Upcoming Videos: 3/4/26: The Irony of Dr. Terry Wahls 3/11/26: Kappa Free Light Chains 3/18/26: Lucid MS 3/25/26: MS Drug Overview www.youtube.com/@DrBrandonBe...

FEBRUARY 2026 LIVE STREAM NOW! ASK ME ANYTHING MULTIPLE SCLEROSIS! by @aaronbostermd.bsky.social www.youtube.com/live/gvsnk3F...

A study on the central vein sign and paramagnetic rim lesions in Asian people with multiple sclerosis shows similar data to other ethnicities. PRL 100% specific but only present in 63% with MS. 6 or more central veins 69.1% sensitivity/98.1% specificity pubmed.ncbi.nlm.nih.gov/41755542

Benign Multiple Sclerosis Stories youtube.com/shorts/FRZFF...

These researchers are using cell phone games to monitor cognitive function in multiple sclerosis www.frontiersin.org/journals/dig...

This study found that risk of pediatric multiple sclerosis is double when both parents are smokers (crude OR 2.03, 95% CI 1.12–3.68). Data from Italy link.springer.com/article/10.1...

Answering Multiple Sclerosis Questions People Ask ChatGPT youtu.be/TZQI8USe5p8?...

Answering Multiple Sclerosis Questions People Ask ChatGPT youtu.be/TZQI8USe5p8?...

In this fascinating study, people with inflammatory bowel disease treated with vedolizumab (entyvio) have a lower risk of multiple sclerosis even though it only binds alpha-4-integrin in the GI tract and not the brain (unlike Tysabri) pubmed.ncbi.nlm.nih.gov/41726318/

This drug reduced multiple sclerosis disability progression in a randomized trial but is very rarely prescribed. Can you guess what it is?

Why This MS Patient Waited 5 Years for Treatment by @aaronbostermd.bsky.social youtu.be/SyWMRsmsBEo?...

Novantrone, no longer used in multiple sclerosis due to risks of heart failure and leukemia actually had fairly impressive data for its time in disability, relapse, and MRI outcomes.

Predictors of worsening disability in multiple sclerosis: being older, having other autoimmune diseases, more disability at baseline, low physical activity, being overweight/obese, smoking, low sun exposure (data from 3567 individuals with newly diagnosed with MS in Sweden).

New remyelinating drug Lucid-MS soon to enter phase 2 clinical trials Courtesy of Pam from the channel "You Me and Multiple Sclerosis" youtu.be/Qp8ASYzNw8o?...

Neuromyelitis Optica NMO Cause youtube.com/shorts/J0pcM...

80 Year old Gary Patton Old breaks the Indoor Mile World Record for the 80-84 year-old age group in 6:38.10 youtu.be/Ko7vX6Lx6Kg?...

Life expectancy in athletes based on a 2024 observational study looking at data between 1862 and 2002 from 183 countries across 44 sports. Pole vaulters lived the longest (8.4 years longer than the general population) pmc.ncbi.nlm.nih.gov/articles/PMC...

Very high doses of melatonin can be toxic to the liver. In this study on very high doses (300mg daily) in primary progressive multiple sclerosis, there was "liver toxicity in three of the four patients randomised to receive melatonin" pubmed.ncbi.nlm.nih.gov/41706381/

Multiple Sclerosis Diagnostic Criteria Explained in graphical form youtu.be/GSHrMn9w0lM?...

Did the FDA make the right decision in not approving tolebrutinib for secondary progressive multiple sclerosis? Professor Gavin Giovannoni @gavingiovannoni.bsky.social and others say "no" in this very interesting editorial. pubmed.ncbi.nlm.nih.gov/41688144/

This analysis of the French MS registry suggests the superiority of highly effective disease modifying therapies in preventing disability progression is primarily due to suppression of relapses and new MRI lesions rather than "PIRA" pubmed.ncbi.nlm.nih.gov/41689266/

In the Mazandaran province in Iran, multiple sclerosis prevalence has increased from about 1 in 500,000 in 1994 to about 1 in 800 in 2023! pubmed.ncbi.nlm.nih.gov/41689909/

Use of "platform" (left) and "highly effective" disease modifying therapies for multiple sclerosis in Saudi Arabia. www.frontiersin.org/journals/neu...

Multiple sclerosis in Nepal is thought to be rare (only about 15 new referrals at a tertiary training center in Kathmandu. They primarily use azathioprine and rituximab as disease modifying therapies. www.neurology.org/doi/10.1212/...

Legendary MS researcher Dr. Stephen Hauser (USCF, known for research on b-cell depleters like rituximab and ocrevus) intends to study NKTR-0165, an antibody which stimulates tumor necrosis factor receptor 2 (TNFR2), expressed in regulatory t-cells. www.prnewswire.com/news-release...

Dr. Jeff Cohen on randomized trials for hematopoietic stem cell transplantation against highly effective disease modifying therapies (i.e. BEAT-MS) and CAR-T therapy. www.neurologylive.com/view/where-s...

Multiple Sclerosis Disease Prognosis youtu.be/02jgfdq5iRk?...

Dr. @aaronbostermd.bsky.social 100,000 Subscriber Tribute! www.youtube.com/watch?v=98s1...

Dr. Aaron Boster @aaronbostermd.bsky.social is nearly at 100,000 subscribers on YouTube! Go to his channel and subscribe: www.youtube.com/@AaronBosterMD

Risk factors for serious infections with ocrevus and kesimpta: low white blood cells (p < 0.0001), long term use (p = 0.0409), progressive MS (p = 0.0001), lower baseline immunoglobulin G (IgG), and older age. journals.sagepub.com/doi/10.1177/...

A randomized trial for Daratumumab (an anti-CD38 agent, on plasma cells and natural killer cells) for Neuromyelitis optica spectrum disorder (NMOSD) reduced relapses by 74%. Not great in my opinion. www.neurologylive.com/view/interpr...

Advice from @aaronbostermd.bsky.social Choosing Your First MS Drug youtu.be/_EaQYD1wqhA?...

#MS_Selfie Q&A 143 - ACTRIMS 2026: BTK inhibition in PPMS “MS at a Crossroads” - a new treatment for Primary Progressive Multiple Sclerosis => buff.ly/zsTJOAK

Do spinal tap results (oligoclonal bands or kappa free light chains) predict progression in primary progressive multiple sclerosis? No. This study (n=121, 5 countries) found no clear correlation. www.frontiersin.org/journals/imm...

k-FLC level in the cerebrospinal fluid (CSF), now part of the diagnostic criteria of MS, is linked with lower normalized brain volume (r = − 0.311, p = 0.003) and faster brain atrophy. link.springer.com/article/10.1...

People with "clinically isolated syndrome" (a first demyelinating event without a formal diagnosis of MS) with a higher κ-FLC Index based on a spinal tap were more likely to develop clinically definite multiple sclerosis uhttps://pubmed.ncbi.nlm.nih.gov/34049994/

Patterns of oligoclonal IgG bands in the cerebrospinal fluid and serum. Type II (OCBs in the CSF but not serum) and type III (OCBs in the CSF and serum, but some OCBs in the CSF not present in the serum) are associated with multiple sclerosis pmc.ncbi.nlm.nih.gov/articles/PMC...

Is it worthwhile to sent serum with CSF when testing for Kappa free light chain index (κFLCi) for the diagnosis of MS? The sensitivity/specific isn't great with different cutoffs (see image). Does it make more sense to just send CSF and not serum and use κ-FLC concentration?

ChatGPT answering the question, "create a caricature of me and my job based on everything you know about me." Somehow it thinks I'm rich and play dungeons and dragons.

Is Multiple Sclerosis prognosis improving over time? H/T @brandon-beaber.bsky.social youtube.com/shorts/5ghnYsERHx4?time_continue=2&embeds_referring_euri=https%3A%2F%2Fx.com%2F&source_ve_path=Mjg2NjY

MS Prognosis is Improving Over Time youtube.com/shorts/5ghnY...

Glatiramer in progressive MS? This small open label unrandomized tial in PPMS with a long acting depot injection showed stable disability (mean EDSS 5.1 at baseline and 4.5 at 3 years), though the rate of brain atrophy was similar untreated progressive MS www.abstractsonline.com/pp8/#!/21408...

#MS_Selfie => What is an MS label? These MS labels have now become sticky and inform clinical practice. What label best describes your MS? => gavingiovannoni.substack.com/p/what-is-an...

Multiple Sclerosis MRI Findings Explained by Neurologist youtu.be/ftc9wvJCW9s?...

Can testing Neurofilament Light Chain predict whether people with multiple sclerosis will respond to a certain medication? Not really. This analysis from Sweden suggests clinical and demographic factors are more prognostic. onlinelibrary.wiley.com/doi/10.1111/...

Ocrevus vs. Tysabri. Which is better for MS? This observational study (not a randomized trial) from Denmark found they were about equal in terms of relapse risk, progression independent of relapse activity (PIRA) and MRI outcomes (image is PIRA). pubmed.ncbi.nlm.nih.gov/41603419/

MS is Caused by Modern Society (10 Reasons Why) youtu.be/H4DoSA1Ifjo?...

Masitinib is back? This tyrosine kinase inhibitor is still undergoing clinical trials, and Japan granted the French pharmaceutical company a patent for progressive MS. multiplesclerosisnewstoday.com/news-posts/2...

How New MS Billing Codes Could Affect Your Care. @aaronbostermd.bsky.social trashes the new ICD codes youtu.be/-5fQJJ82BCA?...

FDA Rejects Tolebrutnib (MS Drug). A commentary. youtu.be/9LFdN-tfXEg?...