@biorxivpreprint.bsky.social There are some cool aspects to this new genetic study, so forgive my poking for fun: 1. HLA is associated control of virus infections (uh, duh?) 2. Is it even significant? (p = 9.1×10-851 ) www.biorxiv.org/content/10.1... @harvardmed.bsky.social

Death from sub-acute sclerosing panencephalitis (SSPE) in a child in Los Angeles SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Simpering cowards one and all. This is almost unbearable to watch.

Beeindruckende Transformation. #Paris

Phase 1 of a hypoimmune allogeneic T cell product, CRISPR deleted TRAC, PD1, HLA-A, HLA-B, CIITA, with a CD19-targeting synthetic TCR and antigen receptor in TRAC locus in 5 patients with severe, refractory #lupus nephritis @naturemedicine.bsky.social www.nature.com/articles/s41...

Fascinating talk by rising star @camilahcoelho.bsky.social - Latin America representing @iuis-online.bsky.social #IUIS2025

Real world effectiveness of maternal RSV vaccination looks pretty awesome: 77% against RSV-associated severe LRTD leading to hospitalisation from birth to age 6 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00156-2/abstract

For me, it raises interesting general questions for medicine: Which diseases should we best categorize and which should we view as continuous states? And how does this change when we let AI "categorize" in an "unbiased" (?) manner?

With the first PhD students graduating, our lab is undergoing a major generational shift. Meet our new team members: - Elif Karay, PhD student (hired by our postdoc Michael) - Mariana Sousa, research assistant - Elischka Schumacher, intern - changmin Yoo, intern www.schoberlab.de/team

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[1/2] "Streptococcus pyogenes leads to 500,000 deaths annually, many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine development." @naturemedicine.bsky.social www.nature.com/articles/s41...

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Wollen Sie mit einer komplizierten Infektion von Infektionsspezialisten behandelt werden oder soll das einfach irgendwer nebenbei "mitmachen"? Die Politik meint: Letzteres muss reichen in Deutschland. Anders ist die Abschaffung der LG Infektiologie nicht zu verstehen. #KHAG @spdfraktion.de #CDUCSU

Preprint: A short-course of low dose IL-2 expanded Tregs and achieved an almost 50% viable pregnancy rate in a high-risk population of women with unexplained recurrent early pregnancy loss (NCT03970954) www.researchsquare.com/article/rs-7...

Data on treatments for bubonic plague are limited. In this open-label, randomized, controlled trial in Madagascar, ciprofloxacin monotherapy was noninferior to a standard aminoglycoside–ciprofloxacin regimen. Full IMASOY trial results: nej.md/3Ugs0kx #MedSky #IDSky

If you're a postdoc interested in starting your own group, please consider the Dunn School at Oxford, UK. It's a fantastic department and university for molecular immunology and all aspects of immune research!

🔬Meet our partner Charité –Universitätsmedizin Berlin🏫 A top EU hospital, Charité leads WP5 in Yellow4FLAVI, exploring how people perceive vaccine immunity & tailoring strategies to boost trust & uptake, focusing on global, cross-cultural communication.🧠💉 More here : www.linkedin.com/posts/yellow...

www.science.org/doi/10.1126/... This is an excellent explainer of the wonderful immunological intricacies of germline targeting.

A good news article in Nature today following up on these papers www.nature.com/articles/d41...

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1... Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

How much of the TCR repertoire can we make sense of? Can your TCR and GEX data be put in the context of other conditions/tissues? How many varieties of T cells are in the repertoire zoo? All these questions (& more) addressed in our latest preprint: MetaCoNGA www.biorxiv.org/content/10.1... . a 🧵

Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers @natcomms.nature.com www.nature.com/articles/s41...

Spike-specific IgG4 generated post BNT162b2 mRNA vaccination is inhibitory when directly competing with functional IgG subclasses @cp-cellreports.bsky.social www.cell.com/cell-reports...

There‘s tons of epitope-TCR prediction tools out there. Wonder how they perform? Check out our benchmarking study, led by Felix Drost and Benni Schubert.

Benchmarking of T cell receptor-epitope predictors with ePytope-TCR www.cell.com/cell-genomic...

Jurkat T-cell lines widely used in research labs to model TCR or CAR T function are genomically unstable and prone to mutations that impact function. "Genotype your cell lines!" www.nature.com/articles/s41...

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." @nature.com nature.com/articles/s41...

STAGGERING: This new study of 133 countries is the first to estimate the impact of all USAID’s work. In 2 decades, it has saved *92M* lives. Current cuts, if not reversed, are forecast to cost up to *14M* lives thru 2030. www.thelancet.com/journals/lan...

🧬 Meet our Partners: Universitätsklinikum Erlangen (UKER)🏫 Prof. Schober’s team studies T cell memory after flavivirus vaccination, revealing keys to long-term immunity. UKER leads WP3 & supports WP2 & WP4 in Yellow4FLAVI. 🤝💉 📸 Photo: Uwe Dettmar. More here: www.linkedin.com/posts/yellow...

“He began to feel that countering anti-vaccine activism was maybe as important as the vaccines he was formulating.” Information, communication, speaking up for what has saved millions of lives is a moral obligation. Not doing so It will affect entire communities with long lasting consequences.

Efficacy, public health impact and optimal use of the Takeda dengue vaccine @naturemedicine.bsky.social www.nature.com/articles/s41...

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...

Today is June 25. On this date in 1903 Marie Curie defended her doctoral thesis on radioactive substances at Université de la Sorbonne in Paris, becoming 1st woman in France to receive a doctoral degree. Image shows the thesis cover.

🎓 Exzellente*r PostDoc in Bayern? Das Junge Kolleg der BAdW fördert interdisziplinäre Forschung & Vernetzung auf höchstem Niveau. ✔️12.000 €/Jahr ✔️außerord. Akademiemitgliedschaft ✔️Austausch über Fächergrenzen hinweg ✍️Jetzt bis 30.09.25 bewerben: badw.de/junges-kolle... #PostDoc #Forschungsförderung

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Victora lab papers are about the only non-T cell papers I consistently read when they come out. Always an exceptional combination of great science and manuscript writing. But this specific work was also of particular interest because of many parallels to what we found for TCR avidity selection.

Our team had such a blast at the #ATCR conference in Antwerp. Beautiful and super interesting city, fantastic line-up of speakers, and a very family-like atmosphere full of TCR geeks. What more can you ask for!

Tuberculosis (TB) was once a leading killer in rich countries, but it’s now rare in those places. But TB still kills almost 1.3 million people every year, making it the world’s deadliest infectious disease.

🔬Spotlight on women’s leadership in Yellow4FLAVI! Dr. Barba-Spaeth @giobarbaspaeth.bsky.social, a molecular & structural virologist, coordinates research on how YF17D vaccine structure drives immunity, unlocking new paths for next-gen vaccines.💉🧠 More on our site: www.yellow4flavi.eu/post/women-s...

Fifth #ATCR25 speaker: @kischober.bsky.social on how T cell receptor avidity influences clonal expansion following antigen exposure in a "natural experiment" (vaccination)

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

Ready to start the #ATCR25 meeting celebrating 10 years of the AUDACIS consortium with this amazing line-up of speakers!

Damn More of this please

Very proud of and happy for our postdoc Michael Hiltensperger who won his first big grant last week with a stellar performance in the oral presentation round after submission of the written proposal. 1 PhD student + consumables by the IZKF @fau.de. Congrats, Michael!

Great work by Anne Krug from our @yellow4flavi.bsky.social consortium.

#Podcast: Wie wurde eigentlich die #Leukämie entdeckt? Der Weg zu unserem heutigen Wissen um #Blutkrebs war weit... #Krebsbesiegen - unsere neue Hör-Doku, jetzt in der BAdW-Mediathek: 🎧 tiny.badw.de/2c87E8, auf Spotify: 🎧 tiny.badw.de/g0skFt ... und überall wo es Podcasts gibt! #Krebs #Forschung

Die vierte und letzte Folge unserer Hör-Doku "Krebs besiegen" ist da! 🥳 Diesmal geht es um Künstliche Intelligenz in der #Krebsmedizin. Werden wir so #Krebs irgendwann endgültig besiegen? 🎧 badw.de/die-akademie... #KuenstlicheIntelligenz #KI #Krebsforschung

Wie immer: diese und alle anderen Folgen unserer Hör-Doku "Krebs besiegen" gibt es auch auf: 🎧 Spotify: open.spotify.com/episode/1gJM... 🎧 Apple Podcasts: podcasts.apple.com/de/podcast/4... 🎧 YouTube: www.youtube.com/watch?v=S6i7... ... und überall, wo es Podcasts gibt!

Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ