German press release: www.uk-erlangen.de/presse/press...

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social

New review in JCO Precision Oncology by the NEWTS group of the @euroewing.bsky.social consortium: Recurrent and Refractory Ewing #Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium ascopubs.org/doi/10.1200/... International collaboration is KEY for clinical trials!

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing #Sarcoma Proliferation and Migration advanced.onlinelibrary.wiley.com/doi/full/10....

New cell lines expanding the diversity of #Ewing #sarcoma models onlinelibrary.wiley.com/doi/10.1002/...

Very proud on our stellar doctoral student, Maxim Kafka, for being awarded with a Mildred-Scheel doctoral scholarship from the German Cancer Aid. Maxim is working @dkfz.bsky.social on a follow-up on our recent paper on #SMARCB1-deficient Epitheloid #Sarcoma onlinelibrary.wiley.com/doi/10.1002/...

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Big congratulations to @elialab.bsky.social who is an alumni of the lab! So well deserved!

NOA Researchers from 13 German sites led by a team from @uniheidelberg.bsky.social @Universitätsklinikum Heidelberg (UKHD) & @dkfz.bsky.social have successfully completed the multicenter study “NCT Neuro Master Match (N2M2)”.

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

Check out our updated preprint! Using functional #metabolomics, we link reduced EWSR1::ETS activity in Ewing #sarcoma to poor outcome and activation of the AHR pathway, which promotes immune evasion characterized by impaired NK cell function and immunoregulatory infiltrates. tinyurl.com/2b6cry3m

Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv! This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵 🔗 www.biorxiv.org/content/10.1...

High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas www.nature.com/articles/s41...

Great back-to-back papers in @natcomms.nature.com tinyurl.com/3dp98bke tinyurl.com/wy9ychb2 on MCL1 as a novel therapeutic target in CIC::DUX #sarcomas These cancers remain challenging (tinyurl.com/kz4h8rws) but these studies spark hope! Glad that our division @dkfz.bsky.social could contribute!

I’m very happy that @dfg.de supports our annual international meeting of the European Lipoprotein Club! eas-elc.org

Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏 @gscnoffice.bsky.social

🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab) Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience. Apply: jobs.dkfz.de/en/jobs/1679... #Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience

We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... 🧵 1/6

Very proud on our stellar Alina Ritter for her frist first-author paper: Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma tinyurl.com/3kcs3bc9 @dkfz.bsky.social @uniheidelberg.bsky.social @nct-heidelberg.bsky.social

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.08.07.669049v1

Exploration of oncogenic cooperation between germline variation and somatic mutation in #prostate cancer progression www.biorxiv.org/content/10.1...

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk #sarcomas www.nature.com/articles/s41...

Advancing #sarcoma diagnostics with expanded DNA methylation-based classification www.medrxiv.org/content/10.1...

I’m happy that research and development in Germany 🇩🇪 are striving - still so many things to do adopt an open and inclusive culture at German universities.

EWS::FLI1-DHX9 interaction promotes Ewing #sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism www.nature.com/articles/s41...

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing #sarcoma www.nature.com/articles/s41...

Der Patienten-Experten-Preis 2025 geht an Rudolf Hauke. 👏 Mit dieser Auszeichnung würdigt das DKFZ sein langjähriges und wegweisendes Engagement für die strukturierte Beteiligung von Patient:innen in der #Krebsforschung. Herzlichen Glückwunsch! @rudolfhauke.bsky.social t1p.de/wi4zt

Die Deutsche Forschungsgemeinschaft @dfg.de hat Aurélie Ernst in das Heisenberg-Programm aufgenommen, ein Förderprogramm, das sich an herausragend qualifizierte Wissenschaftler:innen richtet, die ihre Berufbarkeit auf eine Professur nachweisen können. Herzlichen Glückwunsch! 👏

ERC-Förderung für verbesserte Krebs-Immuntherapien: Fabricio Loayza-Puch und Chong Sun vom DKFZ erhalten schon zum zweiten Mal einen der begehrten "Proof of Concept" (PoC)-Grants. 👏 #ERCPoC @erc.europa.eu t1p.de/4mg2g

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

cIAP1 inhibitor of apoptosis (alias BIRC2) is a tumor suppressor in Ewing #sarcoma www.biorxiv.org/content/10.1... @dkfz.bsky.social @uniheidelberg.bsky.social @nct-heidelberg.bsky.social

Very excited to have joined the @mpi-ie.bsky.social ! Thank you for the warm welcome 🤩🤩

Congratulations to all @tum.de graduates from Freibierfest Freising - Free Beer Festival Freising 🍻 🎉 🍻

We have several open postdoc positions! We do computational biology 🧬🖥️ and deep learning to understand the genomics of genome instability and (somatic) genome evolution in ageing and cancer. Interested? 👉🏻 more details: tu-dresden.de/cmcb/biotec/...

🔥🔥🔥Check out our latest paper on the kidney, wonderful collaboration with Fabian Braun & Christine Kurschat @cecad.bsky.social. Read now: JCI Insight - Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage insight.jci.org/articles/vie...

This work is the result of a great international collaboration! Huge thanks to Darrell Green and Emma Bull for bringing together such a strong multidisciplinary team. Check out our review on paediatric bone sarcomas #PaedsOnc #SarcomaResearch molecular-cancer.biomedcentral.com/articles/10....

Da die @dfg.de ja bis heute in den meisten Verfahren nur zwei Gutachten einholt, bleibt Glück ein sehr wichtiger Faktor bei Entscheidungen - unbefriedigend, seine Karriere darauf zu verwetten!

1/ Spatial transcriptomics technologies are rapidly evolving. We compared five methods—Visium, RNAscope HiPlex, Molecular Cartography, Merscope, and Xenium—and developed technology-agnostic quality control metrics to guide their use: doi.org/10.1186/s130...

How do transcription compartments form — and does phase separation drive gene expression? I enjoyed discussing these questions with @akispapantonis.bsky.social a lot, and we put our thoughts together for @naturerevgenet.bsky.social, now out at rdcu.be/erP1u

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies www.nature.com/articles/s41...

🔬 New @natcomms.nature.com study by CeMM Adjunct PI @floriangrebien.bsky.social's team at CeMM, Vetmeduni Vienna & @stanna-ccri.bsky.social‬ uncovers how NUP98::KDM5A drives #AML via epigenetic rewiring—identifying CDK12 as a druggable target. ➡️ More: bit.ly/3Hm6dVa ➡️ Paper: go.nature.com/3H8eCM3

💡Research team finds CDK12 is a key vulnerability in AML with NUP98 fusions. New hope for targeted therapies in resistant childhood leukemia. Study by Vetmeduni, St. Anna CCRI @floriangrebien.bsky.social & @cemm-vienna.bsky.social in Nature Communications >>> www.nature.com/articles/s41...

Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish www.biorxiv.org/content/10.1... #sarcoma

Targeting metastasis in paediatric bone sarcomas molecular-cancer.biomedcentral.com/articles/10....

Link to full text (open access) www.nature.com/articles/s41...

EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.05.16.654502v1

EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.05.16.654502v1

It's been a long journey...but I finally got my board certification for Microbiology, Virology and Infection Epidemiology! What a fun ride - thanks to all my great mentors at @healthsciences.mcgill.ca 🇨🇦 & @lmumuenchen.bsky.social 🇩🇪!

Meet the people behind #CCE! 👩‍🔬 Today’s spotlight is on @priyachudasama.bsky.social from @nct-heidelberg.bsky.social @dkfz.bsky.social, part of CCE’s Rare Tumors Task Force. Discover more about her CCE journey in this interview👇 www.cancercoreeurope.eu/meet-priya-c...