@brandon-beaber.bsky.social
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Are these MRI findings in people with multiple sclerosis? Shockingly, NO! They actually have Wolfram syndrome (WFS), a rare genetic disorder associated with pathogenic variants in WFS1 and is linked to optic atrophy, hearing loss and diabetes.
www.frontiersin.org/journals/neu...
about 18 hours ago
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Lifestyle predictors of multiple sclerosis in Kuwait. Obesity is associated with triple the risk (adjusted OR = 3.12, 95% CI: 1.34-7.25) and high salt intake is linked to quintiple the risk (adjusted OR = 5.05, 95% CI: 2.22-11.51)
pubmed.ncbi.nlm.nih.gov/41248103/
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The role of dietary and lifestyle factors in multiple sclerosis risk in a middle eastern country: A case-control study - PubMed
This study identified high sodium intake, inadequate vitamin B2 consumption, and obesity as significant risk factors for MS, while regular light physical activity appeared to lower MS risk. Public health initiatives addressing these factors may help reduce MS risk in Kuwait and other similar setting âŠ
https://pubmed.ncbi.nlm.nih.gov/41248103/
about 18 hours ago
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Tyruko, a tysabri biosimilar for multiple sclerosis, is now available in the US.
www.fiercepharma.com/pharma/after...
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After delay, Sandoz's biosimilar Tyruko launches in US to pressure Biogen's blockbuster MS med Tysabri
The clock is up on Biogenâs extra two years of a biosimilar-free U.S. market for its blockbuster multiple sclerosis (MS) med Tysabri. | Biogen has had two years to gear up for the impending launch of ...
https://www.fiercepharma.com/pharma/after-delay-sandozs-biosimilar-tyruko-launches-us-put-pressure-biogens-blockbuster-ms-med
about 18 hours ago
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How I Manage Sleep with MS by Vickie Hadge
youtu.be/aJyhOYAFbCc?...
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How I Manage Sleep with MS - My 8 Top Tips
YouTube video by Multiple Sclerosis? Even So, It Is Well
https://youtu.be/aJyhOYAFbCc?si=3YTwBJljNYDTFZ5c
2 days ago
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Doug Whitney, despite having a presenilin 2 (PSEN2) gene mutation with a "100% risk" early onset Alzheimer's disease is now 75 without cognitive decline despite abundant amyloid plaques in his brain (but low Tau)
youtu.be/uMa1cdahkcA?...
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Why one man with a genetic predisposition for Alzheimer's disease is defying the odds
YouTube video by PBS NewsHour
https://youtu.be/uMa1cdahkcA?si=y_LC_-TMHl43dTQs
3 days ago
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Dr. Mike shares his story of 3 separate "Is a doctor in the house" calls on one flight!
youtu.be/odpibIeCP7s?...
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3 Medical Emergencies On My Flight!
YouTube video by Doctor Mike
https://youtu.be/odpibIeCP7s?si=hoy_UN_jcVWQsz_5
4 days ago
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Paramagnetic rim lesions in multiple sclerosis (which appear dark on SWI sequence and are often periventricular) are associated with nearly triple the risk of disability progression (OR 2.87; 95 % CI: 1.01â8.1; p = 0.05)
pubmed.ncbi.nlm.nih.gov/41205558/
6 days ago
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People who drink coffee have a 22% reduced risk of multiple sclerosis according to this meta analysis:
pubmed.ncbi.nlm.nih.gov/41212037/
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Coffee consumption and risk of multiple sclerosis (MS): a systematic review and meta-analysis - PubMed
Coffee consumption was associated with a lower risk of MS in pooled analysis, but the substantial heterogeneity limits the strength and generalizability of this conclusion. Larger, multi-centric studies are recomended.
https://pubmed.ncbi.nlm.nih.gov/41212037/
6 days ago
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A summary of the 2024 McDonald Diagnostic Criteria for Multiple Sclerosis.
jamanetwork.com/journals/jam...
6 days ago
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The "cascade" (waterfall) sign on coronal images on MRI can be see with multiple sclerosis (image 1), myelin oligodendrocyte glycoprotein associated disease (image 2), glioma (image 3), and behcet's disease (image 5)
journals.lww.com/neur/fulltex...
6 days ago
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The target of various multiple sclerosis drugs. (OCR = ocrevus, INF = interferon, NTZ = tysabri, FTY = gilenya, CLAD = cladribine, ALEM = Lemtrada, GA = copaxone, SPN = Mayzent, OZN = zeposia, PON = Ponvory, TF = tecfidera, MMF = bafiertam)
onlinelibrary.wiley.com/doi/10.1111/...
6 days ago
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Early (Prodromal) Multiple Sclerosis Symptoms Explained by Neurologist
youtu.be/J8HmPoUts5I?...
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Early (Prodromal) Multiple Sclerosis Symptoms Explained by Neurologist
YouTube video by Dr. Brandon Beaber
https://youtu.be/J8HmPoUts5I?si=oX-n0xuBMvE8SUAF
6 days ago
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New data on fenebrutinib. It had similar efficacy to ocrevus in primary progressive MS in the FENTREPID trial and was superior to aubagio in relapsing MS in the FENHANCE trial.
www.fiercebiotech.com/biotech/roch...
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Roche reports phase 3 multiple sclerosis wins for BTK inhibitor, succeeding where rivals failed
Roche has
https://www.fiercebiotech.com/biotech/roche-reports-phase-3-multiple-sclerosis-wins-btk-inhibitor-succeeding-where-rivals-failed
8 days ago
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Multiple sclerosis is generally speaking less heritable than many other neurological diseases.
pmc.ncbi.nlm.nih.gov/articles/PMC...
9 days ago
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Can you switch from Ocrevus or rituximab to Kesimpta for MS. Yes. In this phase 3b (unrandomized) trial (OLIKOS study), changing to kesimpta was linked to a low rate of new MRI lesions (2.3% with new/enlarging lesions) and relapses (0.075 per year).
pubmed.ncbi.nlm.nih.gov/41196386/
9 days ago
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Clay Walker, the country music star who has had multiple sclerosis for 30 years, underwent surgery to install a baclofen pump to treat lower extremity spasticity.
people.com/clay-walker-...
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Clay Walker Says He's 'Going Through a Rough Patch' with MS but Refuses to Give Up: 'I'm Like a Pit Bull' (Exclusive)
Country singer Clay Walker has been living with multiple sclerosis for 30 years. Amid recurring flare-ups, he had a pump implanted in early 2025 to deliver medication into his spinal fluid to ease spa...
https://people.com/clay-walker-multiple-sclerosis-exclusive-11845590
9 days ago
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Foot Drop Devices Explained by Neurologist
youtube.com/shorts/x7Roe...
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Foot Drop Devices Explained by Neurologist
YouTube video by Dr. Brandon Beaber
https://youtube.com/shorts/x7RoeX0IOr8?si=tuPIpCkgob_Z_fc_
11 days ago
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A New B-Cell Drug for MS! Obexelimab Explained by Neurologist
youtu.be/14igQ8fL2d4?...
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A New B-Cell Drug for MS! Obexelimab Explained by Neurologist
YouTube video by Dr. Brandon Beaber
https://youtu.be/14igQ8fL2d4?si=F2h4JqFmPySFP4vA
13 days ago
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Natalie Grabow (age 80) completes an ironman (2.4-mile (3.8 km) swim, a 112-mile (180 km) bike ride, and a 26.2-mile (42.2 km) marathon run)
youtu.be/qNGPtG4Y7h4?...
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Natalie Grabow, 80, becomes oldest woman to finish Ironman World Championship | NewsNation
YouTube video by NewsNation
https://youtu.be/qNGPtG4Y7h4?si=D5XsjZRa5fxCfy6d
14 days ago
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3 multiple sclerosis clinical trials to watch: REMODEL-2: Rhapsido (remibrutinib) vs. aubagio. OVERLORD-MS trial (rituximab vs. ocrevus). ENSURE-1 (vidofludimus calcium vs. placebo).
www.clinicaltrialsarena.com/features/mul...
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Multiple sclerosis: three trials to watch
Following ECTRIMS 2025, Clinical Trials Arena explores the potential of some major Phase III assets in multiple sclerosis (MS).
https://www.clinicaltrialsarena.com/features/multiple-sclerosis-ms-trials-to-watch-phase-iii/?cf-view
16 days ago
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The rate of multiple sclerosis misdiagnosis in Saudi Arabia is 4.4% according to this article
pubmed.ncbi.nlm.nih.gov/41175533/
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Misdiagnosis of multiple sclerosis: Two tertiary centers experience in Saudi Arabia - PubMed
Precise diagnosis is the first and most important management step for any disease. Misdiagnosis of multiple sclerosis (MS) will result in profound consequences for patient morbidity, family, and healthcare systems. Misdiagnosis may delay appropriate care and lead to unnecessary or harmful treatments âŠ
https://pubmed.ncbi.nlm.nih.gov/41175533/
16 days ago
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In a study of 405 Asian people with multiple sclerosis, only one tested positive for Myelin oligodendrocyte glycoprotein immunoglobulin G(MOG-IgG) at 1:100 titer, but their MRI findings are typical of MS. Does this antibody have meaning for those with MS?
onlinelibrary.wiley.com/doi/10.1111/...
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MOGâIgG Frequency in Multiple Sclerosis: Diagnostic Challenges With LowâTiter Results
Background Myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) positivity has been reported in some people with multiple sclerosis (pwMS), posing a diagnostic challenge. However, most stu.....
https://onlinelibrary.wiley.com/doi/10.1111/ene.70356
18 days ago
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10 Strange Things About Multiple Sclerosis
youtu.be/FyTTRLjEpjM?...
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10 Strange Things About Multiple Sclerosis
YouTube video by Dr. Brandon Beaber
https://youtu.be/FyTTRLjEpjM?si=2JmqfFL-LDuuSVFP
20 days ago
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reposted by
Prof G
21 days ago
# MS_Selfie Newsletter - MS and divorce If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer. Do you agree? =>
gavingiovannoni.substack.com/p/ms-and-div...
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MS and divorce
If I were to design a comprehensive MS service, I would ensure that relationship counselling was part of the core services we offer.
https://gavingiovannoni.substack.com/p/ms-and-divorce
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A different type of b-cell drug for MS? Obexelimab inhibits b cell function by binding to CD19 and FcÎłRIIb, and a phase II trial showed a 95% reduction in enhancing lesions [MoonStone trial].
www.fiercebiotech.com/biotech/zena...
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Zenas' lead autoimmune drug prompts 95% reduction in new brain lesions in phase 2 MS study
Zenas Biopharmaâs lead autoimmune drug has been tied to a 95% reduction in a type of brain lesions over 12 weeks in a phase 2 multiple sclerosis (MS) study. | Zenas Biopharmaâs lead autoimmune drug h...
https://www.fiercebiotech.com/biotech/zenas-lead-autoimmune-drug-sees-95-lesion-reduction-phase-2-ms-study
22 days ago
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Another observational study suggesting IVIG is probably an effective treatment of relapsing MOG-antibody associated disease. This study on children with MOGAD found a relapse rate with IVIG compared to 33% with cellcept/imuran/rituximab)
pubmed.ncbi.nlm.nih.gov/41092852/
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Treatment response in children with relapsing MOG-antibody associated disease - PubMed
Our study supports monthly IVIG as maintenance therapy in children after the second MOGAD episode.
https://pubmed.ncbi.nlm.nih.gov/41092852/
22 days ago
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reposted by
Prof G
24 days ago
Will this MSARD Editorial on "When does multiple sclerosis start?" impact the field of MS and change the way we think about the disease? =>
www.msard-journal.com/article/S221...
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When does multiple sclerosis start?
The question of when multiple sclerosis (MS) starts is not a trivial one. It has implications for primary and secondary MS prevention studies (Giovannoni et al., 2025a; Zane et al., 2025). A recentâŠ
https://www.msard-journal.com/article/S2211-0348(25)00460-2/fulltext
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Do carbs cause MS? This study from England found a slight association between higher carbohydrate intake and risk of MS (a 21% increase per quartile of increased consumption)
pmc.ncbi.nlm.nih.gov/articles/PMC...
23 days ago
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Do medications for alzheimer's disease work for people with MS with cognitive impairment? Probably not. The data for Namenda and cholinesterase inhibitors is bad. There is some positive data on stimulants. Image is Symbol digits modalities test.
pmc.ncbi.nlm.nih.gov/articles/PMC...
23 days ago
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61 year old Italian man with progressive MS was started on zeposia and developed this [asymptomatic] abnormality on screening ocular computed tomography (OCT). Diagnosis?
23 days ago
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The TREAT-MS trial is an ongoing randomized trial to see if early use of higher-efficacy disease-modifying therapy (DMT) reduces later risk of disability in multiple sclerosis (MS). Link is baseline participants of the trial participants.
pubmed.ncbi.nlm.nih.gov/41135813/
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The TRaditional versus Early Aggressive Therapy for MS (TREAT-MS) trial: Design and baseline characteristics of participants - PubMed
TREAT-MS seeks to address how early DMT strategy influences MS disability and related outcomes. The results will be generalizable to future individuals newly diagnosed with RRMS who, with their clinicians, will be able to use them to make data-driven DMT decisions about how to maximize their interme âŠ
https://pubmed.ncbi.nlm.nih.gov/41135813/
23 days ago
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Alpha Brain Supplement: My Experience
youtube.com/shorts/YnGSi...
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Alpha Brain: My Experience
YouTube video by Dr. Brandon Beaber
https://youtube.com/shorts/YnGSi8QW3xY?si=vb_nj2UVy8D77OZd
25 days ago
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2025 Nobel Prize in Medicine/Physiology for Peripheral Immune Tolerance
youtu.be/t61mQL9boAQ?...
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2025 Nobel Prize in Medicine/Physiology for Peripheral Immune Tolerance
YouTube video by Dr. Brandon Beaber
https://youtu.be/t61mQL9boAQ?si=e_IFOcVs2_r_UOHb
27 days ago
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A summary of the efficacy of ublituximab (briumvi) on prevention of relapses and MRI activity in multiple sclerosis (data from the ULTIMATE I/II trials)
pmc.ncbi.nlm.nih.gov/articles/PMC...
29 days ago
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Master Health Insurance in Minutes: A Practical Guide by @AaronBosterMD
youtu.be/D5gyy7STIqA?...
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Master Health Insurance in Minutes: A Practical Guide
YouTube video by Aaron Boster MD
https://youtu.be/D5gyy7STIqA?si=yfCwXd61csV15qkd
29 days ago
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Which YouTube Thumbnail do you prefer?
about 1 month ago
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Neurological Disorders Associated with B12 Deficiency
youtube.com/shorts/YHc1n...
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Neurological Disorders Associated with B12 Deficiency
YouTube video by Dr. Brandon Beaber
https://youtube.com/shorts/YHc1n6LGMOs?si=HgHaWIxljP8ocZFU
about 1 month ago
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Shohei Ohtani is good at baseball
about 1 month ago
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Congratulations to 2025 Nobel prize in medicine winners Fred Ramsdell, Mary Brunkow, and Shimon Sakaguchi for discoveries related to immune system tolerance such as Transcription Factor Foxp3, believed to have importance in autoimmune disease
www.nobelprize.org/prizes/medic...
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Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded jointly to Mary E. Brunkow, Frederick J. Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
https://www.nobelprize.org/prizes/medicine/2025/summary/
about 1 month ago
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Octave Multiple Sclerosis Disease Activity (MSDA) Test
youtu.be/KNSXmlJTUUg?...
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Octave Multiple Sclerosis Disease Activity (MSDA)Â Test Explained by Neurologist
YouTube video by Dr. Brandon Beaber
https://youtu.be/KNSXmlJTUUg?si=VNb8ayMRpk_jGRBK
about 1 month ago
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The effect on brain atrophy of different MS disease modifying therapies based on a network meta-analysis (click the image)
pubmed.ncbi.nlm.nih.gov/41080911/
about 1 month ago
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What is the risk of serious infections with ocrevus? According to this meta-analysis, about 6%
www.tandfonline.com/doi/full/10....
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Hypogammaglobulinemia and infections in patients with multiple sclerosis treated with anti-CD20 monoclonal antibodies: a systematic review and meta-analysis of observational studies
Monoclonal antibodies targeting CD20 (anti-CD20 mAbs) used in patients with multiple sclerosis (MS) can cause hypogammaglobulinemia and increase the risk of infections. We aim to identify the propo...
https://www.tandfonline.com/doi/full/10.1080/14740338.2025.2574668
about 1 month ago
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Does anyone have suggestions for YouTube videos I could make about multiple sclerosis?
about 1 month ago
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The O-HAND trial: Ocrevus showed benefits in primary progressive MS [data presented at ECTRIMS, unpublished]. 30% reduction in a composite disability endpoint compared to placebo.
www.neurologylive.com/view/underst...
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Understanding Ocrelizumabâs Impact on Advanced Progressive MS: Insights From Dr. Gavin Giovannoni | NeurologyLive - Clinical Neurology News and Neurology Expert Insights
Gavin Giovannoni, MBBCh, PhD, FCP, FRCP, FRCPath, lead investigator of the phase 3 ORATORIO-HAND trial, provided comment on the results presented at ECTRIMS 2025, highlighting ocrelizumabâs therapeuti...
https://www.neurologylive.com/view/understanding-ocrelizumab-impact-advanced-progressive-ms-insights-from-dr-giovannoni#:~:text=All%20told%2C%20ocrelizumab%20outperformed%20placebo,therapy%20beyond%20traditional%20disability%20cutoffs
about 1 month ago
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Researchers from Saudi Arabia at a tertiary care center report that 6.6% of those referred for multiple sclerosis were actually misdiagnosed. Most were prescribed unnecessary medication.
pubmed.ncbi.nlm.nih.gov/41067083/
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The frequency and characteristics of multiple sclerosis misdiagnosis referrals to a tertiary center in Saudi Arabia - PubMed
MS misdiagnosis is frequent, especially in atypical cases or non-specialist evaluations. Early referral and strict use of McDonald's criteria may reduce diagnostic errors and healthcare costs.
https://pubmed.ncbi.nlm.nih.gov/41067083/
about 1 month ago
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People with higher income with multiple sclerosis in New Zeland were more likely to receive highly effective disease modifying therapy.
pubmed.ncbi.nlm.nih.gov/41072254/
about 1 month ago
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Can you take tysabri during pregnancy? Based on a cohort (n=30, Iran): "continuing [including] during pregnancy, including into the third trimester, appeared to be generally well tolerated and not associated with major maternal or neonatal complications."
pubmed.ncbi.nlm.nih.gov/41076768/
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Maternal and neonatal outcomes associated with natalizumab exposure during pregnancy in Iranian patients with multiple sclerosis - PubMed
In this cohort, continuing NTZ during pregnancy, including into the third trimester, appeared to be generally well tolerated and not associated with major maternal or neonatal complications. While onl...
https://pubmed.ncbi.nlm.nih.gov/41076768/
about 1 month ago
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A thumbnail created by me (left) vs. chat gpt (right). Which do you prefer?
about 1 month ago
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Selma Blair's Multiple Sclerosis Journey
youtube.com/shorts/kuZoI...
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Selma Blair's Multiple Sclerosis Journey
YouTube video by Dr. Brandon Beaber
https://youtube.com/shorts/kuZoIOI2cok?si=wgCeuOlXFQRH5m_X
about 1 month ago
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reposted by
Prof G
about 1 month ago
#MS_Selfie
Newsletter - Nitrofurantoin warning: please read Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs. =>
buff.ly/7gPsotL
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Nitrofurantoin warning: please read
Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections (UTIs) and is also used long-term as a urinary antiseptic to prevent UTIs.
https://gavingiovannoni.substack.com/p/nitrofurantoin-warning-please-read
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