Clemastine as a Remyelinating Agent youtube.com/shorts/L8GtO...

A treatment for Huntington's Disease? The open label phase 2 PIVOT-HD study of PTC518 (votoplam, a gene therapy) showed reduction of neurofilament light chain and reduced disability progression, compared to historical control group, not a randomized trial ir.ptcbio.com/news-release...

Best Multiple Sclerosis Medicine for Preventing Disability youtu.be/3wstm5izx2o?...

Painful brief vision loss can precede typical optic neuritis associated with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) dubbed "Amaurosis Fugax Dolorosa." This case series describes 8 such instances (out of 350 with MOGAD) pubmed.ncbi.nlm.nih.gov/40982779/

About half of people with multiple sclerosis have Paramagnetic Rim Lesions according this meta analysis. They are associated with smouldering inflammation and microglial activation. pubs.rsna.org/doi/10.1148/...

Kappa free light chain index is probably SLIGHTLY associated with worse prognosis in multiple sclerosis (image is YES/NO new brainstem and spinal cord lesions) link.springer.com/article/10.1...

Which YouTube thumbnail is better? My version or the AI version (chat GPT, blue background)?

"FDA pushes back to December its decision on Sanofi’s tolebrutinib," presumably to wait for the results of the PERSEUS trial-tolebrutinib vs. placebo in primary progressive MS) multiplesclerosisnewstoday.com/news-posts/2...

Best exercises for people with multiple sclerosis. With Dr. Gretchen Hawley and @aaronbostermd.bsky.social youtu.be/1KNCPsF_e8o?...

Upcoming videos: 9/24/25: Best MS medicine for disability prevention 10/1/25: Types of brain scans 10/8/25: MS starts long before symptom onset 10/15/25: Octave MSDA test www.youtube.com/@DrBrandonBe...

smoking is bad for MS, if you are taking a highly effective medication, are you in the clear? NO! This study on people taking ocrevus found smokers had more weakness, hospitalizations, and overall mortality. pubmed.ncbi.nlm.nih.gov/40967151/

Spasticity Treatment youtube.com/shorts/mfqAu...

Fasting and Multiple Sclerosis youtu.be/cnnMVxUviac?...

The "cascade" (waterfall) sign has been reported in neuro-Behçet’s disease, but beware! This MRI is actually from a case report of a woman with AQP4-IgG+ neuromyelitis optica. journals.sagepub.com/doi/10.1177/...

A schematic showing potential targets to enhance remyelination in multiple sclerosis pubmed.ncbi.nlm.nih.gov/40956548/

Can multiple sclerosis be very mild? Sometimes yes! This is a case series of 18 people with unexpected "diagnosis" of multiple sclerosis on autopsy. 13/18 had no history of symptoms suggestive of MS pubmed.ncbi.nlm.nih.gov/2741673/

Dr. Parisa Khosravi, a neuroimmunologist at Central Texas Neurology Consultants in Round Rock, describes her experience with multiple sclerosis as a doctor and patient. She was diagnosed 10 years ago after developing tingling on one side of the body www.statesman.com/news/healthc...

Multiple Sclerosis & Personalized Medicine youtu.be/J5PBHb0Hh24?...

6 years prior to multiple sclerosis “symptom onset” Neurofilament light chain (sNfL), a breakdown product of central nervous system tissue, is elevated uhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6745051/

Men have a delay in diagnosis of MS compared to women (median 16.5 months in time of symptom onset to diagnosis vs 5 months for women p = 0.015) Black people had a delay from symptom onset to neurology visit (6 months greater compared to white people) pubmed.ncbi.nlm.nih.gov/40913189/

Kappa Free Light Chain Index has been proposed as an alternative to oligoclonal bands for the diagnosis of MS, but this study found the results are often discordant (16% of the time) pubmed.ncbi.nlm.nih.gov/40913362/

Forget cardio and pump iron? This This network meta-analysis of 31 randomized controlled trials in people with multiple sclerosis suggests resistance training was the most effective exercise. pubmed.ncbi.nlm.nih.gov/40920222/

A talk I gave at a charity event for MS News and Views about disability progression in multiple sclerosis www.youtube.com/watch?v=9Maq...

Best Meds for MS Symptoms: A Neurologist's Guide. by @aaronbostermd.bsky.social Fatigue, depression, neuropathic pain, spasticity, bladder problems, ampyra, insomnia. youtu.be/vY1IoKjyqzE?...

Effects of different diets on multiple sclerosis in scientific studies. pubmed.ncbi.nlm.nih.gov/40871741/

This is a case report of severe psoriasis triggered by the multiple sclerosis drug kesimpta. Has anyone experienced this? pubmed.ncbi.nlm.nih.gov/40873590/

b-cell depleters (ocrevus, kesimpta, rituximab, briumvi) vs. gilenya in pediatric MS. b-cell depleters caused more infections but were better at suppressing MRI activity in this retrospective chart review from MGH. pubmed.ncbi.nlm.nih.gov/40886415/

People with multiple sclerosis who start early highly effective disease modifying therapy are less likely to have new MRI lesions or clinical relapses and are less likely to stop/change medication (data from Norway) pubmed.ncbi.nlm.nih.gov/40886413/

Paramagnetic rim lesions on MRI are highly specific for multiple sclerosis. Oh Really? This study found a specificity of "only" 90%, though 2 ore more lesions had a 95% specificity. pubmed.ncbi.nlm.nih.gov/40893055/

Multiple Sclerosis & Omega 3 Fatty Acids youtu.be/sJmhH9hM-C8?...

Beware of looking at comparisons to "historical controls" or "natural history studies" in lieu of actual randomized trials. This data from the ORATORIO trial (ocrevus vs. placebo in progressive MS) compared to untreated controls shows a big difference www.researchgate.net/publication/...

The first FDA approved drug for multiple sclerosis: Betaseron. This randomized trial published 1993 showed it reduced disability progression by ~29% pubmed.ncbi.nlm.nih.gov/8469318/

A blast to the past. Copaxone reduced multiple sclerosis disability progression by 28% compared to placebo, similar to many modern MS drugs. The CONFIRM copolymer 1 ms trial (1995). www.neurology.org/doi/pdf/10.1...

Tysabri Vs Avonex for Multiple Sclerosis youtube.com/shorts/4vrE2...

Late onset MS can have a surprisingly aggressive prognosis. This case series (mean age 65) showed the mean time to convert to secondary progressive MS was only 3.7 years, and the mean time to reach EDSS 6.0 (requiring a cane to walk) was only 6.3 years. pubmed.ncbi.nlm.nih.gov/40865476/

Can you get PML as a side effect of tysabri/tyruko used for MS even with extended interval dosing (taking it less often than every 4 weeks)? Unfortunately, YES! This is a case series from Japan. pubmed.ncbi.nlm.nih.gov/40875960/

MRI-double inversion recovery sequence may enhance diagnosis of multiple sclerosis (for instance the corpus callosum lesion noted by the yellow arrow in image C.d) bmcneurol.biomedcentral.com/articles/10....

Foralumab for Multiple Sclerosis youtu.be/1KlKHHE9_aY?...

The United Arab Emirates has approved tolebrutinib (a bruton's tyrosine kinase inhibitor) for multiple sclerosis. it is not yet FDA/EMA approved. timesofindia.indiatimes.com/world/middle...

A randomized trial on fasting in MS from Germany showed modest reduction in neurofilament light chain (NfL) (-1.94 pg/mL, p = 0.042) and depression (p = 0.079) but no difference in T2 lesions on MRI. bmcnutr.biomedcentral.com/articles/10....

Is neutropenia (low neutrophils, a type of white blood cell) with b-cell depleters more common than we believed? In this center with 74 people taking ocrevus, 3/74 developed grade 3 or 4 neutropenia. www.msard-journal.com/article/S221...

UNDERSTANDING MORE ABOUT DISABILITY PROGRESSION IN MS with Dr. Ben Thrower. @MSViewsandNews youtu.be/dKd6t2oD4SQ?...

Professor Robert Fox on progressive MS and bruton's tyrosine kinase inhibitors. Tolebrutinib and the HERCULES trial result. www.medscape.com/viewarticle/...

Can you take b-cell depleters like ocrevus, kesimpta, and rituximab less often? According to this meta analysis of 19 studies on the topic, YES! "Extended interval dosing does not increase the risk of relapse, MRI activity, disability progression." www.msard-journal.com/article/S221...

mavenclad vs. rituximab for MS. This Real-World Effectiveness comparison study (not a randomized trial) suggests rituximab is likely superior with less MRI activity, fewer relapses, and less discontinuation over 4 years. www.pharmacytimes.com/view/compara...

Why Do Doctors Check Reflexes? youtu.be/_Z56N31BXAc?...

This updated analysis of randomized trials suggests vitamin D supplementation has a very small but real effect on reducing multiple sclerosis disability (p = 0.03) even thought most individual studies show no effect. eurjmedres.biomedcentral.com/articles/10....

AUGUST LIVE STREAM NOW! with @aaronbostermd.bsky.social ASK ME ANYTHING MULTIPLE SCLEROSIS! www.youtube.com/live/gA4IARR...

The gene HLA-A∗03:01 is associated with increased risk of fever/chills after the Pfizer-BioNTech COVID-19 vaccination and in a separate study is linked to greater benefit from the medication glatiramer acetate (copaxone) in people with multiple sclerosis pmc.ncbi.nlm.nih.gov/articles/PMC...

Multiple Sclerosis and Epstein Barr Virus youtube.com/shorts/kFpmL...