Are these MRI findings in people with multiple sclerosis? Shockingly, NO! They actually have Wolfram syndrome (WFS), a rare genetic disorder associated with pathogenic variants in WFS1 and is linked to optic atrophy, hearing loss and diabetes. www.frontiersin.org/journals/neu...

Lifestyle predictors of multiple sclerosis in Kuwait. Obesity is associated with triple the risk (adjusted OR = 3.12, 95% CI: 1.34-7.25) and high salt intake is linked to quintiple the risk (adjusted OR = 5.05, 95% CI: 2.22-11.51) pubmed.ncbi.nlm.nih.gov/41248103/

Tyruko, a tysabri biosimilar for multiple sclerosis, is now available in the US. www.fiercepharma.com/pharma/after...

How I Manage Sleep with MS by Vickie Hadge youtu.be/aJyhOYAFbCc?...

Doug Whitney, despite having a presenilin 2 (PSEN2) gene mutation with a "100% risk" early onset Alzheimer's disease is now 75 without cognitive decline despite abundant amyloid plaques in his brain (but low Tau) youtu.be/uMa1cdahkcA?...

Dr. Mike shares his story of 3 separate "Is a doctor in the house" calls on one flight! youtu.be/odpibIeCP7s?...

Paramagnetic rim lesions in multiple sclerosis (which appear dark on SWI sequence and are often periventricular) are associated with nearly triple the risk of disability progression (OR 2.87; 95 % CI: 1.01–8.1; p = 0.05) pubmed.ncbi.nlm.nih.gov/41205558/

People who drink coffee have a 22% reduced risk of multiple sclerosis according to this meta analysis: pubmed.ncbi.nlm.nih.gov/41212037/

A summary of the 2024 McDonald Diagnostic Criteria for Multiple Sclerosis. jamanetwork.com/journals/jam...

The "cascade" (waterfall) sign on coronal images on MRI can be see with multiple sclerosis (image 1), myelin oligodendrocyte glycoprotein associated disease (image 2), glioma (image 3), and behcet's disease (image 5) journals.lww.com/neur/fulltex...

The target of various multiple sclerosis drugs. (OCR = ocrevus, INF = interferon, NTZ = tysabri, FTY = gilenya, CLAD = cladribine, ALEM = Lemtrada, GA = copaxone, SPN = Mayzent, OZN = zeposia, PON = Ponvory, TF = tecfidera, MMF = bafiertam) onlinelibrary.wiley.com/doi/10.1111/...

Early (Prodromal) Multiple Sclerosis Symptoms Explained by Neurologist youtu.be/J8HmPoUts5I?...

New data on fenebrutinib. It had similar efficacy to ocrevus in primary progressive MS in the FENTREPID trial and was superior to aubagio in relapsing MS in the FENHANCE trial. www.fiercebiotech.com/biotech/roch...

Multiple sclerosis is generally speaking less heritable than many other neurological diseases. pmc.ncbi.nlm.nih.gov/articles/PMC...

Can you switch from Ocrevus or rituximab to Kesimpta for MS. Yes. In this phase 3b (unrandomized) trial (OLIKOS study), changing to kesimpta was linked to a low rate of new MRI lesions (2.3% with new/enlarging lesions) and relapses (0.075 per year). pubmed.ncbi.nlm.nih.gov/41196386/

Clay Walker, the country music star who has had multiple sclerosis for 30 years, underwent surgery to install a baclofen pump to treat lower extremity spasticity. people.com/clay-walker-...

Foot Drop Devices Explained by Neurologist youtube.com/shorts/x7Roe...

A New B-Cell Drug for MS! Obexelimab Explained by Neurologist youtu.be/14igQ8fL2d4?...

Natalie Grabow (age 80) completes an ironman (2.4-mile (3.8 km) swim, a 112-mile (180 km) bike ride, and a 26.2-mile (42.2 km) marathon run) youtu.be/qNGPtG4Y7h4?...

3 multiple sclerosis clinical trials to watch: REMODEL-2: Rhapsido (remibrutinib) vs. aubagio. OVERLORD-MS trial (rituximab vs. ocrevus). ENSURE-1 (vidofludimus calcium vs. placebo). www.clinicaltrialsarena.com/features/mul...

The rate of multiple sclerosis misdiagnosis in Saudi Arabia is 4.4% according to this article pubmed.ncbi.nlm.nih.gov/41175533/

In a study of 405 Asian people with multiple sclerosis, only one tested positive for Myelin oligodendrocyte glycoprotein immunoglobulin G(MOG-IgG) at 1:100 titer, but their MRI findings are typical of MS. Does this antibody have meaning for those with MS? onlinelibrary.wiley.com/doi/10.1111/...

10 Strange Things About Multiple Sclerosis youtu.be/FyTTRLjEpjM?...

# MS_Selfie Newsletter - MS and divorce If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? => gavingiovannoni.substack.com/p/ms-and-div...

A different type of b-cell drug for MS? Obexelimab inhibits b cell function by binding to CD19 and FcγRIIb, and a phase II trial showed a 95% reduction in enhancing lesions [MoonStone trial]. www.fiercebiotech.com/biotech/zena...

Another observational study suggesting IVIG is probably an effective treatment of relapsing MOG-antibody associated disease. This study on children with MOGAD found a relapse rate with IVIG compared to 33% with cellcept/imuran/rituximab) pubmed.ncbi.nlm.nih.gov/41092852/

Will this MSARD Editorial on "When does multiple sclerosis start?" impact the field of MS and change the way we think about the disease? => www.msard-journal.com/article/S221...

Do carbs cause MS? This study from England found a slight association between higher carbohydrate intake and risk of MS (a 21% increase per quartile of increased consumption) pmc.ncbi.nlm.nih.gov/articles/PMC...

Do medications for alzheimer's disease work for people with MS with cognitive impairment? Probably not. The data for Namenda and cholinesterase inhibitors is bad. There is some positive data on stimulants. Image is Symbol digits modalities test. pmc.ncbi.nlm.nih.gov/articles/PMC...

61 year old Italian man with progressive MS was started on zeposia and developed this [asymptomatic] abnormality on screening ocular computed tomography (OCT). Diagnosis?

The TREAT-MS trial is an ongoing randomized trial to see if early use of higher-efficacy disease-modifying therapy (DMT) reduces later risk of disability in multiple sclerosis (MS). Link is baseline participants of the trial participants. pubmed.ncbi.nlm.nih.gov/41135813/

Alpha Brain Supplement: My Experience youtube.com/shorts/YnGSi...

2025 Nobel Prize in Medicine/Physiology for Peripheral Immune Tolerance youtu.be/t61mQL9boAQ?...

A summary of the efficacy of ublituximab (briumvi) on prevention of relapses and MRI activity in multiple sclerosis (data from the ULTIMATE I/II trials) pmc.ncbi.nlm.nih.gov/articles/PMC...

Master Health Insurance in Minutes: A Practical Guide by @AaronBosterMD youtu.be/D5gyy7STIqA?...

Which YouTube Thumbnail do you prefer?

Neurological Disorders Associated with B12 Deficiency youtube.com/shorts/YHc1n...

Shohei Ohtani is good at baseball

Congratulations to 2025 Nobel prize in medicine winners Fred Ramsdell, Mary Brunkow, and Shimon Sakaguchi for discoveries related to immune system tolerance such as Transcription Factor Foxp3, believed to have importance in autoimmune disease www.nobelprize.org/prizes/medic...

Octave Multiple Sclerosis Disease Activity (MSDA) Test youtu.be/KNSXmlJTUUg?...

The effect on brain atrophy of different MS disease modifying therapies based on a network meta-analysis (click the image) pubmed.ncbi.nlm.nih.gov/41080911/

What is the risk of serious infections with ocrevus? According to this meta-analysis, about 6% www.tandfonline.com/doi/full/10....

Does anyone have suggestions for YouTube videos I could make about multiple sclerosis?

The O-HAND trial: Ocrevus showed benefits in primary progressive MS [data presented at ECTRIMS, unpublished]. 30% reduction in a composite disability endpoint compared to placebo. www.neurologylive.com/view/underst....

Researchers from Saudi Arabia at a tertiary care center report that 6.6% of those referred for multiple sclerosis were actually misdiagnosed. Most were prescribed unnecessary medication. pubmed.ncbi.nlm.nih.gov/41067083/

People with higher income with multiple sclerosis in New Zeland were more likely to receive highly effective disease modifying therapy. pubmed.ncbi.nlm.nih.gov/41072254/

Can you take tysabri during pregnancy? Based on a cohort (n=30, Iran): "continuing [including] during pregnancy, including into the third trimester, appeared to be generally well tolerated and not associated with major maternal or neonatal complications." pubmed.ncbi.nlm.nih.gov/41076768/

A thumbnail created by me (left) vs. chat gpt (right). Which do you prefer?

Selma Blair's Multiple Sclerosis Journey youtube.com/shorts/kuZoI...

#MS_Selfie Newsletter - Nitrofurantoin warning: please read Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. => buff.ly/7gPsotL