A figure from the now famous "Super-spreaders" #hantavirus NEJM paper1️⃣ by the well-published Martínez. After adding Z score, colour & re-sorting Supplementary Appendix 2; the earliest sample's viral load doesn't reliably predict later severity. Also seen in RT-qPCR paper the authors cite2️⃣

'This approach bypasses the need for screening multiple founders for faithful TCR expression, enhancing the versatility & utility of monoclonal TCR mice in basic immunology & preclinical research, such as in the fields of cancer immunotherapy & vax development' Fm Angelina & Johanne @embojournal.org

"we enhance proteostasis via ligase overexpression in combination with checkpoint blockade to boost the efficacy of adoptive cell therapy. Together, these data demonstrate the role of proteostasis in T cell exhaustion and identify a promising avenue for advancing immunotherapy." #Immunology 🧪🩺

Some people are still struggling with manuscript cover letters. Here's my quick guide: onisillos.substack.com/p/demystifyi...

Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS

Type 2 conventional dendritic cells and regulatory T cells form a barrier tissue circuit to control allergic inflammation https://www.biorxiv.org/content/10.64898/2026.05.04.722795v1

Who would have thought 30 yrs ago that there would be > 50 inborn errors of immunity underlying atopy ? This has been the most insightful study of allergy: Primary atopic disorders: Monogenic insights into immunity rupress.org/jhi/article/...

Delighted to share the first preprint from our lab. Here, we define a cDC2-Treg feedback circuit within a barrier tissue that restrains effector Th2 cell expansion, revealing a novel role for tissue cDC2s in controlling Th2 cell biology. #Immunology Congrats to @jmannion.bsky.social and team.

The Cimini lab is hiring for both postdocs and interns! The postdoc role will cover bioimage analysis projects and educational material creation; the intern will be working on our Bilayers project for helping distribute and access deep learning tools for bioimage analysis. Click below to learn more!

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

“Despite the small numbers, evidence that some patients are getting better — and that others are not getting worse — is generating excitement and optimism for people with a disease that diminishes the ability to walk, speak and breathe, often killing patients within five years.”🩺🧪

“when Academic Medical Centers no longer fulfill their four-part mission of providing advanced care, serving as a safety net, advancing medical research, and educating new physicians, they risk losing the trust and grace society and their local communities have granted them” 🩺

Excited to share our paper out today in @science.org! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4) www.science.org/doi/10.1126/...

🧪🩺

This resonates with me as an author, reviewer, mentor, and editor: Science is always unfinished: rethinking the demand for complete stories @cp-trendsbiochem.bsky.social www.cell.com/trends/bioch...

Today is the #DayOfImmunology 🧬 This year’s theme is all about the #RegulatoryT cell, the immune system’s “guardians of balance”. Read this blog to learn about the Nobel Prize winning discovery by Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell - vist.ly/428q6

People seem pretty upset about this #onhere but as someone who works in this hood and bikes most days, this is more functional as a bike lock than the median commenter seems to think. Also I get a dad-joke chuckle out of it as a bicyclic bicycle lock (a bicycle to which you can lock your bicycle 🥁)

If you want to learn more about cytokine delivery to modify the lung immune environment, but don't have time to read our full paper at @sciimmunology.bsky.social, here is a short (5 minute) explainer! youtu.be/fcIiIYNC-2s www.science.org/doi/10.1126/...

Check out the latest from Eric Dang's lab. @ragoninstitute.bsky.social @harvardmed.bsky.social @jem.org @rupress.org rupress.org/jem/article-...

The truly stunning part of this marathon WR is his final full 5K split from 35-40K. 13:42 🤯 That wins most major 5K races

“In 2021, a disabled parrot named Bruce made headlines worldwide for creating his own prosthetic beak. He didn’t stop there: Scientists reported on Monday that Bruce has now become the alpha male of his group.” 🧪

Central dogma* 🧪

I'm looking for #NewPIs (<3 years as lab heads) in the gene regulation/functional genomics space. If you are one or know one, please comment below! 🧪

B lymphocyte protein factories produced by hematopoietic stem cell gene editing | Science www.science.org/doi/10.1126/...

Some day I’ll figure out how to work this into a talk

Hello world, it's a g̶i̶r̶l̶/̶b̶o̶y̶ PhD baby 🎉 Very elated, proud (and relieved!) to announce that my PhD work is now out in @science.org #ScienceImmunology 👇 www.science.org/doi/10.1126/... Read to find out how we made EGFR sexy again! 💃 Thanks to all involved @lloydlab.bsky.social 🙏

For those interested in T cell trafficking to the gut - maybe LPAM is not so dominant during enteric infection... www.biorxiv.org/content/10.6...

Fascinating work! 🧪🩺

This is wild -- JELLYFISH sleep! The reason is a good reminder why we all need consistent and restful sleep: "sleep arose early in animal evolution to help the first neurons repair themselves" www.science.org/content/arti...

“Ten years from now, if children are still dying of conditions we know how to correct, it will not be because the science wasn’t ready. It will be because we lacked the imagination to build a system worthy of it.”🧪🩺

😱 is this a new record ?? via @steveroyle.bsky.social

Awesome image from Artemis. Big!

Uh oh, @guardian, you should take a hint from a lesson @npr learned years ago. If you're going to use a "historical" image in a piece, make sure it actually relates to the history you're talking about. Your Black Death (plague) image is actually leprosy! www.theguardian.com/books/2026/a... 🗃️

RIP Tracy Kidder (November 12, 1945 – March 24, 2026)

If you know a graduating undergraduate looking for the chance to spend 1-2 years in a lab before graduate school, we're hiring! Our lab explores morphogenesis, defining how the cell adhesion & cytoskeletal machinery work together to allow cells to change shape & move tarheels.live/peiferlab/ 1/n RT

Abortive infection: T cells as early, antibody-independent defenders T cells can terminate infection before it is detectable by routine clinical assays, independently of antibodies. www.nature.com/artic... 1/3

One-month treatment for latent tuberculosis. Why aren't we using it? (Hint: We should.) voices.nejm.org/doi/full/10....

This is so, so well-articulated.

"But it could still bounce back, and efforts to eliminate it entirely face formidable challenges. How it spreads between cattle remains unclear. And although candidate vaccines look promising in early tests, farmers and the government may be reluctant to embrace them."🧪🩺

"our findings delineate antigen-specific CD4+ T cell fates in different courses of human viral infections, identifying stem-like subsets as potential immunotherapeutic targets and highlighting the need for tailored strategies to re-direct or boost CD4+ T cell responses." #Immunology 🧪🩺

While this will not have the level of detail that most critics would want, looky here at Princeton's page on the F&A rate by category. I've never seen even this level of description. h/t @jeremymberg.bsky.social finance.princeton.edu/budgeting-fi...

This is cool 🧪🩺 www.nature.com/articles/s41...

Great piece on the problems of corporatization in medicine "In a classic article, Nobel Prize–winning economist Kenneth Arrow argued that physician 'behavior is supposed to be governed by a concern for the customer’s welfare which would not be expected of a salesman.'"🧪🩺

#WeekendRead! #RemeberMe! @snaga13.bsky.social @jbuenrostro.bsky.social &co show @nature.com that intestinal stem cells remember multiple cycle of inflammation by epigenetically favoring AP-1 accessibility, thus increasing proliferation & repair, but also favoring tumorigenesis!

Now for new and competitive renewal awards. The number of awards through March 20th, 2026 is 1452 compared to 4008 in FY2023, 3741 in FY2024, and 2847 in FY2025. NIAAA and NLM have yet to make any awards. 576 R01s, 150 R35s, 259 R21s, 14 F30s, 34 F31s, 15 F32s, 32 K99s, 59 R00s 4/6

“In this study, prime editing of autologous CD34+ cells corrected the molecular defect in p47-CGD and restored neutrophil function to near-healthy levels in the two participants.”🧪🩺

David Botstein was one of the giants of genetics and genomics, and my mentor, colleague and friend for more than 40 years. I’m sad that he is gone, but his larger-than-life persona comes through here. www.nytimes.com/2026/03/20/s...

Sometimes you just get that shot. Anna's hummingbird with a little friend, in my yard. Davis, CA. #birds #ants

Still one of my all time favorites