My ask of any science enthusiasts who tell the story of Rosalind Franklin: Don't make her life be about the DNA debacle. She died far too young, but she was a promising scientist in her own right, a mentor and scientific author. Not for Watson or Crick, but for her legacy.

And here's a YouTube link. www.youtube.com/watch?v=Oj0P...

I helped make a film, out this week, called “Rovina’s Choice,” about the deaths this man without conscience or accountability has caused — already 600,000, ⅔ of them children.

Multi-Year funding analysis, a 🧵 I have been trying to find a robust way of quantifying and understanding multi-year (forward funding). First, some background: Most NIH grants are for multiple years (2 to 5, typically). However, the are usually funded on an annual basis. 1/18

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Literal insanity that a company that made a product that saved millions of lives just a few years ago could go out of business www.statnews.com/2025/10/30/m...

Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells. www.embopress.org/doi/full/10....

Review @cp-immunity.bsky.social Human immune aging www.cell.com/immunity/ful...

'Upon attending a Baltimore scientific group meeting in 1988, at which the cloning of the immunoglobulin recombinase-activating gene RAG1, characterization of (IκB) & critical functional attributes of the c-ABL & BCR/ABL proteins were presented, sabbatical scientist Harold Varmus emerged gobsmacked'

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

“Contrary to the prevailing paradigm of fetal immune quiescence, we uncover widespread memory/activated T cells and tissue-resident memory clones shared across organs, indicating systemic immune activity beyond localized barrier defense.”

🧪#Immunology

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

#WeekendRead! #InterferonPower! Lin, Sayour, Grippin &co show @nature.com that SARSCoV2 #mRNAvaccines potentiate in cancer patients & mouse models immune checkpoint blockade anti-tumor therapy thanks to increased type I interferon signaling! www.nature.com/articles/s41...

Such a clever and impactful idea “And you don’t have to convince people they need it,” she added. “It takes into account the local practices, that people are already wearing their babies and laying them to sleep in the same cloth.”🧪🩺

Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Review @natimmunol.nature.com Antigen-presenting cells as arbiters of mucosal tolerance and immunity www.nature.com/articles/s41...

Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...

BREAKING: Some of the layoffs at CDC are being REVERSED. Here is my updated story. www.washingtonpost.com/health/2025/...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this. www.science.org/doi/... 1/9

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

“Dr Ramsdell, whose phone had been on airplane mode when the Nobel committee tried to call him, told the BBC's Newshour Programme that his first response when his wife said, ‘You've won the Nobel prize’ was: ‘I did not.’”🧪🩺🤣

PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program kcl-mrcdtp.com/project/deco... Applications opening soon! #gdTcells #IBD #gut #organoids

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Beautiful paper, worth a read, lots of #TCR work -of course I am biased as I love #TCRs www.science.org/doi/10.1126/...

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91. Gift link: nyti.ms/48FOuUn

Canaries were used in coal mines MUCH more recently than you might think (1986!), but I have a really neat artifact to share with you & I hope it brightens your day. Canaries were used as indicators for clear & odorless carbon monoxide (CO) gas that was a hazard to human health in deep coal mines.

The fiscal year ends tomorrow. Here are results from NIH Reporter downloaded an hour ago. The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors. 1/3

It’s #MucosalMonday and time for a new podcast episode! This month, @lakmalisilva.bsky.social discusses the oral mucosa with @marionbrunck.bsky.social. Plus medical mysteries with @ashu-mangalam.bsky.social and how RSV can impact the microbiota with @kknoop.bsky.social www.iheart.com/podcast/269-...

It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!

If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping www.biorxiv.org/content/10.1...

“we leveraged new data and measures to consider an alternative history: If the permanent NIH budget had been 40% smaller, how would that have affected the medicines we enjoy today? Results suggest that such large cuts could affect a large share of drug approvals.”🧪🩺

"An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients...Prof Tabrizi says this gene therapy 'is the beginning' and will open the gates for therapies that can reach more people."🧪⚕️

Perspective @cp-immunity.bsky.social A roadmap for defining “extrafollicular” B cell responses www.cell.com/immunity/ful... @stephanieeisen.bsky.social @vinuesalab.bsky.social et al

Great piece by the Alegre lab "it is clear that tolerant CD4 T cells cannot be classified as simply anergic or exhausted...we propose a framework in which the cell states adopted by CD4 T cells in the aforementioned conditions represent a spectrum of closely related tolerogenic states" #Immunosky

We now have a very exciting technician post advertised as part of our long term Wellcome Trust funded team investigating the role of the glycocalyx during CNS inflammation. Supporint the lab, developing glycan analysis and research experience www.jobs.manchester.ac.uk/Job/JobDetai...

'For decades, no intervention had put a dent in elevated levels of sweat chloride (...) Within days to a few weeks after the start of ivacaftor treatment, sweat chloride levels fell dramatically, with a purge of expectorated respiratory mucus and a corresponding gain in lung function.'

Happy to share the first pre-print of the lab! 📢 💡Do you want to know how CD4 T cells decide their fate? We used a mouse vaccination model to trace endogenous polyclonal CD4 T cells on their journey towards Th1 or Tfh differentiation. www.biorxiv.org/content/10.1...

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

It gives me great pleasure to present the latest from our lab, outlining a curious cellular and molecular pathway that limits thymic regeneration after acute insult. www.nature.com/articles/s41...

Lasker Award for clinical medicine to Welsh, Gonzalez, and Negulescu for CFTR modulator therapy. Truly transformative for people with CF. The Lasker foundation has a great summary of their work below 🧪⚕️

Plasmacytoid dendritic cells can transition to become cDC2s under to influence of TNF, while type-I interferon reduces TNFR expression and thereby inhibits transition. These transitioned cDC2 seem fully functional. 🧪 ⑂ Hornero et al 2025 in Nat Immunol www.nature.com/articles/s41...

Adding up the NIH R01s lost to Multi-Year Funding drugmonkey.wordpress.com/2025/09/09/a...

"Here, investigators discuss current and developing methodologies to study human immunity, and the importance of thoughtful experimental design and sample collection for advancing the frontier of immunology research." #Immunology 🧪

Updated update I downloaded the data from NIH Reporter too soon. The large end of the month update had not occurred. Here are the results as of this morning. NIH grants management staff have been busy making awards. 1/2