The @dkfz.bsky.social PhD Program is open, and the Mall Lab is recruiting PhD students. 1: in vivo and organoid models to study and treat autism associated disorders. 2: cancer cell plasticity in brain tumors using single cell genomics and perturbation screens. Apply now: www.dkfz.de/en/career/in...

Werden Sie Teil unseres Teams! Become part of our team! 💡Die Health + Life Science Alliance Heidelberg Mannheim sucht ab sofort in Vollzeit: 👩🏻‍🔬Referent∗in👨‍🔬 (w/m/d) Bewerbungen als PDF-Datei bis 30.11.2025 an: [email protected] adb.zuv.uni-heidelberg.de/info/INFO_FD... #job

Presenting recipients of our 2025 Stimulator Grant: 👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism. 🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social @dkfz.bsky.social

Looking forward to this collab with @moritzmall.bsky.social and Barbara Treutlein! We’ll generate high-throughput multi-modal CRISPR data on ASD risk genes in 🧠 organoids & assembloids, and build an ML model of gene regulation dynamics to analyze the data and enable future in silico experiments.

Since their discovery in 2004, the grid cells in the brain have been regarded as a kind of "GPS in the head." However, scientists at DKFZ and Heidelberg University Hospital have now shown that grid cells work much more flexibly than previously assumed. @nature.com Neuroscience t1p.de/hpj1m

🚨 Registration deadline for the EACR conference on #cancerneuroscience is September 15 ‼️ Please join us in beautiful Bilbao for exciting discussions on the dialogue between the nervous system and cancer 🔬🧠 See you soon!

‪GSCN 2025 Best Publication Award goes to B. Lim, @moritzmall.bsky.social, J. Zaugg, A. Kamal @biomedizin.unibas.ch for joint publication in @naturegenz.bsky.social All infos on www.gscn.org @dkfz.bsky.social @www.helmholtz-munich.de @embl.org @mdc-berlin.bsky.social @bihatcharite.bsky.social

Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏 @gscnoffice.bsky.social

🎉 Herzlichen Dank für den @gscnoffice.bsky.social-Preis „Publication of the Year 2025“ zu unserer @natgenet.nature.com Publikation: www.nature.com/articles/s41... Diese Auszeichnung ist echte Teamleistung—danke an alle Mitwirkenden. Auf zu den nächsten Schritten im Kampf gegen Krebs!

🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab) Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience. Apply: jobs.dkfz.de/en/jobs/1679... #Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience

We're seeking a PhD student passionate about ML, biology, and driving impact in healthcare! You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social. 👉 Project: www.helmholtz.de/assets/hidss... ✍️ Apply: hidss4health.de/application

Hands down the best meeting this year so far! Thanks for the fantastic organization @matlupien.bsky.social @shenhui1986.bsky.social Bonus was a musical finale - who said science cannot be fun :)

What keeps cancer cells in check—and can we tame them? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇 📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1... 📍 Regulatory logic: www.biorxiv.org/content/10.1...

13/ Want to learn more? Read our regulatory paper www.biorxiv.org/content/10.1... and companion spatial multi-omics study www.biorxiv.org/content/10.1... Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Thank you, @hlsalliance.bsky.social! Your backing lets junior teams like ours pursue fundamental, high-risk research to better understand cancer. Excited to keep advancing the frontiers together with many collaborations within the Alliance.

I am very grateful to @uniheidelberg.bsky.social and the Hella Bühler Foundation for this honour. Sharing the prize with the brilliant @venkataramanilab.bsky.social and our amazing teams makes me extremely proud. I am excited to channel this prize into the next wave of cancer-fighting ideas!

Ausgezeichnet für herausragende #Krebsforschung: Den mit 100.000 Euro dotierten diesjährigen Hella Bühler-Preis teilen sich Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, und Varun Venkataramani vom Universitätsklinikum Heidelberg. 👏 @moritzmall.bsky.social 👉 t1p.de/1dnqw

Vielen Dank für die große Ehrung und die starke Unterstützung durch das @dkfz.bsky.social , das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏🔬 #HellaBühlerPreis #TeamScience

Do you want to do your #postdoc in #cancerresearch with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses by May 19. Projects in #cellandmolecularbiology #genomics #bioinformatics #immunology #medicaltechnology, #epidemiology. Apply here: t1p.de/nx6tu

Warum sind #Tierversuche in der #Krebsforschung notwendig? Das erklärt Andreas Trumpp, Abteilungsleiter am DKFZ und geschäftsführender Direktor HI-STEM in diesem Video von @tvvde.bsky.social.

@michael-platten.bsky.social has been selected and nominated as Ambassador for the ERC network. The @erc.europa.eu & the @ercgrantees.bsky.social launched the new Ambassadors on 28 April. This joint initiative aims to promote investment in frontier research and highlight the importance of #research.

Jedes Jahr erkranken in Deutschland etwa 500.000 Menschen an #Krebs. Das Deutsche Krebsforschungszentrum (DKFZ) widmet sich als größte biomedizinische Forschungseinrichtung in Deutschland ganz der Aufgabe, #Krebsforschung zu betreiben.

Visit us at the #AACR25 in #Chicago, where we present #CancerResearch in Germany. 👩🏽‍🔬👨🏽‍🔬 🇩🇪 📍Exhibition at booth #842 from April 27 to 30 @nct-heidelberg.bsky.social @DKTK @theaacr.bsky.social

Movement for prevention, nature for inspiration 🌿🌍 Today's @dkfz.bsky.social Lunch Walk took us to the Botanical Garden—a perfect match for #EarthWeek and our goal to promote #CancerPrevention through regular activity. Thanks to all who joined! #DKFZgeht #HealthyWorkplace #Heidelberg

🚨 Postdoc position open! Join our organoid engineering team in Heidelberg to advance disease modeling & drug testing in cancer & brain disorders using AI, single-cell tech & assembloids. 🧠 5 yrs funding (CZS) 🌐 Apply: bit.ly/heidelberg-o... #Postdoc #Organoids #Neuroscience

Want to decode #cancer & #autism with organoids, stem cells & genomics? We’re hiring PhD students @dkfz.bsky.social via the fully funded International PhD Program! 🌍 Heidelberg 🔗 www.dkfz.de/en/career/in... #PhDopportunity #CancerNeuroscience #Genomics

Join us on April 4 at 11:00 for a @dkfz.bsky.social Distinguished Lecture by Filipe Pereira from @lunduniversity-med.bsky.social: "In Vivo Dendritic Cell Reprogramming for Cancer Immunotherapy" 📍DKFZ Lecture Hall, Heidelberg. Filipe is pioneering #cellreprogramming to evolve #cancer #immunotherapy.

The #iHOME2025 conference is off to a great start at @dkfz.bsky.social! We're excited for 2 days of organoid science from our speakers, like Barbara Treutlein, Max Reichert, Joep Beumer and @kimbakjensen.bsky.social. With @jackstadt-lab.bsky.social @moritzmall.bsky.social @kimboonekamp.bsky.social

Deadline Approaching (Mar 15)! @dkfz.bsky.social Clinician-Scientist Fellowships open for applications—study #autism & brain/liver #cancer by exploring cell fate plasticity. 2-year contract with protected research time. Apply now: www.dkfz.de/clinicianscientist #CancerResearch #Neuroscience #Autism

Just 2 days left to secure one of the last 5 spots for the “International Heidelberg #Organoid Meeting (#iHOME2025)” (20+21 March 2025) at @dkfz.bsky.social , powered by @proteintech.bsky.social, Cenibra, OLS @hlsalliance.bsky.social: indico.dkfz.de/event/1249/

Great piece about our upcoming rally in the Sun-Times by @neilsteinberg.bsky.social Meet the organizers behind Chicago's Stand Up for Science Rally #standupforscience #scienceforall @standupforscience.bsky.social chicago.suntimes.com/columnists/2...

Actually, not so rare at all! #RareDiseaseDay Affecting a substantial part of human kind! Support research on rare diseases! Picture from rarediseaseday.org

🎗️On #RareDiseaseDay, we raise awareness for #MYT1L Syndrome, a rare #autism-associated disorder disrupting brain development. Our research at DKFZ, ZI, and Heidelberg University Hospital shows an epilepsy drug may help—future trials ahead! 📑 www.nature.com/articles/s41... 🎥 youtu.be/nYqNEPIOc-8?...

It was great presenting our work from @dkfz, @hi_stem_lab and UKHD about the new PROTECT project to patients at the second Polyposis day.

Great news! Marisa Karow-Falk is now a tenured professor at FAU’s Medical Faculty in the Biochemistry Department. In her reseach, Marisa focuses on neurodevelopment and stem cells, and teaches biochemistry to medical students. Congratulations, Marisa! @fau.de

If you enjoyed our @naturegenet.bsky.social paper on how PROX1 safeguards hepatocyte identity, check out the behind-the-scenes Research Briefing—both free to read: Paper: rdcu.be/d9IFg Briefing: rdcu.be/eaLYL #CellPlasticity #CancerResearch

Only 1 week left to register for the International Heidelberg Organoid Meeting (iHOME) 2025, March 20–21! Don’t miss the keynote by @kimbakjensen.bsky.social (ReNEW Copenhagen) on guiding intestinal stem cell fate in health & disease. Register now: indico.dkfz.de/event/1249/ #Organoids #StemCells

Don’t miss #iHOME2025 on March 20–21 in Heidelberg! Keynote speaker Dr. Joep Beumer (Institute of Human Biology, Basel) will share how advanced #organoid engineering reveals intestinal cell states and functions. Register for this and more by Feb 28: indico.dkfz.de/event/1249/ #Organoids #Conference

Researchers at @uniheidelberg.bsky.social discovered that #PROX1 can block #CellFate plasticity in #hepatocytes, preventing #LiverCancer in mice. @aryankamal.bsky.social @moritzmall.bsky.social 📃 @naturegenet.bsky.social - go.nature.com/3D9AYuR 🎤 - bit.ly/4k42YAG

Thrilled to announce another #iHOME2025 (Mar 20–21) keynote: Maximilian Reichert @tum.de discussing “Mapping Tumor Cell States in Pancreatic Cancer with Advanced Organoid Technology.” Hear how organoid approaches reveal key cancer plasticity mechanisms! Register here: indico.dkfz.de/event/1249/

Join iHOME 2025 (Mar 20–21 in Heidelberg) for cutting-edge organoid research spanning basic to clinical science! One of many highlights is the keynote speaker, Barbara Treutlein, ETH Zurich, discussing using single-cell tech to map organoid development. Register by Feb 28: indico.dkfz.de/event/1249/

The February issue of @naturegenet.bsky.social is live! Featuring: ✅oncofetal reprogramming in CRC ✅multiancestry GWAS of prostate antigen levels ✅in vivo screening in Huntington’s disease ✅PERFF-seq profiling rare cell states ✅barley pan-transcriptome & more! ⬇️ www.nature.com/ng/volumes/5...

📢ONLINE @naturegenet.bsky.social 📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer. By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

#InternationalChildhoodCancerDay Support medical care and biomedical research for our vulnerable children worldwide! #Science #CancerResearch #ChildhoodCancer #OncoSky #Kinderkrebstag

So excited to announce that our study on the development and evolution of pallial cell types and structures in birds, led by @bassi-z.bsky.social, is now out in @science.org! www.science.org/doi/10.1126/...

In a collaborative study, Group Leaders Judith Zaugg (EMBL) and Moritz Mall (DKFZ) discovered a liver protein, called PROX1, that preserves cell identity and halts cancer formation in preclinical mouse models, paving the way for novel liver cancer therapies. 🧪 www.embl.org/news/science...

🔬 Key Regulators of Cell Fate Identified. Researchers from biomedizin.unibas.ch, embl.org & dkfz.bsky.social reveal that safeguard repressors like PROX1 can preserve cell identity & prevent liver cancer. Study by Aryan Kamal & Bryce Lim. 👉 🔗 www.nature.com/articles/s41... @naturegenet.bsky.social

#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology