Lowering LDL cholesterol to under 55 mg/dL cuts cardiovascular events by 31% in patients with atherosclerotic disease compared to 70 mg/dL. by Lee YJ, Lee SJ (...) Kim BK et 22 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2600283

Mezagitamab Elevates Platelet Counts in Chronic ITP, Showing Promise with Comparable Safety to Placebo by Kuter DJ, Miura K (...) Patwari P et 10 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2513120

Next-generation yellow fever vaccine vYF demonstrates similar immunogenicity and safety to licensed YF-VAX in Phase 2 trial. by Feroldi E, Mulligan MJ (...) Frago C et 18 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2505665

Older adults with past adenomas face higher colorectal cancer risk, yet competing non-CRC deaths overshadow surveillance colonoscopy's relevance. by Gupta S, Liu L (...) May FP et 15 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2847311

Key Indicators for Fluid Overload: Jugular Distention, BNP Levels, and Chest Imaging Enhance Diagnostic Accuracy by Drum B, La Course B (...) Liles EA et 5 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2845382

IL15-Activated Cytokine-Induced Killer Cells Show High Remission Rates After Allogeneic Transplants, Reducing Relapse in High-Risk Leukemia. by Rettinger E, Heckl D (...) Bonig H et 15 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01966

Monkeypox clade IIb lineage A.2.2 identified in the Republic of the Congo, highlighting urgent need for enhanced surveillance and public health response. by Koukouikila-Koussounda F, Kwe Yinda C (...) Roch Niama F et 14 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

FOXP3 and AIRE act as chromatin architects, using multimerization to fine-tune immune tolerance and gene expression programs. by Leng F, Huoh YS and Hur S in Nat Immunol #MedSky 👉 get more here 📖 read the article:

GLP-1 receptor agonists slash cardiovascular risks and slow renal decline in high-risk type 2 diabetes patients while promoting weight loss. by Rosen CJ and Ingelfinger JR in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMra2500106

CRISPR Gene Editing Normalizes Hemoglobin in Sickle Cell Patients; 27 of 28 Remain Vaso-Occlusive Event-Free Post-Treatment. by Hanna R, Frangoul H (...) Walters MC et 13 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2415550

Semaglutide cuts major cardiovascular events by up to 34% and significantly lowers liver fat in high-risk patients. by Meyhöfer SM, Cariou B (...) Kahn SE et 13 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Base editing with risto-cel improves sickle cell disease outcomes, showing rapid engraftment, high HbF levels, and reduced crises. by Gupta AO, Sharma A (...) Heeney MM et 23 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2504835

Metabolic surgery significantly reduces early kidney injury in obese youth with diabetes by blocking mTORC1 and JAK/STAT pathways. by Naik AS, Alakwaa FM (...) Bjornstad P et 38 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/198545

Angiography-guided FFRangio proves noninferior to pressure-wire guidance in reducing major cardiac events after PCI in patients. by Fearon WF, Jeremias A (...) Kirtane AJ et 25 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2600949

Time-restricted eating yields comparable weight loss to daily calorie restriction in women with PCOS, surpassing control group outcomes. by Corapi S, Runchey MC (...) Cienfuegos S et 12 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

AAV9 Gene Therapy in Type II GM1 Gangliosidosis Shows Safety Signals but Limited Clinical Improvement in Phase 1-2 Trial. by Lewis CJ, D'Souza P (...) Tifft CJ et 28 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2510935

Oncology Care Model Cuts Medicare Payments Modestly for Cancer Treatment but Results in $639 Million Loss Over Six Years. by Brooks GA, Trombley M (...) Keating NL et 9 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2846707

EHR interventions significantly boost deprescribing rates in older adults: precommitment led to a 40% increase over usual care. by Lauffenburger JC, Sung M (...) Choudhry NK et 9 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2844545

CD8⁺ T cell responses are regaining attention as potent tools for tackling viral infections and enhancing vaccine efficacy against HIV and COVID-19. by Appay V, Yamamoto T and Sáez-Cirión A in Nat Rev Immunol #MedSky 👉 get more here 📖 read the article:

Obesity rates in the US have soared to 42.5% of adults in 2022, projected to reach nearly 47% by 2035. by DeCleene NK, Kahn E (...) Roth GA et 5 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2844495

Caffeinated coffee and tea boost cognitive health, reducing dementia risk significantly, especially at moderate consumption levels. by Zhang Y, Liu Y (...) Wang DD et 10 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2844764

Azithromycin mass drug administration boosts gut antibiotic resistance, yet fails to impact nasopharyngeal resistance, necessitating careful AMR monitoring. by Doan T, Yan D (...) Lietman TM et 25 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Zolbetuximab with mFOLFOX6 and nivolumab boosts progression-free survival to 18 months in advanced CLDN18.2-positive gastric cancers. by Shitara K, Shoji H (...) Klempner SJ et 16 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

MAP4K2 hinders pancreatic cancer treatment by enhancing Treg differentiation, diminishing immune response and promoting tumor growth. by Chuang HC, Wang CW (...) Tan TH et 6 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/196379

BMSC-derived microvesicles rejuvenate enteric neural precursor cells, improving gastrointestinal function and countering diabetes-induced nerve damage. by Shi H, Yao H (...) Lin R et 8 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/192437

Targeting menopausal women with tailored AD prevention strategies could significantly reduce Alzheimer's risk and improve global health outcomes. by Mosconi L in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/199832

New insights challenge NSAID enteropathy theory; gut microbiome dysbiosis drives gastrointestinal injury more than COX enzyme inhibition alone. by Barekat K, Ghosh S (...) Ricciotti E et 19 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/190575

Olaparib trial reveals limited efficacy for DNA damage response mutations; overall response rate lags at just 6.1%. by Doroshow DB, Shapiro GI (...) Eder JP et 12 al. in Cancer #MedSky 👉 get more here 📖 read the article: https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.70332

Neoadjuvant immunotherapy improves outcomes for melanoma; urgent trials needed for cutaneous squamous cell carcinoma due to limited evidence. by Dessinioti C and Stratigos A in Cancer #MedSky 👉 get more here 📖 read the article: https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.70354

MK-8527, a new HIV-1 inhibitor, reduced viral load by over 1 log10 with single doses as low as 0.5 mg. by Carstens RP, Kapoor Y (...) Gillespie GL et 17 al. in Clin Infect Dis #MedSky 👉 get more here 📖 read the article: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag135/8522943

Cancer vaccines are gaining momentum, revealing key strategies to enhance efficacy and expand T cell responses against tumors. by Haanen JB, Schumacher TNM (...) Wu CJ et 2 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Elevated serum phosphorylated tau levels indicate potential diagnostic utility in distinguishing AL and ATTR amyloidosis from other neuropathies. by Kaeser SA, Schultz SA (...) Jucker M et 13 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Antibiotic use impacts gut microbiome diversity for years, with clindamycin and fluoroquinolones driving the most significant changes. by Baldanzi G, Larsson A (...) Fall T et 17 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Obesity drives 10% of annual cancer diagnoses in the U.S.; significant weight loss may lower associated cancer risk. by Shen S, Brown KA, Green AK and Iyengar NM in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2846256

Tumor-derived IFN reprograms macrophage niches, driving resistance to PARP inhibitors; targeting SPP1 could enhance treatment outcomes. by Liu D, Tao K (...) Gao Q et 19 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/199035

Immediate iFR-guided PCI does not outperform deferred MRI-guided PCI for nonculprit lesions in STEMI patients after three years. by Nijveldt R, Maeng M (...) van Royen N et 44 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2512918

Zorevunersen cuts convulsive seizures by up to 90% in children with Dravet syndrome, showing promise for long-term treatment. by Laux L, Sullivan J (...) Cross JH et 14 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2506295

Neoadjuvant GOLP significantly boosts event-free survival in high-risk intrahepatic cholangiocarcinoma, with manageable safety profile. by Shi GM, Huang XY (...) Fan J et 31 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2513918

Kidney biopsy is essential for diagnosing IgA nephropathy; early treatment can halt progression to kidney failure in at-risk patients. by Stoneman S, Teh JW and O'Shaughnessy MM in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2844446

FNDC4 gene alterations disrupt glutamatergic and GABAergic neuron development, potentially impacting alcohol use disorder treatment and brain function. by Zhu X, John AJ (...) Liu D et 22 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/193204

Fibroblasts drive T cell recruitment in atopic dermatitis, suggesting new therapeutic targets for managing this chronic inflammatory skin condition. by Numata T, Shia M (...) Gallo RL et 9 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/196108

SIRT2 deacetylates MRE11, enhancing its DNA binding and end resection, crucially influencing ATM-dependent DNA damage signaling. by Sesay F, Zhang H (...) Yu DS et 12 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/186711

BCMA CAR-T therapy achieves 100% minimal residual disease negativity in newly diagnosed multiple myeloma patients unsuitable for stem-cell transplantation. by Yan W, Du C (...) An G et 16 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01969

Trastuzumab deruxtecan slashes invasive disease recurrence risk in high-risk HER2-positive breast cancer, outperforming trastuzumab emtansine. by Loibl S, Park YH (...) Geyer CE et 27 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2514661

Prostate Cancer Guidelines Revamped: PCWG4 Update Unifies Terminology, Trial Designs, and Biomarkers to Enhance Patient Outcomes by Armstrong AJ, Morris MJ (...) Scher HI et 47 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-02834

Targeting LARP6 in hepatic stellate cells may offer a novel strategy to halt liver fibrosis linked to metabolic disorders and alcohol. by Kim HY, Mizrahi O (...) Brenner DA et 19 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/197923

Cancer programs significantly boosted smoking cessation assistance from 48% to 68%, highlighting rapid, effective integration into patient care. by Pu T, Burris JL (...) Mullett TW et 7 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01815

HPV vaccination dramatically cuts invasive cervical cancer risk, sustaining protection for over a decade, especially in school-based cohorts. by Wu S, Deng Y (...) Lei J et 5 al. in BMJ #MedSky 👉 get more here 📖 read the article: https://www.bmj.com/content/392/bmj-2025-087326

Lay health worker interventions cut emergency department visits by 53% and hospitalizations by 68% in older cancer patients. by Patel MI, Voskanyan M (...) Milstein A et 3 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2843478

Axitinib Boosts Progression-Free Survival in Advanced Neuroendocrine Tumors, Yet Primary End Point Remains Unmet by Garcia-Carbonero R, Benavent M (...) Capdevila J et 22 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-01808