Nature Reviews Endocrinology (@natrevendo.nature.com)

Interleukin-18 in obesity and obesity-related metabolic diseases Nature Reviews Endocrinology, Published online: 17 October 2025; doi:10.1038/s41574-025-01199-5Interleukin-18 (IL-18), a pyroptosis-related cytokine linking immunity and metabolism, regulates appetite, body weight and glucose homeostasis. IL-18 has paradoxical roles: its deficiency leads to obesity, whereas chronic signalling promotes liver fibrosis. Elevated in obesity and diabetes mellitus, IL-18 remains a compelling therapeutic target, with IL-18 binding protein showing anti-fibrotic potential in preclinical and early clinical studies. https://www.nature.com/articles/s41574-025-01199-5?utm_source=bluesky&utm_medium=social&utm_campaign=nrendo