New Comment Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease www.thelancet.com/journals/lan...

One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc

Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells onlinelibrary.wiley.com/doi/10.1002/... It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).

#PreprintClub is now on Bluesky! Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬

Statistical thinking is a core part of solid biological results. However, many studies still include insufficient sample sizes, have poor experimental design, or select incorrect statistical tests. Here, the authors present ten statistical tips for cell biology www.nature.com/articles/s41...

www.life-science-alliance.org/content/9/1/... New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.

Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed

Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠 Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @cp-immunity.bsky.social offers some hints. cell.com/immunity/ful... Thanks and congratulations to all contributors

🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of: 🔵 RNA Biology 🔵 RNA Medicine 🔵 RNA Technology Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale... Find an overview in this thread. 🧵👇 (1/6)

Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1

Together with Ralf Bartenschlager @ciid-heidelberg.bsky.social we are looking for a PhD student! The project @trr179.bsky.social will revolve around (Hepatitis) viruses and the regulation of pattern recognition receptors in innate antiviral immunity. Contact us if you're interested! #PhDPosition

📢 We are announcing the Adaptive Immune Profiling Challenge 2025! Can you predict immune state labels from adaptive immune receptor repertoires? 💰 $10,000 prize pool! 🗓️ Launches Nov 5 on @kaggle.com More Info: uio-bmi.github.io/adaptive_imm...

Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social www.biorxiv.org/content/10.1...

Eva Brunner joins us as a new PhD student. Eva studied Applied Biochemistry at the Nuremberg Institute of Technology). During her master thesis, she functionally investigated eosinophils in cutaneous leishmaniasis. (1/2)

LJI is recruiting! The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.

Happy World #CRISPR Day, everyone! ✂️🧬

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis: Cell www.cell.com/cell/fulltex...

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | New England Journal of Medicine www.nejm.org/doi/full/10....

For the #lovers of #TCRs -we are looking for #postdocs with interest in #functional and #mutational studies -dare to express 700 #self #antigen #specific #TCRs and #study them in #depth!!!!

Nature or nurture? See www.cell.com/immunity/pdf... in response to www.cell.com/immunity/pdf..., with this reply by the original authors: www.cell.com/action/showP.... We need more "letter arguments" in science on platforms with high visibility. Through critical debate we gain critical insight.

Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells www.biorxiv.org/content/10.1...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Declining child mortality, fast and slow

Does #bluesky still #exist or is it #dead?

Einem Ärzteteam des Uniklinikums Erlangen ist es weltweit erstmals gelungen, eine junge Patientin mit therapieresistenter, schwerer chronisch-entzündlicher Darmerkrankung erfolgreich mit einer CAR-T-Zell-Therapie zu behandeln. Mehr erfahren: go.fau.de/1cb-e

TCR activation impairs CAR-T cytotoxicity against separate target cells https://www.biorxiv.org/content/10.1101/2025.10.07.680634v1

When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete? Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells. www.biorxiv.org/content/10.1...

Killerzellen des Immunsystems vermehren sich, wenn sie auf eine Infektion stoßen, um diese zu bekämpfen. Allerdings gilt das nicht für jede Killerzelle. Woran liegt es, ob es zur Vermehrung kommt oder nicht? FAU-Forschende sind dieser Frage nachgegangen. www.fau.de/2025/10/news...

“I was never working alone—there were people all over the world who shared similar ideas,” he said. “I see this award as one that represents all of those people who have contributed to this research alongside me.” Prices go to individual people, but Sakaguchi shows how to acknowledge the field.

A really nice overview of key Treg discoveries relevant for today's exciting Nobel announcement www.nobelprize.org/uploads/2025...

Free link to paper: sites.google.com/view/schober...

Clonal recruitment after vaccination is governed by a TCR avidity threshold, whereas probabilistic expansion preserves repertoire polyclonality @sciimmunology.bsky.social www.science.org/doi/10.1126/...

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/... Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

This week in #Science #Immunology! 👇

Beautiful paper, worth a read, lots of #TCR work -of course I am biased as I love #TCRs www.science.org/doi/10.1126/...

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

Have we passed peak social media? @jburnmurdoch.ft.com here www.ft.com/content/a072...

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...

@biorxivpreprint.bsky.social There are some cool aspects to this new genetic study, so forgive my poking for fun: 1. HLA is associated control of virus infections (uh, duh?) 2. Is it even significant? (p = 9.1×10-851 ) www.biorxiv.org/content/10.1... @harvardmed.bsky.social

Death from sub-acute sclerosing panencephalitis (SSPE) in a child in Los Angeles SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Simpering cowards one and all. This is almost unbearable to watch.

Beeindruckende Transformation. #Paris

Phase 1 of a hypoimmune allogeneic T cell product, CRISPR deleted TRAC, PD1, HLA-A, HLA-B, CIITA, with a CD19-targeting synthetic TCR and antigen receptor in TRAC locus in 5 patients with severe, refractory #lupus nephritis @naturemedicine.bsky.social www.nature.com/articles/s41...

Fascinating talk by rising star @camilahcoelho.bsky.social - Latin America representing @iuis-online.bsky.social #IUIS2025

Real world effectiveness of maternal RSV vaccination looks pretty awesome: 77% against RSV-associated severe LRTD leading to hospitalisation from birth to age 6 https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00156-2/abstract