Vitamin D for multiple sclerosis. This network meta-analysis of 32 randomized trials suggests vitamin D is modestly effective and was associated with 20% few relapses and slightly less disability (0.22 points lower on the EDSS scale). www.clinicalnutritionjournal.com/article/S026...

Dr. John Corboy on the risk of relapse/new MRI lesions in people who stop disease modifying therapy and observational studies such as DISCOMS and DOTMS. He also discussed extended interval dosing with b-cell depleters. www.neurologylive.com/view/discont...

If you take a b-cell depleting drug (ocrevus, rituximab kesimpta) for multiple sclerosis while breastfeeding, will your infant's b-cell be affected? In this study (n=10), only one infant had b-cell counts below the 5th percentile. pubmed.ncbi.nlm.nih.gov/42226810/

Fenebrutinib Trial Deaths youtube.com/shorts/52jkG...

For people with advanced multiple sclerosis with significant mobility limitations, portable Ultra-low-field MRI for bedside imaging (top) could be an alternative to conventional MRI (bottom) pubmed.ncbi.nlm.nih.gov/42236621/

Coffee consumption is associated with about half the risk of multiple sclerosis in this case control study from Saudi Arabia (AOR = 0.53, 95% CI: [0.30–0.96], p < 0.04). nsj.researchcommons.org/journal/vol3...

How Immunosuppressive Are Multiple Sclerosis Drugs? Explained by Neurologist youtu.be/7-uLwh3oEFI?...

My first venture into the world of personal finance. An article I wrote about Indexed Universal Life (IUL) insurance for the @WCInvestor blog run by Dr. Jim Dahle . www.whitecoatinvestor.com/when-i-was-s...

higher levels of cerebrospinal fluid adenosine deaminase are [slightly] associated with greater disability in multiple sclerosis as measured by EDSS (expanded disability status score) pubmed.ncbi.nlm.nih.gov/42217432/

Dr. @aaronbostermd.bsky.social celebrates the 100,000 Subscribers YouTube silver play button youtu.be/eKw8JHqHjSA?...

The ORATORIO-HAND study, a randomized trial in ocrevus vs. placebo in primary progressive multiple sclerosis, including older patients and those with more advanced disease, is now PUBLISHED. pubmed.ncbi.nlm.nih.gov/42208561/

A 58-year-old woman taking rituximab had an MRI consistent with multiple sclerosis (A), but upon worsening symptoms, a new MRI revealed a large enhancing lesion (b/c). Diagnosis? Hint: you and ChatGPT will fail to guess this one.

Children who underwent tonsillectomy "had a 63% increased odds of MS (adjusted odds ratio (OR) = 1.63, 95% confidence interval (CI) = 1.01-2.64, p = 0.046)." Case control study; senior author Dr. Emmanuelle Waubant (UCSF) pubmed.ncbi.nlm.nih.gov/42212792/

Disability progression in children with MS who initiate high-efficacy disease modifying therapy as children (blue) vs. waiting until adulthood (Red). Mean difference in EDSS increase 0.53. (Data from MSBase; observational study, not a randomized trial) www.neurology.org/doi/10.1212/...

People with lower levels of NCS1 (Neuronal Calcium Sensor 1), expressed in neurons with effects on synaptic transmission and plasticity, have a greater risk of multiple sclerosis decades later. (data from United Kingdom Biobank) onlinelibrary.wiley.com/doi/10.1002/...

Kappa Free Light Chains Explained! youtube.com/shorts/vNXBJ...

Multiple sclerosis tends to lead to a decrease in future income years after diagnosis, even in people who are still able to work (Data from Norway) onlinelibrary.wiley.com/doi/10.1111/...

In this analysis of 10,499 people in the French MS Registry, stronger MS disease modifying therapies were NOT more effective in preventing progression independent of both relapses and MRI activity (PIRMA) compared to modestly effective therapies. academic.oup.com/brain/advanc...

Italy is accusing biogen of trying to block Sandoz's Tyruko, a biosimilar version of Tysabri, by limiting access to the anti-JCV Stratify test to Tysabri Users. The JC virus antibody test assesses the risk of PML, a rare brain infection with these drugs. www.reuters.com/legal/litiga...

Prescriptions for certain medications such as psychotropics and analgesics are slightly increased years prior to multiple sclerosis "onset." Data from Canada. journals.sagepub.com/doi/10.1177/...

Multiple Sclerosis: 9 Stupid Things Doctors Believed youtu.be/VnQKMd5kNu8?...

The incidence of multiple sclerosis in people of African descent on the Caribbean Island of Martinique is a miniscule 1 in 167,000, ~97% lower than the United States. pubmed.ncbi.nlm.nih.gov/42167044/

Kappa Free Light Chains vs Oligoclonal Bands youtube.com/shorts/z--7S...

THIS Gets Misdiagnosed as Multiple Sclerosis youtu.be/FkBuG69iYCU?...

Comedian John Poveromo will host a live 24 hours show on Twitch starting May 27, starting at 8 p.m. ET to support the @mssociety including cast members from popular TV shows “That ’70s Show” and “Sabrina the Teenage Witch.” multiplesclerosisnewstoday.com/news-posts/2...

In Ecuador, multiple sclerosis is very rare with a prevalence of only about 1 in 25,000 www.frontiersin.org/journals/neu...

Wealth causes multiple sclerosis? Prevalence of MS in child bearing age women vs. socio-demographic index. pubmed.ncbi.nlm.nih.gov/42148124/

Why I Don’t Always Dose Every 6 Months (MS Explained) by @aaronbostermd.bsky.social He proposes IgG and absolutely lymphocyte count of 600 as a useful marker of safety for b cell depleters (ocrevus/kesimpta/briumvi/rituximab) youtu.be/tAbwmaI4XJ4?...

Fenebrutinib & Liver Enzyme Elevation youtube.com/shorts/-Z7Ks...

A 12-year-old Italian girl was diagnosed with "radiologically isolated syndrome" (MS plaques without symptoms) after an equipment-test-scan. She was treated with tysabri, and 18 years later, she is stable and works as a geriatric medicine doctor. EDSS=0 pubmed.ncbi.nlm.nih.gov/42133273/

Potential mechanisms of action of Bruton's Tyrosine Kinase Inhibitors (i.e. tolebrutinib, fenebrutinib, evobrutinib) in Multiple Sclerosis pubmed.ncbi.nlm.nih.gov/42126690/

A new AI-powered tool called multiplexed MRI (MRx) may potentially be used to assess active multiple sclerosis plaques, removing the need to use gadolinium based contrast agents. www.nature.com/articles/s41...

Ocrevus in Advanced Progressive Multiple Sclerosis youtu.be/ALSLMzpPw3E?...

A case report of Enteroviral encephalitis in a 37 year old woman taking kesimpta for multiple sclerosis. IgG was normal and IgM was low. MRI brain (image) shows symmetrical lesions in the thalamus. She improved but with ongoing neuropsychiatric symptoms journals.sagepub.com/doi/10.1177/...

Incidence of multiple sclerosis in men and women at different ages (Data from Switzerland) www.msard-journal.com/article/S221...

In MS research, there is a strong correlation between preventing relapses and preventing disability progression, but these authors argue tolebrutinib is unique in that it prevents progression out of proportion to its ability to prevent relapses www.neurology.org/doi/10.1212/...

The FDA approves ocrevus for pediatric multiple sclerosis www.neurologylive.com/view/fda-app...

CLIPPERS Chronic lymphocytic inflammation w/ pontine perivascular enhancement responsive to steroids youtube.com/shorts/4xn4W...

The mechanism of action of medications for multiple sclerosis fatigue. From ChatGPT

a nice description of different forms of fatigue in multiple sclerosis courtesy of ChatGPT. SDMT is "symbol digit modalities test," a measure of processing speed.

Low back pain and arachnoiditis (clumping of the nerve roots) causing low back pain as a complication of Intrathecal Mesenchymal Stem Cell injection as an experimental Progressive Multiple Sclerosis treatment which was ineffective in this randomized trial pubmed.ncbi.nlm.nih.gov/42081777/

Fenebrutinib Deaths. An explanation of the 15 deaths in people taking fenebrutinib, and investigational BTK inhibitor, in multiple sclerosis clinical trials. youtu.be/TxP2ZjwSTXQ?...

How @aaronbostermd.bsky.social uses the Octave MS Blood Test (Real Cases) youtu.be/TBEIW6ByM1U?...

What foods consumed by teenagers predict lower future risk of late onset multiple sclerosis? Dairy (HR 0.21), seafood (HR 0.32), nuts (HR 0.37), fruits (HR 0.22, and vegetables (HR 0.26) [Data from Iran] pubmed.ncbi.nlm.nih.gov/42070054/

Dairy consumption has previously been linked to multiple sclerosis, but this Iranian study looked at late onset MS (mean age 61) vs. prior dairy consumption during adolescence, and those in the top third of dairy consumption had 79% lower risk. pubmed.ncbi.nlm.nih.gov/42070054/

Snoop Dogg is performing at the Race to Erase MS Foundation Benefit Gala June 5, 2026 at the Fairmont Century Plaza in Los Angeles. hiptv.tv/snoop-dogg-m...

Balo's concentric sclerosis (a multiple sclerosis variant). www.youtube.com/shorts/K_Ibc...

Georgia softball pitcher Addisen Fisher reveals that she has multiple sclerosis. proofpointisolation.com/browser?url=...

The OLYMPUS trial (rituximab vs. placebo in primary progressive multiple sclerosis). Rituximab appeared to be most effective in younger people with active lesions (bottom right corner, data is proportion with disability progression). pubmed.ncbi.nlm.nih.gov/19847908/

Risk of Progression independent of relapse and MRI activity (PIRMA) in people with MS on low/moderate efficacy vs. highly effective disease modifying therapy. pubmed.ncbi.nlm.nih.gov/42057337/