One-month treatment for latent tuberculosis. Why aren't we using it? (Hint: We should.) voices.nejm.org/doi/full/10....

This is so, so well-articulated.

"But it could still bounce back, and efforts to eliminate it entirely face formidable challenges. How it spreads between cattle remains unclear. And although candidate vaccines look promising in early tests, farmers and the government may be reluctant to embrace them."🧪🩺

"our findings delineate antigen-specific CD4+ T cell fates in different courses of human viral infections, identifying stem-like subsets as potential immunotherapeutic targets and highlighting the need for tailored strategies to re-direct or boost CD4+ T cell responses." #Immunology 🧪🩺

While this will not have the level of detail that most critics would want, looky here at Princeton's page on the F&A rate by category. I've never seen even this level of description. h/t @jeremymberg.bsky.social finance.princeton.edu/budgeting-fi...

This is cool 🧪🩺 www.nature.com/articles/s41...

Great piece on the problems of corporatization in medicine "In a classic article, Nobel Prize–winning economist Kenneth Arrow argued that physician 'behavior is supposed to be governed by a concern for the customer’s welfare which would not be expected of a salesman.'"🧪🩺

#WeekendRead! #RemeberMe! @snaga13.bsky.social @jbuenrostro.bsky.social &co show @nature.com that intestinal stem cells remember multiple cycle of inflammation by epigenetically favoring AP-1 accessibility, thus increasing proliferation & repair, but also favoring tumorigenesis!

Now for new and competitive renewal awards. The number of awards through March 20th, 2026 is 1452 compared to 4008 in FY2023, 3741 in FY2024, and 2847 in FY2025. NIAAA and NLM have yet to make any awards. 576 R01s, 150 R35s, 259 R21s, 14 F30s, 34 F31s, 15 F32s, 32 K99s, 59 R00s 4/6

“In this study, prime editing of autologous CD34+ cells corrected the molecular defect in p47-CGD and restored neutrophil function to near-healthy levels in the two participants.”🧪🩺

David Botstein was one of the giants of genetics and genomics, and my mentor, colleague and friend for more than 40 years. I’m sad that he is gone, but his larger-than-life persona comes through here. www.nytimes.com/2026/03/20/s...

Sometimes you just get that shot. Anna's hummingbird with a little friend, in my yard. Davis, CA. #birds #ants

Still one of my all time favorites

OMB has posted the full-year apportionments for NIH. openomb.org/file/11511545 I believe this means that NIH now has the spending authority to fund grants! There may be nuances and I will be tracking these as best I can.

Okay this is interesting. In 2013, Casanova et al describe OX40-deficiency in a healthy individual w/ Kaposi sarcoma. Now reports that anti-OX40 biologic may be associated w/ KS. ftp.digitalpharmainnovation.com/biotech/new-... Did OX40 evolve to specifically protect against HHV-8??🧪 #Immunology

Off-target reactivity in clinical monoclonal antibodies: Structure www.cell.com/structure/fu...

Gervais, Trespidi, Ferrari, Rovida, Cobat, Zhang, Casanova, Borghesi et al. show that, in 13 European, Middle-Eastern, and American cohorts, pre-existing autoantibodies neutralizing type I IFNs are causal for WNV encephalitis in about 40% of patients. rupress.org/jhi/article/...

'After consecutive primary heterosubtypic infections, 4–6% of memory B cells in children are cross-group reactive. These imprinted B cells target the central stalk epitope of HA and exhibit major functional differences.' #Immunology www.nature.com/articles/s41...

'This review explores the current state of CAR-T cell therapy for solid tumors, highlighting challenges including the pronounced heterogeneity of tumor antigens and the immunosuppressive tumor microenvironment.' #Immunology #Immunotherapy

"OIT participants achieving sustained unresponsiveness were distinguished by lower baseline TH2-related phenotypes, elevated post-OIT cytotoxicity-related pr effector T cell gene signatures and higher CD39 expression in pr regulatory T cells." #Immunology

Hi @rodrahimi.bsky.social, are you still curating an immunologists on bluesky list? @hiroshi-ichise.bsky.social could be added, he's just come on board www.science.org/doi/10.1126/...

My weekly NIH update... The fiscal year 2026 curve still lies below the other curves but appears to be increasing at close to the normal pace. 1/4

Nature research paper: Natural maternal immunity protects neonates from Escherichia coli sepsis go.nature.com/4lm44sR

“One-third of Americans — an estimated 82 million people — say they are making sacrifices, including skipping meals or driving less, to pay for care, according to a new survey released on Thursday… Those without insurance reported even more trade-offs.”

Excited to announce the opening of the applications for the Master in Biomedical Research. An international, hands-on programme for students to think like scientists, work in real labs, and prepare for PhD training or R&D careers, in Lisbon. GIMM Institute 1/3

My lab is seeking to co-hire another postdoctoral fellow with the @shaonsengupta.bsky.social team. See details below! careers.chop.edu/us/en/job/10...

"tumor cytotoxicity are highly variable at the macroscopic level...Stochastic activation of a rare subpopulation of T cells (so-called Spark T cells), coupled with a paracrine interferon (IFN)-γ-driven positive feedback, accounts for this measured “noise” in immunotherapeutic reactions."🧪#Immunology

TCF1 is a master regulator of T cell stemness – but can it make exhausted cells go backwards? We setup a CRISPR KI system to ask this question, and the answer was unexpected. www.nature.com/articles/s41...

New and competitive renewal awards. The number of awards is 569 compared with more than 2200 through the same date in earlier fiscal years. All ICs have now made awards except for NIAAA, NCCIH, NLM, FIC, and OD. NEI (Eye Institute) made its first award during the new period. 3/4

🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover. 🔗 www.biorxiv.org/content/10.6...

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field www.annualreviews.org/content/jour...

I accept you with minor revisions.

This is such a fun thread on a conceptual head twister of a paper. Bold hypothesis and clever selection scheme. Kudos to the authors!

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Happy birthday to one of my favourite haters, Charles Darwin

"There is grandeur in this view of life - that from so simple a beginning, endless forms most beautiful and most wonderful have been, and are being, evolved." Happy birthday to the only and only Charles Darwin. 🧪

Thrilled to share this study tracking Staph aureus carriage and transmission across the NICU using genomics! Work done w @pjplanet.bsky.social & @ahmedmicrobes.bsky.social and made possible by @centermicrobialmed.bsky.social. Study co-led by the amazing @qianxuan.bsky.social & Lakshmi Srinivasan!

My weekly update. Some good(ish) news. The pace of NIH grantmaking appears to be picking up. 1/4

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

Very cool work from the Beattie lab. Beautiful experiments. #Immunology @forum-gd.bsky.social

To strengthen the European research on early life immunology we have started the EFIS study ELINE Info and seminar announcement 👇🏼 #EFIS#ELINE#immunology

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...

Happy to share a new preprint of one of my post doc projects. For those interested in tissue macrophages, immuno-metabolism and post-translational modification. Feedback welcome!

O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells https://www.biorxiv.org/content/10.64898/2026.02.03.703465v1

@biorxivpreprint.bsky.social The CD8 immgenT framework as a universal reference of mouse CD8 Tαβ cell differentiation states www.biorxiv.org/content/10.6...

Atlas-guided discovery of transcription factors for T cell programming @nature.com @salkinstitute.bsky.social @tcellogic.bsky.social @ucsdmedschool.bsky.social www.nature.com/articles/s41...

My outstanding postdoc is looking for a research job in Albany, NY. Please forward all leads and RT!

Online now: B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells

Fascinating obituary of Peter Duesberg who went from renowned scientist discovering the first viral oncogene to HIV denialist who influenced Thabo Mbeki and HIV policy in S. Africa which led to millions dying. Human beings are complex creatures indeed. www.nytimes.com/2026/01/27/s...