Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity onlinelibrary.wiley.com/doi/10.1002/...

Excited to announce the 1st International Conference on T cells in Health and Disease, a new conference series aiming to bring together T cell biologists across diverse areas, from fundamental biology through to clinical translation, and spanning infection, autoimmunity and cancer.

Interested in understanding how epitope recognition specificity is encoded in your TCR sequences? Try our new interactive page for building TCR specificity profiles on the TCR Motif Atlas: tcrmotifatlas.unil.ch/Building_mot....

One more trick pulled off by antibody-mediated feedback www.cell.com/immunity/ful...

New work from our lab, hot off the press in Nature Immunology (@natureportfolio.nature.com)! How do human T cell responses diversify — and how does this lead to durable protection after vaccination? Paper: www.nature.com/articles/s41... Press release: www.fau.eu/2026/02/news... 1/6

Great work from @hollenbachlab.bsky.social and Michael Wilson's lab at UCSF!

Histidine scanning identifies TCR hotspots capable of forming additional catch bonds, facilitating screens for low-affinity, higher-potency variants lacking off- & on-target toxicity @cellcellpress.bsky.social #Xu #Zhao #Gascoigne www.cell.com/cell/fulltex...

Anti-CD20 Therapy Induces a Persistent Suppression of EBV–Host Interactions in Multiple Sclerosis Despite B-Cell Repopulation papers.ssrn.com/sol3/papers....

🖨️ Hot off the press 🍾 : I am super excited to share that our article on the host control of persistent EBV infection has just been published in Nature Magazine, in an accelerated article preview version: rdcu.be/e4Lg8

Host control of persistent Epstein–Barr virus infection www.nature.com/articles/s41...

BREAKING: NIH director Jay Bhattacharya will take on the additional role of acting director of the Centers for Disease Control and Prevention, two administration officials told @sherylnyt.bsky.social on Wednesday. Bhattacharya will also continue to run the NIH, she reports for @nytimes.com.

#FDA backs down on #Moderna: The agency had refused to review the company's licensure application for an mRNA flu vaccine, but after significant pushback has relented. www.statnews.com/2026/02/18/f...

The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃

Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis www.sciencedirect.com/science/arti...

I am looking for an Illustrator to help with making schematics and diagrams. Might anyone guide me on who to contact? Thanks #science #Illustration #Academia

How does inflammation kill neurons, and what can we do about it? Check out our latest paper where we consider this question: rdcu.be/e4nfP.

Paper alert 📢: What drives variation in humoral responses to viruses? collab with @etienne-patin.bsky.social @darraghduffy.bsky.social @lquintanamurci.bsky.social we show that for ~98k viral epitopes immunodominance vary by genetics, sex and origin: www.nature.com/articles/s41...

@biorxivpreprint.bsky.social EBV reprograms autoreactive anti-CNS B cells as antigen presenting cells in multiple sclerosis www.biorxiv.org/content/10.6... @stanforduniversity.bsky.social @shady-myounis.bsky.social

Congrats Todd & team @bruskolab.bsky.social Large-scale TCR repertoire profiling from peripheral blood reveals type 1 diabetes signatures linked to high-risk HLA alleles www.science.org/doi/10.1126/...

A high-throughput screening system enabled identification of the antigen targets of T cell receptors found in many individuals www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel | Science www.science.org/doi/10.1126/...

EBV reprograms autoreactive B cells as antigen presenting cells in multiple sclerosis https://www.biorxiv.org/content/10.64898/2026.02.11.701910v1

Targeting Epstein-Barr Virus (EBV) for Treatment of Multiple Sclerosis www.sciencedirect.com/science/arti...

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset onlinelibrary.wiley.com/doi/full/10....

A framework for reparative CAR T engineering in the CNS https://www.biorxiv.org/content/10.64898/2026.02.09.703122v1

Scoop: Top FDA official Vinay Prasad overruled the agency’s reviewers when he refused to accept Moderna’s application for a new influenza vaccine, STAT has learned. www.statnews.com/2026/02/11/m...

The findings of a study in Nature Immunology shed vital insight into the role of CD8+ T cells in multiple sclerosis and support an important role of Epstein–Barr virus in MS immunopathology. #Immunosky #medsky 🧪

This won’t come as a surprise to the TCR-antigen gurus, but I did want to share some lessons we learned re: partial TCR sequence alignments as predictions for antigen specificity from this study 1/

B-cell abundance in perivascular cuffs associates with local lesion activity in multiple sclerosis link.springer.com/article/10.1...

Anti-CD320 Autoantibodies and Central Nervous System Vitamin B12 Deficiency in Idiopathic Myelopathy from John Pluvinage and Michael Wilson and colleagues www.medrxiv.org/content/10.6...

Paediatric cerebrospinal fluid immune profiling distinguishes paediatric-onset multiple sclerosis from other paediatric-onset acute neurological disorders www.sciencedirect.com/science/arti...

At UCSF, researchers studied 18 people and found that at least 3 highly expanded CD8+ T cells in the cerebrospinal fluid of MS patients were specific for Epstein–Barr virus. This supports a direct role for EBV in MS immune activity. www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis @jsabatino37.bsky.social www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis www.nature.com/articles/s41...

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

For those in California, please consider signing the petition to support a $23 billion initiative for the California Foundation for Science and Health Research www.fundcascience.org

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. www.nature.com/articles/s41... Beautiful work led by @hhmi-science.bsky.social Gilliam Fellow Yoselin Paucar Iza and postdoc Tyler Park 1/

The αβTCR repertoire at scale in the immgenT dataset https://www.biorxiv.org/content/10.64898/2026.01.30.702900v1

CD8+CD20+ Cytotoxic T Lymphocytes Exhibit Augmented Degranulation and Pro-inflammatory Potential in Multiple Sclerosis https://www.biorxiv.org/content/10.64898/2026.01.29.702512v1

EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis www.neurology.org/doi/10.1212/...

Great commentary on this study by Kristen Wade and @hollenbachlab.bsky.social at UCSF www.nature.com/articles/d41...

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

@CellPressNews For the #love of #TCRs -#Read this >#Scalable #TCR synthesis and screening enable antigen reactivity mapping... www.sciencedirect.com/science/arti...

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases www.nature.com/articles/s41...

CD318 expression defines a novel subset of human CD8+ regulatory T cells www.science.org/doi/10.1126/...

🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year. That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027. A wonky bureaucratic problem with big implications. A short 🧵

Excellent new commentary from Scott Zamvil and Larry Steinman on the 3 recent EBV-MS papers in @cellpress.bsky.social www.sciencedirect.com/science/arti...

🧪IMPORTANT! This graphic explains how science all over the US is funded. Congress approved a 2% increase in the #NIH budget for FY 26. Buried in the bill- Shift of ~40% of grants to MYF. This will still result in a 35% DECREASE in the NUMBER of grants funded per yr. Russel Vought is behind this.

Immcantation.org user or interested in #Bcell & #Tcell repertoire analysis? #AIRRseq 🚨Register now for the "2026 Immcantation Users Group Meeting" 🗓️FREE virtual meeting on January 22, 2026 from 10AM – 1:30PM ET. 🔗Program & registration: immcantation.github.io/users-meetin...

Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides @natimmunol.nature.com www.nature.com/articles/s41...