Perspective @cp-immunity.bsky.social A roadmap for defining “extrafollicular” B cell responses www.cell.com/immunity/ful... @stephanieeisen.bsky.social @vinuesalab.bsky.social et al

Great piece by the Alegre lab "it is clear that tolerant CD4 T cells cannot be classified as simply anergic or exhausted...we propose a framework in which the cell states adopted by CD4 T cells in the aforementioned conditions represent a spectrum of closely related tolerogenic states" #Immunosky

We now have a very exciting technician post advertised as part of our long term Wellcome Trust funded team investigating the role of the glycocalyx during CNS inflammation. Supporint the lab, developing glycan analysis and research experience www.jobs.manchester.ac.uk/Job/JobDetai...

'For decades, no intervention had put a dent in elevated levels of sweat chloride (...) Within days to a few weeks after the start of ivacaftor treatment, sweat chloride levels fell dramatically, with a purge of expectorated respiratory mucus and a corresponding gain in lung function.'

Happy to share the first pre-print of the lab! 📢 💡Do you want to know how CD4 T cells decide their fate? We used a mouse vaccination model to trace endogenous polyclonal CD4 T cells on their journey towards Th1 or Tfh differentiation. www.biorxiv.org/content/10.1...

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

It gives me great pleasure to present the latest from our lab, outlining a curious cellular and molecular pathway that limits thymic regeneration after acute insult. www.nature.com/articles/s41...

Lasker Award for clinical medicine to Welsh, Gonzalez, and Negulescu for CFTR modulator therapy. Truly transformative for people with CF. The Lasker foundation has a great summary of their work below 🧪⚕️

Plasmacytoid dendritic cells can transition to become cDC2s under to influence of TNF, while type-I interferon reduces TNFR expression and thereby inhibits transition. These transitioned cDC2 seem fully functional. 🧪 ⑂ Hornero et al 2025 in Nat Immunol www.nature.com/articles/s41...

Adding up the NIH R01s lost to Multi-Year Funding drugmonkey.wordpress.com/2025/09/09/a...

"Here, investigators discuss current and developing methodologies to study human immunity, and the importance of thoughtful experimental design and sample collection for advancing the frontier of immunology research." #Immunology 🧪

Updated update I downloaded the data from NIH Reporter too soon. The large end of the month update had not occurred. Here are the results as of this morning. NIH grants management staff have been busy making awards. 1/2

New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below: www.jobs.manchester.ac.uk/Job/JobDetai... www.bmh.manchester.ac.uk/research/ins...

“David Baltimore, a biologist who in 1975 won a Nobel Prize for a startling discovery that seemed to rock the foundations of the fledgling field of molecular biology, died on Saturday at his home in Woods Hole, Mass. He was 87.”🧪🩺

New #immunology #preprint fm Roham Parsa, @danmucida.bsky.social et al: TRACK (Tracking Recently Activated Cell Kinetics) mice, "a dual-recombinase fate-mapping system that enables precise spatial and temporal labeling of recently activated CD4⁺ T cells." www.biorxiv.org/content/10.1...

Good news. The House of Representatives stands behind the NIH budget with no cuts.

mRNA technologies: Unlimited potential to improve human health. I spoke with the fantastic Erin Shumaker at POLITICO to discuss this topic and its applications to cancer, autoimmunity and beyond. @erinlschumaker.bsky.social @politico.com @cornertx #mRNA #Cancer politi.co/3VjfRvu

I have NIGMS R35, impact score 12 NIHGRI R21, 4th percentile NHGRI R01, 7th percentile (co-I) and it seems like none will be funded. 0/3. PO (who has been very helpful) said "Unfortunately, I do not expect this application will be selected for funding in FY25." 😭

Check out this beautiful and comprehensive review by Juan Diego and Michael Schotsaert about "Helminth infections affect host immune responses to viral infections and vaccines" in ‪FemsMicroReview. #TrainedImmunity @jgbd.bsky.social @mschotsaert.bsky.social academic.oup.com/femsre/advan...

🚨 New Publication!!! I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”. www.cell.com/cell-reports... [1/4]

Preprint: A short-course of low dose IL-2 expanded Tregs and achieved an almost 50% viable pregnancy rate in a high-risk population of women with unexplained recurrent early pregnancy loss (NCT03970954) www.researchsquare.com/article/rs-7...

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...

Pandemic preparedness in the US has been leveled a crippling blow with the cancellation of multiple #BARDA contracts to help develop mRNA vaccines. No other vaccine platform produces vaccine so quickly; without mRNA, Americans will have a long wait for pandemic vax. www.statnews.com/2025/08/05/m...

“The Florida Department of Health is warning about the risks of drinking raw, unpasteurized milk after 21 people, including six children under the age of 10, were sickened by E. coli and campylobacter bacteria linked to raw milk from the same farm. Seven people have been hospitalized”

Congratulations @kottonnelson.bsky.social!!! 🎉

Check out this beautiful paper from Isaac Chiu lab, with some contributions from our lab. www.science.org/doi/10.1126/... @khannakm.bsky.social

#WeekendRead! #LiveForever & #MicrobiotaPower! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature #inflammaging by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer! doi.org/10.1126/scii...

HR=170

‘Congress has your back’: US senators tell scientists they want to protect NIH budget www.nature.com/articles/d41...

BIG NEWS: “Senate appropriators on Thursday approved an FY26 Labor-HHS bill that included a slight bump in funding for the NIH, with a strong 26–3 bipartisan vote.” Thank you to members of the Senate Appropriations Committee on both sides of the aisle! www.axios.com/pro/health-c...

Per a question to the chair from Senator Durbin: $400 M increase in the bill.

Why do only certain molecules drive allergies? A feature now identified among some allergy-causing proteins is their ability to form pores in cells. @nature.com www.nature.com/articles/d41... www.nature.com/articles/s41...

I’m excited to announce that our paper, describing early and opposing roles for neutrophils and CD4 T cells in determining #TB lesion structure, is out at @jem.org ! Huge thanks to my lab, and the Urdahl, @michael-gerner.bsky.social, and Aitchison labs who made this possible doi.org/10.1084/jem....

🧪🩺

'In 1981, Dr. Rutter and two University of California colleagues founded the Chiron Corporation in Emeryville, Calif. Along with the South San Francisco start-up Genentech, it established the Bay Area as the country’s biotech capital, a counterpart to the computing boom in Silicon Valley.'

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more. Kudos to Joon Choi for his exceptional work. royalsocietypublishing.org/doi/10.1098/...

“[Vought’s] footnote stipulated that the agency’s funding for the remainder of the fiscal year could only go to staff salaries and expenses, not to new grants or certain grants that are up for renewal. Most NIH-funded research is done by outside scientists at labs across the country.” no words

Review @natimmunol.nature.com The immunology of asthma www.nature.com/articles/s41...

“The Senate Committee on Appropriations is scheduled to release its proposal for NIH’s 2026 budget later this week…The committee could include language that would prohibit the multiyear funding plan or extend the timeline for the transition.”🧪

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social Here is a short paper thread. #tuberculosis #macrophages 🦠 www.biorxiv.org/content/10.1...

My take home from reading this is the same as my old paper - feral and adult T cells are fundamentally different and comparing individual features is difficult.. pubmed.ncbi.nlm.nih.gov/21164017/

In today's issue of Cell-->if you are looking for a good distraction from the news (who isn't), check it out! www.cell.com/cell/fulltex...

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

Multi-year funding at NIH: The Quickening drugmonkey.wordpress.com/2025/07/23/m...

High probability forecast that most agencies will be operating under a CR for FY26. This is difficult to reconcile with what is currently happening at NIH, NSF, etc. Huge disconnect between appropriations and political governance that your reps need to hear federalbudgetiq.com/insights/fy2...

These members of the NIH Council of Councils are voicing serious concerns about NIH grant terminations, restructure, and budget cuts go.nature.com/46Vr8t2

EXCLUSIVE @science.org: In an unorthodox approach to needle-free vaccines, researchers have developed a special kind of floss that can protect against infectious disease. “The results are quite impressive.” Cool story by @annikainampudi.bsky.social