#Trump says paracetamol in pregnancy causes autism. #RFK Jr. has long pushed similar myths about vaccines. Both ignore what decades of research show: 🔹 Autism is mostly genetic 🔹 Valproic acid (not paracetamol) is the real medication risk 🔹 Fear spreads faster than science

AI tools reveal 63 distinct behavioral patterns in epilepsy, enhancing understanding of seizure dynamics and SUDEP risks in mouse models. by Shen Y, Thomas J (...) Gu B et 6 al. in Ann Neurol #MedSky 👉 get more here 📖 read the article: https://onlinelibrary.wiley.com/doi/10.1002/ana.78032

Nine-marker signature unlocks key insights into lapatinib resistance, revealing new therapeutic targets for HER2-positive breast cancer. by Steggall J, Rajeeve V (...) Hayat A et 4 al. in Br J Cancer #MedSky 👉 get more here 📖 read the article:

Stressful life events elevate breast cancer risk, particularly among women born before 1950, potentially through epigenetic mechanisms. by Azzi E, Bode H (...) Kaprio J et 3 al. in Int J Cancer #MedSky 👉 get more here 📖 read the article: https://onlinelibrary.wiley.com/doi/10.1002/ijc.70154

AKT drives hepatocellular carcinoma by targeting TSC2 and GSK3, revealing new therapeutic strategies against this aggressive cancer. by Cui G, Zhou Y (...) Wang X et 21 al. in Cancer Res #MedSky 👉 get more here 📖 read the article: https://doi.org/10.1158/0008-5472.CAN-25-1615

YCMAP significantly reduces self-harm risk in adolescents after treatment, improving well-being and satisfaction in Pakistan's healthcare settings. by Husain N, Tofique S (...) Chaudhry N et 24 al. in BMJ #MedSky 👉 get more here 📖 read the article: https://www.bmj.com/content/390/bmj-2024-083272

Rwanda's Marburg virus outbreak reveals 23% mortality; rapid response and investigational therapies may have reduced fatality rates. by Nsanzimana S, Remera E (...) Rwagasore E et 64 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2415816

Microplastics infiltrate human tissue, raising urgent health concerns from immune dysfunction to reproductive and cardiovascular risks. by Lamoree MH, van Boxel J (...) van Duursen MBM et 4 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Targeting peroxiredoxin 2 effectively halts HCC development, enhancing liver function and curbing oncogenic signals in metabolic disease. by Crouchet E, Schaeffer E (...) Schuster C et 28 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/169395

NCD mortality declined in 80% of countries from 2010 to 2019, but improvements lagged behind earlier decadal progress. by None None in Lancet #MedSky 👉 get more here 📖 read the article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01388-1/fulltext

NHS Diabetes Prevention Program participants experience significantly lower rates of type 2 diabetes and associated long-term conditions at 24 months. by Barron E, Chappell P (...) Valabhji J et 14 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Groundbreaking cfDNA Fragmentomics Model Achieves 97.3% Sensitivity for Early Detection of Pancreatic Cancer, Paving Way for Intervention. by Yin L, Cao C (...) Jiang K et 30 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO.24.00287

Neoadjuvant nivolumab and relatlimab yield 80% event-free survival in advanced melanoma, revealing key biomarkers for treatment response. by Burton EM, Milton DR (...) Amaria RN et 25 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-00494

Type 2 diabetes escalates colorectal cancer risk and worsens survival, particularly in tumors with low immune cell infiltration. by Wankhede D, Halama N (...) Hoffmeister M et 2 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-25-00148

WHO analysis reveals stark disparities in global cancer trials, with high-income countries dominating and critical cancers largely overlooked. by Casolino R, Tatah L (...) Ross AL et 3 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

TMEM167A mutations trigger neonatal diabetes, microcephaly, and epilepsy, revealing their critical roles in pancreatic and neuronal function. by Virgilio E, Tielens S (...) De Franco E et 43 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/195756

ZEB1 drives chemo-immune resistance in pancreatic cancer; targeting it enhances therapy effectiveness, boosts immune response, and improves survival. by Zhang S, Hu Y (...) Liu M et 10 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/195970

Ebola vaccination during pregnancy safely boosts maternal and infant immunity without increasing adverse outcomes, strong potential for widespread use. by Nyombayire J, Ingabire R (...) Karita E et 17 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Aging transforms the tumor microenvironment, accelerating cancer progression through epigenetic changes that enhance driver mutations and malignancy risk. by Easwaran H and Weeraratna AT in Nat Rev Cancer #MedSky 👉 get more here 📖 read the article:

Amivantamab-lazertinib boosts overall survival to 60% over 3 years, surpassing osimertinib, despite higher severe adverse events. by Yang JC, Lu S (...) Cho BC et 53 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2503001

We're Eating Plastic, And It's Rewriting The Rules Of Human #Health How invisible fragments from our throwaway culture are infiltrating every meal—and what the science says about the consequences #microplastics

Thank you @llblue.bsky.social!

Distinct immune signatures identified in late-onset myasthenia gravis could pave the way for targeted therapies and biomarkers. by Roy B, Chen J (...) Kaminski HJ et 7 al. in Ann Neurol #MedSky 👉 get more here 📖 read the article: https://onlinelibrary.wiley.com/doi/10.1002/ana.78017

Albuminuria elevates cancer risk; higher urine albumin-to-creatinine ratio linked to multiple cancer types, eGFR shows no correlation. by Mok Y, Surapaneni A (...) Lees JS et 31 al. in Br J Cancer #MedSky 👉 get more here 📖 read the article:

Pridopidine fails to significantly improve function in early-stage Huntington’s disease, but shows promise in untreated patient subgroup. by Reilmann R, Feigin A (...) Hayden MR et 18 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Cholesterol-dependent cytolysins activate NLRP3 inflammasome by remodeling the trans-Golgi network, revealing new insights into bacterial virulence mechanisms. by Xiao N, Kogishi A (...) Chen J et 2 al. in Nat Immunol #MedSky 👉 get more here 📖 read the article:

Rise From Floor Velocity Emerges as Key Sensitive Measure for Becker Muscular Dystrophy in Long-Term Evaluation by Schrama EJ, Koeks Z (...) Niks EH et 11 al. in Neurology #MedSky 👉 get more here 📖 read the article: https://www.neurology.org/doi/10.1212/WNL.0000000000214071

Monoclonal antibodies drive heparin-induced thrombocytopenia, revealing new insights for diagnostics and targeted treatment strategies. by Treverton J, Arnold DM (...) Nazy I et 7 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2507175

Single 2.4 million-unit dose of benzathine penicillin G effectively treats early syphilis, matching three-dose regimen's serologic success. by Hook EW, Dionne JA (...) Newman LM et 12 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2401802

Single doses of MM120 significantly reduce anxiety in patients with moderate to severe GAD, especially at 100 and 200 µg levels. by Robison R, Barrow R (...) Fava M et 9 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2838505

Neutrophil UBA1 depletion triggers VEXAS-like autoinflammatory disease in mice, revealing key insights for understanding this syndrome's mechanisms. by Dong G, Liu J (...) Cai Z et 13 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/193011

Lupus nephritis inflammation mapped into distinct subgroups, revealing unique immune cell trajectories that could guide personalized therapies. by Casella G, Torcasso MS (...) Clark MR et 10 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/192669

High-risk localized prostate cancer features a targetable HER2-high, AR-low subpopulation resistant to ADT, paving the way for novel therapies. by Wilkinson S, Ku AT (...) Sowalsky AG et 28 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/189900

Up to 40% of men over 50 experience lower urinary tract symptoms, but effective treatments can significantly enhance quality of life. by Wei JT, Dauw CA and Brodsky CN in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/article-abstract/2836455

P2Y12 Monotherapy Cuts Bleeding Risk While Maintaining Cardiovascular Safety After PCI in Low-Risk MI Patients by Tarantini G, Honton B (...) Cayla G et 22 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2508808

Aspirin use in high-risk coronary syndrome patients increases cardiovascular events and major bleeding, leading to early trial cessation. by Lemesle G, Didier R (...) Cayla G et 17 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2507532

Immediate complete revascularization for STEMI patients doesn’t outperform staged revascularization, raising questions about clinical guidelines. by Kim MC, Ahn JH (...) Ahn Y et 25 al. in Lancet #MedSky 👉 get more here 📖 read the article: https://www.thelancet.com/retrieve/pii/S0140673625015296

Intensive blood pressure control reduces cardiovascular events but slightly increases adverse effects, yielding a modest net clinical benefit. by Guo X, Sun G (...) Sun Y et 21 al. in Lancet #MedSky 👉 get more here 📖 read the article: https://www.thelancet.com/retrieve/pii/S0140673625013911

Discontinuing anticoagulants post-catheter ablation for AF significantly reduces stroke and bleeding risk compared to ongoing treatment. by Kim D, Shim J (...) Joung B et 20 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2838294

AI-powered EyeFM copilot boosts ophthalmologists' diagnostic accuracy by 17% and self-management compliance by 21% in high-risk patients. by Wu Y, Qian B (...) Sheng B et 71 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Histamine H1 receptor inverse agonists like cyproheptadine significantly reduce osteoarthritis pain and tissue damage in mouse models. by Kurakazu I, Olmer M (...) Lotz MK et 5 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/183588

Fibroblast proliferation fuels pulmonary fibrosis; targeting it may offer new therapeutic avenues for treatment and lung function rescue. by Molina C, Tsukui T (...) Sheppard D et 5 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/191826

Smooth muscle lncRNA CARMN boosts angiogenesis in chronic limb ischemia via miR-143-3p and Hedgehog signaling; a novel target identified. by Zhai M, Jamaiyar A (...) Feinberg MW et 13 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/188559

Global research lags behind shifting disease burdens, risking a widening gap unless strategic investments and coordination are prioritized. by Schmallenbach L, Bley M (...) Lerchenmueller MJ et 3 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

Disparities persist in systemic therapy access for Black and Hispanic Medicare cancer patients, affecting survival rates and outcomes. by Lin JK, Niu J (...) Doshi JA et 12 al. in J Clin Oncol #MedSky 👉 get more here 📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-02440

MISSION Act significantly cut travel times for veterans seeking non-VA cardiovascular care but worsened 30-day outcomes for PCI and CABG. by Wu J, Kanter GP (...) Groeneveld PW et 10 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2837067

Incretin hormones distinctly regulate appetite; dual GIP and GLP-1 receptor agonism offers potent suppression of hunger-promoting AgRP neurons. by McMorrow HE, Cohen AB (...) Beutler LR et 6 al. in J Clin Invest #MedSky 👉 get more here 📖 read the article: https://www.jci.org/articles/view/186652

Melanoma rates soar; effective immunotherapies and targeted therapies dramatically improve survival and recurrence-free rates across stages. by Joshi UM, Kashani-Sabet M and Kirkwood JM in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2838001

Fall prevention program reduces self-reported falls by 30% among rural Chinese older adults, showing promise for broader implementation. by Peng J, Ye P (...) Tian M et 18 al. in JAMA #MedSky 👉 get more here 📖 read the article: https://jamanetwork.com/journals/jama/fullarticle/2838003

Genetically engineered pig lungs successfully transplanted into a brain-dead recipient, but immune rejection and infection pose significant challenges ahead. by He J, Shi J (...) Xu X et 24 al. in Nat Med #MedSky 👉 get more here 📖 read the article: