Excited to share our new paper in @mucosalimmunol.bsky.social ! How do CD4 T cells behave directly inside inflamed intestinal tissue in IBD? Find out below 🧵! paper: sciencedirect.com/science/arti...

"Despite years of failure...doubts about what I was doing with my life...years of lackluster results...my PhD research is not a complete waste" Max's story of how we got checkpoint inhibitors should inspire any PhD worried their work's going nowhere theimmunebeyond.substack.com/p/a-brief-hi...

In a phase 3, randomized trial involving children with achondroplasia (3 to 17 years of age), once-daily oral infigratinib for 1 year significantly increased the annualized height velocity as compared with placebo. Full PROPEL 3 trial results: https://nej.md/4w8vTJc #ICCBH2026

3D reconstruction reveals highly conserved vascular network architecture despite phylogenetic diversity spanning >300M years of evolution. Moer here: www.biorxiv.org/content/10.6...

If you’ve built DNA-barcoded antibody panels, you know the pain: every barcode means another conjugation. In our new preprint we introduce UnO, which transforms antibody conjugation problem into a universal barcode conversion workflow, enabling rapid panel generation. www.biorxiv.org/content/10.6...

"Thus, PD-1 signaling is not simply a brake. It also preserves stemness...therapies such as interleukin-7 that restore or stabilize these renewable compartments may extend the long-term benefit of checkpoint inhibition." 🧪🩺

Reminder — UW #Microbiology has an open search for an Assistant Professor, focusing on fundamental problems in #bacteriology! If you or someone you know would be suitable, here's the ad: apply.interfolio.com/185622

Over the last month I saw that human editors are now stripped of control. I could no longer stop the system from auto-inviting "reviewers" with zero relevant expertise. Even worse - the AI began actively revoking the invitations I manually sent out to actual, qualified experts.

ICYMI, Hopkins will provide $280M in mid-size and large grants to support faculty for 2 years (1) $160M for all life scientists (from basic to bioengineering, from policy to translation) (2) $120M for all science and engineering. This cannot replace federal funding, not even close, but it helps.

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

I am BEYOND thrilled to share my article for Public Health mag: Baltimore has cut its homicide rate by almost 60% (!!!!) by supporting those most at risk of suffering from or committing gun violence. Other cities, take note: magazine.publichealth.jhu.edu/2026/baltimo...

"Kaminski, Naji and their colleagues have since treated four more people with CAR-T therapy, one of whom received a transplant last month after waiting 20 years for a donor kidney. The team expects to enrol another four people by the end of this year."🧪🩺

After the catch-up in testing, the number of new daily cases has stayed near 20/day. Not rising is a really good thing.

The molecular biology KJV:

A lot of anti-vaccine rhetoric accelerated during the pandemic - but for one anti-vax mom, it was a turning point back to vaccines. Loved this interview with Heather Simpson and @aboutpediatrics.bsky.social! www.wbur.org/hereandnow/2...

Can I use this opportunity to recommend a well-reviewed book on the history of our attempts to understand, explain, treat and prevent lung cancer? academic.oup.com/shm/article-...

This is very cool "Although β-arrestins interact with a wide array of signalling effectors at many GPCRs, it is unclear how β-arrestins promote such varied functions. Here we show that β-arrestins undergo liquid–liquid phase separation, forming condensates that regulate GPCR function."🧪

Spoiler alert: it wasn't. 'Shinya Yamanaka didn’t want to get ahead of himself the first time he looked at induced pluripotent stem cells (iPSCs) through a microscope. “Don’t be excited,” he told his colleague Kazutoshi Takahashi. “There’s a 99.9% chance this is a mistake,” said Yamanaka'

Dravet syndrome is a rare, often fatal form of childhood epilepsy. Exciting new research from #HHMIInvestigator David Liu & collaborators found that a single dose of base editing can correct its underlying mutation in mice, reducing seizures & extending survival: bit.ly/4nLvIAM.

“Where were we? Oh, yes, in the Pit of Despair.”

Paper drop where we question the mechanism of action of sotatercept. Think this will only get more important as the drug does lots of interesting things. pubmed.ncbi.nlm.nih.gov/42160453/

Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

'We primarily do comparative analysis using human stem cells/organoids and genetically modified mouse models, with some minor use of frog models. We use this approach because, for developmental anomalies, it is impossible to assess true function without in vivo models' @karenjliu.bsky.social

“Evidence suggests that the Bundibugyo virus has been spreading for around two months, WHO officials said at the briefing.”🧪🩺

The MOSAIC swiss army knife microscope (its previous name) has been published in @natmethods.nature.com: www.nature.com/articles/s41...

Okay this is very cool “Here we describe computational de novo design methods and a high-throughput “receptor diversion” microscopy-based screen for generating GPCR binding miniproteins with high affinity, potency and selectivity.”🧪

Important to read the seminal paper on the discovery of the Bundibugyo virus. It is a different species from Zaire Ebola virus, differing in its genome by up to 32%. The vaccines and monoclonal antibodies for Zaire virus are unlikely to be effective here. journals.plos.org/plospathogen...

A figure from the now famous "Super-spreaders" #hantavirus NEJM paper1️⃣ by the well-published Martínez. After adding Z score, colour & re-sorting Supplementary Appendix 2; the earliest sample's viral load doesn't reliably predict later severity. Also seen in RT-qPCR paper the authors cite2️⃣

'This approach bypasses the need for screening multiple founders for faithful TCR expression, enhancing the versatility & utility of monoclonal TCR mice in basic immunology & preclinical research, such as in the fields of cancer immunotherapy & vax development' Fm Angelina & Johanne @embojournal.org

"we enhance proteostasis via ligase overexpression in combination with checkpoint blockade to boost the efficacy of adoptive cell therapy. Together, these data demonstrate the role of proteostasis in T cell exhaustion and identify a promising avenue for advancing immunotherapy." #Immunology 🧪🩺

Some people are still struggling with manuscript cover letters. Here's my quick guide: onisillos.substack.com/p/demystifyi...

Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS

Type 2 conventional dendritic cells and regulatory T cells form a barrier tissue circuit to control allergic inflammation https://www.biorxiv.org/content/10.64898/2026.05.04.722795v1

Who would have thought 30 yrs ago that there would be > 50 inborn errors of immunity underlying atopy ? This has been the most insightful study of allergy: Primary atopic disorders: Monogenic insights into immunity rupress.org/jhi/article/...

Delighted to share the first preprint from our lab. Here, we define a cDC2-Treg feedback circuit within a barrier tissue that restrains effector Th2 cell expansion, revealing a novel role for tissue cDC2s in controlling Th2 cell biology. #Immunology Congrats to @jmannion.bsky.social and team.

The Cimini lab is hiring for both postdocs and interns! The postdoc role will cover bioimage analysis projects and educational material creation; the intern will be working on our Bilayers project for helping distribute and access deep learning tools for bioimage analysis. Click below to learn more!

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

“Despite the small numbers, evidence that some patients are getting better — and that others are not getting worse — is generating excitement and optimism for people with a disease that diminishes the ability to walk, speak and breathe, often killing patients within five years.”🩺🧪

“when Academic Medical Centers no longer fulfill their four-part mission of providing advanced care, serving as a safety net, advancing medical research, and educating new physicians, they risk losing the trust and grace society and their local communities have granted them” 🩺

Excited to share our paper out today in @science.org! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4) www.science.org/doi/10.1126/...

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This resonates with me as an author, reviewer, mentor, and editor: Science is always unfinished: rethinking the demand for complete stories @cp-trendsbiochem.bsky.social www.cell.com/trends/bioch...

Today is the #DayOfImmunology 🧬 This year’s theme is all about the #RegulatoryT cell, the immune system’s “guardians of balance”. Read this blog to learn about the Nobel Prize winning discovery by Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell - vist.ly/428q6

People seem pretty upset about this #onhere but as someone who works in this hood and bikes most days, this is more functional as a bike lock than the median commenter seems to think. Also I get a dad-joke chuckle out of it as a bicyclic bicycle lock (a bicycle to which you can lock your bicycle 🥁)

If you want to learn more about cytokine delivery to modify the lung immune environment, but don't have time to read our full paper at @sciimmunology.bsky.social, here is a short (5 minute) explainer! youtu.be/fcIiIYNC-2s www.science.org/doi/10.1126/...

Check out the latest from Eric Dang's lab. @ragoninstitute.bsky.social @harvardmed.bsky.social @jem.org @rupress.org rupress.org/jem/article-...

The truly stunning part of this marathon WR is his final full 5K split from 35-40K. 13:42 🤯 That wins most major 5K races

“In 2021, a disabled parrot named Bruce made headlines worldwide for creating his own prosthetic beak. He didn’t stop there: Scientists reported on Monday that Bruce has now become the alpha male of his group.” 🧪

Central dogma* 🧪

I'm looking for #NewPIs (<3 years as lab heads) in the gene regulation/functional genomics space. If you are one or know one, please comment below! 🧪