@adamjrubin.bsky.social
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Excited to share our paper out today in
@science.org
! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4)
www.science.org/doi/10.1126/...
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Disordered protein LAT encodes relative levels of signaling pathways in T cell activation
The disordered adapter protein linker for activation of T cells (LAT) propagates T cell receptor signaling. To interrogate how LAT coordinates multiple downstream pathways, we developed a single-cell ...
https://www.science.org/doi/10.1126/science.ads6847
2 months ago
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reposted by
Ragon Institute of Mass General Brigham, MIT, and Harvard
2 months ago
New in Science from the Shalek Lab: a screen of 132 versions of the T cell protein LAT shows it keeps immune signals in balance. Disrupting any one part weakens all downstream pathways together, helping T cells avoid faulty responses.
https://ow.ly/zGLw50YOFFR
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