New press release from Sanofi - tolebrutinib did NOT meet it's primary endpoint in PP-MS trial www.sanofi.com/en/media-roo...

@nature.com Ten people who helped shape science in 2025 nature.com/immersive/d4...

We have an open call for a group leader at the Rudolf Virchow Center for Integrative and Translational Bioimaging in Würzburg, Germany. Generous starting package, vibrant and highly interdisciplinary biomedical research environment. www.nature.com/naturecareer... Please spread the word.

Less than one week left to apply 🔜

Heute hat die Feierliche Jahressitzung der BAdW im Herkulessaal der Münchner Residenz stattgefunden. Fotos: Kai Neunert/BAdW

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells @nature.com #Germain @niaidnews.bsky.social www.nature.com/articles/s41...

We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...

‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results @nature.com www.nature.com/articles/d41...

Agentic AI systems are becoming available for use in science – but can we trust them?

Excited to see our TIRTL-seq method published in Nature Methods www.nature.com/articles/s41...! Some updates after the revision: (1/4)

We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.

Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...

Excited to announce that I’ve recently transitioned into an Assistant Professor role in the Division of Translational Science and Therapeutics @Fred Hutch.

"We thank the reviewers for their helpful suggestions"

Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias https://www.biorxiv.org/content/10.1101/2025.11.19.688845v1

🚀 New bioRxiv preprint! We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states. 🔗 www.biorxiv.org/content/10.1... (1/5)

Großer Erfolg: Die @dfg.de fördert einen neuen Sonderforschungsbereich an der FAU, der Autoimmunerkrankungen untersucht. Zudem wurde für gleich zwei Transregio-Projekte mit FAU-Beteiligung eine weitere Förderperiode bewilligt. 🥳 👇 Mehr erfahren: www.fau.de/2025/11/news...

Our new paper is out in Nature - online today! Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators. 📄 Open-access paper: www.nature.com/articles/s41...

Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1111/...

Today I appointed Jürgen Held as a Professor at FAU. His work advances fungal diagnostics, metagenomic infection detection, and AI-based risk assessment. He brings science and clinical practice together to identify infections earlier and treat patients more precisely.

New Comment Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease www.thelancet.com/journals/lan...

One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc

Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells onlinelibrary.wiley.com/doi/10.1002/... It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).

#PreprintClub is now on Bluesky! Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬

Statistical thinking is a core part of solid biological results. However, many studies still include insufficient sample sizes, have poor experimental design, or select incorrect statistical tests. Here, the authors present ten statistical tips for cell biology www.nature.com/articles/s41...

www.life-science-alliance.org/content/9/1/... New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.

Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed

Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠 Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @cp-immunity.bsky.social offers some hints. cell.com/immunity/ful... Thanks and congratulations to all contributors

🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of: 🔵 RNA Biology 🔵 RNA Medicine 🔵 RNA Technology Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale... Find an overview in this thread. 🧵👇 (1/6)

Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1

Together with Ralf Bartenschlager @ciid-heidelberg.bsky.social we are looking for a PhD student! The project @trr179.bsky.social will revolve around (Hepatitis) viruses and the regulation of pattern recognition receptors in innate antiviral immunity. Contact us if you're interested! #PhDPosition

📢 We are announcing the Adaptive Immune Profiling Challenge 2025! Can you predict immune state labels from adaptive immune receptor repertoires? 💰 $10,000 prize pool! 🗓️ Launches Nov 5 on @kaggle.com More Info: uio-bmi.github.io/adaptive_imm...

Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social www.biorxiv.org/content/10.1...

Eva Brunner joins us as a new PhD student. Eva studied Applied Biochemistry at the Nuremberg Institute of Technology). During her master thesis, she functionally investigated eosinophils in cutaneous leishmaniasis. (1/2)

LJI is recruiting! The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.

Happy World #CRISPR Day, everyone! ✂️🧬

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis: Cell www.cell.com/cell/fulltex...

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | New England Journal of Medicine www.nejm.org/doi/full/10....

For the #lovers of #TCRs -we are looking for #postdocs with interest in #functional and #mutational studies -dare to express 700 #self #antigen #specific #TCRs and #study them in #depth!!!!

Nature or nurture? See www.cell.com/immunity/pdf... in response to www.cell.com/immunity/pdf..., with this reply by the original authors: www.cell.com/action/showP.... We need more "letter arguments" in science on platforms with high visibility. Through critical debate we gain critical insight.

Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells www.biorxiv.org/content/10.1...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Declining child mortality, fast and slow

Does #bluesky still #exist or is it #dead?

Einem Ärzteteam des Uniklinikums Erlangen ist es weltweit erstmals gelungen, eine junge Patientin mit therapieresistenter, schwerer chronisch-entzündlicher Darmerkrankung erfolgreich mit einer CAR-T-Zell-Therapie zu behandeln. Mehr erfahren: go.fau.de/1cb-e