! It's a watershed moment and we need YOUR HELP. 1/x @standupforscience.net was asked by independent members of the National Academies to support their letter to Congress calling for the reinstatement of the National Science Board. #saveNSB 🔗 www.standupforscience.net/nasem-letter...

The FDA approves ocrevus for pediatric multiple sclerosis www.neurologylive.com/view/fda-app...

Review @pcrosato1.bsky.social Living rent free in your head: resident memory T cells academic.oup.com/immunohorizo...

Review @annualreviews.bsky.social T Cell Receptor Signaling and Immune Tolerance: From Autoimmunity to Cancer Immunity www.annualreviews.org/content/jour...

Now live:preprint for our gRNA screening paper for C9orf72. This was a multiyear effort by Bankole Arogundade and Katie Jing Kay Lam who screened over 120 pairs(!) of gRNAs to excise the C9 repeat expansion in patient iPSCs.

Identify. Attack. Resolve. The immune system follows a perfect defense program: ignore weak/self signals, attack true threats with force, then shut down to avoid damage. (1/2) www.science.org/doi/10.1126/...

Save science, save lives! #SB895 savesciencesavelives.com

Snoop Dogg is performing at the Race to Erase MS Foundation Benefit Gala June 5, 2026 at the Fairmont Century Plaza in Los Angeles. hiptv.tv/snoop-dogg-m...

Risk of Progression independent of relapse and MRI activity (PIRMA) in people with MS on low/moderate efficacy vs. highly effective disease modifying therapy. pubmed.ncbi.nlm.nih.gov/42057337/

Awesome title! Living rent free in your head: resident memory T cells academic.oup.com/immunohorizo...

Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.social

Dr Chu-Yueh Guo summarized some of the clinical trials data in multiple sclerosis presented at the #AANAM 2026 meeting. Tolebrutinib, fenebrutinib, gilenya, and ocrevus. www.medscape.com/viewarticle/...

Cause, consequence, or synergy: the role of T-cell infiltration across neurodegenerative diseases academic.oup.com/brain/advanc...

Fernando Mendoza (Heisman Trophy winner and NFL #1 draft pick) announces a $500,000 donation to support MS research, inspired by his mother who has the disease www.nbcsports.com/nfl/profootb...

Mononucleosis, the infection caused by the epstein barr virus, is associated with a more than double future risk of multiple sclerosis (Data from the Rochester Epidemiology Project) www.neurology.org/doi/10.1212/...

Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype www.sciencedirect.com/science/arti...

Why were there more deaths with fenebrutinib than aubagio in clinical trials? Roche says "infections [including neurocryptococcosis gatti, pneumonia], Type 1 diabetes complications, bleeding, suicide, injuries from an accident and an unknown cause" www.fiercebiotech.com/biotech/roch...

My lab has been studying human genes that control infection HIV infection of CD4+ T cells for over a decade. Today we report a major milestone in Cell: www.cell.com/cell/fulltex...

Distinct contribution of autoreactive B cell Bruton's tyrosine kinase signaling to neuroinflammation https://www.biorxiv.org/content/10.64898/2026.04.14.718534v1

🔬 We’re hiring again! Looking for 1 #PhD student to join the #MSCA-DN TRANSCEND network 🧬 Project on unconventional #Tcells in #MultipleSclerosis with research exchanges in 🇩🇰 Klaus Eyer’s lab, Aarhus 🇳🇴 Victor Greiff’s lab, Oslo ⏳ Deadline: May 10 👉 euraxess.ec.europa.eu/jobs/403235

Utility of Multi-Analyte Protein Assay to Distinguish Multiple Sclerosis Clinical Relapse from Pseudoexacerbation www.researchsquare.com/article/rs-9...

Innate immunity and biomarkers of multiple sclerosis relapse versus remission @masturamonif.bsky.social www.sciencedirect.com/science/arti...

HLA Associations Differ by Ethnicity and Aquaporin-4 Antibody Status in Patients With Neuromyelitis Optica Spectrum Disorders www.neurology.org/doi/10.1212/...

Dynamics of Spinal Fluid Immune Cell Alterations Following Cladribine Tablet Treatment in Multiple Sclerosis www.neurology.org/doi/10.1212/...

COMBO-RATE: An experimentally validated bioinformatic tool to identify promiscuous HLA restrictions https://www.biorxiv.org/content/10.64898/2026.04.14.718521v1

An autoantibody signature predictive for multiple sclerosis: evidence at the protein level and association with histopathological lesion types link.springer.com/article/10.1...

Researchers from Stanford, UCSF, and Berkeley are rallying in Sacramento on May 4 for SB 895 — a $23B investment in California science. Free bus available. Not affiliated? Join as a community member. form.laborbase.org/260746265337... Science needs visible advocates. Come be one.

Spatial TCR profiling has the potential answers to key questions in cancer immunology, including revealing spatially coordinated T cell states in head and neck cancer @sciimmunology.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @bcmfromthelabs.bsky.social

New online! Anne-Katrin Pröbstel: B cells, antibodies and microbiota in autoimmune disease

The preprint on IMMREP25 TCR-epitope prediction challenge is now out on preprint, which reveals that unseen epitopes remains an unsolved problem in the field! doi.org/10.64898/202...

The Role of T Cells in Multiple Sclerosis: Molecular Mechanisms, Drivers, and Therapeutic Targets www.imrpress.com/journal/JIN/...

Why Is MS a More Frequent Complication of EBV Infection in Females? onlinelibrary.wiley.com/doi/10.1111/...