I highly recommend this book. For those whose picture of Darwin is a white-bearded old man sitting in his British study, this will blow your mind. Watch him ride across the pampas with the gauchos in the midst of a revolution and you'll learn his life was a radical as his ideas 🧪

#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...

Two pieces of fun news: 1. We've launched a new website for our lab: www.brysonlab.org 2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!

So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think. Same applies to LLMs for scientific writing.

Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff! www.cell.com/cell/fulltex...

@biorxivpreprint.bsky.social A critical role of the transmembrane anchor in perforin-2 in DCs, and reveal that pore formation occurs with striking spatiotemporal precision to safeguard the integrity of endocytic compartments www.biorxiv.org/content/10.6... @patrycja-kozik.bsky.social

Benchmark @cp-immunity.bsky.social The history and promise of Treg cells www.cell.com/immunity/ful...

We’re hiring! Two postdoctoral research positions are available in our lab - one in mucosal immunology, and one in exposome immunology (MRC CoRE)! Apply by December 22nd!🎄 Position 1: tinyurl.com/2mh44tn4 Position 2: tinyurl.com/5ffzxsfb @kiroxford.bsky.social @exposomeimmunology.bsky.social

Practice changing plenary #ASH25‼️ Iron is hypothesized to feed infxn & IV iron often avoided in that setting. >85k people hospitalized w/5 most common bacterial infxns, compared those who recvd IV iron to those who did not. 🩸greater hemoglobin increase 🩸lower mortality at 14 & 90 days

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

“Since SCID is caused by a faulty gene, scientists collect babies’ stem cells and, in the lab, introduce a healthy copy, using a harmless, disabled form of H.I.V. as the courier. (While the virus can’t replicate, it is still excellent at integrating its genetic cargo into cells’ D.N.A.)”

This is fascinating “Furthermore, these findings raise questions about whether anti-PD-1 blockade during cancer immunotherapy provides a short-term anti-tumour effect at the cost of diminishing efficacy due to progressive loss of these critical high-affinity precursors.” #Immunology

IL-9 enhancement of engineered CAR-T therapies @cp-immunity.bsky.social @pennpress.bsky.social @xrtcell.bsky.social @stanforduniversity.bsky.social www.cell.com/immunity/ful... www.cell.com/immunity/ful...

OMG--read this thread. Remarkable clever use of a trick to visualize plasmid competition that reveals key insights into evolution!!!! 🧪

An education in tolerance: the 2025 Nobel Prize in Physiology or Medicine journals.biologists.com/dmm/article/...

This is cool! "researchers presented a path toward a gene-editing strategy that could eventually be standardized for many different rare diseases, instead of personalized edits for each one."🧪⚕️

This week is particularly remarkable in terms of #CellDeath and infection biology-related discoveries: biomed.news/bims-cediti/... Highlight 1: SIGLEC12 mediates plasma membrane rupture during necroptotic cell death:

Notes on NIH matters as the government opens up again drugmonkey.wordpress.com/2025/11/14/n...

Just got an email from my SRO for the study section that was missed in October. Good news is that they are trying to reschedule ASAP (Dec/Jan). The bad news is that CSR is mandating that only the the top third (not half) of applications will get discussed for the next 2 rounds.

Live look at NIH SROs today….

While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.

www.science.org/doi/10.1126/... “These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.” #SLE #Bcell #EBV

Up to 323 cancelled CSR study sections. That's more than the 204 sections cancelled earlier this year. Rescheduling is going to be a hot mess with NIH staff reductions and study section members heading into finals and holidays that limit availability. 🧪

My ask of any science enthusiasts who tell the story of Rosalind Franklin: Don't make her life be about the DNA debacle. She died far too young, but she was a promising scientist in her own right, a mentor and scientific author. Not for Watson or Crick, but for her legacy.

And here's a YouTube link. www.youtube.com/watch?v=Oj0P...

I helped make a film, out this week, called “Rovina’s Choice,” about the deaths this man without conscience or accountability has caused — already 600,000, ⅔ of them children.

Multi-Year funding analysis, a 🧵 I have been trying to find a robust way of quantifying and understanding multi-year (forward funding). First, some background: Most NIH grants are for multiple years (2 to 5, typically). However, the are usually funded on an annual basis. 1/18

🧪

Literal insanity that a company that made a product that saved millions of lives just a few years ago could go out of business www.statnews.com/2025/10/30/m...

Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells. www.embopress.org/doi/full/10....

Review @cp-immunity.bsky.social Human immune aging www.cell.com/immunity/ful...

'Upon attending a Baltimore scientific group meeting in 1988, at which the cloning of the immunoglobulin recombinase-activating gene RAG1, characterization of (IκB) & critical functional attributes of the c-ABL & BCR/ABL proteins were presented, sabbatical scientist Harold Varmus emerged gobsmacked'

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

“Contrary to the prevailing paradigm of fetal immune quiescence, we uncover widespread memory/activated T cells and tissue-resident memory clones shared across organs, indicating systemic immune activity beyond localized barrier defense.”

🧪#Immunology

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

#WeekendRead! #InterferonPower! Lin, Sayour, Grippin &co show @nature.com that SARSCoV2 #mRNAvaccines potentiate in cancer patients & mouse models immune checkpoint blockade anti-tumor therapy thanks to increased type I interferon signaling! www.nature.com/articles/s41...

Such a clever and impactful idea “And you don’t have to convince people they need it,” she added. “It takes into account the local practices, that people are already wearing their babies and laying them to sleep in the same cloth.”🧪🩺

Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Review @natimmunol.nature.com Antigen-presenting cells as arbiters of mucosal tolerance and immunity www.nature.com/articles/s41...

Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...

BREAKING: Some of the layoffs at CDC are being REVERSED. Here is my updated story. www.washingtonpost.com/health/2025/...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this. www.science.org/doi/... 1/9

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

“Dr Ramsdell, whose phone had been on airplane mode when the Nobel committee tried to call him, told the BBC's Newshour Programme that his first response when his wife said, ‘You've won the Nobel prize’ was: ‘I did not.’”🧪🩺🤣

PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program kcl-mrcdtp.com/project/deco... Applications opening soon! #gdTcells #IBD #gut #organoids

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Beautiful paper, worth a read, lots of #TCR work -of course I am biased as I love #TCRs www.science.org/doi/10.1126/...

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky