Thrilled to share this study tracking Staph aureus carriage and transmission across the NICU using genomics! Work done w @pjplanet.bsky.social & @ahmedmicrobes.bsky.social and made possible by @centermicrobialmed.bsky.social. Study co-led by the amazing @qianxuan.bsky.social & Lakshmi Srinivasan!

My weekly update. Some good(ish) news. The pace of NIH grantmaking appears to be picking up. 1/4

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

Very cool work from the Beattie lab. Beautiful experiments. #Immunology @forum-gd.bsky.social

To strengthen the European research on early life immunology we have started the EFIS study ELINE Info and seminar announcement 👇🏼 #EFIS#ELINE#immunology

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...

Happy to share a new preprint of one of my post doc projects. For those interested in tissue macrophages, immuno-metabolism and post-translational modification. Feedback welcome!

O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells https://www.biorxiv.org/content/10.64898/2026.02.03.703465v1

@biorxivpreprint.bsky.social The CD8 immgenT framework as a universal reference of mouse CD8 Tαβ cell differentiation states www.biorxiv.org/content/10.6...

Atlas-guided discovery of transcription factors for T cell programming @nature.com @salkinstitute.bsky.social @tcellogic.bsky.social @ucsdmedschool.bsky.social www.nature.com/articles/s41...

My outstanding postdoc is looking for a research job in Albany, NY. Please forward all leads and RT!

Online now: B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells

Fascinating obituary of Peter Duesberg who went from renowned scientist discovering the first viral oncogene to HIV denialist who influenced Thabo Mbeki and HIV policy in S. Africa which led to millions dying. Human beings are complex creatures indeed. www.nytimes.com/2026/01/27/s...

An incredible life and legacy “He said the strategy — now known as ‘ring vaccination’ — was based on principles he learned when he spent summers fighting wildfires in the American West as a younger man.”🧪🩺

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma from @rodrahimi.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...

Thrilled to share our new preprint showing that dietary amino acids license the NLRP3 inflammasome via mTOR-dependent mRNA translation! Congrats to co-1st authors @mikelhaggadone.bsky.social, Brian Goldspiel, co-senior author @metabailism.bsky.social & collaborators! www.biorxiv.org/content/10.6...

This is a cool paper "The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology

“In every field, elite youth performers and elite adults were almost entirely separate groups…It is not just that exceptional performance in childhood did not predict exceptional performance as an adult. The two were actually negatively correlated, says Dr Güllich.”🧪

Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...

Don’t forget that the 1961 triplet code paper only became elegant when it was written! The experiments were all a bit of a mess... I suspect the same was true of the other classic papers!

New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social

Our cool new paper depicting fibroblasts more than a scaffold during airway allergy. #Il33 #ILC2 #complement

🪱 Biologist Alejandro Sánchez Alvarado loves planarians. To be fair, these tiny flatworms do embody the ultimate growth mindset: buff.ly/ky5PM6u

Monogenic disorders of immunity: Common variants are not so rare: Cell Genomics www.cell.com/cell-genomic...

Delighted that our latest paper is out at @mucosalimmunol.bsky.social. Here, using bronchoscopies and scRNA- and TCR-seq, we found that T cells isolated from bronchoalveolar lavage versus the airway mucosal are surprisingly distinct. Summary of the original preprint below. #Immunology #PCCM

If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch. IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE. Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

Novel Method to Spur Lung Blood Vessel Growth to Treat bronchopulmonary dysplasia @mingxiagu.bsky.social @cincyresearch.bsky.social scienceblog.cincinnatichildrens.org/study-reveal... www.cell.com/cell-stem-ce... @cp-cellstemcell.bsky.social

@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...

Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

The @natureportfolio.nature.com published a really good spotlight on #influenza two weeks ago. I have not read all the articles yet (but I will). The ones I have read are great, learned a lot. Highly recommend checking them out. #IDSky www.nature.com/collections/...

It's always difficult to pick one favorite paper from the past year, but this one is on my short list. Very elegant experiments that changed the way I think about peripheral tolerance. #Immunology 🧪

New post! There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost. Medical breakthroughs in 2025. Plus a serious note at the end. www.scientificdiscovery.dev/p/medical-br...

'The presence of CD8+ T cells coexpressing residency and exhaustion molecules in chronic diseases often correlate with clinical outcomes; however, the relationship between these cells and conventional tissue-resident memory (TRM) cells or exhausted CD8+ T (TEX) cells is unclear.' #Immunology

“Joel F. Habener, a Harvard University academic whose research paved the way for revolutionary weight-loss drugs Ozempic, Mounjaro and others…died Sunday in Newton, Mass. He was 88.”🧪🩺 I didn’t realize the discovery of GLP-1 started with anglerfish

CNS delivery systems are getting better 'Tividenofusp alfa, comprising iduronate-2-sulfatase fused to an engineered transferrin receptor–binding Fc domain, has been developed to treat neurologic and peripheral manifestations of mucopolysaccharidosis type II (MPS II), a rare lysosomal disorder'

I highly recommend this book. For those whose picture of Darwin is a white-bearded old man sitting in his British study, this will blow your mind. Watch him ride across the pampas with the gauchos in the midst of a revolution and you'll learn his life was a radical as his ideas 🧪

#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...

Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!

So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think. Same applies to LLMs for scientific writing.

Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff! www.cell.com/cell/fulltex...

@biorxivpreprint.bsky.social A critical role of the transmembrane anchor in perforin-2 in DCs, and reveal that pore formation occurs with striking spatiotemporal precision to safeguard the integrity of endocytic compartments www.biorxiv.org/content/10.6... @patrycja-kozik.bsky.social

Benchmark @cp-immunity.bsky.social The history and promise of Treg cells www.cell.com/immunity/ful...

We’re hiring! Two postdoctoral research positions are available in our lab - one in mucosal immunology, and one in exposome immunology (MRC CoRE)! Apply by December 22nd!🎄 Position 1: tinyurl.com/2mh44tn4 Position 2: tinyurl.com/5ffzxsfb @kiroxford.bsky.social @exposomeimmunology.bsky.social

Practice changing plenary #ASH25‼️ Iron is hypothesized to feed infxn & IV iron often avoided in that setting. >85k people hospitalized w/5 most common bacterial infxns, compared those who recvd IV iron to those who did not. 🩸greater hemoglobin increase 🩸lower mortality at 14 & 90 days

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

“Since SCID is caused by a faulty gene, scientists collect babies’ stem cells and, in the lab, introduce a healthy copy, using a harmless, disabled form of H.I.V. as the courier. (While the virus can’t replicate, it is still excellent at integrating its genetic cargo into cells’ D.N.A.)”

This is fascinating “Furthermore, these findings raise questions about whether anti-PD-1 blockade during cancer immunotherapy provides a short-term anti-tumour effect at the cost of diminishing efficacy due to progressive loss of these critical high-affinity precursors.” #Immunology