Congrats Todd & team @bruskolab.bsky.social Large-scale TCR repertoire profiling from peripheral blood reveals type 1 diabetes signatures linked to high-risk HLA alleles www.science.org/doi/10.1126/...

A high-throughput screening system enabled identification of the antigen targets of T cell receptors found in many individuals www.science.org/doi/10.1126/...

Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41... By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.

Preprint: Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22 www.researchsquare.com/article/rs-8... @ohiostatemed.bsky.social

Vaccine-induced immune thrombocytopenia and thrombosis occurs in persons with Ig light-chain allele IGLV3-21*02 or *03 that recognizes a specific epitope on the adenoviral core protein pVII, resulting in misdirection of antibody targeting PF4 @nejm.org www.nejm.org/doi/full/10....

BREAKING: @lizzylawrence.bsky.social reports that CBER director Vinay Prasad overruled career #FDA staff and unilaterally decided to refusal to accept #Moderna 's #flu vaccine submission. www.statnews.com/2026/02/11/m...

HIRING: We recruit postdocs via the CeMM Pre-ERC Postdoc Program (cemm.at/postdoc-prog...). Seeking 3 types of candidates: (1) experimental systems biology in immunity or cancer; (2) bioinformatics & biomedical ML/AI; (3) tech-dev & bioengineering (CRISPR, single-cell, spatial, cell programming).

(1) Did you ever wonder how effector T cells remodel their transcriptome and proteome when they become activated? and how this remodelling drives T cell diffferentiation? Then you might be interested in our newest preprint:👇 www.biorxiv.org/content/10.6...

Absolutely remarkable: striking effects of infusion time-of-day on immunochemotherapy efficacy in nonsmall cell lung cancer in a randomized phase 3 trial www.nature.com/articles/s41...

Online now: Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

Heute am besten lieber mit Schlittenhunden zur Uni fahren 🐕‍🦺

Ich freue mich sehr über diese unglaublich wichtige Förderung unserer Forschung!

Sie sorgen dafür, dass das Immunsystem mit diesem spezifischen Erreger künftig leichter fertig wird. Das diagnostische Potenzial dahinter wird bisher allerdings kaum genutzt. Das soll sich nun ändern: go.fau.de/1dhad (2/2)

@biorxivpreprint.bsky.social The primary and secondary immune response to Epstein-Barr virus #EBV infection of human tonsil organoids www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social A tonsil organoid model reveals Epstein-Barr virus infected germinal center B cell states during primary infection www.biorxiv.org/content/10.6... @bgewurz.bsky.social @harvardmed.bsky.social @ucirvine.bsky.social

Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...

Autoimmunerkrankungen machen den Alltag vieler Menschen schwer. An der FAU wird zur Behandlung von Autoimmunerkrankungen mit CAR-T-Zellen geforscht – und es gibt Grund zur Hoffnung. (1/3) www.fau.de/2026/01/news...

CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia @nejm.org www.nejm.org/doi/full/10....

Etwa 20 bis 30% aller Menschen, die an Schuppenflechte leiden, entwickeln im Laufe der Zeit zusätzlich eine schmerzhafte Gelenkentzündung. FAU-Forschende haben nun herausgefunden, woran das liegt. Die Erkenntnisse liefern zudem neue Ansätze, wie man eine Entzündung verhindern kann. go.fau.de/1dghf

CD19 CAR-T cells for treatment-refractory autoimmune diseases (systemic lupus erythematosus, systemic sclerosis, idiopathic inflammatory myopathies): the phase 1/2 CASTLE basket trial @naturemedicine.bsky.social www.nature.com/articles/s41...

New press release from Sanofi - tolebrutinib did NOT meet it's primary endpoint in PP-MS trial www.sanofi.com/en/media-roo...

@nature.com Ten people who helped shape science in 2025 nature.com/immersive/d4...

We have an open call for a group leader at the Rudolf Virchow Center for Integrative and Translational Bioimaging in Würzburg, Germany. Generous starting package, vibrant and highly interdisciplinary biomedical research environment. www.nature.com/naturecareer... Please spread the word.

Less than one week left to apply 🔜

Heute hat die Feierliche Jahressitzung der BAdW im Herkulessaal der Münchner Residenz stattgefunden. Fotos: Kai Neunert/BAdW

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells @nature.com #Germain @niaidnews.bsky.social www.nature.com/articles/s41...

We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...

‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results @nature.com www.nature.com/articles/d41...

Agentic AI systems are becoming available for use in science – but can we trust them?

Excited to see our TIRTL-seq method published in Nature Methods www.nature.com/articles/s41...! Some updates after the revision: (1/4)

We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.

Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...

Excited to announce that I’ve recently transitioned into an Assistant Professor role in the Division of Translational Science and Therapeutics @Fred Hutch.

"We thank the reviewers for their helpful suggestions"

Antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation bias https://www.biorxiv.org/content/10.1101/2025.11.19.688845v1

🚀 New bioRxiv preprint! We used a standardized SARS-CoV-2 mRNA vaccination model to study antigen-reactive CD4⁺ T cells in their resting and stimulated states. 🔗 www.biorxiv.org/content/10.1... (1/5)

Großer Erfolg: Die @dfg.de fördert einen neuen Sonderforschungsbereich an der FAU, der Autoimmunerkrankungen untersucht. Zudem wurde für gleich zwei Transregio-Projekte mit FAU-Beteiligung eine weitere Förderperiode bewilligt. 🥳 👇 Mehr erfahren: www.fau.de/2025/11/news...

Our new paper is out in Nature - online today! Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators. 📄 Open-access paper: www.nature.com/articles/s41...

Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1111/...

Today I appointed Jürgen Held as a Professor at FAU. His work advances fungal diagnostics, metagenomic infection detection, and AI-based risk assessment. He brings science and clinical practice together to identify infections earlier and treat patients more precisely.

New Comment Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease www.thelancet.com/journals/lan...

One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc

Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells onlinelibrary.wiley.com/doi/10.1002/... It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).

#PreprintClub is now on Bluesky! Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬

Statistical thinking is a core part of solid biological results. However, many studies still include insufficient sample sizes, have poor experimental design, or select incorrect statistical tests. Here, the authors present ten statistical tips for cell biology www.nature.com/articles/s41...

www.life-science-alliance.org/content/9/1/... New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.

Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed